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  1. The Capital Region of Denmark
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  3. Jens Bukh
  4. Publications
The Capital Region of Denmark - a part of Copenhagen University Hospital
Jens Bukh

Jens Bukh

Chief Consultant

1 - 50 out of 195Page size: 50
  1. 2022
  2. E-pub ahead of print

    Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice

    Alzua, G. P., Pihl, A. F., Offersgaard, A., Duarte Hernandez, C. R., Duan, Z., Feng, S., Fahnøe, U., Sølund, C., Weis, N., Law, M., Prentoe, J. C., Christensen, J. P., Bukh, J. & Gottwein, J. M., 2 Aug 2022, (E-pub ahead of print) In: Gut. p. 1-13 13 p.

    Research output: Contribution to journal › Journal article › peer-review

  3. Published

    Novel hepatitis B virus reverse transcriptase mutations in patients with sustained viremia despite long-term tenofovir treatment

    Winckelmann, A., Fahnøe, U., Bajpai, P. S., Dalegaard, M. I., Lundh, A., Ryom, L., Bukh, J. & Weis, N., Jun 2022, In: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 150-151, 105159.

    Research output: Contribution to journal › Journal article › peer-review

  4. E-pub ahead of print

    A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients

    Fahnøe, U., Ronit, A., Berg, R. M. G., Jørgensen, S. E., Mogensen, T. H., Underwood, A. P., Scheel, T. K. H., Bukh, J. & Plovsing, R. R., 27 May 2022, (E-pub ahead of print) In: The Journal of infectious diseases. p. 1-13 13 p., jiac218.

    Research output: Contribution to journal › Journal article › peer-review

  5. Published

    Inactivated whole hepatitis C virus vaccine employing a licensed adjuvant elicits cross-genotype neutralizing antibodies in mice

    Pihl, A. F., Feng, S., Offersgaard, A., Alzua, G. P., Augestad, E. H., Mathiesen, C. K., Jensen, T. B., Krarup, H., Law, M., Prentoe, J., Christensen, J. P., Bukh, J. & Gottwein, J. M., May 2022, In: Journal of Hepatology. 76, 5, p. 1051-1061 11 p.

    Research output: Contribution to journal › Journal article › peer-review

  6. E-pub ahead of print

    Neutralization and receptor use of infectious culture-derived rat hepacivirus as a model for HCV

    Wolfisberg, R., Thorselius, C. E., Salinas, E., Elrod, E., Trivedi, S., Nielsen, L., Fahnøe, U., Kapoor, A., Grakoui, A., Rice, C. M., Bukh, J., Holmbeck, K. & Scheel, T. K. H., 21 Apr 2022, (E-pub ahead of print) In: Hepatology (Baltimore, Md.). p. 1-34 34 p., 32535.

    Research output: Contribution to journal › Journal article › peer-review

  7. E-pub ahead of print

    At the Core of Depression: A Diagnostic Interview of the Core Features of Depression

    Bukh, J. D., Fabrazzo, M., Christensen, E. M., Mikkelsen, R. L., Larsen, J. K., Hageman, I., Bendsen, B. B., Bolwig, T., Vinberg, M., Bech, P., Dam, O. H., Maj, M. & Kessing, L. V., 11 Mar 2022, (E-pub ahead of print) In: Psychopathology. p. 1-7 7 p.

    Research output: Contribution to journal › Journal article › peer-review

  8. Published

    HCV genome-wide analysis for development of efficient culture systems and unravelling of antiviral resistance in genotype 4

    Pham, L. V., Pedersen, M. S., Fahnøe, U., Fernandez-Antunez, C., Humes, D., Schønning, K., Ramirez, S. & Bukh, J., Mar 2022, In: Gut. 71, 3, p. 627-642 16 p., 20323585.

