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The Capital Region of Denmark - a part of Copenhagen University Hospital
  1. 2019
  2. E-pub ahead of print

    The impact of human CES1 genetic variation on enzyme activity assessed by ritalinic acid/methylphenidate ratios

    Stage, C., Dalhoff, K., Rasmussen, H. B., Thomsen, R., Bjerre, D., Ferrero-Miliani, L., Madsen, M. B. & Jürgens, G., 24 Feb 2019, In : Basic & clinical pharmacology & toxicology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2018
  4. Published

    Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate

    INDICES consortium, Aug 2018, In : CPT: pharmacometrics & systems pharmacology. 7, 8, p. 525-533 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Age at first birth in women is genetically associated with increased risk of schizophrenia

    Ni, G., Gratten, J., Wray, N. R., Lee, S. H., Hansen, T. F., Werge, T. M., Olsen, L., Rasmussen, H. B. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 5 Jul 2018, In : Scientific Reports. 8, 1, p. 10168

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework

    LeBlanc, M., Zuber, V., Thompson, W. K., Andreassen, O. A., Frigessi, A., Andreassen, B. K., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Cahn, W., Cai, G., Cairns, M. J., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Hansen, M., Hansen, T., Meier, S., Olsen, L., Rasmussen, H. B., Werge, T. & Schizophrenia and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, 25 Jun 2018, In : BMC Genomics. 19, 1, 494.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

    Ruderfer, D. M., Ripke, S., McQuillin, A., Boocock, J., Stahl, E. A., Pavlides, J. M. W., Mullins, N., Charney, A. W., Ori, A. P. S., Loohuis, L. M. O., Domenici, E., Di Florio, A., Papiol, S., Kalman, J. L., Trubetskoy, V., Adolfsson, R., Agartz, I., Agerbo, E., Akil, H., Albani, D., Albus, M., Alda, M., Alexander, M., Alliey-Rodriguez, N., Als, T. D., Amin, F., Anjorin, A., Arranz, M. J., Awasthi, S., Bacanu, S. A., Badner, J. A., Baekvad-Hansen, M., Bakker, S., Band, G., Barchas, J. D., Barroso, I., Bass, N., Bauer, M., Baune, B. T., Begemann, M., Bellenguez, C., Belliveau, R. A., Hansen, M., Hansen, T., Meier, S., Nordentoft, M., Olsen, L., Pers, T. H., Rasmussen, H. B., Werge, T., Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium douglas.ruderfer@vanderbilt.edu, Psychosis Endophenotypes International Consortium & Wellcome Trust Case-Control Consortium, 14 Jun 2018, In : Cell. 173, 7, p. 1705-1715.e16

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood

    Ni, G., Moser, G., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Hansen, M., Hansen, T., Meier, S., Olsen, L., Rasmussen, H. B., Werge, T., Wellcome Trust Case-Control Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium & Psychosis Endophenotypes International Consortium, 7 Jun 2018, In : American Journal of Human Genetics. 102, 6, p. 1185-1194 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Carboxylesterase 1 genes: systematic review and evaluation of existing genotyping procedures

    Rasmussen, H. B., Madsen, M. B., INDICES Consortium, Plessen, K. J., Jeppesen, P., Houmann, T., Kaalund-Brok, K. & Pagsberg, A. K., 28 Mar 2018, In : Drug Metabolism and Personalized Therapy. 33, 1, p. 3-14 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  10. E-pub ahead of print

    Novel approach for CES1 genotyping: integrating single nucleotide variants and structural variation

    Bjerre, D. & Berg Rasmussen, H., 19 Feb 2018, In : Pharmacogenomics.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Systems genetics analysis of pharmacogenomics variation during antidepressant treatment

    Madsen, M. B., Kogelman, L. J. A., Kadarmideen, H. N. & Rasmussen, H. B., 2018, In : The pharmacogenomics journal. 18, 1, p. 144-152

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2017
  13. Published

    Severe Parkinsonism and Creatine Kinase Increase After Low-Dose Aripiprazole Treatment in a Patient of African Descent

    Jørgensen, A., Thorleifsson, A., Jimenez-Solem, E., Werge, T. & Rasmussen, H. B., Oct 2017, In : Journal of Clinical Psychopharmacology. 37, 5, p. 630-631 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Carboxylesterase 1A2 encoding gene with increased transcription and potential rapid drug metabolism in Asian populations

