Helle Bach Søndergaard

Research output

Research output per year 2009 2011 2019 2021 2023

• 70 Journal article
• 1 Conference abstract in journal
• 1 Review

Research output per year

Research output per year

Search results

• 2023

  Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer's disease

  Frederiksen, K. S., Jensen, C. S., Høgh, P., Gergelyffy, R., Waldemar, G., Andersen, B. B., Gottrup, H., Vestergaard, K., Wermuth, L., Søndergaard, H. B., Sellebjerg, F., Hasselbalch, S. G. & Simonsen, A. H., 2023, In: Frontiers in Neuroscience. 17, p. 1108191 1108191.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Intermediate Filaments 100%
  • Alzheimer Disease 70%
  • Light 64%
  • Exercise 58%
  • Serum 41%

• Cluster headache polygenetic risk and known functional variants of CYP3A4 are not associated with treatment response

  Petersen, A. S., Barloese, M., Lund, N., Pedersen, A. F., Søborg, M-L. K., Chalmer, M. A., Callesen, I., Winsvold, B. S., Zwart, J-A., Ostrowski, S. R., Pedersen, O. B., Sellebjerg, F., Søndergaard, H. B., Hansen, M. B., Jensen, R. H., Hansen, T. F. & DBDS Genomic Consortium, May 2023, In: European Journal of Neurology. 30, 5, p. 1425-1434 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cluster Headache 100%
  • Cytochrome P-450 CYP3A 82%
  • Verapamil 34%
  • Tryptamines 22%
  • Therapeutics 11%
  1 Citation (Scopus)

• The gut microbiota in multiple sclerosis varies with disease activity

  Thirion, F., Sellebjerg, F., Fan, Y., Lyu, L., Hansen, T. H., Pons, N., Levenez, F., Quinquis, B., Stankevic, E., Søndergaard, H. B., Dantoft, T. M., Poulsen, C. S., Forslund, S. K., Vestergaard, H., Hansen, T., Brix, S., Oturai, A., Sørensen, P. S., Ehrlich, S. D. & Pedersen, O., 5 Jan 2023, In: Genome Medicine. 15, 1, p. 1 1.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gastrointestinal Microbiome 100%
  • Multiple Sclerosis 89%
  • Caudovirales 21%
  • Faecalibacterium prausnitzii 18%
  • Blood Cells 18%

• The peripheral endocannabinoid system and its association with biomarkers of inflammation in untreated patients with multiple sclerosis

  Gustavsen, S., Olsson, A., Oturai, A. B., Linnet, K., Thomsen, R., Rasmussen, B. S., Jørgensen, C. F., Langkilde, A. R., Sorensen, P. S., Sellebjerg, F. & Søndergaard, H. B., Oct 2023, In: European Journal of Neurology. 30, 10, p. 3212-3220 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Endocannabinoids 100%
  • Multiple Sclerosis 72%
  • Biomarkers 53%
  • Inflammation 48%
  • Cannabinoid Receptors 11%
• 2022

  Dimethyl fumarate treatment of primary progressive multiple sclerosis: results of an open-label extension study

  Højsgaard Chow, H., Talbot, J., Lundell, H., Marstrand, L., Gøbel Madsen, C., Bach Søndergaard, H., Bredahl Hansen, M., Solberg Sørensen, P., Siebner, H. R. & Sellebjerg, F., 9 Dec 2022, (E-pub ahead of print) In: Multiple Sclerosis and Related Disorders. 70, p. epub 104458.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Dimethyl Fumarate 100%
  • Chronic Progressive Multiple Sclerosis 88%
  • Intermediate Filaments 20%
  • Light 12%
  • Placebos 12%
• 2021

  Biomarkers of systemic inflammation, soluble IL-2Rα and the multiple sclerosis-associated IL2RA SNP rs2104286 in healthy subjects and multiple sclerosis patients

