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The Capital Region of Denmark - a part of Copenhagen University Hospital

Inge Marie Svane

Professor, MD, Director

Herlev Hospital, Herlev Ringvej 75

Building: 81-05-PV9

2730 Herlev

Denmark

  1. 2020
  2. Published

    Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

    Crowther, M. D., Dolton, G., Legut, M., Caillaud, M. E., Lloyd, A., Attaf, M., Galloway, S. A. E., Rius, C., Farrell, C. P., Szomolay, B., Ager, A., Parker, A. L., Fuller, A., Donia, M., McCluskey, J., Rossjohn, J., Svane, I. M., Phillips, J. D. & Sewell, A. K., Feb 2020, In : Nature Immunology. 21, 2, p. 178-185 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Tertiary lymphoid structures improve immunotherapy and survival in melanoma

    Cabrita, R., Lauss, M., Sanna, A., Donia, M., Skaarup Larsen, M., Mitra, S., Johansson, I., Phung, B., Harbst, K., Vallon-Christersson, J., van Schoiack, A., Lövgren, K., Warren, S., Jirström, K., Olsson, H., Pietras, K., Ingvar, C., Isaksson, K., Schadendorf, D., Schmidt, H., Bastholt, L., Carneiro, A., Wargo, J. A., Svane, I. M. & Jönsson, G., Jan 2020, In : Nature. 577, 7791, p. 561-565 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2019
  5. Published

    The real-world outcome of metastatic melanoma: Unknown primary vs. known cutaneous

    Ellebaek, E., Bastholt, L., Schmidt, H., Svane, I. M. & Donia, M., 1 Dec 2019, In : International Journal of Cancer. 145, 11, p. 3173-3174 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Efficacy of Adoptive Therapy with Tumor-infiltrating Lymphocytes and Recombinant Interleukin-2 in Advanced Cutaneous Melanoma: A Systematic Review and Meta-analysis

    Dafni, U., Michielin, O., Lluesma, S. M., Tsourti, Z., Polydoropoulou, V., Karlis, D., Besser, M. J., Haanen, J., Svane, I. M., Ohashi, P. S., Kammula, U. S., Orcurto, A., Zimmermann, S., Trueb, L., Klebanoff, C. A., Lotze, M. T., Kandalaft, L. E. & Coukos, G., Dec 2019, In : Annals of Oncology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Long-Term Exposure to Inflammation Induces Differential Cytokine Patterns and Apoptosis in Dendritic Cells

    Carstensen, L. S., Lie-Andersen, O., Obers, A., Crowther, M. D., Svane, I. M. & Hansen, M., 21 Nov 2019, In : Frontiers in Immunology. 10, p. 2702

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published
  9. Published

    Chimeric antigen receptor-T-cellebehandling

    Müller, K., Ifversen, M., Kielsen, K., Petersen, S. L., Met, Ö. & Svane, I. M., 14 Oct 2019, In : Ugeskrift for Laeger. 181, 20A

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Real-World Impact of Immune Checkpoint Inhibitors in Metastatic Uveal Melanoma

    Bol, K. F., Ellebaek, E., Hoejberg, L., Bagger, M. M., Larsen, M. S., Klausen, T. W., Køhler, U. H., Schmidt, H., Bastholt, L., Kiilgaard, J. F., Donia, M. & Svane, I. M., 3 Oct 2019, In : Cancers. 11, 10

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published
  12. Published
  13. Published

    Age favoured overall survival in a large population-based Danish patient cohort treated with anti-PD1 immune checkpoint inhibitor for metastatic melanoma

    Bastholt, L., Schmidt, H., Bjerregaard, J. K., Herrstedt, J. & Svane, I. M., Sep 2019, In : European journal of cancer (Oxford, England : 1990). 119, p. 122-131 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published
  15. Published

    Peripheral memory T cells specific for Arginase-1

    Martinenaite, E., Ahmad, S. M., Svane, I. M. & Andersen, M. H., Aug 2019, In : Cellular & Molecular Immunology. 16, 8, p. 718-719 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells

    Saini, S. K., Tamhane, T., Anjanappa, R., Saikia, A., Ramskov, S., Donia, M., Svane, I. M., Jakobsen, S. N., Garcia-Alai, M., Zacharias, M., Meijers, R., Springer, S. & Hadrup, S. R., 19 Jul 2019, In : Nature Immunology. 4, 37

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Real-world evidence to guide healthcare policies in oncology

    Donia, M., Hansen, S. W. & Svane, I. M., 16 Jul 2019, In : Oncotarget. 10, 44, p. 4513-4515 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Discontinuation of anti-PD-1 antibody therapy in the absence of disease progression or treatment limiting toxicity: clinical outcomes in advanced melanoma

    Jansen, Y. J. L., Rozeman, E. A., Mason, R., Goldinger, S. M., Geukes Foppen, M. H., Hoejbergs, L., Schmidt, H., van Thienen, J. V., Haanen, J. B. A. G., Tiainen, L., Svane, I. M., Mäkelä, S., Seremet, T., Arance, A., Dummer, R., Bastholt, L., Nyakas, M., Straume, O., Menzies, A. M., Long, G. V., Atkinson, V., Blank, C. U. & Neyns, B., Jul 2019, In : Annals of Oncology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    High-dose interleukin-2 and interferon as first-line immunotherapy for metastatic melanoma: long-term follow-up in a large unselected Danish patient cohort

