Microbiome and metabolome features of the cardiometabolic disease spectrum

Fromentin, S., Forslund, S. K., Chechi, K., Aron-Wisnewsky, J., Chakaroun, R., Nielsen, T., Tremaroli, V., Ji, B., Prifti, E., Myridakis, A., Chilloux, J., Andrikopoulos, P., Fan, Y., Olanipekun, M. T., Alves, R., Adiouch, S., Bar, N., Talmor-Barkan, Y., Belda, E., Caesar, R. & 44 others, Coelho, L. P., Falony, G., Fellahi, S., Galan, P., Galleron, N., Helft, G., Hoyles, L., Isnard, R., Le Chatelier, E., Julienne, H., Olsson, L., Pedersen, H. K., Pons, N., Quinquis, B., Rouault, C., Roume, H., Salem, J. E., Schmidt, T. S. B., Vieira-Silva, S., Li, P., Zimmermann-Kogadeeva, M., Lewinter, C., Søndertoft, N. B., Hansen, T. H., Gauguier, D., Gøtze, J. P., Køber, L., Kornowski, R., Vestergaard, H., Hansen, T., Zucker, J. D., Hercberg, S., Letunic, I., Bäckhed, F., Oppert, J. M., Nielsen, J., Raes, J., Bork, P., Stumvoll, M., Segal, E., Clément, K., Dumas, M. E., Ehrlich, S. D. & Pedersen, O., Feb 2022, In: Nature Medicine. 28, 2, p. 303-314 12 p.

Research output: Contribution to journal › Journal article › peer-review

Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism

MetaCardis Consortium, 11 Jan 2022, (E-pub ahead of print) In: Gut.

Research output: Contribution to journal › Journal article › peer-review

Effects of 18-months metformin versus placebo in combination with three insulin regimens on RNA and DNA oxidation in individuals with type 2 diabetes: A post-hoc analysis of a randomized clinical trial

Larsen, E. L., Kjær, L. K., Lundby-Christensen, L., Boesgaard, T. W., Breum, L., Gluud, C., Hedetoft, C., Krarup, T., Lund, S. S., Mathiesen, E. R., Perrild, H., Sneppen, S. B., Tarnow, L., Thorsteinsson, B., Vestergaard, H., Poulsen, H. E., Madsbad, S. & Almdal, T. P., Jan 2022, In: Free Radical Biology & Medicine. 178, p. 18-25 8 p.

Research output: Contribution to journal › Journal article › peer-review

The power of genetic diversity in genome-wide association studies of lipids

Graham, S. E., Clarke, S. L., Wu, K-H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Hwang, M. Y., Han, S., Narita, A., Choudhury, A., Bentley, A. R., Ekoru, K., Verma, A., Trivedi, B. & 31 others, Martin, H. C., Hunt, K. A., Hui, Q., Klarin, D., Zhu, X., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Ruotsalainen, S. E., Havulinna, A. S., Veturi, Y., Feng, Q., Aadahl, M., Bork-Jensen, J., Kårhus, L. L., Møllehave, L. T., Thuesen, B. H., Vestergaard, H., Hansen, T., Linneberg, A., Dantoft, T. M. & VA Million Veteran Program, 23 Dec 2021, In: Nature. 600, 7890, p. 675-679 5 p.

Research output: Contribution to journal › Journal article › peer-review

Combinatorial, additive and dose-dependent drug–microbiome associations

Forslund, S. K., The MetaCardis Consortium* & Jørgensen, N. R., 8 Dec 2021, In: Nature. 600, 7889, p. 500-505 6 p.

Research output: Contribution to journal › Journal article › peer-review

Once-weekly subcutaneous semaglutide treatment for persons with type 2 diabetes: Real-world data from a diabetes out-patient clinic

Hansen, K. B., Svendstrup, M., Lund, A., Knop, F. K., Vilsbøll, T. & Vestergaard, H., Oct 2021, In: Diabetic Medicine. 38, 10, p. e14655 e14655.