  Buhelt, S., Søndergaard, H. B., Mahler, M. R., Cobanovic, S., Börnsen, L., Ammitzbøll, C., Oturai, A. B. & Sellebjerg, F., Sep 2021, In: Multiple Sclerosis and Related Disorders. 54, p. 103140 103140.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Interleukin-2 Receptors 100%
  • Interleukin-2 76%
  • Multiple Sclerosis 75%
  • Single Nucleotide Polymorphism 71%
  • Healthy Volunteers 57%

• Exposure to passive smoking during adolescence is associated with an increased risk of developing multiple sclerosis

  Oturai, D. B., Bach Søndergaard, H., Koch-Henriksen, N., Andersen, C., Laursen, J. H., Gustavsen, S., Kristensen, J. T., Magyari, M., Sørensen, P. S., Sellebjerg, F., Thørner, L. W., Ullum, H. & Oturai, A. B., Feb 2021, In: Multiple Sclerosis Journal. 27, 2, p. 188-197 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Tobacco Smoke Pollution 100%
  • Multiple Sclerosis 71%
  • Smokers 45%
  • Odds Ratio 17%
  • Propensity Score 14%

• IL2RA Methylation and Gene Expression in Relation to the Multiple Sclerosis-Associated Gene Variant rs2104286 and Soluble IL-2Rα in CD8+ T Cells

  Buhelt, S., Laigaard, H-M., von Essen, M. R., Ullum, H., Oturai, A., Sellebjerg, F. & Søndergaard, H. B., 2021, In: Frontiers in Immunology. 12, p. 676141 676141.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Interleukin-2 Receptors 100%
  • Methylation 77%
  • Multiple Sclerosis 75%
  • Single Nucleotide Polymorphism 53%
  • T-Lymphocytes 52%

• Neutrophil-to-lymphocyte ratio and CRP as biomarkers in multiple sclerosis: A systematic review

  Olsson, A., Gustavsen, S., Gisselø Lauridsen, K., Chenoufi Hasselbalch, I., Sellebjerg, F., Bach Søndergaard, H. & Oturai, A., Jun 2021, In: Acta Neurologica Scandinavica. 143, 6, p. 577-586 10 p.

  Research output: Contribution to journal › Review › peer-review

  • Multiple Sclerosis 100%
  • C-Reactive Protein 99%
  • Neutrophils 88%
  • Systematic Reviews 83%
  • Lymphocytes 78%
  16 Citations (Scopus)

• Serum Short-Chain Fatty Acids and Associations With Inflammation in Newly Diagnosed Patients With Multiple Sclerosis and Healthy Controls

  Olsson, A., Gustavsen, S., Nguyen, T. D., Nyman, M., Langkilde, A. R., Hansen, T. H., Sellebjerg, F., Oturai, A. B. & Bach Søndergaard, H., 2021, In: Frontiers in Immunology. 12, p. 661493 661493.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Volatile Fatty Acids 100%
  • Multiple Sclerosis 69%
  • Butyrates 66%
  • Acetates 52%
  • Inflammation 46%

• Smoking, cardiovascular risk factors and LRP2 gene variation: Associations with disease severity, cognitive function and brain structure in primary progressive multiple sclerosis

  Chow, H. H., Talbot, J., Marstrand, L., Lundell, H., Roman Siebner, H., Bach Søndergaard, H. & Sellebjerg, F., Nov 2021, In: Multiple Sclerosis and Related Disorders. 56, p. 1-7 7 p., 103296.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lipoprotein Receptors 100%
  • Chronic Progressive Multiple Sclerosis 96%
  • Cognition 55%
  • Smoking 50%
  • Multiple Sclerosis 41%
  1 Citation (Scopus)

• The association of selected multiple sclerosis symptoms with disability and quality of life: a large Danish self-report survey

  Gustavsen, S., Olsson, A., Søndergaard, H. B., Andresen, S. R., Sørensen, P. S., Sellebjerg, F. & Oturai, A., 2021, In: BMC Neurology. 21, 1, 12 p., 317.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Self Report 100%
  • Multiple Sclerosis 99%
  • Quality of Life 72%
  • Fatigue 68%
  • Registries 63%
• 2020

