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  1. The Capital Region of Denmark
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  3. Jens Bukh
  4. Publications
The Capital Region of Denmark - a part of Copenhagen University Hospital
Jens Bukh

Jens Bukh

Chief Consultant

1 - 50 out of 171Page size: 50
  1. 2021
  2. E-pub ahead of print

    HCV genome-wide analysis for development of efficient culture systems and unravelling of antiviral resistance in genotype 4

    Pham, L. V., Pedersen, M. S., Fahnøe, U., Fernandez-Antunez, C., Humes, D., Schønning, K., Ramirez, S. & Bukh, J., 8 Apr 2021, (E-pub ahead of print) In: Gut.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. E-pub ahead of print

    Pathogenesis, miR-122 gene-regulation, and protective immune responses after acute equine hepacivirus infection

    Tomlinson, J. E., Wolfisberg, R., Fahnøe, U., Patel, R. S., Trivedi, S., Kumar, A., Sharma, H., Nielsen, L., McDonough, S. P., Bukh, J., Tennant, B. C., Kapoor, A., Rosenberg, B. R., Rice, C. M., Divers, T. J., Van de Walle, G. R. & Scheel, T. K. H., 13 Mar 2021, (E-pub ahead of print) In: Hepatology (Baltimore, Md.).

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. E-pub ahead of print

    Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins

    Chen, F., Tzarum, N., Lin, X., Giang, E., Velázquez-Moctezuma, R., Augestad, E. H., Nagy, K., He, L., Hernandez, M., Fouch, M. E., Grinyó, A., Chavez, D., Doranz, B. J., Prentoe, J., Stanfield, R. L., Lanford, R., Bukh, J., Wilson, I. A., Zhu, J. & Law, M., 3 Mar 2021, (E-pub ahead of print) In: Immunity.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Lipid Droplets Accumulation during Hepatitis C Virus Infection in Cell-Culture Varies among Genotype 1-3 Strains and Does Not Correlate with Virus Replication

    Galli, A., Ramirez, S. & Bukh, J., 28 Feb 2021, In: Viruses. 13, 3, p. 1-18 18 p., 389.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Global evolutionary analysis of chronic hepatitis C patients revealed significant effect of baseline viral resistance, including novel non-target sites, for DAA-based treatment and retreatment outcome

    Fahnøe, U., Pedersen, M. S., Sølund, C., Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, J., Thielsen, P., Madsen, L. G., Pedersen, A. G., Schønning, K., Weis, N. & Bukh, J., Feb 2021, In: Journal of Viral Hepatitis. 28, 2, p. 302-316 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. E-pub ahead of print

    Vaccines against hepatitis C: a travel into neutralisation space

    Bukh, J., 25 Jan 2021, (E-pub ahead of print) In: Gut. gutjnl-2020-323377.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  8. 2020
  9. Published

    Mutations Identified in the Hepatitis C Virus (HCV) Polymerase of Patients with Chronic HCV Treated with Ribavirin Cause Resistance and Affect Viral Replication Fidelity

    Mejer, N., Fahnøe, U., Galli, A., Ramirez, S., Weiland, O., Benfield, T. & Bukh, J., 17 Nov 2020, In: Antimicrobial Agents and Chemotherapy. 64, 12

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Identification of specific amino acid residues in the border disease virus glycoprotein E2 that modify virus growth in pig cells but not in sheep cells

    Fahnøe, U., Deng, Y., Davids, N. A., Lohse, L., Bukh, J., Belsham, G. J. & Rasmussen, T. B., Nov 2020, In: The Journal of general virology. 101, 11, p. 1170-1181

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Insights into the unique characteristics of hepatitis C virus genotype 3 revealed by development of a robust sub-genomic DBN3a replicon

    Ward, J. C., Bowyer, S., Chen, S., Fernandes Campos, G. R., Ramirez, S., Bukh, J. & Harris, M., Nov 2020, In: The Journal of general virology. 101, 11, p. 1182-1190 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Analysis of virus population profiles within pigs infected with virulent Classical Swine Fever viruses; evidence for bottlenecks in transmission but absence of tissue specific virus variants

    Johnston, C. M., Fahnøe, U., Lohse, L., Bukh, J., Belsham, G. J. & Rasmussen, T. B., 1 Oct 2020, In: Journal of Virology. 94, 19, e01119-20.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Development of a downstream process for the production of an inactivated whole hepatitis C virus vaccine

