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The Capital Region of Denmark - a part of Copenhagen University Hospital
Ismo Mattila

Ismo Mattila

Forsker

Niels Steensens Vej 2-4

Building: NSA

2820 Gentofte

Denmark

  1. 2020
  2. Published

    Lipidomic profiles, lipid trajectories and clinical biomarkers in female elite endurance athletes

    Varga, T. V., Ali, A., Herrera, J. A. R., Ahonen, L. L., Mattila, I. M., Al-Sari, N. H., Legido-Quigley, C., Skouby, S., Brunak, S. & Tornberg, Å. B., 11 Feb 2020, In : Scientific Reports. 10, 1, 2349.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2019
  4. Published
  5. Published
  6. Published

    Circulating metabolites are associated with present and future renal impairment in type 1 Diabetes

    Tofte, N., Suvitaival, T., Trošt, K., Mattila, I., Theilade, S., Winther, S. A., Ahluwalia, T. S., Frimodt-Møller, M., Legido-Quigley, C. & Rossing, P., Sep 2019, In : Diabetologia. 62, Suppl 1, p. 30 1 p., 57.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  7. Published

    Renal function dominates the landscape of the metabolome in type 1 diabetes

    Suvitaival, T., Tofte, N., Mattila, I., Trošt, K., Theilade, S., Winther, S. A., Ahluwalia, T. S., Frimodt-Møller, M., Rossing, P. & Legido-Quigley, C., Sep 2019, In : Diabetologia. 62, Suppl 1, p. 455 1 p., 936.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  8. Published

    Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children

    Madrid-Gambin, F., Föcking, M., Sabherwal, S., Heurich, M., English, J. A., O'Gorman, A., Suvitaival, T., Ahonen, L., Cannon, M., Lewis, G., Mattila, I., Scaife, C., Madden, S., Hyötyläinen, T., Orešič, M., Zammit, S., Cagney, G., Cotter, D. R. & Brennan, L., 1 Jul 2019, In : Biological Psychiatry. 86, 1, p. 25-34 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published
  10. Published

    Lipidomics of human adipose tissue reveals diversity between bod areas

    Al-Sari, N. H., Suvitaival, T., Mattila, I., Ali, A., Ahonen, L., Trošt, K., Henriksen, T. F., Pociot, F., Dragsted, L. O. & Legido-Quigley, C., 2019.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  11. 2018
  12. Published

    Serum metabolites associate with CT findings following TBI

    Dickens, A. M., Posti, J. P., Takala, R. S., Ala-Seppälä, H. M., Mattila, I., Coles, J. C., Frantzén, J., Hutchinson, P. J., Katila, A. J., Kyllönen, A., Maanpää, H-R., Newcombe, V., Outtrim, J., Tallus, J., Carpenter, K., Menon, D., Hyotylainen, T., Tenovuo, O. & Oresic, M., 1 Nov 2018, In : Journal of Neurotrauma. 35, 22, p. 2673–2683 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Plasma Metabolomics Profiling in Auto-Antibody-Positive Individuals Progressing to Type 1 Diabetes

    Suvitaival, T., Wesley, J. D., Ali, A., Trošt, K., Ahonen, L. L., Overgaard, A. J., Mattila, I., Hagopian, W., von Herrath, M., Rossing, P., Pociot, F. & Legido-Quigley, C., 27 Oct 2018.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  14. Published

    SERUM METABOLITES ASSOCIATE WITH HEAD COMPUTED TOMOGRAPHY FINDINGS FOLLOWING TRAUMATIC BRAIN INJURY

    Posti, J. P., Dickens, A., Takala, R. S., Ala-Seppala, H., Mattila, I., Coles, J. P., Frantzen, J., Hutchinson, P. J., Katila, A., Kyllonen, A., Maanpaa, H-R., Newcombe, V., Outtrim, J., Tallus, J., Carpenter, K. L. H., Menon, D. K., Hyotylainen, T., Tenovuo, O. & Oresic, M., 1 Aug 2018, In : Journal of Neurotrauma. 35, 16, p. A67 1 p., PS1.04.33.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  15. Published