    Research output: Contribution to journal › Journal article › peer-review

  9. Published

    High-Titer Hepatitis C Virus Production in a Scalable Single-Use High Cell Density Bioreactor

    Offersgaard, A., Duarte Hernandez, C. R., Pihl, A. F., Venkatesan, N. P., Krarup, H., Lin, X., Reichl, U., Bukh, J., Genzel, Y. & Gottwein, J. M., 7 Feb 2022, In: Vaccines. 10, 2, p. 1-23 23 p., 249.

    Research output: Contribution to journal › Journal article › peer-review

  10. Published

    Neutralizing Antibodies Against Hepatitis C Virus and Their Role in Vaccine Immunity

    Bukh, J., Feb 2022, In: Gastroenterology. 162, 2, p. 396-398 3 p.

    Research output: Contribution to journal › Editorial › peer-review

  11. Published

    Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and Replication

    Fahnøe, U., Pham, L. V., Fernandez-Antunez, C., Costa, R., Rivera-Rangel, L. R., Galli, A., Feng, S., Mikkelsen, L. S., Gottwein, J. M., Scheel, T. K. H., Ramirez, S. & Bukh, J., 18 Jan 2022, In: Viruses. 14, 2, p. 1-16 16 p., 172.

    Research output: Contribution to journal › Journal article › peer-review

  12. Published

    Analysis of Neutralization Titers against SARS-CoV-2 in Health-Care Workers Vaccinated with Prime-Boost mRNA-mRNA or Vector-mRNA COVID-19 Vaccines

    Sølund, C., Underwood, A. P., Fernandez-Antunez, C., Bollerup, S., Mikkelsen, L. S., Villadsen, S. L., Fahnøe, U., Winckelmann, A. A., Feng, S., Nørløv Vinten, C. A., Dalegaard, M. I., Vizgirda, G., Sørensen, A-L., Ramirez, S., Bukh, J. & Weis, N., 4 Jan 2022, In: Vaccines. 10, 1, p. 1-15 15 p., 75.

    Research output: Contribution to journal › Journal article › peer-review

  13. Published

    High recombination rate of hepatitis C virus revealed by a green fluorescent protein reconstitution cell system

    Galli, A., Fahnøe, U. & Bukh, J., 2022, In: Virus evolution. 8, 1, p. 1-11 11 p., veab106.

    Research output: Contribution to journal › Journal article › peer-review

  14. 2021
  15. Published

    Inferior cure rate in pilot study of 4-week glecaprevir/pibrentasvir treatment with or without ribavirin of chronic hepatitis C

    Wulff Madsen, L., Brehm Christensen, P., Fahnøe, U., Pedersen, M. S., Bukh, J. & Øvrehus, A., Nov 2021, In: Liver international : official journal of the International Association for the Study of the Liver. 41, 11, p. 2601-2610 10 p., 14991.

    Research output: Contribution to journal › Journal article › peer-review

  16. Published

    Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure

    STOP-HCV Consortium, 20 Oct 2021, In: Nature Communications. 12, 1, p. 1-11 11 p., 6105.

    Research output: Contribution to journal › Journal article › peer-review

  17. Published

    Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro

    Zhou, Y., Gammeltoft, K. A., Galli, A., Offersgaard, A., Fahnøe, U., Ramirez, S., Bukh, J. & Gottwein, J. M., 15 Oct 2021, In: Viruses. 13, 10, p. 1-11 11 p., 2082.

    Research output: Contribution to journal › Journal article › peer-review

  18. Published

    Characterization of a Novel Hepatitis C Virus Genotype 1 Subtype from a Patient Failing 4 Weeks of Glecaprevir-Pibrentasvir Treatment

    Pedersen, M. S., Fahnøe, U., Madsen, L. W., Christensen, P. B., Øvrehus, A. & Bukh, J., 14 Oct 2021, In: Microbiology Resource Announcements. 10, 41, p. 1-3 3 p., e0075521.

    Research output: Contribution to journal › Journal article › peer-review

  19. Published

    Hepatitis C virus envelope protein dynamics and the link to hypervariable region 1

    Augestad, E. H., Bukh, J. & Prentoe, J., Oct 2021, In: Current opinion in virology. 50, p. 69-75 7 p.