  Biomarkers of inflammation and epithelial barrier function in multiple sclerosis

  Olsson, A., Gustavsen, S., Hasselbalch, I. C., Langkilde, A. R., Sellebjerg, F., Oturai, A. B. & Søndergaard, H. B., Nov 2020, In: Multiple Sclerosis and Related Disorders. 46, p. 102520

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Multiple Sclerosis 100%
  • Biomarkers 73%
  • Inflammation 66%
  • Leukocyte L1 Antigen Complex 58%
  • Intermediate Filaments 31%

• Multiplex assessment of cerebrospinal fluid biomarkers in multiple sclerosis

  Mahler, M. R., Søndergaard, H. B., Buhelt, S., von Essen, M. R., Romme Christensen, J., Enevold, C. & Sellebjerg, F., Oct 2020, In: Multiple Sclerosis and Related Disorders. 45, p. 102391

  Research output: Contribution to journal › Journal article › Research › peer-review

  • B-Cell Maturation Antigen 100%
  • Multiple Sclerosis 50%
  • Cerebrospinal Fluid 49%
  • Biomarkers 37%
  • Chitinases 29%

• Pregnancy-Induced Changes in microRNA Expression in Multiple Sclerosis

  Søndergaard, H. B., Airas, L., Christensen, J. R., Nielsen, B. R., Börnsen, L., Oturai, A. & Sellebjerg, F., 2020, In: Frontiers in Immunology. 11, p. 552101

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Multiple Sclerosis 100%
  • MicroRNAs 95%
  • Pregnancy 68%
  • Natural Killer Cells 58%
  • Third Pregnancy Trimester 53%
• 2019

  Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort

  Andersen, C., Søndergaard, H. B., Bang Oturai, D., Laursen, J. H., Gustavsen, S., Larsen, N. K., Magyari, M., Just-Østergaard, E., Thørner, L. W., Sellebjerg, F., Ullum, H. & Oturai, A. B., Oct 2019, In: Multiple sclerosis. 25, 12, p. 1572-1579

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Alcohol Drinking 100%
  • Multiple Sclerosis 96%
  • Odds Ratio 46%
  • Confidence Intervals 43%
  • Logistic Models 23%
  11 Citations (Scopus)

• Evidence for oestrogen sensitivity in perinatal depression: pharmacological sex hormone manipulation study

  Mehta, D., Rex-Haffner, M., Søndergaard, H. B., Pinborg, A., Binder, E. B. & Frokjaer, V. G., Sep 2019, In: British Journal of Psychiatry. 215, 3, p. 519-527 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gonadal Steroid Hormones 100%
  • Estrogens 75%
  • Pharmacology 61%
  • Depression 60%
  • Gonadotropin-Releasing Hormone 57%
  21 Citations (Scopus)

• Expression of melanoma cell adhesion molecule-1 (MCAM-1) in natalizumab-treated multiple sclerosis

  Petersen, E. R., Ammitzbøll, C., Søndergaard, H. B., Oturai, A. B., Sørensen, P. S., Nilsson, A. C., Börnsen, L., von Essen, M. & Sellebjerg, F., 15 Dec 2019, In: Journal of Neuroimmunology. 337, p. 577085

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CD146 Antigen 100%
  • Natalizumab 80%
  • Cell Adhesion Molecule-1 78%
  • Multiple Sclerosis 49%
  • Activated-Leukocyte Cell Adhesion Molecule 37%

• Genome-wide gene expression in a pharmacological hormonal transition model and its relation to depressive symptoms

  Mehta, D., Rex-Haffner, M., Søndergaard, H. B., Pinborg, A., Binder, E. B. & Frokjaer, V. G., Jul 2019, In: Acta Psychiatrica Scandinavica. 140, 1, p. 77-84 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gonadotropin-Releasing Hormone 100%
  • Genome 67%
  • Pharmacology 66%
  • Depression 65%
  • Gonadal Steroid Hormones 65%
  4 Citations (Scopus)