    Bastholt, L., Svane, I. M., Bjerregaard, J. K., Herrstedt, J., Hróbjartsson, A. & Schmidt, H., Jul 2019, In : European journal of cancer (Oxford, England : 1990). 115, p. 61-67 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Immunterapi til patienter med malignt melanom og hjernemetastaser

    Simonsen, L. T., Schmidt, A. M. S., Øllegaard, T. H., Svane, I. M., Bastholt, L., Luczak, A. A. & Schmidt, H., 10 Jun 2019, In : Ugeskrift for Laeger. 181, 24

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Dabrafenib, trametinib and pembrolizumab or placebo in BRAF-mutant melanoma

    Ascierto, P. A., Ferrucci, P. F., Fisher, R., Del Vecchio, M., Atkinson, V., Schmidt, H., Schachter, J., Queirolo, P., Long, G. V., Di Giacomo, A. M., Svane, I. M., Lotem, M., Bar-Sela, G., Couture, F., Mookerjee, B., Ghori, R., Ibrahim, N., Moreno, B. H. & Ribas, A., Jun 2019, In : Nature Medicine. 25, 6, p. 941-946 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Survival Outcomes in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma Treated With Nivolumab Therapy: Three-Year Follow-up of a Randomized Phase 3 Trial

    Ascierto, P. A., Long, G. V., Robert, C., Brady, B., Dutriaux, C., Di Giacomo, A. M., Mortier, L., Hassel, J. C., Rutkowski, P., McNeil, C., Kalinka-Warzocha, E., Savage, K. J., Hernberg, M. M., Lebbé, C., Charles, J., Mihalcioiu, C., Chiarion-Sileni, V., Mauch, C., Cognetti, F., Ny, L., Arance, A., Svane, I. M., Schadendorf, D., Gogas, H., Saci, A., Jiang, J., Rizzo, J. & Atkinson, V., May 2019, In : JAMA Oncology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Evaluation of Two Dosing Regimens for Nivolumab in Combination With Ipilimumab in Patients With Advanced Melanoma: Results From the Phase IIIb/IV CheckMate 511 Trial

    Lebbé, C., Meyer, N., Mortier, L., Marquez-Rodas, I., Robert, C., Rutkowski, P., Menzies, A. M., Eigentler, T., Ascierto, P. A., Smylie, M., Schadendorf, D., Ajaz, M., Svane, I. M., Gonzalez, R., Rollin, L., Lord-Bessen, J., Saci, A., Grigoryeva, E. & Pigozzo, J., 10 Apr 2019, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37, 11, p. 867-875 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Correction: Tumour-reactive T cell subsets in the microenvironment of ovarian cancer

    Westergaard, M. C. W., Andersen, R., Chong, C., Kjeldsen, J. W., Pedersen, M., Friese, C., Hasselager, T., Lajer, H., Coukos, G., Bassani-Sternberg, M., Donia, M. & Svane, I. M., Apr 2019, In : British Journal of Cancer. 120, 8, p. 870

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Peptide Super-Agonist Enhances T-Cell Responses to Melanoma

    Galloway, S. A. E., Dolton, G., Attaf, M., Wall, A., Fuller, A., Rius, C., Bianchi, V., Theaker, S., Lloyd, A., Caillaud, M. E., Svane, I. M., Donia, M., Cole, D. K., Szomolay, B., Rizkallah, P. & Sewell, A. K., 13 Mar 2019, In : Frontiers in Immunology. 10, p. 319

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Collagen density regulates the activity of tumor-infiltrating T cells

    Kuczek, D. E., Larsen, A. M. H., Thorseth, M-L., Carretta, M., Kalvisa, A., Siersbæk, M. S., Simões, A. M. C., Roslind, A., Engelholm, L. H., Noessner, E., Donia, M., Svane, I. M., Straten, P. T., Grøntved, L. & Madsen, D. H., 12 Mar 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, p. 68

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Cancerimmunterapi til behandling af hæmatologisk cancer

    Holmström, M. O., Klausen, U., Jørgensen, N. G., Holmberg, S., Grauslund, J., Met, Ö., Svane, I. M., Pedersen, L. M., Knudsen, L. M., Hasselbalch, H. C. & Andersen, M. H., 4 Mar 2019, In : Ugeskrift for Laeger. 181, 10

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    HER2 CAR-T cells eradicate uveal melanoma and T cell therapy-resistant human melanoma in interleukin-2 (IL-2) transgenic NOD/SCID IL-2 receptor knockout mice

    Forsberg, E. M., Lindberg, M. F., Jespersen, H., Alsén, S., Olofsson Bagge, R., Donia, M., Svane, I. M., Nilsson, O., Ny, L., Nilsson, L. M. & Nilsson, J. A., Mar 2019, In : Cancer Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Tumour-reactive T cell subsets in the microenvironment of ovarian cancer

