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  1. The Capital Region of Denmark
  2. Researchers
  3. Jens Bukh
  4. Publications
The Capital Region of Denmark - a part of Copenhagen University Hospital
Jens Bukh

Jens Bukh

Chief Consultant

1 - 50 out of 153Page size: 50
  1. 2020
  2. Published

    Ribavirin inhibition of cell-culture infectious hepatitis C genotype 1-3 viruses is strain-dependent

    Mejer, N., Galli, A., Ramirez, S., Fahnøe, U., Benfield, T. & Bukh, J., 15 Jan 2020, In : Virology. 540, p. 132-140 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2019
  4. E-pub ahead of print

    Cell culture studies of the efficacy and barrier to resistance of sofosbuvir/velpatasvir and glecaprevir/pibrentasvir against hepatitis C virus genotypes 2a, 2b and 2c

    Ramirez, S., Fernandez-Antunez, C., Mikkelsen, L. S., Pedersen, J., Li, Y-P. & Bukh, J., 9 Dec 2019, In : Antimicrobial Agents and Chemotherapy.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. E-pub ahead of print

    Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B cell-Based Vaccine Development

    Chen, F., Nagy, K., Chavez, D., Willis, S., McBride, R., Giang, E., Honda, A., Bukh, J., Ordoukhanian, P., Zhu, J., Frey, S., Lanford, R. & Law, M., 3 Dec 2019, In : Gastroenterology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Genome Sequence of an Unknown Subtype of Hepatitis C Virus Genotype 6: Another Piece for the Taxonomic Puzzle

    Pedersen, M. S., Mollerup, S., Nielsen, L. G., Jenssen, H., Bukh, J. & Schønning, K., 17 Oct 2019, In : Microbiology Resource Announcements. 8, 42, e01030-19.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus

    Fahnøe, U., Pedersen, A. G., Johnston, C. M., Orton, R. J., Höper, D., Beer, M., Bukh, J., Belsham, G. J. & Rasmussen, T. B., 10 Oct 2019, In : Viruses. 11, 10

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen

    Filskov, J., Andersen, P., Agger, E. M. & Bukh, J., 1 Oct 2019, In : Scientific Reports. 9, 14085.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Replicons of a rodent hepatitis C model virus permit selection of highly permissive cells

    Wolfisberg, R., Holmbeck, K., Nielsen, L., Kapoor, A., Rice, C. M., Bukh, J. & Scheel, T. K. H., 1 Oct 2019, In : Journal of Virology. 93, 19

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

    Jensen, S. B., Fahnøe, U., Pham, L. V., Serre, S., Tang, Q., Ghanem, L., Pedersen, M. S., Ramirez, S., Humes, D., Pihl, A. F., Filskov, J., Sølund, C. S., Dietz, J., Fourati, S., Pawlotsky, J-M., Sarrazin, C., Weis, N., Schønning, K., Krarup, H., Bukh, J. & Gottwein, J. M., Sep 2019, In : Hepatology (Baltimore, Md.). 70, 3, p. 771-787 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations

    Prentoe, J., Velázquez-Moctezuma, R., Augestad, E. H., Galli, A., Wang, R., Law, M., Alter, H. & Bukh, J., 14 May 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10039-10047 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

    Keck, Z-Y., Pierce, B. G., Lau, P., Lu, J., Wang, Y., Underwood, A., Bull, R. A., Prentoe, J., Velázquez-Moctezuma, R., Walker, M. R., Luciani, F., Guest, J. D., Fauvelle, C., Baumert, T. F., Bukh, J., Lloyd, A. R. & Foung, S. K. H., May 2019, In : PLoS pathogens. 15, 5, e1007772.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape

    Pham, L. V., Jensen, S. B., Fahnøe, U., Pedersen, M. S., Tang, Q., Ghanem, L., Ramirez, S., Humes, D., Serre, S. B. N., Schønning, K., Bukh, J. & Gottwein, J. M., 1 Mar 2019, In : Journal of Hepatology. 70, 3, p. 388-397 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Hepatitis C virus escape studies of human antibody AR3a reveal a high barrier to resistance and novel insights on viral antibody evasion mechanisms