• GPR15+ T cells are Th17 like, increased in smokers and associated with multiple sclerosis

  Ammitzbøll, C., von Essen, M. R., Börnsen, L., Petersen, E. R., McWilliam, O., Ratzer, R., Romme Christensen, J., Oturai, A. B., Søndergaard, H. B. & Sellebjerg, F., Feb 2019, In: Journal of Autoimmunity. 97, p. 114-121 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Multiple Sclerosis 100%
  • Smokers 96%
  • Smoking 82%
  • T-Lymphocytes 70%
  • Myelin Basic Protein 69%

• IL-6, IL-12, and IL-23 STAT-Pathway Genetic Risk and Responsiveness of Lymphocytes in Patients with Multiple Sclerosis

  von Essen, M. R., Søndergaard, H. B., Petersen, E. R. S. & Sellebjerg, F., 26 Mar 2019, In: Cells. 8, 3

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Interleukin-23 100%
  • Cohesion 95%
  • Interleukin-12 80%
  • Multiple Sclerosis 69%
  • Interleukin-6 60%

• Illegal cannabis use is common among Danes with multiple sclerosis

  Gustavsen, S., Søndergaard, H. B., Andresen, S. R., Magyari, M., Sørensen, P. S., Sellebjerg, F. & Oturai, A. B., Aug 2019, In: Multiple Sclerosis and Related Disorders. 33, p. 5-12 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cannabis 100%
  • Multiple Sclerosis 83%
  • Medical Marijuana 21%
  • Sleep 11%
  • Medicine 10%
  15 Citations (Scopus)

• Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

  International Multiple Sclerosis Genetics Consortium. Electronic address: chris.cotsapas@yale.edu, Søndergaard, H. B., Sellebjerg, F. T. & Sørensen, P. S., 27 Jun 2019, In: Cell. 178, 1, p. 262

  Research output: Contribution to journal › Journal article › Research › peer-review

• Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

  Ammitzbøll, C., Börnsen, L., Petersen, E. R., Oturai, A. B., Søndergaard, H. B., Grandjean, P. & Sellebjerg, F., 15 May 2019, In: Journal of Neuroimmunology. 330, p. 90-95 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Multiple Sclerosis 100%
  • perfluorooctane sulfonic acid 88%
  • EBV-encoded nuclear antigen 1 43%
  • Smoking 20%
  • Phenotype 17%

• Relationship between Multiple Sclerosis-Associated IL2RA Risk Allele Variants and Circulating T Cell Phenotypes in Healthy Genotype-Selected Controls

  Buhelt, S., Søndergaard, H. B., Oturai, A., Ullum, H., von Essen, M. R. & Sellebjerg, F., 25 Jun 2019, In: Cells. 8, 6, p. 634 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Multiple Sclerosis 100%
  • Nucleotide 93%
  • Alleles 82%
  • Single Nucleotide Polymorphism 81%
  • Genotype 81%

• Serum and cerebrospinal fluid neurofilament levels predict longitudinal atrophy of the cervical spinal cord in progressive MS

  Lundell, H., Christensen, J. R., Börnsen, L. S., Ammitzbøll, C., Søndergaard, H. B., Jensen, P. E. H., Iversen, P., Sørensen, P. S., Garde, E., Sellebjerg, F. T. & Siebner, H. R., 10 Sep 2019, In: Multiple Sclerosis Journal. 25, 2_suppl, p. 469-470 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Smoking is associated with increased disease activity during natalizumab treatment in multiple sclerosis