Research output: Contribution to journal › Journal article › peer-review

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

Tura, A., Grespan, E., Göbl, C. S., Koivula, R. W., Franks, P. W., Pearson, E. R., Walker, M., Forgie, I. M., Giordano, G. N., Pavo, I., Ruetten, H., Dermitzakis, E. T., McCarthy, M. I., Pedersen, O., Schwenk, J. M., Adamski, J., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A. & 17 others, Mahajan, A., McDonald, T. J., Kokkola, T., Vangipurapu, J., Cederberg, H., Laakso, M., Rutters, F., Elders, P. J. M., Koopman, A. D. M., Beulens, J. W., Ridderstråle, M., Hansen, T. H., Allin, K. H., Hansen, T., Vestergaard, H., Mari, A. & IMI-DIRECT consortium, 1 Sep 2021, In: Diabetes. 70, 9, p. 2092-2106 15 p.

Research output: Contribution to journal › Journal article › peer-review

Effect of metformin and insulin vs. placebo and insulin on whole body composition in overweight patients with type 2 diabetes: a randomized placebo-controlled trial

Nordklint, A. K., Almdal, T. P., Vestergaard, P., Lundby-Christensen, L., Boesgaard, T. W., Breum, L., Gade-Rasmussen, B., Sneppen, S. B., Gluud, C., Hemmingsen, B., Perrild, H., Madsbad, S., Mathiesen, E. R., Tarnow, L., Thorsteinsson, B., Vestergaard, H., Lund, S. S. & Eiken, P., Sep 2021, In: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 32, 9, p. 1837-1848 12 p.

Research output: Contribution to journal › Journal article › peer-review

The trans-ancestral genomic architecture of glycemic traits

Chen, J., Spracklen, C. N., Marenne, G., Varshney, A., Corbin, L. J., Luan, J., Willems, S. M., Wu, Y., Zhang, X., Horikoshi, M., Boutin, T. S., Mägi, R., Waage, J., Li-Gao, R., Chan, K. H. K., Yao, J., Anasanti, M. D., Chu, A. Y., Claringbould, A., Heikkinen, J. & 31 others, Hong, J., Hottenga, J-J., Huo, S., Kaakinen, M. A., Louie, T., März, W., Moreno-Macias, H., Ndungu, A., Nelson, S. C., Nolte, I. M., North, K. E., Raulerson, C. K., Ray, D., Rohde, R., Rybin, D., Schurmann, C., Sim, X., Ahluwalia, T. S., Sparsø, T., Astrup, A., Jørgensen, M. E., Linneberg, A., Thuesen, B., Vestergaard, H., Bisgaard, H., Bønnelykke, K., Hansen, T., Schwarz, P., Sørensen, T. I. A., Wareham, N. J. & LifeLines Cohort study, Jun 2021, In: Nature Genetics. 53, 6, p. 840-860 21 p.

Research output: Contribution to journal › Journal article › peer-review

Genetic markers of abdominal obesity and weight loss after gastric bypass surgery

Aasbrenn, M., Svendstrup, M., Schnurr, T. M., Lindqvist Hansen, D., Worm, D., Balslev-Harder, M., Grarup, N., Burgdorf, K. S., Vestergaard, H., Pedersen, O., Ängquist, L., Fenger, M., Sørensen, T. I. A., Madsbad, S. & Hansen, T., 28 May 2021, In: PLoS One. 16, 5, p. 1-11 11 p., e0252525.

Research output: Contribution to journal › Journal article › peer-review

Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India

Alvarez-Silva, C., Kashani, A., Hansen, T. H., Pinna, N. K., Anjana, R. M., Dutta, A., Saxena, S., Støy, J., Kampmann, U., Nielsen, T., Jørgensen, T., Gnanaprakash, V., Gnanavadivel, R., Sukumaran, A., Rani, C. S. S., Færch, K., Radha, V., Balasubramanyam, M., Nair, G. B., Das, B. & 6 others, Vestergaard, H., Hansen, T., Mande, S. S., Mohan, V., Arumugam, M. & Pedersen, O., 3 Mar 2021, In: Genome Medicine. 13, 1, p. 37 37.

