Research output per year
Research output per year
Personal profile
Expertises
Pharmacological studies of cranial arteries; in vitro studies of isolated arteries; in vivo studies of dural and pial arteries; qRT-PCR; RT-PCR; Western Blotting; immunohistochemistry; mast cell degranulation studies; release of CGRP from isolated tissue; NOS activity in isolated tissue
Main research areas
Role of PACAP in the trigeminovascular system and characterization of it's receptors; pharmacological characterization of possible new targets for migraine treatment; development and refinement of animal models for migraine and headache
Current research
1. Characterization of PACAP receptors in the trigeminovascular system;
2. The role of TRPA1 channels in dural and pial arteries
3. Differences in transcriptomic expression between the cephalic and non-cephalic pain pathways
4. Transcriptomic changes in the trigeminovascular sytem after infusion of the migraine provoking substance GTN
5. Development of reliable headache models
Potential conflicts of interest
None
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Collaborations and top research areas from the last five years
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Research output
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ATP-sensitive potassium channel opener levcromakalim induces hypersensitivity in mice via endothelial nitric oxide synthase and peroxynitrite generation
Hansen, R. H., Ernstsen, C., Holm, A., Prehn Lauritzen, S., Obelitz-Ryom, K., Kristensen, D. M., Jansen-Olesen, I., Olesen, J. & Christensen, S. L. T., 2023, p. 20. 1 p.Research output: Contribution to conference › Conference abstract for conference › Communication
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Pharmacological Profiling of KATP Channel Modulators: An Outlook for New Treatment Opportunities for Migraine
Dyhring, T., Jansen-Olesen, I., Christophersen, P. & Olesen, J., 1 Feb 2023, In: Pharmaceuticals (Basel, Switzerland). 16, 2, 225.Research output: Contribution to journal › Journal article › Research › peer-review
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The ATP sensitive potassium channel (KATP) is a novel target for migraine drug development
Clement, A., Christensen, S. L., Jansen-Olesen, I., Olesen, J. & Guo, S., 2023, In: Frontiers in Molecular Neuroscience. 16, 1182515.Research output: Contribution to journal › Review › peer-review
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ATP-Sensitive Potassium Channels in Migraine: Translational Findings and Therapeutic Potential
Clement, A., Guo, S., Jansen-Olesen, I. & Christensen, S. L., 2022, In: Cells. 11, 15, 23 p., 2406.Research output: Contribution to journal › Review › peer-review
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Characterization of erenumab and rimegepant on calcitonin gene-related peptide induced responses in Xenopus Laevis oocytes expressing the calcitonin gene-related peptide receptor and the amylin-1 receptor
Hage La Cour, S., Juhler, K., Kogelman, L. J. A., Olesen, J., Klærke, D. A., Kristensen, D. M. & Jansen-Olesen, I., 26 May 2022, In: The Journal of Headache and Pain Online. 23, 1, p. 1-12 12 p., 59.Research output: Contribution to journal › Journal article › Research › peer-review