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The Capital Region of Denmark - a part of Copenhagen University Hospital

Joachim Weischenfeldt

Phd. MSc

Københavns Biocenter, Ole Maaløes Vej 5

2200 København N

Denmark

  1. 2019
  2. E-pub ahead of print

    Response to Olaparib in a PALB2 Germline Mutated Prostate Cancer and Genetic Events Associated with Resistance

    Horak, P., Weischenfeldt, J., von Amsberg, G., Beyer, B., Schutte, A., Uhrig, S., Gieldon, L., Klink, B., Feuerbach, L., Hubschmann, D., Kreutzfeldt, S., Heining, C., Maier, S., Hutter, B., Penzel, R., Schlesner, M., Eils, R., Sauter, G., Stenzinger, A., Brors, B., Schröck, E., Glimm, H., Fröhling, S. & Schlomm, T., 4 Mar 2019, In : Cold Spring Harbor Molecular Case Studies.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2018
  4. Published

    Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories

    Gerhauser, C., Favero, F., Risch, T., Simon, R., Feuerbach, L., Assenov, Y., Heckmann, D., Sidiropoulos, N., Waszak, S. M., Hübschmann, D., Urbanucci, A., Girma, E. G., Kuryshev, V., Klimczak, L. J., Saini, N., Stütz, A. M., Weichenhan, D., Böttcher, L-M., Toth, R., Hendriksen, J. D., Koop, C., Lutsik, P., Matzk, S., Warnatz, H-J., Amstislavskiy, V., Feuerstein, C., Raeder, B., Bogatyrova, O., Schmitz, E-M., Hube-Magg, C., Kluth, M., Huland, H., Graefen, M., Lawerenz, C., Henry, G. H., Yamaguchi, T. N., Malewska, A., Meiners, J., Schilling, D., Reisinger, E., Eils, R., Schlesner, M., Strand, D. W., Bristow, R. G., Boutros, P. C., von Kalle, C., Gordenin, D., Sültmann, H., Brors, B., Sauter, G., Plass, C., Yaspo, M-L., Korbel, J. O., Schlomm, T. & Weischenfeldt, J., 10 Dec 2018, In : Cancer Cell. 34, 6, p. 996-1011.e8

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

    Waszak, S. M., Northcott, P. A., Buchhalter, I., Robinson, G. W., Sutter, C., Groebner, S., Grund, K. B., Brugières, L., Jones, D. T. W., Pajtler, K. W., Morrissy, A. S., Kool, M., Sturm, D., Chavez, L., Ernst, A., Brabetz, S., Hain, M., Zichner, T., Segura-Wang, M., Weischenfeldt, J., Rausch, T., Mardin, B. R., Zhou, X., Baciu, C., Lawerenz, C., Chan, J. A., Varlet, P., Guerrini-Rousseau, L., Fults, D. W., Grajkowska, W., Hauser, P., Jabado, N., Ra, Y-S., Zitterbart, K., Shringarpure, S. S., De La Vega, F. M., Bustamante, C. D., Ng, H-K., Perry, A., MacDonald, T. J., Hernáiz Driever, P., Bendel, A. E., Bowers, D. C., McCowage, G., Chintagumpala, M. M., Cohn, R., Hassall, T., Fleischhack, G., Eggen, T., Wesenberg, F., Feychting, M., Lannering, B., Schüz, J., Johansen, C., Andersen, T. V., Röösli, M., Kuehni, C. E., Grotzer, M., Kjaerheim, K., Monoranu, C. M., Archer, T. C., Duke, E., Pomeroy, S. L., Shelagh, R., Frank, S., Sumerauer, D., Scheurlen, W., Ryzhova, M. V., Milde, T., Kratz, C. P., Samuel, D., Zhang, J., Solomon, D. A., Marra, M., Eils, R., Bartram, C. R., von Hoff, K., Rutkowski, S., Ramaswamy, V., Gilbertson, R. J., Korshunov, A., Taylor, M. D., Lichter, P., Malkin, D., Gajjar, A., Korbel, J. O. & Pfister, S. M., 1 Jun 2018, In : Lancet Oncology. 19, 6, p. 785-798

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The landscape of genomic alterations across childhood cancers