  Petersen, E. R., Søndergaard, H. B., Laursen, J. H., Olsson, A. G., Börnsen, L., Soelberg Sørensen, P., Sellebjerg, F. & Bang Oturai, A., Aug 2019, In: Multiple sclerosis. 25, 9, p. 1298-1305 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Natalizumab 100%
  • HLA Antigens 63%
  • Multiple Sclerosis 61%
  • Smoking 50%
  • Relapsing-Remitting Multiple Sclerosis 28%
  25 Citations (Scopus)

• The transcriptome of peripheral blood mononuclear cells in patients with clinical subtypes of late age-related macular degeneration

  Subhi, Y., Nielsen, M. K., Molbech, C. R., Liisborg, C., Søndergaard, H. B., Sellebjerg, F. & Sørensen, T. L., 2019, In: Immunity and Ageing. 16, p. e20

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Macular Degeneration 100%
  • Transcriptome 87%
  • Blood Cells 78%
  • Geographic Atrophy 61%
  • Genes 38%
• 2018

  Bone microarchitecture and bone mineral density in multiple sclerosis

  Olsson, A., Oturai, A. B., Søndergaard, H. B., Sellebjerg, F. & Oturai, P. S., 2018, In: Acta Neurologica Scandinavica. 137, 3, p. 363-69

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cancellous Bone 100%
  • Bone Density 86%
  • Multiple Sclerosis 83%
  • Bone and Bones 56%
  • Smoking 17%
  8 Citations (Scopus)

• Smoking affects the interferon beta treatment response in multiple sclerosis

  Petersen, E. R., Oturai, A. B., Koch-Henriksen, N., Magyari, M., Sørensen, P. S., Sellebjerg, F. & Søndergaard, H. B., 13 Feb 2018, In: Neurology. 90, 7, p. e593-e600

  Research output: Contribution to journal › Journal article › Research › peer-review

  • N-acetyltransferase 1 100%
  • Relapsing-Remitting Multiple Sclerosis 95%
  • Interferon-beta 89%
  • HLA Antigens 79%
  • Multiple Sclerosis 67%

• The neutrophil-to-lymphocyte ratio is associated with multiple sclerosis

  Hasselbalch, I. C., Søndergaard, H. B., Koch-Henriksen, N., Olsson, A., Ullum, H., Sellebjerg, F. & Oturai, A. B., 6 Dec 2018, In: Multiple sclerosis journal - experimental, translational and clinical. 4, 4, p. 1-8

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Multiple Sclerosis 100%
  • Neutrophils 88%
  • Lymphocytes 78%
  • Propensity Score 22%
  • Odds Ratio 13%
• 2017

  Genetic burden of MS risk variants distinguish patients from healthy individuals but are not associated with disease activity

  Søndergaard, H. B., Petersen, E. R., Magyari, M., Sellebjerg, F. & Oturai, A. B., Apr 2017, In: Multiple Sclerosis and Related Disorders. 13, p. 25-27 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Interferon-beta 100%
  • Alleles 21%
  • Recurrence 16%
  • Therapeutics 14%
  • Genes 11%
  13 Citations (Scopus)

• Relationship between soluble CD25 and gene expression in healthy individuals and patients with multiple sclerosis

  Buhelt, S., Ratzer, R. L., Christensen, J. R., Börnsen, L., Sellebjerg, F. & Søndergaard, H. B., May 2017, In: Cytokine. 93, p. 15-25 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Multiple Sclerosis 100%
  • Gene Expression 67%
  • Plasma Concentration 65%
  • Microarrays 61%
  • Genes 45%
  11 Citations (Scopus)

• Smoking reduces circulating CD26hiCD161hi MAIT cells in healthy individuals and patients with multiple sclerosis

  Ammitzbøll, C., Börnsen, L., Romme Christensen, J., Ratzer, R., Romme Nielsen, B., Søndergaard, H. B., von Essen, M. R. & Sellebjerg, F., May 2017, In: Journal of Leukocyte Biology. 101, 5, p. 1211-1220 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mucosal-Associated Invariant T Cells 100%
  • Multiple Sclerosis 52%
  • Smoking 43%
  • Non-Smokers 37%
  • T-Lymphocytes 27%
  15 Citations (Scopus)