    Velázquez-Moctezuma, R., Galli, A., Law, M., Bukh, J. & Prentoe, J., 1 Feb 2019, In : Journal of Virology. 93, 4, e0190918.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies

    Tzarum, N., Giang, E., Kong, L., He, L., Prentoe, J., Augestad, E., Hua, Y., Castillo, S., Lauer, G. M., Bukh, J., Zhu, J., Wilson, I. A. & Law, M., 1 Jan 2019, In : Scientific American. 5, 1, p. eaav1882 eaav1882.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Hepatitis C virus escape studies for human monoclonal antibody AR4A reveal isolate-specific resistance and a high barrier to resistance

    Velázquez-Moctezuma, R., Galli, A., Law, M., Bukh, J. & Prentoe, J., 1 Jan 2019, In : The Journal of infectious diseases. 219, 1, p. 68-79 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Full-Length Open Reading Frame Amplification of Hepatitis C Virus

    Fahnøe, U. & Bukh, J., 2019, In : Methods in molecular biology (Clifton, N.J.). 1911, p. 85-91 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    In Vitro Neutralization Assay Using Cultured Hepatitis C Virus

    Prentoe, J. & Bukh, J., 2019, In : Methods in molecular biology (Clifton, N.J.). 1911, p. 433-439 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. 2018
  20. Published

    High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals

    Pihl, A. F., Offersgaard, A. F., Mathiesen, C. K., Prentoe, J., Fahnøe, U., Krarup, H., Bukh, J. & Gottwein, J. M., 30 Nov 2018, In : Scientific Reports. 8, 17505

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    High-titer HCV full-length genotype 2b infectious cell culture systems and applications thereof.

    Ramirez, S., Li, Y., Gottwein, J. & Bukh, J., 23 Oct 2018

    Research output: Patent › Research

  22. Published

    Outcome and adverse events in patients with chronic hepatitis C treated with direct-acting antivirals: A clinical randomized study

    Sølund, C., Andersen, E. S., Mössner, B., Laursen, A. L., Røge, B. T., Kjær, M. S., Gerstoft, J., Christensen, P. B., Pedersen, M. S., Schønning, K., Fahnøe, U., Bukh, J. & Weis, N., 1 Oct 2018, In : European Journal of Gastroenterology and Hepatology. 30, 10, p. 1177-1186 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Current status and future development of infectious cell-culture models for the major genotypes of hepatitis C virus: Essential tools in testing of antivirals and emerging vaccine strategies

    Ramirez, S. & Bukh, J., Oct 2018, In : Antiviral Research. 158, p. 264-287

    Research output: Contribution to journal › Review › Research › peer-review

  24. Published

    Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry

    Prentoe, J. & Bukh, J., 27 Sep 2018, In : Frontiers in Immunology. 9, 2146, p. 1-11

    Research output: Contribution to journal › Review › Research › peer-review

  25. Published

    Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies

    Humes, D., Ramirez, S., Jensen, T. B., Li, Y-P., Gottwein, J. M. & Bukh, J., 1 Sep 2018, In : Virology. 522, p. 177-192 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    A near full-length open reading frame next generation sequencing assay for genotyping and identification of resistance-associated variants in hepatitis C virus

    Pedersen, M. S., Fahnøe, U., Hansen, T. A., Pedersen, A. G., Jenssen, H., Bukh, J. & Schønning, K., 1 Aug 2018, In : Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 105, p. 49-56 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Ribavirin-induced mutagenesis across the complete open reading frame of hepatitis C virus genotypes 1a and 3a

    Mejer, N., Fahnøe, U., Galli, A., Ramirez, S., Benfield, T. & Bukh, J., 1 Aug 2018, In : The Journal of general virology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    HCV Genotype 6a Escape From and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models

    Pham, L. V., Ramirez, S., Gottwein, J. M., Fahnøe, U., Li, Y-P., Pedersen, J. & Bukh, J., 1 Jun 2018, In : Gastroenterology. 154, 8, p. 2194-2208