    Gröbner, S. N., Worst, B. C., Weischenfeldt, J., Buchhalter, I., Kleinheinz, K., Rudneva, V. A., Johann, P. D., Balasubramanian, G. P., Segura-Wang, M., Brabetz, S., Bender, S., Hutter, B., Sturm, D., Pfaff, E., Hübschmann, D., Zipprich, G., Heinold, M., Eils, J., Lawerenz, C., Erkek, S., Lambo, S., Waszak, S., Blattmann, C., Borkhardt, A., Kuhlen, M., Eggert, A., Fulda, S., Gessler, M., Wegert, J., Kappler, R., Baumhoer, D., Burdach, S., Kirschner-Schwabe, R., Kontny, U., Kulozik, A. E., Lohmann, D., Hettmer, S., Eckert, C., Bielack, S., Nathrath, M., Niemeyer, C., Richter, G. H., Schulte, J., Siebert, R., Westermann, F., Molenaar, J. J., Vassal, G., Witt, H., Burkhardt, B., Kratz, C. P. & ICGC PedBrain-Seq Project, 15 Mar 2018, In : Nature. 555, 7696, p. 321-327 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    SvABA: genome-wide detection of structural variants and indels by local assembly

    Wala, J. A., Bandopadhayay, P., Greenwald, N., O'Rourke, R., Sharpe, T., Stewart, C., Schumacher, S., Li, Y., Weischenfeldt, J., Yao, X., Nusbaum, C., Campbell, P., Getz, G., Meyerson, M., Zhang, C-Z., Imielinski, M. & Beroukhim, R., 13 Mar 2018, In : Genome Research. 28, 4, p. 581-591

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2017
  9. Published

    Mitochondrial mutations drive prostate cancer aggression

    Hopkins, J. F., Sabelnykova, V. Y., Weischenfeldt, J., Simon, R., Aguiar, J. A., Alkallas, R., Heisler, L. E., Zhang, J., Watson, J. D., Chua, M. L. K., Fraser, M., Favero, F., Lawerenz, C., Plass, C., Sauter, G., McPherson, J. D., van der Kwast, T., Korbel, J., Schlomm, T., Bristow, R. G. & Boutros, P. C., 22 Sep 2017, In : Nature Communications. 8, 1, p. e656

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Genomes of early onset prostate cancer

    Weischenfeldt, J. & Korbel, J. O., Sep 2017, In : Current Opinion in Urology. 27, 5, p. 481-487 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The whole-genome landscape of medulloblastoma subtypes

    Northcott, P. A., Buchhalter, I., Morrissy, A. S., Hovestadt, V., Weischenfeldt, J., Ehrenberger, T., Gröbner, S., Segura-Wang, M., Zichner, T., Rudneva, V. A., Warnatz, H-J., Sidiropoulos, N., Phillips, A. H., Schumacher, S., Kleinheinz, K., Waszak, S. M., Erkek, S., Jones, D. T. W., Worst, B. C., Kool, M., Zapatka, M., Jäger, N., Chavez, L., Hutter, B., Bieg, M., Paramasivam, N., Heinold, M., Gu, Z., Ishaque, N., Jäger-Schmidt, C., Imbusch, C. D., Jugold, A., Hübschmann, D., Risch, T., Amstislavskiy, V., Gonzalez, F. G. R., Weber, U. D., Wolf, S., Robinson, G. W., Zhou, X., Wu, G., Finkelstein, D., Liu, Y., Cavalli, F. M. G., Luu, B., Ramaswamy, V., Wu, X., Koster, J., Ryzhova, M., Cho, Y-J., Pomeroy, S. L., Herold-Mende, C., Schuhmann, M., Ebinger, M., Liau, L. M., Mora, J., McLendon, R. E., Jabado, N., Kumabe, T., Chuah, E., Ma, Y., Moore, R. A., Mungall, A. J., Mungall, K. L., Thiessen, N., Tse, K., Wong, T., Jones, S. J. M., Witt, O., Milde, T., Von Deimling, A., Capper, D., Korshunov, A., Yaspo, M-L., Kriwacki, R., Gajjar, A., Zhang, J., Beroukhim, R., Fraenkel, E., Korbel, J. O., Brors, B., Schlesner, M., Eils, R., Marra, M. A., Pfister, S. M., Taylor, M. D. & Lichter, P., 19 Jul 2017, In : Nature. 547, 7663, p. 311-317 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Deletion lengthening at chromosomes 6q and 16q targets multiple tumor suppressor genes and is associated with an increasingly poor prognosis in prostate cancer

    Kluth, M., Jung, S., Habib, O., Eshagzaiy, M., Heinl, A., Amschler, N., Masser, S., Mader, M., Runte, F., Barow, P., Frogh, S., Omari, J., Möller-Koop, C., Hube-Magg, C., Weischenfeldt, J., Korbel, J., Steurer, S., Krech, T., Huland, H., Graefen, M., Minner, S., Sauter, G., Schlomm, T. & Simon, R., 1 Jan 2017, In : Oncotarget. 8, 65, p. 108923-108935 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2016
  14. Published

    Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking

    Weischenfeldt, J., Dubash, T., Drainas, A. P., Mardin, B. R., Chen, Y., Stütz, A. M., Waszak, S. M., Bosco, G., Halvorsen, A. R., Raeder, B., Efthymiopoulos, T., Erkek, S., Siegl, C., Brenner, H., Brustugun, O. T., Dieter, S. M., Northcott, P. A., Petersen, I., Pfister, S. M., Schneider, M., Solberg, S. K., Thunissen, E., Weichert, W., Zichner, T., Thomas, R., Peifer, M., Helland, A., Ball, C. R., Jechlinger, M., Sotillo, R., Glimm, H. & Korbel, J. O., 21 Nov 2016, In : Nature Genetics. 49, 1, p. 65-74

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Heterogeneity of ERG expression in prostate cancer: A large section mapping study of entire prostatectomy specimens from 125 patients

    Tsourlakis, M. C., Stender, A., Quaas, A., Kluth, M., Wittmer, C., Haese, A., Graefen, M., Steurer, S., Simon, R., Korbel, J., Weischenfeldt, J., Huland, H., Sauter, G., Schlomm, T. & Minner, S., 17 Aug 2016, In : BMC Cancer. 16, 1, 641.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Immortalization capacity of HPV types is inversely related to chromosomal instability

    Schütze, D. M., Krijgsman, O., Snijders, P. J. F., Ylstra, B., Weischenfeldt, J., Mardin, B. R., Stütz, A. M., Korbel, J. O., de Winter, J. P., Meijer, C. J. L. M., Quint, W. G. V., Bosch, L., Wilting, S. M. & Steenbergen, R. D. M., 1 Jan 2016, In : Oncotarget. 7, 25, p. 37608-37621 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2015
  18. Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency

    Kovac, M., Blattmann, C., Ribi, S., Smida, J., Mueller, N. S., Engert, F., Castro-Giner, F., Weischenfeldt, J., Kovacova, M., Krieg, A., Andreou, D., Tunn, P. U., Dürr, H. R., Rechl, H., Schaser, K. D., Melcher, I., Burdach, S., Kulozik, A., Specht, K., Heinimann, K., Fulda, S., Bielack, S., Jundt, G., Tomlinson, I., Korbel, J. O., Nathrath, M. & Baumhoer, D., 3 Dec 2015, In : Nature Communications. 6, 8940.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation

    Kunz, J. B., Rausch, T., Bandapalli, O. R., Eilers, J., Pechanska, P., Schuessele, S., Assenov, Y., Stütz, A. M., Kirschner-Schwabe, R., Hof, J., Eckert, C., von Stackelberg, A., Schrappe, M., Stanulla, M., Koehler, R., Avigad, S., Elitzur, S., Handgretinger, R., Benes, V., Weischenfeldt, J., Korbel, J. O., Muckenthaler, M. U. & Kulozik, A. E., 31 Oct 2015, In : Haematologica. 100, 11, p. 1442-1450 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. A cell-based model system links chromothripsis with hyperploidy

    Mardin, B. R., Drainas, A. P., Waszak, S. M., Weischenfeldt, J., Isokane, M., Stütz, A. M., Raeder, B., Efthymiopoulos, T., Buccitelli, C., Segura-Wang, M., Northcott, P., Pfister, S. M., Lichter, P., Ellenberg, J. & Korbel, J. O., 1 Sep 2015, In : Molecular Systems Biology. 11, 9, 828.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Prevalence of chromosomal rearrangements involving non-ETS genes in prostate cancer

    Kluth, M., Galal, R., Krohn, A., Weischenfeldt, J., Tsourlakis, C., Paustian, L., Ahrary, R., Ahmed, M., Scherzai, S., Meyer, A., Sirma, H., Korbel, J., Sauter, G., Schlomm, T., Simon, R. & Minner, S., 1 Jan 2015, In : International Journal of Oncology. 46, 4, p. 1637-1642 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. The Aging Prostate Is Never "Normal": Implications from the Genomic Characterization of Multifocal Prostate Cancers

    Schlomm, T., Weischenfeldt, J., Korbel, J. & Sauter, G., 1 Jan 2015, In : European Urology. 68, 3, p. 348-350 3 p., 6171.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2014
  24. TMPRSS2-ERG fusions are strongly linked to young patient age in low-grade prostate cancer