    Rasmussen, H. B., Madsen, M. B., Lyauk, Y. K., Hansen, P. R., Hughes, T. P., INDICES Consortium, Jeppesen, P., Pagsberg, A. K., Plessen, K. J., Houmann, T. & Kaalund-Brok, K., Sep 2017, In : Drug Metabolism and Personalized Therapy. 32, 3, p. 163-168

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Reappraisal of the genetic diversity and pharmacogenetic assessment of CES1

    Ferrero-Miliani, L., Bjerre, D., Stage, C., Madsen, M. B., Jűrgens, G., Dalhoff, K. P. & Rasmussen, H. B., Aug 2017, In : Pharmacogenomics. 18, 13, p. 1241-1257 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The impact of CES1 genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects

    Stage, C., Jürgens, G., Guski, L. S., Thomsen, R., Bjerre, D., Ferrero-Miliani, L., Lyauk, Y. K., Rasmussen, H. B., Dalhoff, K. & INDICES Consortium, Jul 2017, In : British Journal of Clinical Pharmacology. 83, 7, p. 1506-1514

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    The Pharmacokinetics of Enalapril in Relation to CES1 Genotype in Healthy Danish Volunteers

    Stage, C., Jürgens, G., Guski, L. S., Thomsen, R., Bjerre, D., Ferrero-Miliani, L., Lyauk, Y. K., Rasmussen, H. B., Dalhoff, K., INDICES Consortium (for members of this consortium-see Supplementum) & INDICES consortium, Jul 2017, In : Basic & clinical pharmacology & toxicology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Novel procedure with improved resolution and specificity for amplification and differentiation of variants of the gene encoding carboxylesterase 1

    Bjerre, D., Rasmussen, H. B. & INDICES Consortium, Apr 2017, In : Pharmacogenetics and Genomics. 27, 4, p. 155-158 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Association of Carboxylesterase 1 Gene (CES1) Polymorphism with Weight loss in Children with Attention Deficit Hyperactivity Disorder during Methylphenidate Treatment

    Oxenbøll, M., Kaalund-Brok, K., Rasmussen, S., Bjerre, D., Jürgens, G., Hansen, E. H., Plessen, K. J., Rasmussen, H. B., Pagsberg, A. K. & The INDICES Consortium, 21 Mar 2017, In : SM Journal of Bioinformatics and Proteomics. 2, 1, p. 1-8 8 p., 1010.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

    McLaughlin, R. L., Schijven, D., van Rheenen, W., van Eijk, K. R., O'Brien, M., Kahn, R. S., Ophoff, R. A., Goris, A., Bradley, D. G., Al-Chalabi, A., van den Berg, L. H., Luykx, J. J., Hardiman, O., Veldink, J. H., Project MinE GWAS Consortium, Werge, T. M. & Rasmussen, H. B., 21 Mar 2017, In : Nature Communications. 8, p. 14774

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Nomenclature for alleles of the human carboxylesterase 1 gene

    Rasmussen, H. B., Madsen, M. B., Hansen, P. R. & INDICES Consortium, Feb 2017, In : Pharmacogenetics and Genomics. 27, 2, p. 78-80 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  22. 2016
  23. Published

    Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 (CES1) Variants

    Lyauk, Y. K., Stage, C., Bergmann, T. K., Ferrero-Milliani, L., Bjerre, D., Thomsen, R., Dalhoff, K. P., Rasmussen, H. B. & Jürgens, G., Dec 2016, In : Clinical and Translational Science. 9, 6, p. 337-345 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Kromosomforandringer, der involverer dopamintransportøren, som årsag til psykiske lidelser

    Høffding, L. K. E., Duong, L. & Rasmussen, H. B., 22 Nov 2016, In : BestPractice.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Pharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors

    Nelveg-Kristensen, K. E., Bie, P., Ferrero, L., Bjerre, D., Bruun, N. E., Egfjord, M., Rasmussen, H. B., Hansen, P. R., INDICES Consortium(Members Kerstin Plessen, Pia Jeppesen, Tine Houmann, Kristine Kaalund-Brok, Anne Katrine Pagsberg, Plessen, K. J., Jeppesen, P., Houmann, T., Kaalund-Brok, K. & Pagsberg, A. K., 24 Sep 2016, In : P L o S One. 11, 9, p. e0163341 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Investigating the impact of missense mutations in hCES1 by in silico structure-based approaches

    Nzabonimpa, G. S., Rasmussen, H. B., Brunak, S., Taboureau, O., INDICES Consortium, Plessen, K. J., Jeppesen, P., Houmann, T., Kaalund-Brok, K. & Pagsberg, A. K., 1 Jun 2016, In : Drug Metabolism and Personalized Therapy. 31, 2, p. 97-106