Research output: Contribution to journal › Journal article › peer-review

Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study

Bizzotto, R., Jennison, C., Jones, A. G., Kurbasic, A., Tura, A., Kennedy, G., Bell, J. D., Thomas, E. L., Frost, G., Eriksen, R., Koivula, R. W., Brage, S., Kaye, J., Hattersley, A. T., Heggie, A., McEvoy, D., 't Hart, L. M., Beulens, J. W., Elders, P., Musholt, P. B. & 28 others, Ridderstråle, M., Hansen, T. H., Allin, K. H., Hansen, T., Vestergaard, H., Lundgaard, A. T., Thomsen, H. S., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T. J., Kokkola, T., Forgie, I. M., Giordano, G. N., Pavo, I., Ruetten, H., Dermitzakis, E., McCarthy, M. I., Pedersen, O., Schwenk, J. M., Adamski, J., Franks, P. W., Walker, M., Pearson, E. R., Mari, A. & IMI-DIRECT consortium, 1 Feb 2021, In: Diabetes Care. 44, 2, p. 511-518 8 p.

Research output: Contribution to journal › Journal article › peer-review

A reference map of potential determinants for the human serum metabolome

Bar, N., Korem, T., Weissbrod, O., Zeevi, D., Rothschild, D., Leviatan, S., Kosower, N., Lotan-Pompan, M., Weinberger, A., Le Roy, C. I., Menni, C., Visconti, A., Falchi, M., Spector, T. D., Vestergaard, H., Arumugam, M., Hansen, T., Allin, K., Hansen, T., Hong, M. G. & 31 others, Schwenk, J., Haussler, R., Dale, M., Giorgino, T., Rodriquez, M., Perry, M., Nice, R., McDonald, T., Hattersley, A., Jones, A., Graefe-Mody, U., Baum, P., Grempler, R., Thomas, C. E., Masi, F. D., Brorsson, C. A., Mazzoni, G., Allesøe, R., Rasmussen, S., Gudmundsdóttir, V., Nielsen, A. M., Banasik, K., Tsirigos, K., Nilsson, B., Pedersen, H., Brunak, S., Karaderi, T., Lundgaard, A. T., Ridderstråle, M., Engelbrechtsen, L. & The IMI DIRECT consortium, 3 Dec 2020, In: Nature. 588, 7836, p. 135-140 6 p.

Research output: Contribution to journal › Journal article › peer-review

Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

Gudmundsdottir, V., Pedersen, H. K., Mazzoni, G., Allin, K. H., Artati, A., Beulens, J. W., Banasik, K., Brorsson, C., Cederberg, H., Chabanova, E., De Masi, F., Elders, P. J., Forgie, I., Giordano, G. N., Grallert, H., Gupta, R., Haid, M., Hansen, T., Hansen, T. H., Hattersley, A. T. & 36 others, Heggie, A., Hong, M-G., Jones, A. G., Koivula, R., Kokkola, T., Laakso, M., Løngreen, P., Mahajan, A., Mari, A., McDonald, T. J., McEvoy, D., Musholt, P. B., Pavo, I., Prehn, C., Ruetten, H., Ridderstråle, M., Rutters, F., Sharma, S., Slieker, R. C., Syed, A., Tajes, J. F., Thomas, C. E., Thomsen, H. S., Vangipurapu, J., Vestergaard, H., Viñuela, A., Wesolowska-Andersen, A., Walker, M., Adamski, J., Schwenk, J. M., McCarthy, M. I., Pearson, E., Dermitzakis, E., Franks, P. W., Pedersen, O. & Brunak, S., 1 Dec 2020, In: Genome Medicine. 12, 1, p. 109

Research output: Contribution to journal › Journal article › peer-review

Data integration for prediction of weight loss in randomized controlled dietary trials

Nielsen, R. L., Helenius, M., Garcia, S. L., Roager, H. M., Aytan-Aktug, D., Hansen, L. B. S., Lind, M. V., Vogt, J. K., Dalgaard, M. D., Bahl, M. I., Jensen, C. B., Muktupavela, R., Warinner, C., Aaskov, V., Gøbel, R., Kristensen, M., Frøkiær, H., Sparholt, M. H., Christensen, A. F., Vestergaard, H. & 8 others, Hansen, T., Kristiansen, K., Brix, S., Petersen, T. N., Lauritzen, L., Licht, T. R., Pedersen, O. & Gupta, R., 18 Nov 2020, In: Scientific Reports. 10, 1, p. 20103

Research output: Contribution to journal › Journal article › peer-review

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

MetaCardis Consortium, Jørgensen, N. R. & Gøtze, J. P., 18 Nov 2020, In: Nature Communications. 11, 1, 5881.

