Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
  1. 2019
  2. Published

    Novel DNA methylation biomarkers show high sensitivity and specificity for blood-based detection of colorectal cancer-a clinical biomarker discovery and validation study

    Jensen, S. Ø., Øgaard, N., Ørntoft, M-B. W., Rasmussen, M. H., Bramsen, J. B., Kristensen, H., Mouritzen, P., Madsen, M. R., Madsen, A. H., Sunesen, K. G., Iversen, L. H., Laurberg, S., Christensen, I. J., Nielsen, H. J. & Andersen, C. L., 14 Nov 2019, In : Clinical Epigenetics. 11, 1, p. 158

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Evaluation of algorithm development approaches: Development of biomarker panels for early detection of colorectal lesions

    Danish Research Group on Early Detection of Colorectal Cancer, Nov 2019, In : Clinica chimica acta; international journal of clinical chemistry. 498, p. 108-115 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. E-pub ahead of print

    The concentration of the cleaved suPAR forms in pre- and postoperative plasma samples improves the prediction of survival in colorectal cancer: A nationwide multicenter validation and discovery study

    Danish Collaborative Research Group on Colorectal Cancer, 23 Oct 2019, In : Journal of Surgical Oncology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Genome-wide cell-free DNA fragmentation in patients with cancer

    Cristiano, S., Leal, A., Phallen, J., Fiksel, J., Adleff, V., Bruhm, D. C., Jensen, S. Ø., Medina, J. E., Hruban, C., White, J. R., Palsgrove, D. N., Niknafs, N., Anagnostou, V., Forde, P., Naidoo, J., Marrone, K., Brahmer, J., Woodward, B. D., Husain, H., van Rooijen, K. L., Ørntoft, M-B. W., Madsen, A. H., van de Velde, C. J. H., Verheij, M., Cats, A., Punt, C. J. A., Vink, G. R., van Grieken, N. C. T., Koopman, M., Fijneman, R. J. A., Johansen, J. S., Nielsen, H. J., Meijer, G. A., Andersen, C. L., Scharpf, R. B. & Velculescu, V. E., Jun 2019, In : Nature. 570, 7761, p. 385-389 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  6. Published

    Increased serological, cancer-associated protein biomarker levels at diagnosis of large bowel adenoma: Risk of subsequent primary malignancy?

    Piper, T. B., Jørgensen, L. N., Olsen, J., Nielsen, K. T., Davis, G., Johansen, J. S., Jarle Christensen, I. & Nielsen, H. J., 2019, In : Acta Oncologica. 58, sup1: Advanced Adenomas of the Colon and Rectum, p. S42-S48 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2018
  8. Published

    Triage for selection to colonoscopy?

    Danish Collaborative Group on Early Detection of Colorectal Neoplasia, Jørgensen, L. N., Vilandt, J. & Hillig, T., Oct 2018, In : European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 44, 10, p. 1539-1541 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published
  10. Published

    Clean Colorectum at Diagnostic Colonoscopy: Subsequent Detection of Extracolonic Malignancies by Plasma Protein Biomarkers?

    Wilhelmsen, M., Christensen, I. J., Jørgensen, L. N., Madsen, M. R., Vilandt, J., Hillig, T., Klærke, M., Nielsen, K. T., Laurberg, S., Gawel, S., Yang, X., Davis, G., Heijboer, A. M., Martens, F. & Nielsen, H. J., Jun 2018, In : Biomarkers in Cancer. 10, p. 1-9

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2017
  12. Published

    Circulating cell-free nucleosomes as biomarkers for early detection of colorectal cancer

    Rasmussen, L., Christensen, I. J., Herzog, M., Micallef, J. & Nielsen, H. J., 17 Oct 2017, In : Oncotarget. 9, 12, p. 10247-10258 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Clinical Implications of Monitoring Circulating Tumor DNA in Patients with Colorectal Cancer

