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The Capital Region of Denmark - a part of Copenhagen University Hospital

Inge Marie Svane

Professor, MD, Director, professor, MD

Herlev Hospital, Herlev Ringvej 75

Building: 81-05-PV9

2730 Herlev

Denmark

  1. 2019
  2. Published

    Peripheral memory T cells specific for Arginase-1

    Martinenaite, E., Ahmad, S. M., Svane, I. M. & Andersen, M. H., Aug 2019, In : Cellular & Molecular Immunology. 16, 8, p. 718-719 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells

    Saini, S. K., Tamhane, T., Anjanappa, R., Saikia, A., Ramskov, S., Donia, M., Svane, I. M., Jakobsen, S. N., Garcia-Alai, M., Zacharias, M., Meijers, R., Springer, S. & Hadrup, S. R., 19 Jul 2019, In : Nature Immunology. 4, 37

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Real-world evidence to guide healthcare policies in oncology

    Donia, M., Hansen, S. W. & Svane, I. M., 16 Jul 2019, In : Oncotarget. 10, 44, p. 4513-4515 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. E-pub ahead of print
  6. E-pub ahead of print

    MERTK Acts as a Costimulatory Receptor on Human CD8+ T Cells

    Peeters, M. J. W., Dulkeviciute, D., Draghi, A., Ritter, C., Rahbech, A., Skadborg, S. K., Seremet, T., Carnaz Simões, A. M., Martinenaite, E., Halldórsdóttir, H. R., Andersen, M. H., Olofsson, G. H., Svane, I. M., Rasmussen, L. J., Met, Ö., Becker, J. C., Donia, M., Desler, C. & Thor Straten, P., 2 Jul 2019, In : Cancer immunology research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    High-dose interleukin-2 and interferon as first-line immunotherapy for metastatic melanoma: long-term follow-up in a large unselected Danish patient cohort

    Bastholt, L., Svane, I. M., Bjerregaard, J. K., Herrstedt, J., Hróbjartsson, A. & Schmidt, H., Jul 2019, In : European journal of cancer (Oxford, England : 1990). 115, p. 61-67 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    undersøges !!

    Simonsen, L. T., Schmidt, A. M. S., Øllegaard, T. H., Svane, I. M., Bastholt, L., Luczak, A. A. & Schmidt, H., 10 Jun 2019, In : Ugeskrift for Laeger. 181, 24

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Dabrafenib, trametinib and pembrolizumab or placebo in BRAF-mutant melanoma

    Ascierto, P. A., Ferrucci, P. F., Fisher, R., Del Vecchio, M., Atkinson, V., Schmidt, H., Schachter, J., Queirolo, P., Long, G. V., Di Giacomo, A. M., Svane, I. M., Lotem, M., Bar-Sela, G., Couture, F., Mookerjee, B., Ghori, R., Ibrahim, N., Moreno, B. H. & Ribas, A., Jun 2019, In : Nature Medicine. 25, 6, p. 941-946 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Evaluation of Two Dosing Regimens for Nivolumab in Combination With Ipilimumab in Patients With Advanced Melanoma: Results From the Phase IIIb/IV CheckMate 511 Trial

    Lebbé, C., Meyer, N., Mortier, L., Marquez-Rodas, I., Robert, C., Rutkowski, P., Menzies, A. M., Eigentler, T., Ascierto, P. A., Smylie, M., Schadendorf, D., Ajaz, M., Svane, I. M., Gonzalez, R., Rollin, L., Lord-Bessen, J., Saci, A., Grigoryeva, E. & Pigozzo, J., 10 Apr 2019, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37, 11, p. 867-875 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Correction: Tumour-reactive T cell subsets in the microenvironment of ovarian cancer

    Westergaard, M. C. W., Andersen, R., Chong, C., Kjeldsen, J. W., Pedersen, M., Friese, C., Hasselager, T., Lajer, H., Coukos, G., Bassani-Sternberg, M., Donia, M. & Svane, I. M., Apr 2019, In : British Journal of Cancer. 120, 8, p. 870

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. E-pub ahead of print

    Discontinuation of anti-PD-1 antibody therapy in the absence of disease progression or treatment limiting toxicity: clinical outcomes in advanced melanoma