Research output: Contribution to journal › Journal article › peer-review

Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes

Winckler, K., Thorsteinsson, B., Wiinberg, N., Jensen, A. K., Lundby-Christensen, L., Heitmann, B. L., Lund, S. S., Krarup, T., Jensen, T., Vestergaard, H., Breum, L., Sneppen, S., Boesgaard, T., Madsbad, S., Gluud, C., Vaag, A., Almdal, T. P., Tarnow, L. & CIMT Trial group, Oct 2020, In: Journal of Diabetes and its Complications. 34, 10, p. 107681 107681.

Research output: Contribution to journal › Journal article › peer-review

Effect of Metformin vs. Placebo in Combination with Insulin Analogues on Bone Markers P1NP and CTX in Patients with Type 2 Diabetes Mellitus

Nordklint, A. K., Almdal, T. P., Vestergaard, P., Lundby-Christensen, L., Jørgensen, N. R., Boesgaard, T. W., Breum, L., Gade-Rasmussen, B., Sneppen, S. B., Gluud, C., Hemmingsen, B., Krarup, T., Madsbad, S., Mathiesen, E. R., Perrild, H., Tarnow, L., Thorsteinsson, B., Vestergaard, H., Lund, S. S. & Eiken, P., Aug 2020, In: Calcified Tissue International. 107, 2, p. 160-169 10 p.

Research output: Contribution to journal › Journal article › peer-review

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A. G., Thomas, E. L., Koivula, R. W., Kurbasic, A., Mutie, P. M., Fitipaldi, H., Fernandez, J., Dawed, A. Y., Giordano, G. N., Forgie, I. M., McDonald, T. J., Rutters, F., Cederberg, H., Chabanova, E. & 43 others, Dale, M., Masi, F. D., Thomas, C. E., Allin, K. H., Hansen, T. H., Heggie, A., Hong, M-G., Elders, P. J. M., Kennedy, G., Kokkola, T., Pedersen, H. K., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Häussler, R. S., Sharma, S., Thomsen, H. S., Vangipurapu, J., Vestergaard, H., 't Hart, L. M., Adamski, J., Musholt, P. B., Brage, S., Brunak, S., Dermitzakis, E., Frost, G., Hansen, T., Laakso, M., Pedersen, O., Ridderstråle, M., Ruetten, H., Hattersley, A. T., Walker, M., Beulens, J. W. J., Mari, A., Schwenk, J. M., Gupta, R., McCarthy, M. I., Pearson, E. R., Bell, J. D., Pavo, I. & Franks, P. W., Jun 2020, In: PLOS Medicine. 17, 6, p. e1003149

Research output: Contribution to journal › Journal article › peer-review

Haploinsufficiency of ARHGAP42 is associated with hypertension

Fjorder, A. S., Rasmussen, M. B., Mehrjouy, M. M., Nazaryan-Petersen, L., Hansen, C., Bak, M., Grarup, N., Nørremølle, A., Larsen, L. A., Vestergaard, H., Hansen, T., Tommerup, N. & Bache, I., 1 Aug 2019, In: European journal of human genetics : EJHG. 27, 8, p. 1296-1303 8 p.

Research output: Contribution to journal › Journal article › peer-review

Genetic Determinants of Weight Loss After Bariatric Surgery

Aasbrenn, M., Schnurr, T. M., Have, C. T., Svendstrup, M., Hansen, D. L., Worm, D., Balslev-Harder, M., Hollensted, M., Grarup, N., Burgdorf, K. S., Vestergaard, H., Pedersen, O., Sørensen, T. I. A., Fenger, M., Madsbad, S. & Hansen, T., Aug 2019, In: Obesity Surgery. 29, 8, p. 2554-2561 8 p.

Research output: Contribution to journal › Journal article › peer-review

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 31 others, Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Bang, L. E., Benn, M., Bork-Jensen, J., Friedrich, N., Frikke-Schmidt, R., Hansen, T., Jensen, G. B., Jørgensen, M. E., Jørgensen, T., Kamstrup, P. R., Linneberg, A., Nielsen, S. F., Nordestgaard, B. G., Pers, T. H., Petersen, E. R. B., Thuesen, B. H., Tybjaerg-Hansen, A., Varbo, A., Vestergaard, H. & CHD Exome+ Consortium, Jul 2019, In: Nature Genetics. 51, 7, p. 1191-1192 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study

Bryrup, T., Thomsen, C. W., Kern, T., Allin, K. H., Brandslund, I., Jørgensen, N. R., Vestergaard, H., Hansen, T., Hansen, T. H., Pedersen, O. & Nielsen, T., Jun 2019, In: Diabetologia. 62, 6, p. 1024-1035 12 p.