    Lothert, K., Offersgaard, A. F., Pihl, A. F., Mathiesen, C. K., Jensen, T. B., Alzua, G. P., Fahnøe, U., Bukh, J., Gottwein, J. M. & Wolff, M. W., 1 Oct 2020, In: Scientific Reports. 10, 1, p. 16261 16261.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity

    Augestad, E. H., Castelli, M., Clementi, N., Ströh, L. J., Krey, T., Burioni, R., Mancini, N., Bukh, J. & Prentoe, J., Aug 2020, In: Science Advances. 6, 35, p. eabb5938 eabb5938.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    An alternate conformation of HCV E2 neutralizing face as an additional vaccine target

    Tzarum, N., Giang, E., Kadam, R. U., Chen, F., Nagy, K., Augestad, E. H., Velázquez-Moctezuma, R., Keck, Z-Y., Hua, Y., Stanfield, R. L., Dreux, M., Prentoe, J., Foung, S. K. H., Bukh, J., Wilson, I. A. & Law, M., 1 Jul 2020, In: Science Advances. 6, 30, abb5642.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis

    Tomlinson, J. E., Wolfisberg, R., Fahnøe, U., Sharma, H., Renshaw, R., Nielsen, L., Nishiuchi, E., Holm, C., Dubovi, E., Rosenberg, B. R., Tennant, B. C., Bukh, J., Kapoor, A., Divers, T. J., Rice, C. M., Van de Walle, G. R. & Scheel, T. K. H., Jul 2020, In: P L o S Pathogens. 16, 7, e1008677.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Specific Antibodies Induced by Immunization with Hepatitis B Virus-Like Particles Carrying Hepatitis C Virus Envelope Glycoprotein 2 Epitopes Show Differential Neutralization Efficiency

    Czarnota, A., Offersgaard, A., Pihl, A. F., Prentoe, J., Bukh, J., Gottwein, J. M., Bieńkowska-Szewczyk, K. & Grzyb, K., 10 Jun 2020, In: Human Vaccines. 8, 2, p. 1-19 19 p., 294.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Evolutionary selection of pestivirus variants with altered or no microRNA dependency

    Kokkonos, K. G., Fossat, N., Nielsen, L., Holm, C., Hepkema, W. M., Bukh, J. & Scheel, T. K. H., 4 Jun 2020, In: Nucleic Acids Research. 48, 10, p. 5555-5571 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B cell-Based Vaccine Development

    Chen, F., Nagy, K., Chavez, D., Willis, S., McBride, R., Giang, E., Honda, A., Bukh, J., Ordoukhanian, P., Zhu, J., Frey, S., Lanford, R. & Law, M., 1 Mar 2020, In: Gastroenterology. 158, 4, p. 1058-1071.e6 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Elimination af hepatitis C-virus i Danmark

    Døssing, A., Røge, B. T., Madsen, L. G., Laursen, A. L., Hansen, J. B., Bukh, J. & Weis, N., 24 Feb 2020, In: Ugeskrift for Laeger. 182, 9

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Cell culture studies of the efficacy and barrier to resistance of sofosbuvir/velpatasvir and glecaprevir/pibrentasvir against hepatitis C virus genotypes 2a, 2b and 2c

    Ramirez, S., Fernandez-Antunez, C., Mikkelsen, L. S., Pedersen, J., Li, Y-P. & Bukh, J., 21 Feb 2020, In: Antimicrobial Agents and Chemotherapy. 64, 3, e01888.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Reflections on the History of HCV: A Posthumous Examination

    Alter, H. J., Farci, P., Bukh, J. & Purcell, R. H., Feb 2020, In: Clinical Liver Disease. 15, Suppl 1, p. S64-S71

    Research output: Contribution to journal › Review › peer-review

  23. Published

    Ribavirin inhibition of cell-culture infectious hepatitis C genotype 1-3 viruses is strain-dependent

    Mejer, N., Galli, A., Ramirez, S., Fahnøe, U., Benfield, T. & Bukh, J., 15 Jan 2020, In: Virology. 540, p. 132-140 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. 2019
  25. Published

    Genome Sequence of an Unknown Subtype of Hepatitis C Virus Genotype 6: Another Piece for the Taxonomic Puzzle

    Pedersen, M. S., Mollerup, S., Nielsen, L. G., Jenssen, H., Bukh, J. & Schønning, K., 17 Oct 2019, In: Microbiology Resource Announcements. 8, 42, e01030-19.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus

    Fahnøe, U., Pedersen, A. G., Johnston, C. M., Orton, R. J., Höper, D., Beer, M., Bukh, J., Belsham, G. J. & Rasmussen, T. B., 10 Oct 2019, In: Viruses. 11, 10, 932.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen

    Filskov, J., Andersen, P., Agger, E. M. & Bukh, J., 1 Oct 2019, In: Scientific Reports. 9, 14085.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Replicons of a rodent hepatitis C model virus permit selection of highly permissive cells

    Wolfisberg, R., Holmbeck, K., Nielsen, L., Kapoor, A., Rice, C. M., Bukh, J. & Scheel, T. K. H., 1 Oct 2019, In: Journal of Virology. 93, 19

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

    Jensen, S. B., Fahnøe, U., Pham, L. V., Serre, S., Tang, Q., Ghanem, L., Pedersen, M. S., Ramirez, S., Humes, D., Pihl, A. F., Filskov, J., Sølund, C. S., Dietz, J., Fourati, S., Pawlotsky, J-M., Sarrazin, C., Weis, N., Schønning, K., Krarup, H., Bukh, J. & Gottwein, J. M., Sep 2019, In: Hepatology (Baltimore, Md.). 70, 3, p. 771-787 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations

    Prentoe, J., Velázquez-Moctezuma, R., Augestad, E. H., Galli, A., Wang, R., Law, M., Alter, H. & Bukh, J., 14 May 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10039-10047 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

    Keck, Z-Y., Pierce, B. G., Lau, P., Lu, J., Wang, Y., Underwood, A., Bull, R. A., Prentoe, J., Velázquez-Moctezuma, R., Walker, M. R., Luciani, F., Guest, J. D., Fauvelle, C., Baumert, T. F., Bukh, J., Lloyd, A. R. & Foung, S. K. H., May 2019, In: PLoS pathogens. 15, 5, e1007772.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape

    Pham, L. V., Jensen, S. B., Fahnøe, U., Pedersen, M. S., Tang, Q., Ghanem, L., Ramirez, S., Humes, D., Serre, S. B. N., Schønning, K., Bukh, J. & Gottwein, J. M., 1 Mar 2019, In: Journal of Hepatology. 70, 3, p. 388-397 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Hepatitis C virus escape studies of human antibody AR3a reveal a high barrier to resistance and novel insights on viral antibody evasion mechanisms

    Velázquez-Moctezuma, R., Galli, A., Law, M., Bukh, J. & Prentoe, J., 1 Feb 2019, In: Journal of Virology. 93, 4, e0190918.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies

    Tzarum, N., Giang, E., Kong, L., He, L., Prentoe, J., Augestad, E., Hua, Y., Castillo, S., Lauer, G. M., Bukh, J., Zhu, J., Wilson, I. A. & Law, M., 1 Jan 2019, In: Scientific American. 5, 1, p. eaav1882 eaav1882.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Hepatitis C virus escape studies for human monoclonal antibody AR4A reveal isolate-specific resistance and a high barrier to resistance

    Velázquez-Moctezuma, R., Galli, A., Law, M., Bukh, J. & Prentoe, J., 1 Jan 2019, In: The Journal of infectious diseases. 219, 1, p. 68-79 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Full-Length Open Reading Frame Amplification of Hepatitis C Virus

    Fahnøe, U. & Bukh, J., 2019, In: Methods in molecular biology. 1911, p. 85-91 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    In Vitro Neutralization Assay Using Cultured Hepatitis C Virus

    Prentoe, J. & Bukh, J., 2019, In: Methods in molecular biology. 1911, p. 433-439 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. 2018
  39. Published

    High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals

    Pihl, A. F., Offersgaard, A. F., Mathiesen, C. K., Prentoe, J., Fahnøe, U., Krarup, H., Bukh, J. & Gottwein, J. M., 30 Nov 2018, In: Scientific Reports. 8, 17505

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    High-titer HCV full-length genotype 2b infectious cell culture systems and applications thereof.