    Research output: Contribution to journalReviewResearchpeer-review

  27. Published
  28. Published

    Switch in Therapy from Methylphenidate to Atomoxetine in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: An Analysis of Patient Records

    Warrer, P., Thomsen, P. H., Dalsgaard, S., Hansen, E. H., Aagaard, L., Wallach Kildemoes, H. & Rasmussen, H. B., 2016, In : Journal of Child and Adolescent Psychopharmacology. 26, 4, p. 354-361

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2015
  30. Published

    Linkage and whole genome sequencing identify a locus on 6q25-26 for formal thought disorder and implicate MEF2A regulation

    Thygesen, J. H., Zambach, S. K., Ingason, A., Lundin, P., Hansen, T. F., Berlatan, M., Rosengren, A., Bjerre, D., Ferrero-Miliani, L., Rasmussen, H. B., Parnas, J. & Werge, T., Dec 2015, In : Schizophrenia Research. 169, 1-3, p. 441–446

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Identification of rare high-risk copy number variants affecting the dopamine transporter gene in mental disorders

    Hoeffding, L. K., Duong, L. T. T., Ingason, A., Rosengren, A., Sorbanski, E., Witt, S. H., Djurovic, S., Andreassen, O. A., Hansen, T. F., Werge, T. & Rasmussen, H. B., 11 Nov 2015, In : Nordic Journal of Psychiatry. p. 1-4 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

    Lee, S. H., Byrne, E. M., Hultman, C. M., Kähler, A., Vinkhuyzen, A. A., Ripke, S., Andreassen, O. A., Frisell, T., Gusev, A., Hu, X., Karlsson, R., Mantzioris, V. X., McGrath, J. J., Mehta, D., Stahl, E. A., Zhao, Q., Kendler, K. S., Sullivan, P. F., Price, A. L., O'Donovan, M., Okada, Y., Mowry, B. J., Raychaudhuri, S., Wray, N. R., Byerley, W., Cahn, W., Cantor, R. M., Cichon, S., Cormican, P., Curtis, D., Djurovic, S., Escott-Price, V., Gejman, P. V., Georgieva, L., Giegling, I., Hansen, T. F., Ingason, A., Kim, Y., Konte, B., Lee, P. H., McIntosh, A., McQuillin, A., Morris, D. W., Nöthen, M. M., O'Dushlaine, C., Olincy, A., Olsen, L., Pato, C. N., Rasmussen, H. B., Werge, T. & Schizophrenia Working Group of the Psychiatric Genomics Consortium and Rheumatoid Arthritis Consortium International, Oct 2015, In : International Journal of Epidemiology. 44, 5, p. 1706-1721

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Risk factors and mortality among patients with severe muco-cutaneous drug reactions

    Crüger, A-M. T., Kaur-Knudsen, D., Zachariae, C., Rasmussen, H. B. & Thomsen, S. F., Aug 2015, In : Danish Medical Bulletin (Online). 62, 8, A5122.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics

    Rasmussen, H. B., Bjerre, D., Linnet, K., Jürgens, G., Dalhoff, K., Stefansson, H., Hankemeier, T., Kaddurah-Daouk, R., Taboureau, O., Brunak, S., Houmann, T., Jeppesen, P., Pagsberg, A. K., Plessen, K., Dyrborg, J., Hansen, P. R., Hansen, P. E., Hughes, T., Werge, T., INDICES Consortium & Kaalund-Brok, K., 21 Apr 2015, In : Pharmacogenomics. 16, 6, p. 649-665 17 p.

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published
  36. Published

    LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

    Bulik-Sullivan, B. K., Loh, P-R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., Daly, M. J., Price, A. L., Neale, B. M. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, Mar 2015, In : Nature Genetics. 47, 3, p. 291-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published
  38. Published

    Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

    The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium, 19 Jan 2015, In : Nature Neuroscience.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci

    Andreassen, O. A., Harbo, H. F., Wang, Y., Thompson, W. K., Schork, A. J., Mattingsdal, M., Zuber, V., Bettella, F., Ripke, S., Kelsoe, J. R., Kendler, K. S., O'Donovan, M. C., Sklar, P., McEvoy, L. K., Desikan, R. S., Lie, B. A., Djurovic, S., Dale, A. M. & The Psychiatric Genomics Consortium (PGC) Bipolar Disorder and Schizophrenia Work Groups, 2015, In : Molecular Psychiatry. 20, 2, p. 207-214 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published
  41. Published