    Research output: Contribution to journal › Review › peer-review

  20. Published

    Neutralisation titres against SARS-CoV-2 are sustained 6 months after onset of symptoms in individuals with mild COVID-19

    Underwood, A. P., Sølund, C., Fernandez-Antunez, C., Villadsen, S. L., Winckelmann, A. A., Bollerup, S., Mikkelsen, L. S., Sørensen, A-L., Feng, S., Fahnøe, U., Lassauniere, R., Fomsgaard, A., Ramirez, S., Weis, N. & Bukh, J., Sep 2021, In: EBioMedicine. 71, p. 1-10 10 p., 103519.

    Research output: Contribution to journal › Journal article › peer-review

  21. Published

    Pathogenesis, MicroRNA-122 Gene-Regulation, and Protective Immune Responses After Acute Equine Hepacivirus Infection

    Tomlinson, J. E., Wolfisberg, R., Fahnøe, U., Patel, R. S., Trivedi, S., Kumar, A., Sharma, H., Nielsen, L., McDonough, S. P., Bukh, J., Tennant, B. C., Kapoor, A., Rosenberg, B. R., Rice, C. M., Divers, T. J., Van de Walle, G. R. & Scheel, T. K. H., Sep 2021, In: Hepatology (Baltimore, Md.). 74, 3, p. 1148-1163 16 p., 31802.

    Research output: Contribution to journal › Journal article › peer-review

  22. Published

    Vaccines against hepatitis C: a travel into neutralisation space

    Bukh, J., Sep 2021, In: Gut. 70, 9, p. 1609-1610 2 p., 323377.

    Research output: Contribution to journal › Comment/debate › peer-review

  23. Published

    Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 in Vitro

    Gammeltoft, K. A., Zhou, Y., Duarte Hernandez, C. R., Galli, A., Offersgaard, A., Costa, R., Pham, L. V., Fahnøe, U., Feng, S., Scheel, T. K. H., Ramirez, S., Bukh, J. & Gottwein, J. M., 17 Aug 2021, In: Antimicrobial Agents and Chemotherapy. 65, 9, p. 1-24 24 p., e0268020.

    Research output: Contribution to journal › Journal article › peer-review

  24. Published

    Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

    Prentoe, J., Janitzek, C. M., Velázquez-Moctezuma, R., Goksøyr, L., Olsen, R. W., Fanalista, M., Augestad, E. H., Thrane, S., Pihl, A. F., Gottwein, J. M., Sander, A. F. & Bukh, J., 30 Jul 2021, In: PLoS One. 16, 7, p. 1-18 18 p., e0255336.

    Research output: Contribution to journal › Journal article › peer-review

  25. Published

    In vitro efficacy of artemisinin-based treatments against SARS-CoV-2

    Zhou, Y., Gilmore, K., Ramirez, S., Settels, E., Gammeltoft, K. A., Pham, L. V., Fahnøe, U., Feng, S., Offersgaard, A., Trimpert, J., Bukh, J., Osterrieder, K., Gottwein, J. M. & Seeberger, P. H., 16 Jul 2021, In: Scientific Reports. 11, 1, p. 1-14 14 p., 14571.

    Research output: Contribution to journal › Journal article › peer-review

  26. Published

    In vitro adaptation and characterization of attenuated hypervariable region 1 swap chimeras of hepatitis C virus

    Olesen, C. H., Augestad, E. H., Troise, F., Bukh, J. & Prentoe, J., Jul 2021, In: P L o S Pathogens. 17, 7, p. 1-29 29 p., e1009720.

    Research output: Contribution to journal › Journal article › peer-review

  27. Published

    SARS-CoV-2 Production in a Scalable High Cell Density Bioreactor

    Offersgaard, A., Duarte Hernandez, C. R., Pihl, A. F., Costa, R., Venkatesan, N. P., Lin, X., Van Pham, L., Feng, S., Fahnøe, U., Scheel, T. K. H., Ramirez, S., Reichl, U., Bukh, J., Genzel, Y. & Gottwein, J. M., 29 Jun 2021, In: Vaccines. 9, 7, p. 1-17 17 p., 706.