    Jansen, Y. J. L., Rozeman, E. A., Mason, R., Goldinger, S. M., Geukes Foppen, M. H., Hoejbergs, L., Schmidt, H., van Thienen, J. V., Haanen, J. B. A. G., Tiainen, L., Svane, I. M., Mäkelä, S., Seremet, T., Arance, A., Dummer, R., Bastholt, L., Nyakas, M., Straume, O., Menzies, A. M., Long, G. V., Atkinson, V., Blank, C. U. & Neyns, B., 28 Mar 2019, In : Annals of Oncology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Peptide Super-Agonist Enhances T-Cell Responses to Melanoma

    Galloway, S. A. E., Dolton, G., Attaf, M., Wall, A., Fuller, A., Rius, C., Bianchi, V., Theaker, S., Lloyd, A., Caillaud, M. E., Svane, I. M., Donia, M., Cole, D. K., Szomolay, B., Rizkallah, P. & Sewell, A. K., 13 Mar 2019, In : Frontiers in Immunology. 10, p. 319

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Collagen density regulates the activity of tumor-infiltrating T cells

    Kuczek, D. E., Larsen, A. M. H., Thorseth, M-L., Carretta, M., Kalvisa, A., Siersbæk, M. S., Simões, A. M. C., Roslind, A., Engelholm, L. H., Noessner, E., Donia, M., Svane, I. M., Straten, P. T., Grøntved, L. & Madsen, D. H., 12 Mar 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, p. 68

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Undersøges !!

    Holmström, M. O., Klausen, U., Jørgensen, N. G., Holmberg, S., Grauslund, J., Met, Ö., Svane, I. M., Pedersen, L. M., Knudsen, L. M., Hasselbalch, H. C. & Andersen, M. H., 4 Mar 2019, In : Ugeskrift for Laeger. 181, 10

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Tumour-reactive T cell subsets in the microenvironment of ovarian cancer

    Westergaard, M. C. W., Andersen, R., Chong, C., Kjeldsen, J. W., Pedersen, M., Friese, C., Hasselager, T., Lajer, H., Coukos, G., Bassani-Sternberg, M., Donia, M. & Svane, I. M., 19 Feb 2019, In : British Journal of Cancer. 120, 4, p. 424-434 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    The real-world impact of modern treatments on the survival of patients with metastatic melanoma

    Donia, M., Ellebaek, E., Øllegaard, T. H., Duval, L., Aaby, J. B., Hoejberg, L., Køhler, U. H., Schmidt, H., Bastholt, L. & Svane, I. M., Feb 2019, In : European journal of cancer (Oxford, England : 1990). 108, p. 25-32 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published
  19. E-pub ahead of print

    HER2 CAR-T cells eradicate uveal melanoma and T cell therapy-resistant human melanoma in interleukin-2 (IL-2) transgenic NOD/SCID IL-2 receptor knockout mice

    Forsberg, E. M., Lindberg, M. F., Jespersen, H., Alsén, S., Olofsson Bagge, R., Donia, M., Svane, I. M., Nilsson, O., Ny, L., Nilsson, L. M. & Nilsson, J. A., 8 Jan 2019, In : Cancer Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Principles of adoptive T cell therapy in cancer

    Met, Ö., Jensen, K. M., Chamberlain, C. A., Donia, M. & Svane, I. M., Jan 2019, In : Seminars in Immunopathology. 41, 1, p. 49-58 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    Immunoprofiles of colorectal cancer from Lynch syndrome

    Walkowska, J., Kallemose, T., Jönsson, G., Jönsson, M., Andersen, O., Andersen, M. H., Svane, I. M., Langkilde, A., Nilbert, M. & Therkildsen, C., 2019, In : OncoImmunology. 8, 1, p. e1515612 e1515612.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2018
  23. E-pub ahead of print
  24. Published

    Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients

    Jensen, C., Madsen, D. H., Hansen, M., Schmidt, H., Svane, I. M., Karsdal, M. A. & Willumsen, N., 19 Dec 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, p. 152

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published
  26. E-pub ahead of print

    Survival Outcomes in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma Treated With Nivolumab Therapy: Three-Year Follow-up of a Randomized Phase 3 Trial

    Ascierto, P. A., Long, G. V., Robert, C., Brady, B., Dutriaux, C., Di Giacomo, A. M., Mortier, L., Hassel, J. C., Rutkowski, P., McNeil, C., Kalinka-Warzocha, E., Savage, K. J., Hernberg, M. M., Lebbé, C., Charles, J., Mihalcioiu, C., Chiarion-Sileni, V., Mauch, C., Cognetti, F., Ny, L., Arance, A., Svane, I. M., Schadendorf, D., Gogas, H., Saci, A., Jiang, J., Rizzo, J. & Atkinson, V., 25 Oct 2018, In : JAMA Oncology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published
  28. Published