Research output: Contribution to journal › Journal article › peer-review

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

CHD Exome+ Consortium, 1 Mar 2019, In: Nature Genetics. 51, 3, p. 452-469 18 p.

Research output: Contribution to journal › Journal article › peer-review

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L. & 132 others, Richardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W-J., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de Las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kerrison, N. D., Larson, N. B., Lin, K-H., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W. H-H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpeläinen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sørensen, T. I. A., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y-D. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., de Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., 3 Jan 2019, In: American Journal of Human Genetics. 104, 1, p. 112-138 27 p.

Research output: Contribution to journal › Journal article › peer-review

Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial

Roager, H. M., Vogt, J. K., Kristensen, M., Hansen, L. B. S., Ibrügger, S., Mærkedahl, R. B., Bahl, M. I., Lind, M. V., Nielsen, R. L., Frøkiær, H., Gøbel, R. J., Landberg, R., Ross, A. B., Brix, S., Holck, J., Meyer, A. S., Sparholt, M. H., Christensen, A. F., Carvalho, V., Holst, J. J. & 17 others, Rumessen, J. J., Linneberg, A., Sicheritz-Pontén, T., Dalgaard, M. D., Blennow, A., Frandsen, H. L., Villas-Bôas, S., Kristiansen, K., Vestergaard, H., Hansen, T., Ekstrøm, C. T., Ritz, C., Nielsen, H. B., Pedersen, O. B., Gupta, R., Lauritzen, L. & Licht, T. R., 1 Jan 2019, In: Gut. 68, 1, p. 83-93 11 p.

Research output: Contribution to journal › Journal article › peer-review

A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

Hansen, L. B. S., Roager, H. M., Søndertoft, N. B., Gøbel, R. J., Kristensen, M., Vallès-Colomer, M., Vieira-Silva, S., Ibrügger, S., Lind, M. V., Mærkedahl, R. B., Bahl, M. I., Madsen, M. L., Havelund, J., Falony, G., Tetens, I., Nielsen, T., Allin, K. H., Frandsen, H. L., Hartmann, B., Holst, J. J. & 32 others, Sparholt, M. H., Holck, J., Blennow, A., Moll, J. M., Meyer, A. S., Hoppe, C., Poulsen, J. H., Carvalho, V., Sagnelli, D., Dalgaard, M. D., Christensen, A. F., Lydolph, M. C., Ross, A. B., Villas-Bôas, S., Brix, S., Sicheritz-Pontén, T., Buschard, K., Linneberg, A., Rumessen, J. J., Ekstrøm, C. T., Ritz, C., Kristiansen, K., Nielsen, H. B., Vestergaard, H., Færgeman, N. J., Raes, J., Frøkiær, H., Hansen, T., Lauritzen, L., Gupta, R., Licht, T. R. & Pedersen, O., 13 Nov 2018, In: Nature Communications. 9, 4630, p. 4630

Research output: Contribution to journal › Journal article › peer-review

Is abdominal obesity at baseline influencing weight changes in observational studies and during weight loss interventions?

Svendstrup, M., Allin, K. H., Ängquist, L., Schnohr, P., Jensen, G. B., Linneberg, A., Thuesen, B., Astrup, A., Saris, W. H. M., Vestergaard, H. & Sørensen, T. I. A., 1 Nov 2018, In: The American journal of clinical nutrition. 108, 5, p. 913-921 9 p.

Research output: Contribution to journal › Journal article › peer-review

The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial

Nordklint, A. K., Almdal, T. P., Vestergaard, P., Lundby-Christensen, L., Boesgaard, T. W., Breum, L., Gade-Rasmussen, B., Sneppen, S. B., Gluud, C., Hemmingsen, B., Jensen, T., Krarup, T., Madsbad, S., Mathiesen, E. R., Perrild, H., Tarnow, L., Thorsteinsson, B., Vestergaard, H., Lund, S. S. & Eiken, P., Nov 2018, In: Osteoporosis International. 29, 11, p. 2517-2526