    Research output: Contribution to journal › Journal article › peer-review

  28. Published

    In vitro Characterization of Fitness and Convalescent Antibody Neutralization of SARS-CoV-2 Cluster 5 Variant Emerging in Mink at Danish Farms

    Lassaunière, R., Fonager, J., Rasmussen, M., Frische, A., Polacek, C., Rasmussen, T. B., Lohse, L., Belsham, G. J., Underwood, A., Winckelmann, A. A., Bollerup, S., Bukh, J., Weis, N., Sækmose, S. G., Aagaard, B., Alfaro-Núñez, A., Mølbak, K., Bøtner, A. & Fomsgaard, A., 25 Jun 2021, In: Frontiers in Microbiology. 12, p. 1-9 9 p., 698944.

    Research output: Contribution to journal › Journal article › peer-review

  29. Published

    Overcoming culture restriction for SARS-CoV-2 in human cells facilitates the screening of compounds inhibiting viral replication

    Ramirez, S., Fernandez-Antunez, C., Galli, A., Underwood, A., Pham, L. V., Ryberg, L. A., Feng, S., Pedersen, M. S., Mikkelsen, L. S., Belouzard, S., Dubuisson, J., Sølund, C., Weis, N., Gottwein, J. M., Fahnøe, U. & Bukh, J., 17 Jun 2021, In: Antimicrobial Agents and Chemotherapy. 65, 7, p. 1-20 20 p., e0009721.

    Research output: Contribution to journal › Journal article › peer-review

  30. Published

    Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins

    Chen, F., Tzarum, N., Lin, X., Giang, E., Velázquez-Moctezuma, R., Augestad, E. H., Nagy, K., He, L., Hernandez, M., Fouch, M. E., Grinyó, A., Chavez, D., Doranz, B. J., Prentoe, J., Stanfield, R. L., Lanford, R., Bukh, J., Wilson, I. A., Zhu, J. & Law, M., 13 Apr 2021, In: Immunity. 54, 4, p. 781-796 16 p., e4.

    Research output: Contribution to journal › Journal article › peer-review

  31. Published

    Lipid Droplets Accumulation during Hepatitis C Virus Infection in Cell-Culture Varies among Genotype 1-3 Strains and Does Not Correlate with Virus Replication

    Galli, A., Ramirez, S. & Bukh, J., Mar 2021, In: Viruses. 13, 3, p. 1-18 18 p., 389.

    Research output: Contribution to journal › Journal article › peer-review

  32. Published

    Global evolutionary analysis of chronic hepatitis C patients revealed significant effect of baseline viral resistance, including novel non-target sites, for DAA-based treatment and retreatment outcome

    Fahnøe, U., Pedersen, M. S., Sølund, C., Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, J., Thielsen, P., Madsen, L. G., Pedersen, A. G., Schønning, K., Weis, N. & Bukh, J., Feb 2021, In: Journal of Viral Hepatitis. 28, 2, p. 302-316 15 p., 13430.

    Research output: Contribution to journal › Journal article › peer-review

  33. 2020
  34. Published

    Mutations Identified in the Hepatitis C Virus (HCV) Polymerase of Patients with Chronic HCV Treated with Ribavirin Cause Resistance and Affect Viral Replication Fidelity

    Mejer, N., Fahnøe, U., Galli, A., Ramirez, S., Weiland, O., Benfield, T. & Bukh, J., 17 Nov 2020, In: Antimicrobial Agents and Chemotherapy. 64, 12, p. 1-16 16 p.

