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The Capital Region of Denmark - a part of Copenhagen University Hospital
  1. 2021
  2. E-pub ahead of print
  3. E-pub ahead of print

    Oxygenation targets in ICU patients with COVID-19: a post-hoc sub-group analysis of the HOT-ICU trial

    Rasmussen, B. S., Klitgaard, T. L., Perner, A., Brand, B. A., Hildebrandt, T., Siegemund, M., Hollinger, A., Aagaard, S. R., Bestle, M. H., Marcussen, K. V., Brøchner, A. C., Sølling, C. G., Poulsen, L. M., Laake, J. H., Aslam, T. N., Bäcklund, M., Okkonen, M., Morgan, M., Sharman, M., Lange, T., Wetterslev, J. & Schjørring, O. L., 23 Aug 2021, (E-pub ahead of print) In: Acta Anaesthesiologica Scandinavica.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published
  5. Published

    A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions

    Barbateskovic, M., Koster, T. M., Eck, R. J., Maagaard, M., Afshari, A., Blokzijl, F., Cronhjort, M., Dieperink, W., Fabritius, M. L., Feinberg, J., French, C., Gareb, B., Geisler, A., Granholm, A., Hiemstra, B., Hu, R., Imberger, G., Jensen, B. T., Jonsson, A. B., Karam, O., Kong, D. Z., Korang, S. K., Koster, G., Lai, B., Liang, N., Lundstrøm, L. H., Marker, S., Meyhoff, T., Nielsen, E. E., Nørskov, A. K., Munch, M. W., Risom, E. C., Rygård, S. L., Safi, S., Sethi, N., Sjövall, F., Lauridsen, S. V., van Bakelen, N., Volbeda, M., van der Horst, I., Gluud, C., Perner, A., Møller, M. H., Keus, F. & Wetterslev, J., Jul 2021, In: Journal of Clinical Epidemiology. 135, p. 29-41 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Assessment of assumptions of statistical analysis methods in randomised clinical trials: the what and how

    Nørskov, A. K., Lange, T., Nielsen, E. E., Gluud, C., Winkel, P., Beyersmann, J., de Uña-Álvarez, J., Torri, V., Billot, L., Putter, H., Wetterslev, J., Thabane, L. & Jakobsen, J. C., Jun 2021, In: BMJ Evidence-Based Medicine. 26, 3, p. 121-126 6 p., 111268.

    Research output: Contribution to journalReviewResearchpeer-review

  7. Published

    Considerations on the strengths and limitations of using disease-related mortality as an outcome in clinical research

    Jakobsen, J. C., Wetterslev, J. & Gluud, C., Jun 2021, In: BMJ Evidence-Based Medicine. 26, 3, p. 127-130 4 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  8. Published

    Carotid endarterectomy with patch angioplasty versus primary closure in patients with symptomatic and significant stenosis: a systematic review with meta-analyses and trial sequential analysis of randomized clinical trials

    Marsman, M. S., Wetterslev, J., Jahrome, A. K., Gluud, C., Moll, F. L., Keus, F. & Koning, G. G., 6 May 2021, In: Systematic Reviews. 10, 1, p. 139 139.

    Research output: Contribution to journalReviewResearchpeer-review

  9. Published
  10. Published

    Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

    Schjørring, O. L., Klitgaard, T. L., Perner, A., Wetterslev, J., Lange, T., Siegemund, M., Bäcklund, M., Keus, F., Laake, J. H., Morgan, M., Thormar, K. M., Rosborg, S. A., Bisgaard, J., Erntgaard, A. E. S., Lynnerup, A-S. H., Pedersen, R. L., Crescioli, E., Gielstrup, T. C., Behzadi, M. T., Poulsen, L. M., Estrup, S., Laigaard, J. P., Andersen, C., Mortensen, C. B., Brand, B. A., White, J., Jarnvig, I-L., Møller, M. H., Quist, L., Bestle, M. H., Schønemann-Lund, M., Kamper, M. K., Hindborg, M., Hollinger, A., Gebhard, C. E., Zellweger, N., Meyhoff, C. S., Hjort, M., Bech, L. K., Grøfte, T., Bundgaard, H., Østergaard, L. H. M., Thyø, M. A., Hildebrandt, T., Uslu, B., Sølling, C. G., Møller-Nielsen, N., Gøttrup Pedersen, U., Andreasen, A. S., Engstrøm, J., Kjær, M-B. N., HOT-ICU Investigators, Bertelsen Jensen, D., Mørk Sørensen, K., Sprogøe Rasmussen, P., Rovsing Hjortdal, A., Reiter, N., Clausen, N. E., Hein, L., Ibsen, M. & Sigurðsson, S. Þ., 8 Apr 2021, In: The New England journal of medicine. 384, 14, p. 1301-1311 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Effect of low vs. high haemoglobin transfusion trigger on cardiac output in patients undergoing elective vascular surgery: Post-hoc analysis of a randomized trial