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Direct acting antiviral treatment of chronic hepatitis C in Denmark: factors associated with and barriers to treatment initiation

    Sølund, C., Hallager, S., Pedersen, M. S., Fahnøe, U., Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, J., Bélard, E., Madsen, L. G., Schønning, K., Pedersen, A. G., Bukh, J., Weis, N. & Group, T. DANHEP., 1 May 2018, In : Scandinavian Journal of Gastroenterology. 53, 7, p. 849-856

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    IDENTIFICATION OF PIPERAZINYLBENZENESULFONAMIDES AS NEW INHIBITORS OF CLAUDIN-1 TRAFFICKING AND HEPATITIS C VIRUS ENTRY

    Riva, L., Song, O-R., Prentoe, J., Helle, F., L'homme, L., Gattolliat, C-H., Vandeputte, A., Fénéant, L., Belouzard, S., Baumert, T. F., Asselah, T., Bukh, J., Brodin, P., Cocquerel, L., Rouillé, Y. & Dubuisson, J., 1 May 2018, In : Journal of Virology. 92, 10

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1-7 and Escape Variants

    Gottwein, J. M., Pham, L. V., Mikkelsen, L. S., Ghanem, L., Ramirez, S., Scheel, T. K. H., Carlsen, T. H. R. & Bukh, J., Apr 2018, In : Gastroenterology. 154, 5, p. 1435-1448

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model

    Galli, A., Mens, H., Gottwein, J. M., Gerstoft, J. & Bukh, J., 1 Mar 2018, In : Scientific Reports. 8, 4619

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies

    Bartenschlager, R., Baumert, T. F., Bukh, J., Houghton, M., Lemon, S. M., Lindenbach, B. D., Lohmann, V., Moradpour, D., Pietschmann, T., Rice, C. M., Thimme, R. & Wakita, T., Mar 2018, In : Virus Genes. 248, p. 53-62

    Research output: Contribution to journal › Review › Research › peer-review

  34. Published

    Novel HCV culture systems and direct-acting antiviral sensitivity

    Li, Y., Ramirez, S., Humes, D., Gottwein, J. & Bukh, J., 2018

    Research output: Patent › Research

  35. 2017
  36. Published

    Unraveling protease inhibitor resistance in hepatitis C virus genotypes 1-6: Identification and characterization of resistant variants and study of evolutionary pathways to viral resistance

    Brun Jensen, S., Gottwein, J. & Bukh, J., Dec 2017

    Research output: Book/Report › Ph.D. thesis › Research

  37. Published

    Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae

    Smith, D. B., Meyers, G., Bukh, J., Gould, E. A., Monath, T., Scott Muerhoff, A., Pletnev, A., Rico-Hesse, R., Stapleton, J. T., Simmonds, P. & Becher, P., 1 Aug 2017, In : The Journal of general virology. 98, 8, p. 2106-2112

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Broadening CD4(+) and CD8(+) T cell responses against hepatitis C virus by vaccination with NS3 overlapping peptide panels in cross-priming liposomes

    Filskov, J., Mikkelsen, M., Hansen, P. R., Christensen, J. P., Thomsen, A. R., Andersen, P., Bukh, J. & Agger, E. M., 1 Jul 2017, In : Journal of Virology. 91, 14

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Mouse models of acute and chronic hepacivirus infection

    Billerbeck, E., Wolfisberg, R., Fahnøe, U., Xiao, J. W., Quirk, C., Luna, J. M., Cullen, J. M., Hartlage, A. S., Chiriboga, L., Ghoshal, K., Lipkin, W. I., Bukh, J., Scheel, T. K. H., Kapoor, A. & Rice, C. M., 1 Jul 2017, In : Science. 357, 6347, p. 204-208

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Efficient hepatitis C virus genotype 1b Core-NS5A recombinants permit efficacy testing of protease and NS5A inhibitors

    Van Pham, L., Ramirez, S., Carlsen, T. H. R., Li, Y-P., Gottwein, J. M. & Bukh, J., 1 Jun 2017, In : Antimicrobial Agents and Chemotherapy. 61, 6