    Synthetic cannabimimetic agents metabolized by carboxylesterases

    Thomsen, R., Nielsen, L. M., Holm, N. B., Rasmussen, H. B., Linnet, K., the INDICES Consortium, Plessen, K. J., Jeppesen, P., Houmann, T., Kaalund-Brok, K. & Pagsberg, A. K., 2015, In : Drug Testing and Analysis. 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. 2014
  43. Published

    Biological insights from 108 schizophrenia-associated genetic loci

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 24 Jul 2014, In : Nature. 511, 7510, p. 421-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Metabolomics has the potential to improve drug therapy

    Stage, C., Jürgens, G., Dalhoff, K. P. & Rasmussen, H. B., 17 Mar 2014, In : Ugeskrift for læger [online]. 176, 6

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors

    Thomsen, R., Rasmussen, H. B., Linnet, K. & INDICES Consortium, Jan 2014, In : Drug Metabolism and Disposition. 42, 1, p. 126-33 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. 2013
  47. Published
  48. Published

    Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

    Lee, S. H., Ripke, S., Neale, B. M., Faraone, S. V., Purcell, S. M., Perlis, R. H., Mowry, B. J., Thapar, A., Goddard, M. E., Witte, J. S., Absher, D., Agartz, I., Akil, H., Amin, F., Andreassen, O. A., Anjorin, A., Anney, R., Anttila, V., Arking, D. E., Asherson, P., Azevedo, M. H., Backlund, L., Badner, J. A., Bailey, A. J., Banaschewski, T., Barchas, J. D., Barnes, M. R., Barrett, T. B., Bass, N., Battaglia, A., Bauer, M., Bayés, M., Bellivier, F., Bergen, S. E., Berrettini, W., Betancur, C., Bettecken, T., Biederman, J., Binder, E. B., Black, D. W., Blackwood, D. H. R., Bloss, C. S., Boehnke, M., Boomsma, D. I., Breen, G., Hansen, T. F., Ingason, A., Olsen, L., Rasmussen, H. B., Werge, T. & Cross-Disorder Group of the Psychiatric Genomics Consortium, 11 Aug 2013, In : Nature Genetics. p. 984-994 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published
  50. Published

    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

    Cross-Disorder Group of the Psychiatric Genomics Consortium, 20 Apr 2013, In : Lancet. 381, 9875, p. 1371-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs

    Tobacco and Genetics Consortium & The Schizophrenia Psychiatric Genomics Consortium, Apr 2013, In : P L o S Genetics (Online). 9, 4, p. e1003449

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Genetisk variation i effekten af clopidogrel

    Kristensen, K. E., Rasmussen, H. B. & Hansen, P. R., 11 Mar 2013, In : Ugeskrift for Laeger. 175, 11, p. 729-32 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Improved Detection of Common Variants Associated with Schizophrenia by Leveraging Pleiotropy with Cardiovascular-Disease Risk Factors

    International Consortium for Blood Pressure GWAS & Psychiatric Genomics Consortium Schizophrenia Working Group, Feb 2013, In : American Journal of Human Genetics. 92, 2, p. 197-209 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function

    Friedrichsen, M., Poulsen, P. H., Wojtaszewski, J., Hansen, P. R., Vaag, A. & Rasmussen, H. B., 2013, In : P L o S One. 8, 2, p. e56861

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Does routine CYP2D6 and CYP2C19 genotyping reduce the risk of adverse events related to antipsychotic drug treatment?

    Jürgens, G., Andersen, S. E., Jensen, H., Rasmussen, H. B., Werge, T. M. & Nordentoft, M., 2013, In : Clinical Toxicology. 51, 4, p. 325-325 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  56. Published

    Genetic Schizophrenia Risk Variants Jointly Modulate Total Brain and White Matter Volume

    Terwisscha van Scheltinga, A. F., Bakker, S. C., van Haren, N. E. M., Derks, E. M., Buizer-Voskamp, J. E., Boos, H. B. M., Cahn, W., Hulshoff Pol, H. E., Ripke, S., Ophoff, R. A., Kahn, R. S. & the Psychiatric Genome-wide Association Study Consortium, 2013, In : Advances in Biological Psychiatry. 73, 6, p. 525-531

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Risk of hemorrhagic events in patients co-treated with clopidogrel and angiotensin-converting enzyme inhibitors after myocardial infarction

    Kristensen, K. E., Gislason, G. H., Torp-Pedersen, C., Rasmussen, H. B. & Hansen, P. R., 2013, In : Eur.Heart J.. 34, Suppl. 1, p. 471, No. P2513

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

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