    Schøler, L. V., Reinert, T., Ørntoft, M-B. W., Kassentoft, C. G., Árnadóttir, S. S., Vang, S., Nordentoft, I., Knudsen, M., Lamy, P., Andreasen, D., Mortensen, F. V., Knudsen, A. R., Stribolt, K., Sivesgaard, K., Mouritzen, P., Nielsen, H. J., Laurberg, S., Ørntoft, T. F. & Andersen, C. L., 15 Sep 2017, In : Clinical Cancer Research. 23, 18, p. 5437-5445 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Direct detection of early-stage cancers using circulating tumor DNA

    Phallen, J., Sausen, M., Adleff, V., Leal, A., Hruban, C. A., White, J. R., Anagnostou, V., Fiksel, J., Cristiano, S., Papp, E., Speir, S., Reinert, T., Orntoft, M-B. W., Woodward, B. D., Murphy, D., Parpart-Li, S., Riley, D., Nesselbush, M., Sengamalay, N., Georgiadis, A., Li, Q. K., Madsen, M. R., Mortensen, F. V., Huiskens, J., Punt, C. J. A., van Grieken, N. C. T., Fijneman, R. J. A., Meijer, G. A., Husain, H., Scharpf, R. B., Diaz, L. A., Jones, S., Angiuoli, S., Ørntoft, T. F., Nielsen, H. J., Andersen, C. L. & Velculescu, V. E., 1 Aug 2017, In : Science translational medicine. 9, 403

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Discovery and validation of a colorectal cancer classifier in a new blood test with improved performance for high-risk subjects

    Croner, L. J., Dillon, R., Kao, A., Kairs, S. N., Benz, R. W., Christensen, I. J., Nielsen, H. J., Blume, J. E. & Wilcox, B. E., 1 Jul 2017, In : Clinical Proteomics. 14, 28, p. 1-12

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer

    Yu, J., Feng, Q., Wong, S. H., Zhang, D., Liang, Q. Y., Qin, Y., Tang, L., Zhao, H., Stenvang, J., Li, Y., Wang, X., Xu, X., Chen, N., Wu, W. K. K., Al-Aama, J., Nielsen, H. J., Kiilerich, P., Jensen, B. A. H., Yau, T. O., Lan, Z., Jia, H., Li, J., Xiao, L., Lam, T. Y. T., Ng, S. C., Cheng, A. S-L., Wong, V. W-S., Chan, F. K. L., Xu, X., Yang, H., Madsen, L., Datz, C., Tilg, H., Wang, J., Brünner, N., Kristiansen, K., Arumugam, M., Sung, J. J-Y. & Wang, J., Jan 2017, In : Gut. 66, 1, p. 70-78

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Detection of colorectal neoplasia: Combination of eight blood-based, cancer-associated protein biomarkers

    Wilhelmsen, M., Christensen, I. J., Rasmussen, L., Jørgensen, L. N., Madsen, M. R., Vilandt, J., Hillig, T., Klaerke, M., Nielsen, K. T., Laurberg, S., Brünner, N., Gawel, S., Yang, X., Davis, G., Heijboer, A. M., Martens, F. & Nielsen, H. J., 2017, In : International Journal of Cancer. 140, 6, p. 1436-1446

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Serological biomarkers in triage of FIT-positive subjects?

    Nielsen, H. J., Christensen, I. J., Andersen, B., Rasmussen, M., Friis-Hansen, L. J., Bygott, T., MiCallef, J. & Danish–Belgian Research Group on Early Detection of Colorectal Cancer, 2017, In : Scandinavian Journal of Gastroenterology. 52, 6-7, p. 742-744 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2016
  20. Published

    miRNA profiling of circulating EpCAM(+) extracellular vesicles: promising biomarkers of colorectal cancer

    Ostenfeld, M. S., Jensen, S. G., Jeppesen, D. K., Christensen, L-L., Thorsen, S. B., Stenvang, J., Hvam, M. L., Thomsen, A., Mouritzen, P., Rasmussen, M. H., Nielsen, H. J., Ørntoft, T. F. & Andersen, C. L., Oct 2016, In : Journal of Extracellular Vesicles. 5, p. 31488

