Personal profile
Expertises
cancer genomics; genomic structural variants; data analysis; next-generation sequencing; bioinformatics; tumour heterogeneity
Main research areas
mechanisms and functional consequences of genomic alterations in cancer; integrative data analysis; prostate cancer; glioblastoma; chromatin conformation and influence on mutation rate; precision oncology
Current research
Our research is focused on two main areas i) integrating high-throughput sequencing data with clinical, genomic and chromatin conformation data to identify causes and consequences of genomic alterations in cancer and ii) utilize the information to guide better treatment (precision oncology). We are pursuing analysis in single tumour entities (prostate cancer and glioblastoma) as well as across different tumour entities (pan-cancer), to identify common, and distinct mechanisms.
My group is affiliated with Biotech Research & Innovation Centre (BRIC), Copenhagen University, where we share infrastructure and scientific seminars. I am responsible for the next-generation sequencing core facility at BRIC.
Potential conflicts of interest
None
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Collaborations and top research areas from the last five years
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Epigenomics-guided precision oncology: Chromatin variants in prostate tumor evolution
Furlano, K., Keshavarzian, T., Biernath, N., Fendler, A., de Santis, M., Weischenfeldt, J. & Lupien, M., 15 Jan 2026, In: International Journal of Cancer. 158, 2, p. 314-332 19 p.Research output: Contribution to journal › Review › peer-review
3 Citations (Scopus) -
PTEN Deletions Are Associated With Tumor Progression But Unrelated to Patient Prognosis in Muscle-Invasive Urothelial Bladder Carcinomas: A Large Multi-Center Validation Study on 2710 Urothelial Bladder Carcinomas
Kluth, M., Plage, H., Furlano, K., Hofbauer, S., Weinberger, S., Fendler, A., Ralla, B., Schallenberg, S., Elezkurtaj, S., Lennartz, M., Marx, A. H., Samtleben, H., Fisch, M., Rink, M., Slojewski, M., Kaczmarek, K., Ecke, T., Adamini, N., Weischenfeldt, J. & Zecha, H. & 5 others, , Jan 2026, In: Genes, Chromosomes & Cancer. 65, 1, p. e70105 e70105.Research output: Contribution to journal › Journal article › Research › peer-review
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Resolving clonal evolution and selection of extrachromosomal DNA at single-cell resolution
Hendriksen, J. D., Locallo, A., Schlotmann, B. C., González, F. G. R., Skjøth-Rasmussen, J., Yde, C. W., Nørøxe, D. S., Poulsen, H. S., Lassen, U. & Weischenfeldt, J., 29 Jan 2026, In: Genome Biology (Online Edition). 27, 1, p. 10 10.Research output: Contribution to journal › Journal article › Research › peer-review
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Causes of evolutionary divergence in prostate cancer
Esentürk, E., Sahli, A., Haberland, V., Ziuboniewicz, A., Wirth, C., Bova, G. S., Bristow, R. G., Brook, M. N., Brors, B., Butler, A., Cancel-Tassin, G., Cheng, K. C., Cooper, C. S., Corcoran, N. M., Cussenot, O., Eeles, R. A., Favero, F., Gerhauser, C., Gihawi, A. & Girma, E. G. & 35 others, , 17 Mar 2025, (ArXiv).Research output: Working paper › Preprint
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Clinical, Radiological, and Molecular Insights into Extracranial Metastases from Adult Gliomas
Jacobsen, J., Locallo, A., O'Rourke, C. J., Carlsen, J. F., Cohen, J., Ewald, J. D., Scheie, D., Grunnet, K., Schmidt, A. Y., Melchior, L. C., Larsen, V. A., Andersen, J. B., Poulsen, H. S., Weischenfeldt, J., Broholm, H., Michaelsen, S. R. & Kristensen, B. W., 16 Aug 2025, (E-pub ahead of print) In: Neuro-Oncology.Research output: Contribution to journal › Journal article › Research › peer-review