    Westergaard, M. C. W., Andersen, R., Chong, C., Kjeldsen, J. W., Pedersen, M., Friese, C., Hasselager, T., Lajer, H., Coukos, G., Bassani-Sternberg, M., Donia, M. & Svane, I. M., 19 Feb 2019, In : British Journal of Cancer. 120, 4, p. 424-434 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    The real-world impact of modern treatments on the survival of patients with metastatic melanoma

    Donia, M., Ellebaek, E., Øllegaard, T. H., Duval, L., Aaby, J. B., Hoejberg, L., Køhler, U. H., Schmidt, H., Bastholt, L. & Svane, I. M., Feb 2019, In : European journal of cancer (Oxford, England : 1990). 108, p. 25-32 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published
  32. Published

    Principles of adoptive T cell therapy in cancer

    Met, Ö., Jensen, K. M., Chamberlain, C. A., Donia, M. & Svane, I. M., Jan 2019, In : Seminars in Immunopathology. 41, 1, p. 49-58 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  33. Published

    Immunoprofiles of colorectal cancer from Lynch syndrome

    Walkowska, J., Kallemose, T., Jönsson, G., Jönsson, M., Andersen, O., Andersen, M. H., Svane, I. M., Langkilde, A., Nilbert, M. & Therkildsen, C., 2019, In : OncoImmunology. 8, 1, p. e1515612 e1515612.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients

    Viborg, N., Ramskov, S., Andersen, R. S., Sturm, T., Fugmann, T., Bentzen, A. K., Rafa, V. M., Straten, P. T., Svane, I. M., Met, Ö. & Hadrup, S. R., 2019, In : OncoImmunology. 8, 12, p. e1663107

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2018
  36. Published

    Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients

    Jensen, C., Madsen, D. H., Hansen, M., Schmidt, H., Svane, I. M., Karsdal, M. A. & Willumsen, N., 19 Dec 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, p. 152

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published
  38. Published
  39. Published

    Cancerimmunterapi

    Kjeldsen, J. W., Donia, M. & Svane, I. M., 21 May 2018, In : Ugeskrift for Laeger. 180, 21, p. 2-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Cancer immunotherapy in patients with brain metastases

    Caponnetto, S., Draghi, A., Borch, T. H., Nuti, M., Cortesi, E., Svane, I. M. & Donia, M., May 2018, In : Cancer immunology, immunotherapy : CII. 67, 5, p. 703-711 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  41. Published

    Peptide-MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations

    Rius, C., Attaf, M., Tungatt, K., Bianchi, V., Legut, M., Bovay, A., Donia, M., Thor Straten, P., Peakman, M., Svane, I. M., Ott, S., Connor, T., Szomolay, B., Dolton, G. & Sewell, A. K., 1 Apr 2018, In : Journal of immunology (Baltimore, Md. : 1950). 200, 7, p. 2263-2279 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published
  43. Published

    Immunterapi er kræftbehandling med en helt ny bivirkningsprofil

    Kondrup, M., Raunkilde, L., Svane, I. M., Schmidt, H. & Bastholt, L., Feb 2018, In : Ugeskrift for Laeger. 179, 40, p. 2-6 5 p., 2017;179:V05170365.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Adoptive cell therapy with tumor-infiltrating lymphocytes in patients with metastatic ovarian cancer: a pilot study

    Pedersen, M., Westergaard, M. C. W., Milne, K., Nielsen, M., Borch, T. H., Poulsen, L. G., Hendel, H. W., Kennedy, M., Briggs, G., Ledoux, S., Nøttrup, T. J., Andersen, P., Hasselager, T., Met, Ö., Nelson, B. H., Donia, M. & Svane, I. M., 2018, In : OncoImmunology. 7, 12, p. e1502905

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Development of anti-drug antibodies is associated with shortened survival in patients with metastatic melanoma treated with ipilimumab

    Kverneland, A. H., Enevold, C., Donia, M., Bastholt, L., Svane, I. M. & Nielsen, C. H., 2018, In : OncoImmunology. 7, 5, p. e1424674

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published
  47. Published
  48. Published
  49. Published
  50. Published

    The calreticulin (CALR) exon 9 mutations are promising targets for cancer immune therapy

    Holmström, M. O., Martinenaite, E., Ahmad, S. M., Met, Ö., Friese, C., Kjær, L., Riley, C. H., Thor Straten, P., Svane, I. M., Hasselbalch, H. C. & Andersen, M. H., 2018, In : Leukemia. 32, 2, p. 429-437 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy

    Ahmad, S. M., Martinenaite, E., Holmström, M., Jørgensen, M. A., Met, Ö., Nastasi, C., Klausen, U., Donia, M., Pedersen, L. M., Munksgaard, L., Ødum, N., Woetmann, A., Svane, I. M. & Andersen, M. H., 2018, In : OncoImmunology. 7, 2, p. e1390641

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. 2017
  53. Published

    Checkpoint inhibitors in breast cancer - Current status

    Polk, A., Svane, I-M., Andersson, M. & Nielsen, D., 14 Dec 2017, In : Evidence-based Oncology. 63, p. 122-134 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  54. Published
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