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published
  22. Published

    Protocol Outlines for Parts 1 and 2 of the Prospective Endoscopy III Study for the Early Detection of Colorectal Cancer: Validation of a Concept Based on Blood Biomarkers

    Rasmussen, L., Wilhelmsen, M., Christensen, I. J., Andersen, J., Jørgensen, L. N., Rasmussen, M., Hendel, J. W., Madsen, M. R., Vilandt, J., Hillig, T., Klærke, M., Münster, A-M. B., Andersen, L. M., Andersen, B., Hornung, N., Erlandsen, E. J., Khalid, A. & Nielsen, H. J., 13 Sep 2016, In : JMIR research protocols. 5, 3, p. e182

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    TIMP-1 is under regulation of the EGF signaling axis and promotes an aggressive phenotype in KRAS-mutated colorectal cancer cells: A potential novel approach to the treatment of metastatic colorectal cancer

    Tarpgaard, L. S., Ørum-Madsen, M. S., Christensen, I. J., Nordgaard, C., Noer, J., Guren, T. K., Glimelius, B., Sorbye, H., Ikdahl, T., Kure, E. H., Tveit, K. M., Nielsen, H. J., Pfeiffer, P., Brünner, N. & Moreira, J. M. A., Sep 2016, In : Oncotarget. 7, 37, p. 59441-59457

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published
  25. Published

    Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer (†)

    Hvolris, M. H., Piper, T. B., Hammer, E., Jørgensen, L. N., Olsen, J., Rahr, H. B., Nielsen, K. T., Laurberg, S., Christensen, I. J., Brünner, N., Johansen, J. S., Davis, G. J., Dowell, B. L. & Nielsen, H. J., Jul 2016, In : Scandinavian Journal of Gastroenterology. 51, 7, p. 860-5 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Increased serological cancer-associated biomarkers and risk of development of primary malignancy after large bowel endoscopy

    Nielsen, H. J., Jul 2016, In : Scandinavian Journal of Gastroenterology. 51, 10, p. 1272-1272

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published
  28. Published

    Discovery and validation of plasma-protein biomarker panels for the detection of colorectal cancer and advanced adenoma in a danish collection of samples from patients referred for diagnostic colonoscopy

    Blume, J. E., Wilhelmsen, M., Benz, R. W., Niels, B., Christensen, I. J., Croner, L. J., Dillon, R., Hillig, T., Jones, J. J., Jørgensen, L. N., Kao, A., Klaerke, M., Laurberg, S., Madsen, M. R., Nielsen, K. T., Vilandt, J., Wilcox, B. E., You, J. & Nielsen, H. J., 2016, In : The Journal of Applied Laboratory Medicine. 1, 2, p. 181-193

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2015
  30. Published

    Plasma levels of OLFM4 in normals and patients with gastrointestinal cancer

    Clemmensen, S. N., Glenthøj, A. J., Heebøll, S., Nielsen, H. J., Koch, C. & Borregaard, N., Dec 2015, In : Journal of Cellular and Molecular Medicine (Online). 19, 12, p. 2865-2873

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Intact and cleaved plasma soluble urokinase receptor in patients with metastatic colorectal cancer treated with oxaliplatin with or without cetuximab

    Tarpgaard, L. S., Christensen, I. J., Høyer-Hansen, G., Lund, I. K., Guren, T. K., Glimelius, B., Sorbye, H., Tveit, K. M., Nielsen, H. J., Moreira, J. M. A., Pfeiffer, P. & Brünner, N., 15 Nov 2015, In : International journal of cancer. Journal international du cancer. 137, 10, p. 2470-77

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Phospho-ERK1/2 levels in cancer cell nuclei predict responsiveness to radiochemotherapy of rectal adenocarcinoma