    Cancerimmunterapi

    Kjeldsen, J. W., Donia, M. & Svane, I. M., 21 May 2018, In : Ugeskrift for Laeger. 180, 21, p. 2-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Cancer immunotherapy in patients with brain metastases

    Caponnetto, S., Draghi, A., Borch, T. H., Nuti, M., Cortesi, E., Svane, I. M. & Donia, M., May 2018, In : Cancer immunology, immunotherapy : CII. 67, 5, p. 703-711 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    Peptide-MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations

    Rius, C., Attaf, M., Tungatt, K., Bianchi, V., Legut, M., Bovay, A., Donia, M., Thor Straten, P., Peakman, M., Svane, I. M., Ott, S., Connor, T., Szomolay, B., Dolton, G. & Sewell, A. K., 1 Apr 2018, In : Journal of immunology (Baltimore, Md. : 1950). 200, 7, p. 2263-2279 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published
  32. Published

    Immunterapi er kræftbehandling med en helt ny bivirkningsprofil

    Kondrup, M., Raunkilde, L., Svane, I. M., Schmidt, H. & Bastholt, L., Feb 2018, In : Ugeskrift for Laeger. 179, 40, p. 2-6 5 p., 2017;179:V05170365.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Adoptive cell therapy with tumor-infiltrating lymphocytes in patients with metastatic ovarian cancer: a pilot study

    Pedersen, M., Westergaard, M. C. W., Milne, K., Nielsen, M., Borch, T. H., Poulsen, L. G., Hendel, H. W., Kennedy, M., Briggs, G., Ledoux, S., Nøttrup, T. J., Andersen, P., Hasselager, T., Met, Ö., Nelson, B. H., Donia, M. & Svane, I. M., 2018, In : OncoImmunology. 7, 12, p. e1502905

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Development of anti-drug antibodies is associated with shortened survival in patients with metastatic melanoma treated with ipilimumab

    Kverneland, A. H., Enevold, C., Donia, M., Bastholt, L., Svane, I. M. & Nielsen, C. H., 2018, In : OncoImmunology. 7, 5, p. e1424674

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published
  36. Published
  37. Published
  38. Published
  39. Published

    The calreticulin (CALR) exon 9 mutations are promising targets for cancer immune therapy

    Holmström, M. O., Martinenaite, E., Ahmad, S. M., Met, Ö., Friese, C., Kjær, L., Riley, C. H., Thor Straten, P., Svane, I. M., Hasselbalch, H. C. & Andersen, M. H., 2018, In : Leukemia. 32, 2, p. 429-437 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy

    Ahmad, S. M., Martinenaite, E., Holmström, M., Jørgensen, M. A., Met, Ö., Nastasi, C., Klausen, U., Donia, M., Pedersen, L. M., Munksgaard, L., Ødum, N., Woetmann, A., Svane, I. M. & Andersen, M. H., 2018, In : OncoImmunology. 7, 2, p. e1390641

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. 2017
  42. Published

    Checkpoint inhibitors in breast cancer - Current status

    Polk, A., Svane, I-M., Andersson, M. & Nielsen, D., 14 Dec 2017, In : Evidence-based Oncology. 63, p. 122-134 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  43. Published
  44. Published

    Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

    Lauss, M., Donia, M., Harbst, K., Andersen, R., Mitra, S., Rosengren, F., Salim, M., Vallon-Christersson, J., Törngren, T., Kvist, A., Ringnér, M., Svane, I. M. & Jönsson, G., 23 Nov 2017, In : Nature Communications. 8, 1, p. 1738

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    PD-1+ Polyfunctional T Cells Dominate the Periphery after Tumor-Infiltrating Lymphocyte Therapy for Cancer

    Donia, M., Kjeldsen, J. W., Andersen, R., Westergaard, M. C. W., Bianchi, V., Legut, M., Attaf, M., Szomolay, B., Ott, S., Dolton, G., Lyngaa, R. B., Hadrup, S. R., Sewell, A. K. & Svane, I. M., 1 Oct 2017, In : Clinical Cancer Research. 23, 19, p. 5779-5788 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model

    Jespersen, H., Lindberg, M. F., Donia, M., Söderberg, E. M. V., Andersen, R., Keller, U., Ny, L., Svane, I. M., Nilsson, L. M. & Nilsson, J. A., 27 Sep 2017, In : Nature Communications. 8, 1, p. 707

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Predictors of responses to immune checkpoint blockade in advanced melanoma

