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The Capital Region of Denmark - a part of Copenhagen University Hospital
  1. 2021
  2. E-pub ahead of print

    HCV genome-wide analysis for development of efficient culture systems and unravelling of antiviral resistance in genotype 4

    Pham, L. V., Pedersen, M. S., Fahnøe, U., Fernandez-Antunez, C., Humes, D., Schønning, K., Ramirez, S. & Bukh, J., 8 Apr 2021, (E-pub ahead of print) In: Gut.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. E-pub ahead of print

    Pathogenesis, miR-122 gene-regulation, and protective immune responses after acute equine hepacivirus infection

    Tomlinson, J. E., Wolfisberg, R., Fahnøe, U., Patel, R. S., Trivedi, S., Kumar, A., Sharma, H., Nielsen, L., McDonough, S. P., Bukh, J., Tennant, B. C., Kapoor, A., Rosenberg, B. R., Rice, C. M., Divers, T. J., Van de Walle, G. R. & Scheel, T. K. H., 13 Mar 2021, (E-pub ahead of print) In: Hepatology (Baltimore, Md.).

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. E-pub ahead of print

    Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins

    Chen, F., Tzarum, N., Lin, X., Giang, E., Velázquez-Moctezuma, R., Augestad, E. H., Nagy, K., He, L., Hernandez, M., Fouch, M. E., Grinyó, A., Chavez, D., Doranz, B. J., Prentoe, J., Stanfield, R. L., Lanford, R., Bukh, J., Wilson, I. A., Zhu, J. & Law, M., 3 Mar 2021, (E-pub ahead of print) In: Immunity.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Lipid Droplets Accumulation during Hepatitis C Virus Infection in Cell-Culture Varies among Genotype 1-3 Strains and Does Not Correlate with Virus Replication

    Galli, A., Ramirez, S. & Bukh, J., 28 Feb 2021, In: Viruses. 13, 3, p. 1-18 18 p., 389.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Global evolutionary analysis of chronic hepatitis C patients revealed significant effect of baseline viral resistance, including novel non-target sites, for DAA-based treatment and retreatment outcome

    Fahnøe, U., Pedersen, M. S., Sølund, C., Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, J., Thielsen, P., Madsen, L. G., Pedersen, A. G., Schønning, K., Weis, N. & Bukh, J., Feb 2021, In: Journal of Viral Hepatitis. 28, 2, p. 302-316 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. E-pub ahead of print

    Vaccines against hepatitis C: a travel into neutralisation space

    Bukh, J., 25 Jan 2021, (E-pub ahead of print) In: Gut. gutjnl-2020-323377.

    Research output: Contribution to journalComment/debateResearchpeer-review

  8. 2020
  9. Published
  10. Published

    Identification of specific amino acid residues in the border disease virus glycoprotein E2 that modify virus growth in pig cells but not in sheep cells

    Fahnøe, U., Deng, Y., Davids, N. A., Lohse, L., Bukh, J., Belsham, G. J. & Rasmussen, T. B., Nov 2020, In: The Journal of general virology. 101, 11, p. 1170-1181

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Insights into the unique characteristics of hepatitis C virus genotype 3 revealed by development of a robust sub-genomic DBN3a replicon

    Ward, J. C., Bowyer, S., Chen, S., Fernandes Campos, G. R., Ramirez, S., Bukh, J. & Harris, M., Nov 2020, In: The Journal of general virology. 101, 11, p. 1182-1190 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Analysis of virus population profiles within pigs infected with virulent Classical Swine Fever viruses; evidence for bottlenecks in transmission but absence of tissue specific virus variants

    Johnston, C. M., Fahnøe, U., Lohse, L., Bukh, J., Belsham, G. J. & Rasmussen, T. B., 1 Oct 2020, In: Journal of Virology. 94, 19, e01119-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Development of a downstream process for the production of an inactivated whole hepatitis C virus vaccine

    Lothert, K., Offersgaard, A. F., Pihl, A. F., Mathiesen, C. K., Jensen, T. B., Alzua, G. P., Fahnøe, U., Bukh, J., Gottwein, J. M. & Wolff, M. W., 1 Oct 2020, In: Scientific Reports. 10, 1, p. 16261 16261.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity

    Augestad, E. H., Castelli, M., Clementi, N., Ströh, L. J., Krey, T., Burioni, R., Mancini, N., Bukh, J. & Prentoe, J., Aug 2020, In: Science Advances. 6, 35, p. eabb5938 eabb5938.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    An alternate conformation of HCV E2 neutralizing face as an additional vaccine target