    Development and comparison of sample preparation methods for LC-MS based lipidomics on fecal samples

    Ahonen, L. L., Stanstrup, J., Mattila, I., Christiansen, N., Rossing, P. & Dragsted, L. O., 4 Jun 2018.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  16. Published

    Metabolomics approaches to study metabolic co-morbidities in psychotic disorders

    Hyotylainen, T., Suvitaival, T., Geng, D., Poho, P., Mattila, I., Suvisaari, J. & Oresic, M., 1 Apr 2018, In : Schizophrenia Bulletin. 44, Suppl1, p. S69 1 p., 42.3.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  17. Published

    Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor

    Orešič, M., Anderson, G., Mattila, I., Manoucheri, M., Soininen, H., Hyötyläinen, T. & Basignani, C., 9 Jan 2018, In : Frontiers in Neuroscience. 11, p. 747

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2017
  19. Published

    Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort

    O'Gorman, A., Suvitaival, T., Ahonen, L., Cannon, G. M., Zammit, S., Lewis, G., Roche, H. M., Mattila, I., Hyotylainen, T., Orešič, M., Brennan, L. & Cotter, D. R., 26 Sep 2017, In : Translational psychiatry. 7, 9, p. e1240

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Interactions of Insoluble Residue from Enzymatic Hydrolysis of Brewer's Spent Grain with Intestinal Microbiota in Mice

    Maukonen, J., Aura, A. M., Niemi, P., Raza, G. S., Niemelä, K., Walkowiak, J., Mattila, I., Poutanen, K., Buchert, J. & Herzig, K-H., 10 May 2017, In : Journal of Agricultural and Food Chemistry. 65, 18, p. 3748-3756 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Effect of Bioprocessing on the In Vitro Colonic Microbial Metabolism of Phenolic Acids from Rye Bran Fortified Breads

    Koistinen, V. M., Nordlund, E., Katina, K., Mattila, I., Poutanen, K., Hanhineva, K. & Aura, A. M., 8 Mar 2017, In : Journal of Agricultural and Food Chemistry. 65, 9, p. 1854-1864 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2016
  23. Serum metabolite profile associates with the development of metabolic co-morbidities in first-episode psychosis

    Suvitaival, T., Mantere, O., Kieseppä, T., Mattila, I., Pöhö, P., Hyotylainen, T., Suvisaari, J. & Orešič, M., 15 Nov 2016, In : Translational psychiatry. 6, 11, p. e951

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury

    Orešič, M., Posti, J. P., Kamstrup-Nielsen, M. H., Takala, R. S. K., Lingsma, H. F., Mattila, I., Jäntti, S., Katila, A. J., Carpenter, K. L. H., Ala-Seppälä, H., Kyllönen, A., Maanpää, H-R., Tallus, J., Coles, J. P., Heino, I., Frantzén, J., Hutchinson, P. J., Menon, D. K., Tenovuo, O. & Hyotylainen, T., Oct 2016, In : EBioMedicine. 12, p. 118-126 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI)

    Kurko, J., Tringham, M., Tanner, L., Näntö-Salonen, K., Vähä-Mäkilä, M., Nygren, H., Pöhö, P., Lietzen, N., Mattila, I., Olkku, A., Hyötyläinen, T., Orešič, M., Simell, O., Niinikoski, H. & Mykkänen, J., Sep 2016, In : Metabolism: Clinical and Experimental. 65, 9, p. 1361-75 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Human gut microbes impact host serum metabolome and insulin sensitivity

