Brief presentation

Consultant in Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet & Professor in Experimental and Clinical Physiology, University of Copenhagen. 

Positions

2008-: Professor in Experimental and Clinical Physiology, Faculty of Health Science, University of Copenhagen.

2010-2014 Member of the Ethical Committee for the Capital Region.

2013-2016 Principal professor (ordførende professor) in Clinical Physiology and Nuclear Medicine, Institute of Clinical Medicine, University of Copenhagen.

2014-: Professor II, Department of Circulation and Medical Imaging, The Norwegian University of Technology and Science (NTNU), Trondheim, Norway.

2015-: Head of Functional Imaging Unit, Consultant in Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Rigshospitalet-Glostrup.

Teaching and areas of guidance

Supervisor for 26 PhD and Master Students since 1995. At present supervisor of one Post Doc, involved in measurement of the blood brain barrier permeability in MS patients and one PhD student involved in methodological development of MR methods capable of measuring cerebral perfusion and oxygen consumption. Co-supervisor for 4 PhD students.  

Main research areas

Collaboration with professor I Awad, The University of Chicago Medicine, USA; Associated professor I Galea, University of Southampton, UK; and Dr. S Maier, University of Freiburg, GE.  

Main research areas

Functional and physiological MR imaging in order to obtain physiological and patophysiological information in diseases as: Multiple Sclerosis, Neurodegenerative diseases (Alzheimer's dementia), small and large vessel brain diseases, ageing and brain tumors.

Expertises

Magnetic Resonance physics related to MR imaging and spectroscopy;

Mathematical modeling especially related to tracer kinetic theory;

Brain physiology related to oxygen metabolism, lactate production, perfusion, capillary transit time, blood brain barrier permeability;

Functional brain activation using BOLD imaging;

Non-linear BOLD response.Quantitative myocardial perfusion imaging;

Matlab programming.

MR sequence development.

Current research

Blood brain barrier permeability in normal appearing brain tissue in patients with Multiple Sclerosis and its relation to efficacy of various treatment regimes.

Perfusion and blood brain barrier permeability in brain tumors.

Brain metabolism - oxygen consumption, CBF and lactate- in healthy subjects, in free dives, in diseases as Multiple Sclerosis, Diabetes, Obstructive sleep apnea and vascular brain diseases.

Tracer kinetic models for estimation of capillary transit time heterogeneity.

Quantitative susceptibility imaging.

Deconvolving point spread function in MR imaging.

Estimation of water permeability of the blood brain barrier.

Potential conflicts of interest

none