    Tzarum, N., Giang, E., Kadam, R. U., Chen, F., Nagy, K., Augestad, E. H., Velázquez-Moctezuma, R., Keck, Z-Y., Hua, Y., Stanfield, R. L., Dreux, M., Prentoe, J., Foung, S. K. H., Bukh, J., Wilson, I. A. & Law, M., 1 Jul 2020, In: Science Advances. 6, 30, abb5642.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis

    Tomlinson, J. E., Wolfisberg, R., Fahnøe, U., Sharma, H., Renshaw, R., Nielsen, L., Nishiuchi, E., Holm, C., Dubovi, E., Rosenberg, B. R., Tennant, B. C., Bukh, J., Kapoor, A., Divers, T. J., Rice, C. M., Van de Walle, G. R. & Scheel, T. K. H., Jul 2020, In: P L o S Pathogens. 16, 7, e1008677.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Specific Antibodies Induced by Immunization with Hepatitis B Virus-Like Particles Carrying Hepatitis C Virus Envelope Glycoprotein 2 Epitopes Show Differential Neutralization Efficiency

    Czarnota, A., Offersgaard, A., Pihl, A. F., Prentoe, J., Bukh, J., Gottwein, J. M., Bieńkowska-Szewczyk, K. & Grzyb, K., 10 Jun 2020, In: Human Vaccines. 8, 2, p. 1-19 19 p., 294.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Evolutionary selection of pestivirus variants with altered or no microRNA dependency

    Kokkonos, K. G., Fossat, N., Nielsen, L., Holm, C., Hepkema, W. M., Bukh, J. & Scheel, T. K. H., 4 Jun 2020, In: Nucleic Acids Research. 48, 10, p. 5555-5571 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B cell-Based Vaccine Development

    Chen, F., Nagy, K., Chavez, D., Willis, S., McBride, R., Giang, E., Honda, A., Bukh, J., Ordoukhanian, P., Zhu, J., Frey, S., Lanford, R. & Law, M., 1 Mar 2020, In: Gastroenterology. 158, 4, p. 1058-1071.e6 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Elimination af hepatitis C-virus i Danmark

    Døssing, A., Røge, B. T., Madsen, L. G., Laursen, A. L., Hansen, J. B., Bukh, J. & Weis, N., 24 Feb 2020, In: Ugeskrift for Laeger. 182, 9

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published
  22. Published

    Reflections on the History of HCV: A Posthumous Examination

    Alter, H. J., Farci, P., Bukh, J. & Purcell, R. H., Feb 2020, In: Clinical Liver Disease. 15, Suppl 1, p. S64-S71

    Research output: Contribution to journalReviewpeer-review

  23. Published

    Ribavirin inhibition of cell-culture infectious hepatitis C genotype 1-3 viruses is strain-dependent

    Mejer, N., Galli, A., Ramirez, S., Fahnøe, U., Benfield, T. & Bukh, J., 15 Jan 2020, In: Virology. 540, p. 132-140 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2019
  25. Published

    Genome Sequence of an Unknown Subtype of Hepatitis C Virus Genotype 6: Another Piece for the Taxonomic Puzzle

    Pedersen, M. S., Mollerup, S., Nielsen, L. G., Jenssen, H., Bukh, J. & Schønning, K., 17 Oct 2019, In: Microbiology Resource Announcements. 8, 42, e01030-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus

    Fahnøe, U., Pedersen, A. G., Johnston, C. M., Orton, R. J., Höper, D., Beer, M., Bukh, J., Belsham, G. J. & Rasmussen, T. B., 10 Oct 2019, In: Viruses. 11, 10, 932.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen

    Filskov, J., Andersen, P., Agger, E. M. & Bukh, J., 1 Oct 2019, In: Scientific Reports. 9, 14085.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Replicons of a rodent hepatitis C model virus permit selection of highly permissive cells

    Wolfisberg, R., Holmbeck, K., Nielsen, L., Kapoor, A., Rice, C. M., Bukh, J. & Scheel, T. K. H., 1 Oct 2019, In: Journal of Virology. 93, 19