    Gudmundsdottir, V., Hyötyläinen, T., Nielsen, T., Jensen, B. A. H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., Le Chatelier, E., Levenez, F., Doré, J., Mattila, I., Plichta, D. R., Pöhö, P., Hellgren, L. I., Arumugam, M., Sunagawa, S., Vieira-Silva, S., Jørgensen, T., Holm, J. B., Trošt, K., Consortium, MIT., Kristiansen, K., Brix, S., Raes, J., Wang, J., Hansen, T., Bork, P., Brunak, S., Orešič, M., Ehrlich, S. D. & Pedersen, O., 13 Jul 2016, In : Nature. 535, p. 376-81

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary metabolites

    Vetrani, C., Rivellese, A. A., Annuzzi, G., Adiels, M., Borén, J., Mattila, I., Orešič, M. & Aura, A-M., Jul 2016, In : The Journal of nutritional biochemistry. 33, p. 111-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease

    Hyötyläinen, T., Jerby, L., Petäjä, E. M., Mattila, I., Jäntti, S., Auvinen, P., Gastaldelli, A., Yki-Järvinen, H., Ruppin, E. & Orešič, M., 3 Feb 2016, In : Nature Communications. 7, p. 8994

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2015
  30. The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes

    DIABIMMUNE Study Group, 11 Feb 2015, In : Cell Host & Microbe. 17, 2, p. 260-73 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. The influence of sample collection methodology and sample preprocessing on the blood metabolic profile

    Jørgenrud, B., Jäntti, S., Mattila, I., Pöhö, P., Rønningen, K. S., Yki-Järvinen, H., Orešič, M. & Hyötyläinen, T., 2015, In : Bioanalysis. 7, 8, p. 991-1006 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. 2014
  33. Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight: a Big Mac challenge

    Bondia-Pons, I., Maukonen, J., Mattila, I., Rissanen, A., Saarela, M., Kaprio, J., Hakkarainen, A., Lundbom, J., Lundbom, N., Hyötyläinen, T., Pietiläinen, K. H. & Orešič, M., Sep 2014, In : FASEB Journal. 28, 9, p. 4169-79 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2013
  35. Release of small phenolic compounds from brewer's spent grain and its lignin fractions by human intestinal microbiota in vitro

    Aura, A-M., Niemi, P., Mattila, I., Niemelä, K., Smeds, A., Tamminen, T., Faulds, C., Buchert, J. & Poutanen, K., 9 Oct 2013, In : Journal of Agricultural and Food Chemistry. 61, 40, p. 9744-53 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids

    Orešič, M., Hyötyläinen, T., Kotronen, A., Gopalacharyulu, P., Nygren, H., Arola, J., Castillo, S., Mattila, I., Hakkarainen, A., Borra, R. J. H., Honka, M-J., Verrijken, A., Francque, S., Iozzo, P., Leivonen, M., Jaser, N., Juuti, A., Sørensen, T. I. A., Nuutila, P., Van Gaal, L. & Yki-Järvinen, H., Oct 2013, In : Diabetologia. 56, 10, p. 2266-74 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Interactions of a lignin-rich fraction from brewer's spent grain with gut microbiota in vitro

    Niemi, P., Aura, A-M., Maukonen, J., Smeds, A. I., Mattila, I., Niemelä, K., Tamminen, T., Faulds, C. B., Buchert, J. & Poutanen, K., 10 Jul 2013, In : Journal of Agricultural and Food Chemistry. 61, 27, p. 6754-62 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Characterization of cerebrospinal fluid by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry

    Hartonen, M., Mattila, I., Ruskeepää, A-L., Orešič, M. & Hyötyläinen, T., 7 Jun 2013, In : Journal of chromatography. A. 1293, p. 142-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches

    Aura, A-M., Mattila, I., Hyötyläinen, T., Gopalacharyulu, P., Cheynier, V., Souquet, J-M., Bes, M., Le Bourvellec, C., Guyot, S. & Orešič, M., Mar 2013, In : European Journal of Nutrition. 52, 2, p. 833-46 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. 2012
  41. Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance

    Hyötyläinen, T., Mattila, I., Wiedmer, S. K., Koivuniemi, A., Taskinen, M-R., Yki-Järvinen, H. & Orešič, M., Oct 2012, In : Molecular BioSystems. 8, 10, p. 2559-65 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Formation of phenolic microbial metabolites and short-chain fatty acids from rye, wheat, and oat bran and their fractions in the metabolical in vitro colon model

    Nordlund, E., Aura, A-M., Mattila, I., Kössö, T., Rouau, X. & Poutanen, K., 22 Aug 2012, In : Journal of Agricultural and Food Chemistry. 60, 33, p. 8134-45 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. 2011
  44. Metabolome in progression to Alzheimer's disease

    Orešič, M., Hyötyläinen, T., Herukka, S-K., Sysi-Aho, M., Mattila, I., Seppänan-Laakso, T., Julkunen, V., Gopalacharyulu, P. V., Hallikainen, M., Koikkalainen, J., Kivipelto, M., Helisalmi, S., Lötjönen, J. & Soininen, H., 13 Dec 2011, In : Translational psychiatry. 1, p. e57

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm rye bread versus white wheat bread

    Bondia-Pons, I., Nordlund, E., Mattila, I., Katina, K., Aura, A-M., Kolehmainen, M., Orešič, M., Mykkänen, H. & Poutanen, K., 19 Oct 2011, In : Nutrition Journal. 10, p. 116

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Metabolic regulation in progression to autoimmune diabetes

    Sysi-Aho, M., Ermolov, A., Gopalacharyulu, P. V., Tripathi, A., Seppänen-Laakso, T., Maukonen, J., Mattila, I., Ruohonen, S. T., Vähätalo, L., Yetukuri, L., Härkönen, T., Lindfors, E., Nikkilä, J., Ilonen, J., Simell, O., Saarela, M., Knip, M., Kaski, S., Savontaus, E. & Orešič, M., Oct 2011, In : PLOS Computational Biology. 7, 10, p. e1002257

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry

    Castillo, S., Mattila, I., Miettinen, J., Orešič, M. & Hyötyläinen, T., 15 Apr 2011, In : Analytical Chemistry. 83, 8, p. 3058-67 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Metabolome in schizophrenia and other psychotic disorders: a general population-based study

    Orešič, M., Tang, J., Seppänen-Laakso, T., Mattila, I., Saarni, S. E., Saarni, S. I., Lönnqvist, J., Sysi-Aho, M., Hyötyläinen, T., Perälä, J. & Suvisaari, J., 23 Mar 2011, In : Genome Medicine. 3, 3, p. 19

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro

    Aura, A-M., Mattila, I., Hyötyläinen, T., Gopalacharyulu, P., Bounsaythip, C., Orešič, M. & Oksman-Caldentey, K-M., Feb 2011, In : Molecular BioSystems. 7, 2, p. 437-46 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Bioprocessing of wheat bran in whole wheat bread increases the bioavailability of phenolic acids in men and exerts antiinflammatory effects ex vivo

    Mateo Anson, N., Aura, A-M., Selinheimo, E., Mattila, I., Poutanen, K., van den Berg, R., Havenaar, R., Bast, A. & Haenen, G. R. M. M., Jan 2011, In : The Journal of Nutrition. 141, 1, p. 137-43 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Metabolomic analysis of plasma metabolites that may mediate effects of rye bread on satiety and weight maintenance in postmenopausal women

    Lankinen, M., Schwab, U., Seppänen-Laakso, T., Mattila, I., Juntunen, K., Mykkänen, H., Poutanen, K., Gylling, H. & Oresic, M., Jan 2011, In : The Journal of Nutrition. 141, 1, p. 31-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. 2010
  53. Ketogenic diet slows down mitochondrial myopathy progression in mice