Research output: Contribution to journal › Journal article › peer-review

Fasting decreases plasma FGF21 in obese subjects and the expression of FGF21 receptors in adipose tissue in both lean and obese subjects

Nygaard, E. B., Ørskov, C., Almdal, T., Vestergaard, H. & Andersen, B., 1 Oct 2018, In: Journal of Endocrinology. 239, 1, p. 73–80

Research output: Contribution to journal › Journal article › peer-review

Bone turnover, calcium homeostasis, and vitamin D status in Danish vegans

Hansen, T. H., Madsen, M. T. B., Jørgensen, N. R., Cohen, A. S., Hansen, T., Vestergaard, H., Pedersen, O. & Allin, K. H., Jul 2018, In: European Journal of Clinical Nutrition. 72, p. 1046-1054 8 p.

Research output: Contribution to journal › Journal article › peer-review

Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial

Safai, N., Suvitaival, T., A, A., Spégel, P., Al-Majdoub, M., Carstensen, B., Vestergaard, H., Ridderstråle, M., CIMT Trial Group, Lundby-Christensen, L., Tarnow, L., Thorsteinsson, B., Gluud, C., Røder, M. E. & Wiinberg, N., Jul 2018, In: Diabetic Medicine Online. 35, 7, p. 944-953 9 p.

Research output: Contribution to journal › Journal article › peer-review

Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation

Engelbrechtsen, L., Gybel-Brask, D., Mahendran, Y., Crusell, M., Hansen, T. H., Schnurr, T. M., Hogdall, E., Skibsted, L., Hansen, T. & Vestergaard, H., 30 May 2018, In: Scientific Reports. 8, 1, p. 8376

Research output: Contribution to journal › Journal article › peer-review

Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum

Crusell, M. K. W., Hansen, T. H., Nielsen, T., Allin, K. H., Rühlemann, M. C., Damm, P., Vestergaard, H., Rørbye, C., Jørgensen, N. R., Christiansen, O. B., Heinsen, F-A., Franke, A., Hansen, T., Lauenborg, J. & Pedersen, O., 15 May 2018, In: Microbiome. 6, 1, p. 89

Research output: Contribution to journal › Journal article › peer-review

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 31 others, Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Bang, L. E., Benn, M., Bork-Jensen, J., Friedrich, N., Frikke-Schmidt, R., Hansen, T., Jensen, G. B., Jørgensen, M. E., Jørgensen, T., Kamstrup, P. R., Linneberg, A., Nielsen, S. F., Nordestgaard, B. G., Pers, T. H., Petersen, E. R. B., Thuesen, B. H., Tybjaerg-Hansen, A., Varbo, A., Vestergaard, H. & CHD Exome+ Consortium, May 2018, In: Nature Genetics. 50, 5, p. 765-766 2 p.

Research output: Contribution to journal › Journal article › peer-review

One-carbon metabolism markers are associated with cardiometabolic risk factors

Lind, M. V., Lauritzen, L., Vestergaard, H., Hansen, T., Pedersen, O., Kristensen, M. & Ross, A. B., 1 Apr 2018, In: Nutrition, metabolism, and cardiovascular diseases : NMCD. 28, 4, p. 402-410 8 p.

Research output: Contribution to journal › Journal article › peer-review

Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures

Svendstrup, M., Appel, E. V. R., Sandholt, C. H., Ahluwalia, T. S., Ängquist, L. H., Thuesen, B. H., Jørgensen, M. E., Pedersen, O., Grarup, N., Hansen, T., Sørensen, T. I. A. & Vestergaard, H., Apr 2018, In: Obesity (Silver Spring, Md.). 26, 4, p. 747-754 7 p.

Research output: Contribution to journal › Journal article › peer-review

Impact of a multifactorial treatment programme on clinical outcomes and cardiovascular risk estimates: a retrospective cohort study from a specialised diabetes centre in Denmark

Safai, N., Carstensen, B., Vestergaard, H. & Ridderstråle, M., 17 Mar 2018, In: BMJ Open. 8, 3, p. e019214

Research output: Contribution to journal › Journal article › peer-review

Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

Engelbrechtsen, L., Mahendran, Y., Jonsson, A., Gjesing, A. P., Weeke, P. E., Jørgensen, M. E., Færch, K., Witte, D. R., Holst, J. J., Jørgensen, T., Grarup, N., Pedersen, O., Vestergaard, H., Torekov, S., Kanters, J. K. & Hansen, T., 16 Mar 2018, In: BMC Genetics. 19, 1, p. 15