    Research output: Contribution to journal › Journal article › peer-review

  35. Published

    Identification of specific amino acid residues in the border disease virus glycoprotein E2 that modify virus growth in pig cells but not in sheep cells

    Fahnøe, U., Deng, Y., Davids, N. A., Lohse, L., Bukh, J., Belsham, G. J. & Rasmussen, T. B., Nov 2020, In: The Journal of general virology. 101, 11, p. 1170-1181

    Research output: Contribution to journal › Journal article › peer-review

  36. Published

    Insights into the unique characteristics of hepatitis C virus genotype 3 revealed by development of a robust sub-genomic DBN3a replicon

    Ward, J. C., Bowyer, S., Chen, S., Fernandes Campos, G. R., Ramirez, S., Bukh, J. & Harris, M., Nov 2020, In: The Journal of general virology. 101, 11, p. 1182-1190 9 p.

    Research output: Contribution to journal › Journal article › peer-review

  37. Published

    Analysis of virus population profiles within pigs infected with virulent Classical Swine Fever viruses; evidence for bottlenecks in transmission but absence of tissue specific virus variants

    Johnston, C. M., Fahnøe, U., Lohse, L., Bukh, J., Belsham, G. J. & Rasmussen, T. B., 1 Oct 2020, In: Journal of Virology. 94, 19, e01119-20.

    Research output: Contribution to journal › Journal article › peer-review

  38. Published

    Development of a downstream process for the production of an inactivated whole hepatitis C virus vaccine

    Lothert, K., Offersgaard, A. F., Pihl, A. F., Mathiesen, C. K., Jensen, T. B., Alzua, G. P., Fahnøe, U., Bukh, J., Gottwein, J. M. & Wolff, M. W., 1 Oct 2020, In: Scientific Reports. 10, 1, p. 16261 16261.

    Research output: Contribution to journal › Journal article › peer-review

  39. Published

    Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity

    Augestad, E. H., Castelli, M., Clementi, N., Ströh, L. J., Krey, T., Burioni, R., Mancini, N., Bukh, J. & Prentoe, J., Aug 2020, In: Science Advances. 6, 35, p. eabb5938 eabb5938.

    Research output: Contribution to journal › Journal article › peer-review

  40. Published

    An alternate conformation of HCV E2 neutralizing face as an additional vaccine target

    Tzarum, N., Giang, E., Kadam, R. U., Chen, F., Nagy, K., Augestad, E. H., Velázquez-Moctezuma, R., Keck, Z-Y., Hua, Y., Stanfield, R. L., Dreux, M., Prentoe, J., Foung, S. K. H., Bukh, J., Wilson, I. A. & Law, M., 1 Jul 2020, In: Science Advances. 6, 30, abb5642.

    Research output: Contribution to journal › Journal article › peer-review

  41. Published

    Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis

    Tomlinson, J. E., Wolfisberg, R., Fahnøe, U., Sharma, H., Renshaw, R., Nielsen, L., Nishiuchi, E., Holm, C., Dubovi, E., Rosenberg, B. R., Tennant, B. C., Bukh, J., Kapoor, A., Divers, T. J., Rice, C. M., Van de Walle, G. R. & Scheel, T. K. H., Jul 2020, In: P L o S Pathogens. 16, 7, e1008677.

    Research output: Contribution to journal › Journal article › peer-review

  42. Published

    Specific Antibodies Induced by Immunization with Hepatitis B Virus-Like Particles Carrying Hepatitis C Virus Envelope Glycoprotein 2 Epitopes Show Differential Neutralization Efficiency

    Czarnota, A., Offersgaard, A., Pihl, A. F., Prentoe, J., Bukh, J., Gottwein, J. M., Bieńkowska-Szewczyk, K. & Grzyb, K., 10 Jun 2020, In: Human Vaccines. 8, 2, p. 1-19 19 p., 294.

    Research output: Contribution to journal › Journal article › peer-review

  43. Published

    Evolutionary selection of pestivirus variants with altered or no microRNA dependency

    Kokkonos, K. G., Fossat, N., Nielsen, L., Holm, C., Hepkema, W. M., Bukh, J. & Scheel, T. K. H., 4 Jun 2020, In: Nucleic Acids Research. 48, 10, p. 5555-5571 17 p., gkaa300.