• The interaction between smoking and HLA genes in multiple sclerosis: replication and refinement

  Hedström, A. K., Katsoulis, M., Hössjer, O., Bomfim, I. L., Oturai, A., Sondergaard, H. B., Sellebjerg, F., Ullum, H., Thørner, L. W., Gustavsen, M. W., Harbo, H. F., Obradovic, D., Gianfrancesco, M. A., Barcellos, L. F., Schaefer, C. A., Hillert, J., Kockum, I., Olsson, T. & Alfredsson, L., Oct 2017, In: European Journal of Epidemiology. 32, 10, p. 909-919 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Multiple Sclerosis 100%
  • Smoking 82%
  • HLA-A Antigens 70%
  • Smokers 48%
  • Genes 45%
  38 Citations (Scopus)
• 2016

  Association between age at onset of multiple sclerosis and vitamin D level-related factors

  Laursen, J. H., Søndergaard, H. B., Sørensen, P. S., Sellebjerg, F. & Oturai, A. B., 5 Jan 2016, In: Neurology. 86, 1, p. 88-93 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Age of Onset 100%
  • Vitamin D 98%
  • Multiple Sclerosis 93%
  • HLA-DRB1 Chains 84%
  • Single Nucleotide Polymorphism 53%
  21 Citations (Scopus)

• Identification of Suitable Reference Genes for Peripheral Blood Mononuclear Cell Subset Studies in Multiple Sclerosis

  Oturai, D. B., Søndergaard, H. B., Börnsen, L., Sellebjerg, F. & Christensen, J. R., Jan 2016, In: Scandinavian Journal of Immunology. 83, 1, p. 72-80 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Relapsing-Remitting Multiple Sclerosis 100%
  • Multiple Sclerosis 71%
  • Blood Cells 66%
  • Genes 32%
  • Interferons 14%
  31 Citations (Scopus)

• Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies

  George, M. F., Briggs, F. B. S., Shao, X., Gianfrancesco, M. A., Kockum, I., Harbo, H. F., Celius, E. G., Bos, S. D., Hedström, A., Shen, L., Bernstein, A., Alfredsson, L., Hillert, J., Olsson, T., Patsopoulos, N. A., De Jager, P. L., Oturai, A. B., Søndergaard, H. B., Sellebjerg, F., Sorensen, P. S., & 14 othersGomez, R., Caillier, S. J., Cree, B. A. C., Oksenberg, J. R., Hauser, S. L., D'Alfonso, S., Leone, M. A., Martinelli Boneschi, F., Sorosina, M., van der Mei, I., Taylor, B. V., Zhou, Y., Schaefer, C. & Barcellos, L. F., Aug 2016, In: Neurology. Genetics. 2, 4, p. e87

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Multiple Sclerosis 100%
  • HLA-DRB1 Chains 30%
  • Age of Onset 21%
  • Single Nucleotide Polymorphism 19%
  • Meta-Analysis 16%
  64 Citations (Scopus)

• Shift work at young age is associated with increased risk of multiple sclerosis in a Danish population

  Gustavsen, S., Søndergaard, H. B., Oturai, D. B., Laursen, B., Laursen, J. H., Magyari, M., Ullum, H., Larsen, M. H., Sellebjerg, F. & Oturai, A. B., Sep 2016, In: Multiple Sclerosis and Related Disorders. 9, p. 104-9 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Multiple Sclerosis 100%
  • Population 44%
  • Life Style 15%
  • Logistic Models 12%
  • Odds Ratio 12%
  20 Citations (Scopus)

• Soluble serum VCAM-1, whole blood mRNA expression and treatment response in natalizumab-treated multiple sclerosis