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A

    Velázquez-Moctezuma, R., Law, M., Bukh, J. & Prentoe, J., 1 Feb 2017, In : PLoS pathogens. 13, 2

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    ICTV Virus Taxonomy Profile: Flaviviridae

    Simmonds, P., Becher, P., Bukh, J., Gould, E. A., Meyers, G., Monath, T., Muerhoff, S., Pletnev, A., Rico-Hesse, R., Smith, D. B., Stapleton, J. T. & Ictv Report Consortium, 1 Jan 2017, In : The Journal of general virology. 98, 1, p. 2-3

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. 2016
  44. Published

    HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice

    Prentoe, J., Verhoye, L., Velázquez Moctezuma, R., Buysschaert, C., Farhoudi, A., Wang, R., Alter, H., Meuleman, P. & Bukh, J., Dec 2016, In : Gut. 65, p. 1988-1997

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity

    Prentoe, J., Velázquez-Moctezuma, R., Foung, S. K. H., Law, M. & Bukh, J., Dec 2016, In : Hepatology (Baltimore, Md.). 64, 6, p. 1881-1892

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family

    Smith, D. B., Becher, P., Bukh, J., Gould, E. A., Meyers, G., Monath, T., Muerhoff, A. S., Pletnev, A., Rico-Hesse, R., Stapleton, J. T. & Simmonds, P., Nov 2016, In : The Journal of general virology. 97, 11, p. 2894-29070

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir

    Ramirez, S., Mikkelsen, L. S., Gottwein, J. M. & Bukh, J., Oct 2016, In : Gastroenterology. 151, p. 973-985

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control

    Bukh, J., Oct 2016, In : Journal of Hepatology. 65, 1 , p. S2-S21

    Research output: Contribution to journal › Review › Research › peer-review

  49. Published

    JFH-1 based HCV cell culture systems for NS5A of genotype 1-7. Patent # 9,388,389

    Scheel, T., Gottwein, J., Jensen, T. B. & Bukh, J., 12 Jul 2016

    Research output: Patent › Research

  50. Published

    HCV full-length infectious cell culture systems and applications thereof. Patent # 9,382,517

    Li, Y., Ramirez, S., Gottwein, J., Scheel, T. & Bukh, J., 5 Jul 2016

    Research output: Patent › Research

  51. Published

    Functional analysis of microRNA-122 binding sequences of hepatitis C virus and identification of variants with high resistance against specific antagomir

    Li, Y-P., Pham, V. L., Uzcategui, N. & Bukh, J., Jul 2016, In : The Journal of general virology. 97, p. 1381-1394

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Hepatitis C Virus Genotype 1-6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness and Resistance Patterns in the Context of the Infectious Viral Life Cycle

    Serre, S. B. N., Brun Jensen, S., Ghanem, L., Humes, D. G., Ramirez, S., Li, Y-P., Krarup, H., Bukh, J. & Gottwein, J. M., Jun 2016, In : Antimicrobial Agents and Chemotherapy. 60, 6, p. 3563-3578

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Neutralizing antibodies in patients with chronic hepatitis C and correlation to liver cirrhosis and estimated duration of infection

    Pedersen, J., Lundbo, L. F., Krarup, H., Bukh, J. & Weis, N., Jun 2016, In : Journal of Medical Virology. 88, 10, p. 1791-1803

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    The validity of dysthymia to predict clinical depressive symptoms as measured by the Hamilton Depression Scale at the 5-year follow-up of patients with first episode depression

    Bech, P., Kessing, L. V. & Bukh, J. D., 16 May 2016, In : Nordic Journal of Psychiatry. 70/8, p. 563-566 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. 2015
  56. Published

    Substitutions at Hepatitis C Virus Genotypes 2-6 NS3 Residues 155, 156, or 168 Induce Complex Patterns of Protease Inhibitor Resistance

    Brun Jensen, S., Serre, S. B. N., Humes, D. G., Ramirez, S., Li, Y-P., Bukh, J. & Gottwein, J. M., Dec 2015, In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7426-7436

    Research output: Contribution to journal › Journal article › Research › peer-review

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