    Research output: Contribution to journal › Journal article › peer-review

  44. Published

    Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B cell-Based Vaccine Development

    Chen, F., Nagy, K., Chavez, D., Willis, S., McBride, R., Giang, E., Honda, A., Bukh, J., Ordoukhanian, P., Zhu, J., Frey, S., Lanford, R. & Law, M., 1 Mar 2020, In: Gastroenterology. 158, 4, p. 1058-1071.e6 14 p.

    Research output: Contribution to journal › Journal article › peer-review

  45. Published

    Elimination af hepatitis C-virus i Danmark

    Døssing, A., Røge, B. T., Madsen, L. G., Laursen, A. L., Hansen, J. B., Bukh, J. & Weis, N., 24 Feb 2020, In: Ugeskrift for Laeger. 182, 9

    Research output: Contribution to journal › Journal article › peer-review

  46. Published

    Cell culture studies of the efficacy and barrier to resistance of sofosbuvir/velpatasvir and glecaprevir/pibrentasvir against hepatitis C virus genotypes 2a, 2b and 2c

    Ramirez, S., Fernandez-Antunez, C., Mikkelsen, L. S., Pedersen, J., Li, Y-P. & Bukh, J., 21 Feb 2020, In: Antimicrobial Agents and Chemotherapy. 64, 3, e01888.

    Research output: Contribution to journal › Journal article › peer-review

  47. Published

    Reflections on the History of HCV: A Posthumous Examination

    Alter, H. J., Farci, P., Bukh, J. & Purcell, R. H., Feb 2020, In: Clinical Liver Disease. 15, Suppl 1, p. S64-S71

    Research output: Contribution to journal › Review › peer-review

  48. Published

    Ribavirin inhibition of cell-culture infectious hepatitis C genotype 1-3 viruses is strain-dependent

    Mejer, N., Galli, A., Ramirez, S., Fahnøe, U., Benfield, T. & Bukh, J., 15 Jan 2020, In: Virology. 540, p. 132-140 9 p.

    Research output: Contribution to journal › Journal article › peer-review

  49. 2019
  50. Published

    Genome Sequence of an Unknown Subtype of Hepatitis C Virus Genotype 6: Another Piece for the Taxonomic Puzzle

    Pedersen, M. S., Mollerup, S., Nielsen, L. G., Jenssen, H., Bukh, J. & Schønning, K., 17 Oct 2019, In: Microbiology Resource Announcements. 8, 42, e01030-19.

    Research output: Contribution to journal › Journal article › peer-review

  51. Published

    Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus

    Fahnøe, U., Pedersen, A. G., Johnston, C. M., Orton, R. J., Höper, D., Beer, M., Bukh, J., Belsham, G. J. & Rasmussen, T. B., 10 Oct 2019, In: Viruses. 11, 10, 932.

    Research output: Contribution to journal › Journal article › peer-review

  52. Published

    HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen

    Filskov, J., Andersen, P., Agger, E. M. & Bukh, J., 1 Oct 2019, In: Scientific Reports. 9, 14085.

    Research output: Contribution to journal › Journal article › peer-review

  53. Published

    Replicons of a rodent hepatitis C model virus permit selection of highly permissive cells

    Wolfisberg, R., Holmbeck, K., Nielsen, L., Kapoor, A., Rice, C. M., Bukh, J. & Scheel, T. K. H., 1 Oct 2019, In: Journal of Virology. 93, 19

    Research output: Contribution to journal › Journal article › peer-review

  54. Published

    Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

    Jensen, S. B., Fahnøe, U., Pham, L. V., Serre, S., Tang, Q., Ghanem, L., Pedersen, M. S., Ramirez, S., Humes, D., Pihl, A. F., Filskov, J., Sølund, C. S., Dietz, J., Fourati, S., Pawlotsky, J-M., Sarrazin, C., Weis, N., Schønning, K., Krarup, H., Bukh, J. & 1 others, Gottwein, J. M., Sep 2019, In: Hepatology (Baltimore, Md.). 70, 3, p. 771-787 17 p.

    Research output: Contribution to journal › Journal article › peer-review

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