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

    Jensen, S. B., Fahnøe, U., Pham, L. V., Serre, S., Tang, Q., Ghanem, L., Pedersen, M. S., Ramirez, S., Humes, D., Pihl, A. F., Filskov, J., Sølund, C. S., Dietz, J., Fourati, S., Pawlotsky, J-M., Sarrazin, C., Weis, N., Schønning, K., Krarup, H., Bukh, J. & Gottwein, J. M., Sep 2019, In: Hepatology (Baltimore, Md.). 70, 3, p. 771-787 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published
  31. Published

    Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

    Keck, Z-Y., Pierce, B. G., Lau, P., Lu, J., Wang, Y., Underwood, A., Bull, R. A., Prentoe, J., Velázquez-Moctezuma, R., Walker, M. R., Luciani, F., Guest, J. D., Fauvelle, C., Baumert, T. F., Bukh, J., Lloyd, A. R. & Foung, S. K. H., May 2019, In: PLoS pathogens. 15, 5, e1007772.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published
  33. Published
  34. Published

    Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies

    Tzarum, N., Giang, E., Kong, L., He, L., Prentoe, J., Augestad, E., Hua, Y., Castillo, S., Lauer, G. M., Bukh, J., Zhu, J., Wilson, I. A. & Law, M., 1 Jan 2019, In: Scientific American. 5, 1, p. eaav1882 eaav1882.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published
  36. Published

    Full-Length Open Reading Frame Amplification of Hepatitis C Virus

    Fahnøe, U. & Bukh, J., 2019, In: Methods in molecular biology. 1911, p. 85-91 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    In Vitro Neutralization Assay Using Cultured Hepatitis C Virus

    Prentoe, J. & Bukh, J., 2019, In: Methods in molecular biology. 1911, p. 433-439 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. 2018
  39. Published

    High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals

    Pihl, A. F., Offersgaard, A. F., Mathiesen, C. K., Prentoe, J., Fahnøe, U., Krarup, H., Bukh, J. & Gottwein, J. M., 30 Nov 2018, In: Scientific Reports. 8, 17505

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published
  41. Published

    Outcome and adverse events in patients with chronic hepatitis C treated with direct-acting antivirals: A clinical randomized study

    Sølund, C., Andersen, E. S., Mössner, B., Laursen, A. L., Røge, B. T., Kjær, M. S., Gerstoft, J., Christensen, P. B., Pedersen, M. S., Schønning, K., Fahnøe, U., Bukh, J. & Weis, N., 1 Oct 2018, In: European Journal of Gastroenterology and Hepatology. 30, 10, p. 1177-1186 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published
  43. Published
  44. Published
  45. Published
  46. Published
  47. Published
  48. Published

    Direct acting antiviral treatment of chronic hepatitis C in Denmark: factors associated with and barriers to treatment initiation

    Sølund, C., Hallager, S., Pedersen, M. S., Fahnøe, U., Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, J., Bélard, E., Madsen, L. G., Schønning, K., Pedersen, A. G., Bukh, J., Weis, N. & Group, T. DANHEP., 1 May 2018, In: Scandinavian Journal of Gastroenterology. 53, 7, p. 849-856

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    IDENTIFICATION OF PIPERAZINYLBENZENESULFONAMIDES AS NEW INHIBITORS OF CLAUDIN-1 TRAFFICKING AND HEPATITIS C VIRUS ENTRY

    Riva, L., Song, O-R., Prentoe, J., Helle, F., L'homme, L., Gattolliat, C-H., Vandeputte, A., Fénéant, L., Belouzard, S., Baumert, T. F., Asselah, T., Bukh, J., Brodin, P., Cocquerel, L., Rouillé, Y. & Dubuisson, J., 1 May 2018, In: Journal of Virology. 92, 10

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1-7 and Escape Variants

    Gottwein, J. M., Pham, L. V., Mikkelsen, L. S., Ghanem, L., Ramirez, S., Scheel, T. K. H., Carlsen, T. H. R. & Bukh, J., Apr 2018, In: Gastroenterology. 154, 5, p. 1435-1448

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published
  52. Published

    Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies

    Bartenschlager, R., Baumert, T. F., Bukh, J., Houghton, M., Lemon, S. M., Lindenbach, B. D., Lohmann, V., Moradpour, D., Pietschmann, T., Rice, C. M., Thimme, R. & Wakita, T., Mar 2018, In: Virus Genes. 248, p. 53-62

    Research output: Contribution to journalReviewpeer-review

  53. Published
  54. 2017
  55. Published
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