    Jacquelot, N., Roberti, M. P., Enot, D. P., Rusakiewicz, S., Ternès, N., Jegou, S., Woods, D. M., Sodré, A. L., Hansen, M., Meirow, Y., Sade-Feldman, M., Burra, A., Kwek, S. S., Flament, C., Messaoudene, M., Duong, C. P. M., Chen, L., Kwon, B. S., Anderson, A. C., Kuchroo, V. K., Weide, B., Aubin, F., Borg, C., Dalle, S., Beatrix, O., Ayyoub, M., Balme, B., Tomasic, G., Di Giacomo, A. M., Maio, M., Schadendorf, D., Melero, I., Dréno, B., Khammari, A., Dummer, R., Levesque, M., Koguchi, Y., Fong, L., Lotem, M., Baniyash, M., Schmidt, H., Svane, I. M., Kroemer, G., Marabelle, A., Michiels, S., Cavalcanti, A., Smyth, M. J., Weber, J. S., Eggermont, A. M. & Zitvogel, L., 19 Sep 2017, In : Nature Communications. 8, 1, p. 592

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Survival of metastatic melanoma patients after dendritic cell vaccination correlates with expression of leukocyte phosphatidylethanolamine-binding protein 1/Raf kinase inhibitory protein

    Buschow, S. I., Ramazzotti, M., Reinieren-Beeren, I. M. J., Heinzerling, L. M., Westdorp, H., Stefanini, I., Beltrame, L., Hato, S. V., Ellebaek, E., Gross, S., Nguyen, V. A., Weinlich, G., Ragoussis, J., Baban, D., Schuler-Thurner, B., Svane, I. M., Romani, N., Austyn, J. M., De Vries, I. J. M., Schuler, G., Cavalieri, D. & Figdor, C. G., 15 Sep 2017, In : Oncotarget. 8, 40, p. 67439-67456 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Acquired Immune Resistance Follows Complete Tumor Regression without Loss of Target Antigens or IFNγ Signaling

    Donia, M., Harbst, K., van Buuren, M., Kvistborg, P., Lindberg, M. F., Andersen, R., Idorn, M., Munir Ahmad, S., Ellebæk, E., Mueller, A., Fagone, P., Nicoletti, F., Libra, M., Lauss, M., Hadrup, S. R., Schmidt, H., Andersen, M. H., Thor Straten, P., Nilsson, J. A., Schumacher, T. N., Seliger, B., Jönsson, G. & Svane, I. M., 1 Sep 2017, In : Cancer Research. 77, 17, p. 4562-4566 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Sorted peripheral blood cells identify CALR mutations in B- and T-lymphocytes

    Kjaer, L., Holmström, M. O., Cordua, S., Andersen, M. H., Svane, I. M., Thomassen, M., Kruse, T. A., Pallisgaard, N., Skov, V. & Hasselbalch, H. C., 9 Aug 2017, In : Leukemia and Lymphoma. 59, 4, p. 973-977 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    PD-L1 expression and survival among melanoma patients treated with standard immunotherapy or chemotherapy

    Steiniche, T., Vestergaard Danielsen, A., Wang, Z., Feng, Y., Switten Nielsen, P., Bastholt, L., Schmidt, H., Svane, I. M., Dolled-Filhart, M., Emancipator, K., Weiner, R., Busch-Sørensen, M. & Zhou, W., Jul 2017, In : Journal of the European Academy of Dermatology and Venereology : JEADV. 31, 7, p. e319-e321

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: a randomised, double-blind, multicentre, phase 3 trial

    Ascierto, P. A., Del Vecchio, M., Robert, C., Mackiewicz, A., Chiarion-Sileni, V., Arance, A., Lebbé, C., Bastholt, L., Hamid, O., Rutkowski, P., McNeil, C., Garbe, C., Loquai, C., Dreno, B., Thomas, L., Grob, J-J., Liszkay, G., Nyakas, M., Gutzmer, R., Pikiel, J., Grange, F., Hoeller, C., Ferraresi, V., Smylie, M., Schadendorf, D., Mortier, L., Svane, I. M., Hennicken, D., Qureshi, A. & Maio, M., May 2017, In : Lancet Oncology. 18, 5, p. 611-622 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Influence of ipilimumab on expanded tumour derived T cells from patients with metastatic melanoma

    Bjoern, J., Lyngaa, R., Andersen, R., Rosenkrantz, L. H., Hadrup, S. R., Donia, M. & Svane, I. M., 18 Apr 2017, In : Oncotarget. 8, 16, p. 27062-27074 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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