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The Capital Region of Denmark - a part of Copenhagen University Hospital
Hanne Frederiksen

Hanne Frederiksen

MSc, PhD

Afdeling for Vækst og Reproduktion, GR-5064 Rigshospitalet, Københavns Universitets Hospital Blegdamsvej 9, 2100 København Ø

Building: afsnit 5071, rum 7314A

2100 Kønenhavn Ø

Denmark

Phone: +45 35456359
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Education and academic degrees

Education    

2004: PhD, Department of Life Sciences and Chemistry, Roskilde University

1999: Master of Science (MSc) in chemistry and molecular biology, Department of Life Sciences and Chemistry, Roskilde University

1982: Laboratory technician certification, Laboratory Technician School, Copenhagen

Positions

Since 2006: Senior scientist and leader of the analytical chemistry laboratory, Dep. of Growth and Reproduction, Rigshospitalet, University of Copenhagen

2006: Scientist in the group of bioactive food components and vitamins at Department of Food Chemistry, Danish Institute for Food and Veterinary Research

2003-05: Post doc in the group of prevention and life style diseases, Department of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research

2000-03: PhD student at the EU-project: Heterocyclic Amines in cooked foods - Role in Human Health. Institute of Food Safety and Nutrition, Danish Institute for Food and Veterinary Research

1983-92: Laboratory Technician, the National Museum of Denmark

1982: Laboratory Technician, S. Dyrup and CO, Søborg, Denmark

1981-82: Laboratory Trainee, Technical University of Denmark and the National Museum of Denmark

Main research areas

As senior scientist my primary research area since 2006 has been 1) development of advanced multiple LC-MS/MS methods for the analysis of steroid hormones and non-persistent endocrine disrupting chemicals (EDCs) in biological matrices and 2) human biomonitoring (HBM) and research on exposure to EDCs and their metabolic distribution, breakdown and excretion as well as interactions between EDCs and natural steroid hormones and other effects on human reproductive health and 3) development of human reference materials for steroid hormones based on LC-MS/MS measurements for use in the clinic and research projects. I participate in national as well as international research projects such as e.g. project leader in HBM studies for the National Centre on Endocrine Disrupters (cend.dk)

Comments to list of publications

Publications with peer review

Total number of original papers (Aug. 2019): 94, H-index: 32 (ISI, web of science), 36 (google scholar), Total citations: >3200 (ISI, web of science), >4700 (google scholar)

Other publications: 4, Book chapters: 2, Scientific reports: 13

ORCID:               0000-0002-3180-9879

Expertises

Senior researcher and laboratory leader with specific experience in analysis of non-persistent endocrine disrupting chemicals (EDCs) and steroid hormones based on LC-MS/MS technologies. As leader of the analytical chemistry laboratory at Dep. of Growth and Reproduction, I am overall responsible for development, operating and maintenance of all analytical methods based on LC-MS/MS technologies in the department. The laboratory analyzes more than 12.000 patient and research samples per year and cover over methods for steroid hormones, EDCs and peptide hormones including from 3 to 38 analytes per method. The laboratory is DANAK accredited and participates in inter-laboratory validation and control programs and serves as reference laboratory in international harmonized approach programs for HMB (HBM4EU).

Current research

1. Development of new analytical methods based on LC-MS/MS for estrogens and new chemical substitutes of "old" well-known EDCs.

2. Human bio-monitoring of several EDCs in different subgroups of the Danes.

3. Distribution of UV filters to different human matrices (urine, serum, amniotic fluid and seminal plasma) and possible associations between exposure to UV filters and human reproductive health.

4. Association between exposure to several different EDCs and growth and puberty development in Danish children and adolescents from the Copenhagen Puberty Study. 

Potential conflicts of interest

No

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