    Holck, S., Nielsen, H. J., Pedersen, N. & Larsson, L-I., 21 Sep 2015, In : Oncotarget. 6, 33, p. 34321-8

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Plasma TIMP-1 and CEA as Markers for Detection of Primary Colorectal Cancer: A Prospective Validation Study Including Symptomatic and Non-symptomatic Individuals

    Christensen, I. J., Brünner, N., Dowell, B., Davis, G., Nielsen, H. J., Newstead, G. & King, D., Sep 2015, In : Anticancer Research. 35, 9, p. 4935-41 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers

    Sønderstrup, I. M. H., Nygård, S. B., Poulsen, T. S., Linnemann, D., Stenvang, J., Nielsen, H. J., Bartek, J., Brünner, N., Nørgaard, P. H. & Riis, L., Jun 2015, In : Molecular Oncology. 9, 6, p. 1207-17 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published
  36. Published

    Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery

    Reinert, T., Schøler, L. V., Thomsen, R., Tobiasen, H., Vang, S., Nordentoft, I. K., Lamy, P., Kannerup, A-S., Mortensen, F. V., Stribolt, K., Hamilton-Dutoit, S., Nielsen, H. J., Laurberg, S., Pallisgaard, N., Pedersen, J. S., Ørntoft, T. F. & Andersen, C. L., 4 Feb 2015, In : Gut.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    IQGAP1 in rectal adenocarcinomas. Localization and protein expression before and after radiochemotherapy

    Holck, S., Nielsen, H. J., Hammer, E., Christensen, I. J. & Larsson, L-I., 28 Jan 2015, In : Cancer Letters. 356, 2, p. 556-560

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published
  39. Published
  40. Published

    Blood-based Biomarkers at Large Bowel Endoscopy and Prediction of Future Malignancies

    Kring, T. S., Piper, T. B., Jørgensen, L. N., Olsen, J., Rahr, H. B., Nielsen, K. T., Laurberg, S., Davis, G., Dowell, B., Johansen, J. S., Christensen, I. J., Brünner, N. & Nielsen, H. J., 2015, In : Biomarkers in Cancer. 7, p. 57-61 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Evaluation of complement proteins as screening markers for colorectal cancer

    Storm, L., Christensen, I. J., Jensenius, J. C., Nielsen, H. J., Thiel, S., the Danish Study Group on Early Detection of Colorectal Cancer, Jørgensen, L. N., Vilandt, J. & Hillig, T., 2015, In : Cancer immunology, immunotherapy : CII. 64, 1, p. 41-50

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Performance of the colorectal cancer screening marker Sept9 is influenced by age, diabetes and arthritis: a nested case-control study

    Ørntoft, M-B. W., Nielsen, H. J., Ørntoft, T. F., Andersen, C. L. & Danish Study Group on Early Detection of Colorectal Cancer, 2015, In : B M C Cancer. 15, p. 819

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Time course for the recovery of physical performance, blood hemoglobin, and ferritin content after blood donation

    Ziegler, A. K., Grand, J., Stangerup, I., Nielsen, H. J., Dela, F., Magnussen, K. & Helge, J. W., 2015, In : Transfusion. 155, 4, p. e898-905

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    TIMP-1 and CEA as biomarkers in third-line treatment with irinotecan and cetuximab for metastatic colorectal cancer

    Spindler, K-L. G., Christensen, I. J., Nielsen, H. J., Jakobsen, A. & Brünner, N., 2015, In : Tumor Biology. 36, 6, p. 4301-4308

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2014
  46. Published

    Determinants of recurrence after intended curative resection for colorectal cancer

    Wilhelmsen, M., Kring, T., Jorgensen, L. N., Madsen, M. R., Jess, P., Bulut, O., Nielsen, K. T., Andersen, C. L. & Nielsen, H. J., Dec 2014, In : Scandinavian Journal of Gastroenterology. 49, 12, p. 1399-408 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Positron emission tomography/computed tomography for optimized colon cancer staging and follow up