    Steurer, S., Mayer, P. S., Adam, M., Krohn, A., Koop, C., Ospina-Klinck, D., Tehrani, A. A., Simon, R., Tennstedt, P., Graefen, M., Wittmer, C., Brors, B., Plass, C., Korbel, J., Weischenfeldt, J., Sauter, G., Huland, H., Tsourlakis, M. C., Minner, S. & Schlomm, T., 1 Dec 2014, In : European Urology. 66, 6, p. 978-981 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer

    Brocks, D., Assenov, Y., Minner, S., Bogatyrova, O., Simon, R., Koop, C., Oakes, C., Zucknick, M., Lipka, D. B., Weischenfeldt, J., Feuerbach, L., Cowper-Sallari, R., Lupien, M., Brors, B., Korbel, J., Schlomm, T., Tanay, A., Sauter, G., Gerhäuser, C. & Plass, C., 7 Aug 2014, In : Cell Reports. 8, 3, p. 798-806 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2013
  27. Integrative Genomic Analyses Reveal an Androgen-Driven Somatic Alteration Landscape in Early-Onset Prostate Cancer

    Weischenfeldt, J., Simon, R., Feuerbach, L., Schlangen, K., Weichenhan, D., Minner, S., Wuttig, D., Warnatz, H. J., Stehr, H., Rausch, T., Jäger, N., Gu, L., Bogatyrova, O., Stütz, A. M., Claus, R., Eils, J., Eils, R., Gerhäuser, C., Huang, P. H., Hutter, B., Kabbe, R., Lawerenz, C., Radomski, S., Bartholomae, C. C., Fälth, M., Gade, S., Schmidt, M., Amschler, N., Haß, T., Galal, R., Gjoni, J., Kuner, R., Baer, C., Masser, S., von Kalle, C., Zichner, T., Benes, V., Raeder, B., Mader, M., Amstislavskiy, V., Avci, M., Lehrach, H., Parkhomchuk, D., Sultan, M., Burkhardt, L., Graefen, M., Huland, H., Kluth, M., Krohn, A. & Sirma, H., 11 Feb 2013, In : Cancer Cell. 23, 2, p. 159-170 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Phenotypic impact of genomic structural variation: Insights from and for human disease

    Weischenfeldt, J., Symmons, O., Spitz, F. & Korbel, J. O., 1 Feb 2013, In : Nature Reviews Genetics. 14, 2, p. 125-138 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  29. 2012
  30. Dissecting the genomic complexity underlying medulloblastoma

    ICGC PedBrain-Seq Project, 2 Aug 2012, In : Nature. 488, 7409, p. 100-105 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

    Rausch, T., Jones, D. T. W., Zapatka, M., Stütz, A. M., Zichner, T., Weischenfeldt, J., Jäger, N., Remke, M., Shih, D., Northcott, P. A., Pfaff, E., Tica, J., Wang, Q., Massimi, L., Witt, H., Bender, S., Pleier, S., Cin, H., Hawkins, C., Beck, C., Von Deimling, A., Hans, V., Brors, B., Eils, R., Scheurlen, W., Blake, J., Benes, V., Kulozik, A. E., Witt, O., Martin, D., Zhang, C., Porat, R., Merino, D. M., Wasserman, J., Jabado, N., Fontebasso, A., Bullinger, L., Rücker, F. G., Döhner, K., Döhner, H., Koster, J., Molenaar, J. J., Versteeg, R., Kool, M., Tabori, U., Malkin, D., Korshunov, A., Taylor, M. D., Lichter, P. & Pfister, S. M., 20 Jan 2012, In : Cell. 148, 1-2, p. 59-71 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

    Weischenfeldt, J., Waage, J., Tian, G., Zhao, J., Damgaard, I., Jakobsen, J. S., Kristiansen, K., Krogh, A. S., Wang, J. & Porse, B. T., 2012, In : Genome Biology (Online Edition). 13, 5, p. R35

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. 2008
  34. Bone marrow-derived macrophages (BMM): Isolation and applications

    Weischenfeldt, J. & Porse, B., 1 Dec 2008, In : Cold Spring Harbor Protocols. 3, 12

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

    Weischenfeldt, J., Damgaard, I., Bryder, D., Theilgaard-Mönch, K., Thoren, L. A., Nielsen, F. C., Jacobsen, S. E. W., Nerlov, C. & Porse, B. T., 15 May 2008, In : Genes and Development. 22, 10, p. 1381-1396 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. 2005
  37. Published

    Messenger RNA surveillance: Neutralizing natural nonsense

    Weischenfeldt, J., Lykke-Andersen, J. & Porse, B., 26 Jul 2005, In : Current Biology. 15, 14

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 38676074