    Møller, A., Wetterslev, J., Shahidi, S., Hellemann, D., Secher, N. H., Pedersen, O. B., Marcussen, K. V., Ramsing, B. G. U., Mortensen, A. & Nielsen, H. B., Mar 2021, In: Acta Anaesthesiologica Scandinavica. 65, 3, p. 302-312 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Higher vs Lower Oxygenation Strategies in Acutely Ill Adults: A Systematic Review With Meta-Analysis and Trial Sequential Analysis

    Barbateskovic, M., Schjørring, O. L., Krauss, S. R., Meyhoff, C. S., Jakobsen, J. J., Rasmussen, B. S., Perner, A. & Wetterslev, J., Jan 2021, In: Chest. 159, 1, p. 154-173 20 p.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Risk factors for long-term cognitive impairment in ICU survivors: A multicenter, prospective cohort study

    Collet, M. O., Egerod, I., Thomsen, T., Wetterslev, J., Lange, T., Ebdrup, B. H. & Perner, A., Jan 2021, In: Acta Anaesthesiologica Scandinavica. 65, 1, p. 92-99 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2020
  15. Published
  16. Published

    The Agents Intervening against Delirium in the Intensive Care Unit-Trial (AID-ICU trial):- a detailed statistical analysis plan

    Andersen-Ranberg, N., Poulsen, L. M., Perner, A., Wetterslev, J., Mathiesen, O., Mortensen, C. B., Estrup, S., Ebdrup, B. H., Hästbacka, J., Citerio, G., Caballero, J., Morgan, M. P. G., Oxenbøll-Collet, M., Weber, S-O., Andreasen, A. S., Bestle, M. H., Pedersen, H. B. S., Nielsen, L. G., Uslu, B., Jensen, T. B., Thee, C., Dey, N. & Lange, T., 1 Oct 2020, In: Acta Anaesthesiologica Scandinavica. 64, 9, p. 1357-1364 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published
  18. Published

    The PANSAID Randomized Clinical Trial: A pre-planned 1-year follow-up regarding harm

    Thybo, K. H., Hägi-Pedersen, D., Wetterslev, J., Overgaard, S. & Mathiesen, O., Aug 2020, In: Acta Anaesthesiologica Scandinavica. 64, 7, p. 910-912 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published
  20. Published

    Response

    Meyhoff, T. S., Møller, M. H., Hjortrup, P. B., Cronhjort, M., Perner, A. & Wetterslev, J., Jul 2020, In: Chest. 158, 1, p. 428-428

    Research output: Contribution to journalComment/debateResearchpeer-review

  21. Published

    The handling oxygenation targets in the intensive care unit (HOT-ICU) trial: Detailed statistical analysis plan

    Schjørring, O. L., Klitgaard, T. L., Perner, A., Wetterslev, J., Lange, T., Keus, F., Laake, J. H., Morgan, M., Bäcklund, M., Siegemund, M., Thormar, K. M. & Rasmussen, B. S., Jul 2020, In: Acta Anaesthesiologica Scandinavica. 64, 6, p. 847-856 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Lower vs Higher Fluid Volumes During Initial Management of Sepsis: A Systematic Review With Meta-Analysis and Trial Sequential Analysis

    Meyhoff, T. S., Møller, M. H., Hjortrup, P. B., Cronhjort, M., Perner, A. & Wetterslev, J., Jun 2020, In: Chest. 157, 6, p. 1478-1496 19 p., pii: S0012-3692.