  Petersen, E. R., Søndergaard, H. B., Oturai, A. B., Jensen, P. E. H., Sorensen, P. S., Sellebjerg, F. & Börnsen, L., Nov 2016, In: Multiple Sclerosis and Related Disorders. 10, p. 66-72 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Natalizumab 100%
  • Vascular Cell Adhesion Molecule-1 80%
  • Multiple Sclerosis 61%
  • Messenger RNA 39%
  • Serum 31%
  5 Citations (Scopus)

• Vitamin D supplementation reduces relapse rate in relapsing-remitting multiple sclerosis patients treated with natalizumab

  Laursen, J. H., Søndergaard, H. B., Sørensen, P. S., Sellebjerg, F. & Oturai, A. B., Nov 2016, In: Multiple Sclerosis and Related Disorders. 10, p. 169-173 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Natalizumab 100%
  • Relapsing-Remitting Multiple Sclerosis 86%
  • Vitamin D 64%
  • Recurrence 39%
  • Multiple Sclerosis 24%
  57 Citations (Scopus)
• 2015

  Class II HLA interactions modulate genetic risk for multiple sclerosis

  Oturai, A., Søndergaard, H. B. & International Multiple Sclerosis Genetics Consortium, Oct 2015, In: Nature Genetics. 47, 10, p. 1107-13 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • HLA-D Antigens 100%
  • HLA Antigens 69%
  • Multiple Sclerosis 59%
  • Alleles 20%
  • HLA-DQB1 antigen 11%
  233 Citations (Scopus)

• Endogenous Interferon-β-Inducible Gene Expression and Interferon-β-Treatment Are Associated with Reduced T Cell Responses to Myelin Basic Protein in Multiple Sclerosis

  Börnsen, L., Romme Christensen, J., Ratzer, R., Hedegaard, C., Søndergaard, H. B., Krakauer, M., Hesse, D., Nielsen, C. H., Sorensen, P. S. & Sellebjerg, F., 2015, In: P L o S One. 10, 3, p. e0118830

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Myelin Basic Protein 100%
  • Interferons 75%
  • Multiple Sclerosis 72%
  • T-Lymphocytes 50%
  • Gene Expression 49%
  17 Citations (Scopus)

• Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis

  Laursen, J. H., Søndergaard, H. B., Albrechtsen, A., Frikke-Schmidt, R., Koch-Henriksen, N., Soelberg Sørensen, P., Sellebjerg, F. & Oturai, A., 2015, In: Multiple sclerosis. 21, 11, p. 1414-22

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 25-hydroxyvitamin D 100%
  • Multiple Sclerosis 75%
  • Single Nucleotide Polymorphism 71%
  • Vitamin D 47%
  • Genome-Wide Association Study 35%
  12 Citations (Scopus)

• Genetic variants are major determinants of CSF antibody levels in multiple sclerosis

  Goris, A., Pauwels, I., Gustavsen, M. W., van Son, B., Hilven, K., Bos, S. D., Celius, E. G., Berg-Hansen, P., Aarseth, J., Myhr, K-M., D'Alfonso, S., Barizzone, N., Leone, M. A., Martinelli Boneschi, F., Sorosina, M., Liberatore, G., Kockum, I., Olsson, T., Hillert, J., Alfredsson, L., & 27 othersBedri, S. K., Hemmer, B., Buck, D., Berthele, A., Knier, B., Biberacher, V., van Pesch, V., Sindic, C., Oturai, A., Søndergaard, H. B., Sellebjerg, F., Jensen, P. E. H., Comabella, M., Montalban, X., Pérez-Boza, J., Malhotra, S., Lechner-Scott, J., Broadley, S., Slee, M., Taylor, B., Kermode, A. G., Gourraud, P-A., Sawcer, S. J., Andreassen, B. K., Dubois, B., Harbo, H. F. & International Multiple Sclerosis Genetics Consortium, Mar 2015, In: Brain. 138, Pt 3, p. 632-43 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Oligoclonal Bands 100%
  • Multiple Sclerosis 62%
  • Immunoglobulin G 53%
  • Antibodies 39%
  • Major Histocompatibility Complex 30%
  47 Citations (Scopus)

• Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect

  Voldsgaard, A., Bager, P., Garde, E., Åkeson, P., Leffers, A. M., Madsen, C. G., Kapel, C., Roepstorff, A., Thamsborg, S. M., Melbye, M., Siebner, H., Søndergaard, H. B., Sellebjerg, F. & Sørensen, P. S., Nov 2015, In: Multiple sclerosis. 21, 13, p. 1723-9 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Trichuris 100%
  • Ovum 72%
  • Multiple Sclerosis 62%
  • Helminths 17%
  • Magnetic Resonance Imaging 14%
  48 Citations (Scopus)
• 2014

  A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility

  Damotte, V., Guillot-Noel, L., Patsopoulos, N. A., Madireddy, L., El Behi, M., Ban, M., Baranzini, S., Barcellos, L., Beecham, G., Beecham, A., Bernardinelli, L., Booth, D., Bos, S., Buck, D., Bush, W., Comabella, M., Compston, A., Cotsapas, C., Cournu-Rebeix, I., Cree, B., & 31 othersD'Alfonso, S., Daly, M., Damotte, V., Davis, M., de Bakker, P., De Jager, P. L., Dubois, B., Esposito, F., Fontaine, B., Goris, A., Gourraud, P-A., Green, T., Gulowsen Celius, E., Hadjixenofontos, A., Hafler, D., Haines, J., Flinstad, H. F., Hauser, S., Hawkins, C., Hemmer, B., Hillert, J., Hintzen, R., Horáková, D., Ivinson, A. J., Kemppinen, A., Kira, J-I., Oturai, A., Sellebjerg, F., Soendergaard, H., Soelberg Sorensen, P. & International Multiple Sclerosis Genetics Consortium, 16 Jan 2014, In: Genes and Immunity. 15, p. 126-32

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Multiple Sclerosis 100%
  • Cell Adhesion Molecules 55%
  • Genes 45%
  • Genome-Wide Association Study 26%
  • Single Nucleotide Polymorphism 21%
  25 Citations (Scopus)

• JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants

  Sundqvist, E., Buck, D., Warnke, C., Albrecht, E., Gieger, C., Khademi, M., Lima Bomfim, I., Fogdell-Hahn, A., Link, J., Alfredsson, L., Søndergaard, H. B., Hillert, J., Oturai, A. B., Hemme, B., Kockum, I., Olsson, T. & International Multiple Sclerosis Genetics Consortium, Apr 2014, In: P L o S Pathogens (Online). 10, 4, p. e1004084

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Human polyomavirus 2 100%
  • Polyomavirus Infections 90%
  • HLA antigens 82%
  • JC Virus 80%
  • HLA Antigens 58%
  40 Citations (Scopus)

• Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general

  Gustavsen, M. W., Viken, M. K., Celius, E. G., Berge, T., Mero, I-L., Berg-Hansen, P., Aarseth, J. H., Myhr, K-M., Søndergaard, H. B., Sellebjerg, F., Oturai, A. B., Hillert, J., Alfredsson, L., Olsson, T., Kockum, I., Lie, B. A. & Harbo, H. F., 15 Sep 2014, In: Journal of Neuroimmunology. 274, 1-2, p. 174-9 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • KIR Receptors 100%
  • Oligoclonal Bands 99%
  • Multiple Sclerosis 61%
  • Alleles 51%
  • Ligands 49%
  6 Citations (Scopus)

• Prediction of response to interferon therapy in multiple sclerosis

  Sellebjerg, F., Søndergaard, H. B., Koch-Henriksen, N., Sørensen, P. S. & Oturai, A. B., Oct 2014, In: Acta Neurologica Scandinavica. 130, 4, p. 268-75 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Interferons 100%
  • Multiple Sclerosis 96%
  • Glypicans 80%
  • Recurrence 54%
  • Single Nucleotide Polymorphism 34%
  20 Citations (Scopus)