    Ramirez, S., Li, Y., Gottwein, J. & Bukh, J., 23 Oct 2018

    Research output: Patent

  41. Published

    Outcome and adverse events in patients with chronic hepatitis C treated with direct-acting antivirals: A clinical randomized study

    Sølund, C., Andersen, E. S., Mössner, B., Laursen, A. L., Røge, B. T., Kjær, M. S., Gerstoft, J., Christensen, P. B., Pedersen, M. S., Schønning, K., Fahnøe, U., Bukh, J. & Weis, N., 1 Oct 2018, In: European Journal of Gastroenterology and Hepatology. 30, 10, p. 1177-1186 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Current status and future development of infectious cell-culture models for the major genotypes of hepatitis C virus: Essential tools in testing of antivirals and emerging vaccine strategies

    Ramirez, S. & Bukh, J., Oct 2018, In: Antiviral Research. 158, p. 264-287

    Research output: Contribution to journal › Review › peer-review

  43. Published

    Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry

    Prentoe, J. & Bukh, J., 27 Sep 2018, In: Frontiers in Immunology. 9, 2146, p. 1-11

    Research output: Contribution to journal › Review › peer-review

  44. Published

    Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies

    Humes, D., Ramirez, S., Jensen, T. B., Li, Y-P., Gottwein, J. M. & Bukh, J., 1 Sep 2018, In: Virology. 522, p. 177-192 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    A near full-length open reading frame next generation sequencing assay for genotyping and identification of resistance-associated variants in hepatitis C virus

    Pedersen, M. S., Fahnøe, U., Hansen, T. A., Pedersen, A. G., Jenssen, H., Bukh, J. & Schønning, K., 1 Aug 2018, In: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 105, p. 49-56 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Ribavirin-induced mutagenesis across the complete open reading frame of hepatitis C virus genotypes 1a and 3a

    Mejer, N., Fahnøe, U., Galli, A., Ramirez, S., Benfield, T. & Bukh, J., 1 Aug 2018, In: The Journal of general virology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    HCV Genotype 6a Escape From and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models

    Pham, L. V., Ramirez, S., Gottwein, J. M., Fahnøe, U., Li, Y-P., Pedersen, J. & Bukh, J., 1 Jun 2018, In: Gastroenterology. 154, 8, p. 2194-2208

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Direct acting antiviral treatment of chronic hepatitis C in Denmark: factors associated with and barriers to treatment initiation

    Sølund, C., Hallager, S., Pedersen, M. S., Fahnøe, U., Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, J., Bélard, E., Madsen, L. G., Schønning, K., Pedersen, A. G., Bukh, J., Weis, N. & Group, T. DANHEP., 1 May 2018, In: Scandinavian Journal of Gastroenterology. 53, 7, p. 849-856

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    IDENTIFICATION OF PIPERAZINYLBENZENESULFONAMIDES AS NEW INHIBITORS OF CLAUDIN-1 TRAFFICKING AND HEPATITIS C VIRUS ENTRY

    Riva, L., Song, O-R., Prentoe, J., Helle, F., L'homme, L., Gattolliat, C-H., Vandeputte, A., Fénéant, L., Belouzard, S., Baumert, T. F., Asselah, T., Bukh, J., Brodin, P., Cocquerel, L., Rouillé, Y. & Dubuisson, J., 1 May 2018, In: Journal of Virology. 92, 10

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1-7 and Escape Variants

    Gottwein, J. M., Pham, L. V., Mikkelsen, L. S., Ghanem, L., Ramirez, S., Scheel, T. K. H., Carlsen, T. H. R. & Bukh, J., Apr 2018, In: Gastroenterology. 154, 5, p. 1435-1448

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model

    Galli, A., Mens, H., Gottwein, J. M., Gerstoft, J. & Bukh, J., 1 Mar 2018, In: Scientific Reports. 8, 4619

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies

    Bartenschlager, R., Baumert, T. F., Bukh, J., Houghton, M., Lemon, S. M., Lindenbach, B. D., Lohmann, V., Moradpour, D., Pietschmann, T., Rice, C. M., Thimme, R. & Wakita, T., Mar 2018, In: Virus Genes. 248, p. 53-62

    Research output: Contribution to journal › Review › peer-review

  53. Published

    Novel HCV culture systems and direct-acting antiviral sensitivity

    Li, Y., Ramirez, S., Humes, D., Gottwein, J. & Bukh, J., 2018

    Research output: Patent

  54. 2017
  55. Published

    Unraveling protease inhibitor resistance in hepatitis C virus genotypes 1-6: Identification and characterization of resistant variants and study of evolutionary pathways to viral resistance

    Brun Jensen, S., Gottwein, J. & Bukh, J., Dec 2017

    Research output: Book/Report › Ph.D. thesis

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