    Research output: Contribution to journalReviewResearchpeer-review

  23. Published

    Eversion technique versus conventional endarterectomy with patch angioplasty in carotid surgery: protocol for a systematic review with meta-analyses and trial sequential analysis of randomised clinical trials

    Marsman, M. S., Wetterslev, J., Vriens, P. W. H. E., Bleys, R. L. A. W., Jahrome, A. K., Moll, F. L., Keus, F. & Koning, G. G., 19 Apr 2020, In: BMJ Open. 10, 4, p. e030503 e030503.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Arterial oxygen tensions in mechanically ventilated ICU patients and mortality: a retrospective, multicentre, observational cohort study

    Schjørring, O. L., Jensen, A. K. G., Nielsen, C. G., Ciubotariu, A., Perner, A., Wetterslev, J., Lange, T. & Rasmussen, B. S., Apr 2020, In: British Journal of Anaesthesia. 124, 4, p. 420-429 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial

    Granholm, A., Marker, S., Krag, M., Zampieri, F. G., Thorsen-Meyer, H-C., Kaas-Hansen, B. S., van der Horst, I. C. C., Lange, T., Wetterslev, J., Perner, A. & Møller, M. H., Apr 2020, In: Intensive Care Medicine. 46, 4, p. 717-726 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published
  27. Published

    Long-term patient-important outcomes after septic shock: a protocol for 1-year follow-up of the CLASSIC-trial

    Kjaer, M-B. N., Meyhoff, T. S., Madsen, M. B., Hjortrup, P. B., Møller, M. H., Egerod, I., Wetterslev, J., Lange, T., Cronhjort, M., Laake, J. H., Jakob, S. M., Nalos, M., Pettilä, V., van der Horst, I. C. C., Ostermann, M., Mouncey, P., Cecconi, M., Ferrer, R., L N G Malbrain, M., Ahlstedt, C., Hoffmann, S., Bestle, M. H., Gyldensted, L., Nebrich, L., Russell, L., Vang, M., Sølling, C., Brøchner, A. C., Rasmussen, B. S. & Perner, A., Mar 2020, In: Acta Anaesthesiologica Scandinavica. 64, 3, p. 410–416 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Benefits and harm of paracetamol and ibuprofen in combination for postoperative pain: preplanned subgroup analyses of the multicenter randomized PANSAID trial

    Thybo, K. H., Hägi-Pedersen, D., Wetterslev, J., Dahl, J. B., Jakobsen, J. C., Pedersen, N. A., Jakobsen, K., Bülow, H. H., Ibsen, L., Overgaard, S. & Mathiesen, O., Feb 2020, In: Acta Anaesthesiologica Scandinavica. 64, 2, p. 245-253 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Haloperidol for the treatment of delirium in critically ill patients: a systematic review with meta-analysis and Trial Sequential Analysis

    Barbateskovic, M., Krauss, S. R., Collet, M. O., Andersen-Ranberg, N. C., Mathiesen, O., Jakobsen, J. C., Perner, A. & Wetterslev, J., Feb 2020, In: Acta Anaesthesiologica Scandinavica. 64, 2, p. 254-266 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    Plexus anesthesia versus general anesthesia in patients for carotid endarterectomy with patch angioplasty: Protocol for a systematic review with meta-analyses and Trial Sequential Analysis of randomized clinical trials

    Marsman, M. S., Wetterslev, J., Keus, F., van Aalst, D., van Rooij, F. G., Heyligers, J. M. M., Moll, F. L., Jahrome, A. K., Vriens, P. W. H. E. & Koning, G. G., 2020, In: International Journal of Surgery Protocols. 19, p. 1-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. 2019
  32. Published

    DEBATE-statistical analysis plans for observational studies

    Hiemstra, B., Keus, F., Wetterslev, J., Gluud, C. & van der Horst, I. C. C., 9 Dec 2019, In: BMC Medical Research Methodology. 19, 1, p. 233 233.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Higher versus lower fraction of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit

    Barbateskovic, M., Schjørring, O. L., Russo Krauss, S., Jakobsen, J. C., Meyhoff, C. S., Dahl, R. M., Rasmussen, B. S., Perner, A. & Wetterslev, J., 27 Nov 2019, In: Cochrane Database of Systematic Reviews. 2019, 11, p. CD012631 CD012631.

