Research
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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Main research areas

In many diseases, changes at the cellular and molecular levels occur before any symptoms of disease. Several recent studies suggest that various metabolic signatures are associated with the development in type 1 diabetes.

My research aims to characterize cellular bioenergetic changes and understand how it affects the development and course of diabetes but also other systemic metabolic diseases. Using the Seahorse extracellular flux technology, it is possible to study in real-time metabolic changes at the cellular level.

Current research

Cellular catabolism is affected in different metabolic disorders, including diabetes. Using several different cell models, I investigate changes in the cellular intake of different metabolites and their break down into usable energetic molecules by glycolysis and mitochondrial respiration cellular processes.

A project I am involved in is in collaoration with the department of Clinical Diabetes Prevention, where I investigate blood cell bioenergetics at the cellular level before and after a 13-week time-restricted eating intervention in individuals with a high risk of developing type 2 diabetes.

I am also involved in a project addressing if identified candidate lipid biomarkers, in a cohort of adolescents newly diagnosed with type 1 diabetes, have a direct negative effect on beta cell and islet function. Such studies will provide insight into the molecular mechanisms of T1D-associated lipid species and identify possible targets for intervention.

Expertises

Molecular biology, energy metabolism; mitochondrial bioenergetics; Seahorse XF technology; Translational type 1 diabetes pathobiology; beta-cell biology, pancreatic islet biology, apoptosis; insulin secretion; cytokines; signal transduction

Potential conflicts of interest

none

ID: 58522556