    Engelmann, B., Loft, A., Kjær, A., Nielsen, H. J., Berthelsen, A. K., Binderup, T., Brinch, K., Brünner, N. A., Gerds, T. A., Høyer-Hansen, G., Kristensen, M. H., Kurt, E. Y., Latocha, J. E., Lindblom, G., Sloth, C. & Højgaard, L., 29 Nov 2014, In : Scandinavian Journal of Gastroenterology. 49, 2, p. 191-201

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Mannan-binding lectin polymorphisms and serum levels in patients with endometriosis

    Kruse, C., Steffensen, R., Nielsen, H. J. & Jensenius, J. C., Oct 2014, In : European journal of obstetrics, gynecology, and reproductive biology. 181, p. 256-8 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    TIMP-1 in patients with cirrhosis: relation to liver dysfunction, portal hypertension, and hemodynamic changes

    Busk, T. M., Bendtsen, F., Nielsen, H. J., Jensen, V., Brünner, N. & Møller, S., Sep 2014, In : Scandinavian Journal of Gastroenterology. 49, 9, p. 1103-10 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Urokinase-type plasminogen activator receptor (uPAR) on tumor-associated macrophages is a marker of poor prognosis in colorectal cancer

    Illemann, M., Laerum, O. D., Hasselby, J. P., Sørensen, T. T., Høyer-Hansen, G., Nielsen, H. J., Christensen, I. J. & the Danish Study Group on Early Detection of Colorectal Cancer, 1 Aug 2014, In : C M E Cancer Medicine. 3, 4, p. 855 864 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Prognostic and predictive value of cathepsin X in serum from colorectal cancer patients

    Vižin, T., Christensen, I. J., Wilhelmsen, M., Nielsen, H. J. & Kos, J., 13 Apr 2014, In : B M C Cancer. 14, p. 259

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Metoder til screening for kolorektal cancer kan forbedres

    Rasmussen, L., Jørgensen, L. N., Madsen, M. R., Vilandt, J., Klærke, M., Andersen, J., Nielsen, K. T., Khalid, A., Laurberg, S., Andersen, C. L., Christensen, I. J., Brünner, N. & Nielsen, H. J., 10 Mar 2014, In : Ugeskrift for læger [online]. 176, 11B, p. 1211-14

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Positron emission tomography/computed tomography and biomarkers for early treatment response evaluation in metastatic colon cancer

    Engelmann, B. E., Loft, A., Kjær, A., Nielsen, H. J., Gerds, T. A., Benzon, E. V., Brünner, N., Christensen, I. J., Hansson, S. H., Holländer, N. H., Kristensen, M. H., Löfgren, J., Markova, E., Sloth, C. & Højgaard, L., Feb 2014, In : The oncologist. 19, 2, p. 164-72 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Assessment of the topoisomerase I gene copy number as a predictive biomarker of objective response to irinotecan in metastatic colorectal cancer

    Nygård, S. B., Christensen, I. J., Nielsen, S. L., Nielsen, H. J., Brünner, N. & Spindler, K-L. G., Jan 2014, In : Scandinavian Journal of Gastroenterology. 49, 1, p. 84-91 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Measuring ERCC1 protein expression in cancer specimens: validation of a novel antibody

    Smith, D. H., Kanstrup, A-M. F., Fogh, L., Christensen, I. J., Hansen, T. P., Stenvang, J., Nielsen, H. J., Nielsen, K. V., Hasselby, J. P., Brünner, N. & Jensen, S. S., 2014, In : Scientific Reports. 4, p. 4313

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    The Association between Mutations Detected in Tissue and Plasma from Patients with Colorectal Adenoma and Adenocarcinoma

    Nielsen, H. J., 2014, In : Journal of Cancer Therapy. 5, 14, p. 1399-1401

    Research output: Contribution to journalJournal articleResearchpeer-review

Previous 1 2 3 4 5 Next

ID: 12016