    Research output: Contribution to journalReviewResearchpeer-review

  34. Published

    Low Dose Low-Molecular-Weight Heparin for Thrombosis Prophylaxis: Systematic Review with Meta-Analysis and Trial Sequential Analysis

    Eck, R. J., Bult, W., Wetterslev, J., Gans, R. O. B., Meijer, K., van der Horst, I. C. C. & Keus, F., 21 Nov 2019, In: Journal of Clinical Medicine. 8, 12, p. pii:E2039

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published

    Agents Intervening against Delirium in the Intensive Care Unit (AID-ICU) - Protocol for a randomised placebo-controlled trial of haloperidol in patients with delirium in the ICU

    Andersen-Ranberg, N., Poulsen, L. M., Perner, A., Wetterslev, J., Estrup, S., Lange, T., Ebdrup, B., Hästbacka, J., Morgan, M. P. G., Citerio, G., Zafrani, L., Caballero, J., Collet, M. O., Weber, S., Andreasen, A. S., Bestle, M., Pedersen, H. B. S., Hildebrandt, T., Thee, C., Jensen, T. B., Dey, N., Nielsen, L. G. & Mathiesen, O., Nov 2019, In: Acta Anaesthesiologica Scandinavica. 63, 10, p. 1426-1433 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Storage time of red blood cells among ICU patients with septic shock

    Rygård, S. L., Grønlykke, L., Perner, A., Winkel, P., Lange, T., Holst, L. B., Johansson, P. I., Aneman, A., Brodersen, T., Laurén, E., Ullum, H. & Wetterslev, J., Nov 2019, In: Acta Anaesthesiologica Scandinavica. 63, 10, p. 1366-1377 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Apparently conclusive meta-analyses on interventions in critical care may be inconclusive - a meta-epidemiological study

    Koster, T. M., Wetterslev, J., Gluud, C., Jakobsen, J. C., Kaufmann, T., Eck, R. J., Koster, G., Hiemstra, B., van der Horst, I. C. C. & Keus, F., 1 Oct 2019, In: Journal of Clinical Epidemiology. 114, p. 1-10 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  38. Published

    Clinical Examination for the Prediction of Mortality in the Critically Ill: The Simple Intensive Care Studies-I

    Hiemstra, B., Eck, R. J., Wiersema, R., Kaufmann, T., Koster, G., Scheeren, T. W. L., Snieder, H., Perner, A., Pettilä, V., Wetterslev, J., Keus, F. & van der Horst, I. C. C., 1 Oct 2019, In: Critical Care Medicine. 47, 10, p. 1301-1309 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Outcomes of Prophylactic Pantoprazole in Adult Intensive Care Unit Patients Receiving Dialysis: Results of a Randomized Trial

    Schefold, J. C., Krag, M., Marker, S., Perner, A., Wetterslev, J., Wise, M. P., Borthwick, M., Bendel, S., Keus, F., Guttormsen, A. B., Lange, T., the SUP-ICU investigators & Møller, M. H., 1 Oct 2019, In: American Journal of Nephrology. 50, 4, p. 312-319 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published
  41. Published

    A difficulty with the DIFFMASK score is the difficult statistics - a reply

    Lundstrøm, L. H., Rosenstock, C. V., Wetterslev, J. & Nørskov, A. K., Oct 2019, In: Anaesthesia. 74, 10, p. 1338 1 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  42. Published

    Conservative vs liberal fluid therapy in septic shock (CLASSIC) trial—Protocol and statistical analysis plan

    Meyhoff, T. S., Hjortrup, P. B., Møller, M. H., Wetterslev, J., Lange, T., Kjaer, M-B. N., Jonsson, A. B., Hjortsø, C. J. S., Cronhjort, M., Laake, J. H., Jakob, S. M., Nalos, M., Pettilä, V., van der Horst, I., Ostermann, M., Mouncey, P., Rowan, K., Cecconi, M., Ferrer, R., Malbrain, M. L. N. G., Ahlstedt, C., Hoffmann, S., Bestle, M. H., Nebrich, L., Russell, L., Vang, M., Rasmussen, M. L., Sølling, C., Rasmussen, B. S., Brøchner, A. C. & Perner, A., Oct 2019, In: Acta Anaesthesiologica Scandinavica. 63, 9, p. 1262-1271 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Heterogeneity of treatment effect of stress ulcer prophylaxis in ICU patients: A secondary analysis protocol

    Granholm, A., Marker, S., Krag, M., Zampieri, F. G., Thorsen-Meyer, H-C., Kaas-Hansen, B. S., van der Horst, I. C. C., Lange, T., Wetterslev, J., Perner, A. & Møller, M. H., Oct 2019, In: Acta Anaesthesiologica Scandinavica. 63, 9, p. 1251-1256 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Pantoprazole in ICU patients at risk for gastrointestinal bleeding-1-year mortality in the SUP-ICU trial