Research output: Contribution to journal › Journal article › peer-review

Aberrant intestinal microbiota in individuals with prediabetes

Allin, K. H., Tremaroli, V., Caesar, R., Jensen, B. A. H., Damgaard, M. T. F., Bahl, M. I., Licht, T. R., Hansen, T. H., Nielsen, T., Dantoft, T. M., Linneberg, A., Jørgensen, T., Vestergaard, H., Kristiansen, K., Franks, P. W., Hansen, T., Bäckhed, F., Pedersen, O. & IMI-DIRECT consortium, 29 Jan 2018, In: Diabetologia. 61, 4, p. 810-820

Research output: Contribution to journal › Journal article › peer-review

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 31 others, Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Bang, L. E., Benn, M., Bork-Jensen, J., Frikke-Schmidt, R., Jensen, G. B., Jørgensen, M. E., Jørgensen, T., Kamstrup, P. R., Linneberg, A., Nielsen, S. F., Nordestgaard, B. G., Pers, T. H., Thuesen, B. H., Tybjaerg-Hansen, A., Varbo, A., Vestergaard, H. & CHD Exome+ Consortium, Jan 2018, In: Nature Genetics. 50, 1, p. 26-41 16 p.

Research output: Contribution to journal › Journal article › peer-review

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

Andersen, M. K., Vestergaard, H., Linneberg, A. & Bone Mineral Density in Childhood Study, 2018, In: Diabetes Care. 41, 11, p. 2396-2403

Research output: Contribution to journal › Journal article › peer-review

Genetic risk scores for body fat distribution attenuate weight loss in women during dietary intervention

Svendstrup, M., Allin, K. H., Sørensen, T. I. A., Hansen, T. H., Grarup, N., Hansen, T. & Vestergaard, H., 2018, In: International journal of obesity (2005). 42, p. 370-375 5 p.

Research output: Contribution to journal › Journal article › peer-review

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Understanding Society Scientific Group, 2018, In: Wellcome Open Research. 3, p. 4

Research output: Contribution to journal › Journal article › peer-review

Treatment with liraglutide may improve markers of CVD reflected by reduced levels of apoB

Engelbrechtsen, L., Lundgren, J., Wewer Albrechtsen, N. J., Mahendran, Y., Iepsen, E. W., Finocchietto, P., Jonsson, A. E., Madsbad, S., Holst, J. J., Vestergaard, H., Hansen, T. & Torekov, S. S., Dec 2017, In: Obesity Science & Practice. 3, 4, p. 425-433 9 p.

Research output: Contribution to journal › Journal article › peer-review

Higher intake of fish and fat is associated with lower plasma s-adenosylhomocysteine: a cross-sectional study

Lind, M. V., Lauritzen, L., Pedersen, O., Vestergaard, H., Stark, K. D., Hansen, T., Ross, A. B. & Kristensen, M., Oct 2017, In: Nutrition Research. 46, p. 78-87 9 p.

Research output: Contribution to journal › Journal article › peer-review

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

Graff, M., Scott, R. A., Justice, A. E., Young, K. L., Feitosa, M. F., Barata, L., Winkler, T. W., Chu, A. Y., Mahajan, A., Hadley, D., Xue, L., Workalemahu, T., Heard-Costa, N. L., den Hoed, M., Ahluwalia, T. S., Qi, Q., Ngwa, J. S., Renström, F., Quaye, L., Eicher, J. D. & 31 others, Hayes, J. E., Cornelis, M., Kutalik, Z., Lim, E., Luan, J., Huffman, J. E., Zhang, W., Zhao, W., Griffin, P. J., Haller, T., Ahmad, S., Marques-Vidal, P., Bien, S., Yengo, L., Teumer, A., Smith, A. V., Kumari, M., Harder, M. N., Justesen, J. M., Kleber, M. E., Hollensted, M., Lohman, K., Rivera, N. V., Whitfield, J. B., Zhao, J. H., Aadahl, M., Færch, K., Vestergaard, H., Sørensen, T. I. A., Linneberg, A. & CHARGE Consortium, Aug 2017, In: P L o S Genetics. 13, 8, p. e1006972

Research output: Contribution to journal › Comment/debate › peer-review