    Ahola-Erkkilä, S., Carroll, C. J., Peltola-Mjösund, K., Tulkki, V., Mattila, I., Seppänen-Laakso, T., Oresic, M., Tyynismaa, H. & Suomalainen, A., 15 May 2010, In : Human Molecular Genetics. 19, 10, p. 1974-84 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Metabolomics in angiotensin II-induced cardiac hypertrophy

    Mervaala, E., Biala, A., Merasto, S., Lempiäinen, J., Mattila, I., Martonen, E., Eriksson, O., Louhelainen, M., Finckenberg, P., Kaheinen, P., Muller, D. N., Luft, F. C., Lapatto, R. & Oresic, M., Feb 2010, In : Hypertension. 55, 2, p. 508-15 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains

    Canelas, A. B., Harrison, N., Fazio, A., Zhang, J., Pitkänen, J-P., van den Brink, J., Bakker, B. M., Bogner, L., Bouwman, J., Castrillo, J. I., Cankorur, A., Chumnanpuen, P., Daran-Lapujade, P., Dikicioglu, D., van Eunen, K., Ewald, J. C., Heijnen, J. J., Kirdar, B., Mattila, I., Mensonides, F. I. C., Niebel, A., Penttilä, M., Pronk, J. T., Reuss, M., Salusjärvi, L., Sauer, U., Sherman, D., Siemann-Herzberg, M., Westerhoff, H., de Winde, J., Petranovic, D., Oliver, S. G., Workman, C. T., Zamboni, N. & Nielsen, J., 2010, In : Nature Communications. 1, p. 145

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. 2009
  57. Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome

    Kajander, K., Myllyluoma, E., Kyrönpalo, S., Rasmussen, M., Sipponen, P., Mattila, I., Seppänen-Laakso, T., Vapaatalo, H., Oresic, M. & Korpela, R., 28 Dec 2009, In : World Journal of Gastroenterology. 15, 48, p. 6068-74 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Bioprocessing of wheat bran improves in vitro bioaccessibility and colonic metabolism of phenolic compounds

    Anson, N. M., Selinheimo, E., Havenaar, R., Aura, A-M., Mattila, I., Lehtinen, P., Bast, A., Poutanen, K. & Haenen, G. R. M. M., 22 Jul 2009, In : Journal of Agricultural and Food Chemistry. 57, 14, p. 6148-55 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Novel Coprinopsis cinerea polyesterase that hydrolyzes cutin and suberin

    Kontkanen, H., Westerholm-Parvinen, A., Saloheimo, M., Bailey, M., Rättö, M., Mattila, I., Mohsina, M., Kalkkinen, N., Nakari-Setälä, T. & Buchert, J., Apr 2009, In : Applied and Environmental Microbiology. 75, 7, p. 2148-57 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. 2008
  61. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

    Oresic, M., Simell, S., Sysi-Aho, M., Näntö-Salonen, K., Seppänen-Laakso, T., Parikka, V., Katajamaa, M., Hekkala, A., Mattila, I., Keskinen, P., Yetukuri, L., Reinikainen, A., Lähde, J., Suortti, T., Hakalax, J., Simell, T., Hyöty, H., Veijola, R., Ilonen, J., Lahesmaa, R., Knip, M. & Simell, O., 22 Dec 2008, In : Journal of Experimental Medicine. 205, 13, p. 2975-84 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Factors affecting the conversion of apple polyphenols to phenolic acids and fruit matrix to short-chain fatty acids by human faecal microbiota in vitro

    Bazzocco, S., Mattila, I., Guyot, S., Renard, C. M. G. C. & Aura, A-M., Dec 2008, In : European Journal of Nutrition. 47, 8, p. 442-52 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Application of lipidomics and metabolomics to the study of adipose tissue

    Mattila, I., Seppänen-Laakso, T., Suortti, T. & Oresic, M., 2008, In : Methods in molecular biology (Clifton, N.J.). 456, p. 123-30 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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