    Marker, S., Krag, M., Perner, A., Wetterslev, J., Lange, T., Wise, M. P., Borthwick, M., Bendel, S., Keus, F., Guttormsen, A. B., Schefold, J. C., Rasmussen, B. S., Elkmann, T., Bestle, M., Arenkiel, B., Laake, J. H., Kamper, M. K., Lång, M., Pawlowicz-Dworzanska, M. B., Karlsson, S., Liisanantti, J., Dey, N., Knudsen, H., Granholm, A., SUP-ICU trial investigators & Møller, M. H., Oct 2019, In: Acta Anaesthesiologica Scandinavica. 63, 9, p. 1184-1190 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Time to onset of gastrointestinal bleeding in the SUP-ICU trial: a preplanned substudy

    Granholm, A., Lange, T., Anthon, C. T., Marker, S., Krag, M., Meyhoff, T. S., Wise, M. P., Borthwick, M., Bendel, S., Keus, F., Guttormsen, A. B., Schefold, J. C., Wetterslev, J., Perner, A. & Møller, M. H., 23 Aug 2019, In: Acta Anaesthesiologica Scandinavica. 63, 10, p. 1346-1356 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure

    Schjørring, O. L., Perner, A., Wetterslev, J., Lange, T., Keus, F., Laake, J. H., Okkonen, M., Siegemund, M., Morgan, M., Thormar, K. M., and the HOT-ICU Investigators & Rasmussen, B. S., Aug 2019, In: Acta Anaesthesiologica Scandinavica. 63, 7, p. 956-965 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  47. Published

    Power estimations for non-primary outcomes in randomised clinical trials

    Jakobsen, J. C., Ovesen, C., Winkel, P., Hilden, J., Gluud, C. & Wetterslev, J., 1 Jun 2019, In: BMJ Open. 9, 6, p. e027092 e027092.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Pantoprazole prophylaxis in ICU patients with high severity of disease: a post hoc analysis of the placebo-controlled SUP-ICU trial

    Marker, S., Perner, A., Wetterslev, J., Krag, M., Lange, T., Wise, M. P., Borthwick, M., Bendel, S., Keus, F., Guttormsen, A. B., Schefold, J. C., SUP-ICU investigators & Møller, M. H., May 2019, In: Intensive Care Medicine. 45, 5, p. 609-618 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Assessing assumptions for statistical analyses in randomised clinical trials

    Nielsen, E. E., Nørskov, A. K., Lange, T., Thabane, L., Wetterslev, J., Beyersmann, J., de Uña-Álvarez, J., Torri, V., Billot, L., Putter, H., Winkel, P., Gluud, C. & Jakobsen, J. C., 4 Apr 2019, In: BMJ Evidence-Based Medicine. 24, 5, p. 185-189 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Carotid endarterectomy with primary closure versus patch angioplasty in patients with symptomatic and significant stenosis: protocol for a systematic review with meta-analyses and trial sequential analysis of randomised clinical trials

    Marsman, M. S., Wetterslev, J., Jahrome, A. K., Gluud, C., Moll, F. L., Karimi, A., Keus, F. & Koning, G. G., 1 Apr 2019, In: BMJ Open. 9, 4, p. e026419 026419.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Dexmedetomidine for the management of delirium in critically ill patients-A protocol for a systematic review

    Maagaard, M., Barbateskovic, M., Perner, A., Jakobsen, J. C. & Wetterslev, J., Apr 2019, In: Acta Anaesthesiologica Scandinavica. 63, 4, p. 549-557 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  52. Published

    Dexmedetomidine for the prevention of delirium in critically ill patients - A protocol for a systematic review

    Maagaard, M., Barbateskovic, M., Perner, A., Jakobsen, J. C. & Wetterslev, J., Apr 2019, In: Acta Anaesthesiologica Scandinavica. 63, 4, p. 540-548 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  53. Published

    Dopamine in critically ill patients with cardiac dysfunction: A systematic review with meta-analysis and trial sequential analysis

    Hiemstra, B., Koster, G., Wetterslev, J., Gluud, C., Jakobsen, J. C., Scheeren, T. W. L., Keus, F. & van der Horst, I. C. C., Apr 2019, In: Acta Anaesthesiologica Scandinavica. 63, 4, p. 424-437 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

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