Research output per year
Research output per year
Personal profile
Expertises
In vivo evaluation of novel positron emission tomography (PET) radioligands for different targets (proteins or enzymes) in the pig brain; PET-MR imaging of non-human primates; PET-MR imaging of healthy subjects; Good clinical practise (GCP) experience with regards to PET-MR imaging in humans; Project management of various pre-clinicial and clinical projects; Supervision of master and PhD students.
Main research areas
PET-MR imaging; radioligand development; pre-clinical imaging, clinical imaging, pharmacology
Current research
Cerebral pharmacodynamic effects of 5-HT1B receptor stimulation - A translational study: With PET-MR imaging I'm investigating the effects of different drugs targeting the serotonin 1B (5-HT1B) receptor in the brain. This is a proof-of-concept that PET-MR imaging can be used to identify the functionality of these drugs (i.e. whether they are agonist or antagonists), blood brain barrier penetration and target involvement.
Radioligand development: At NRU we continue to develop new PET radioligands mainly for the serotonin system. We have develop radioligands for the 5-HT2A receptor and the 5-HT7 receptor.
Epigenentics and PET: With a novel radioligand targeting the histone deacetylase (HDAC) enzymes we will investigate what effect different pharmacological interventions has on the epigenetic machinery in pigs. This project has the potential to find epigenetic changes in vivo (using PET imaging) and correlate these findings with downstream mechanism, which we will identify with various in vitro methods.
Potential conflicts of interest
No potential conflict of interest
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Kinetic models for estimating occupancy from single-scan PET displacement studies
Laurell, G. L., Plavén-Sigray, P., Johansen, A., Raval, N. R., Nasser, A., Aabye Madsen, C., Madsen, J., Hansen, H. D., Donovan, L. L., Knudsen, G. M., Lammertsma, A. A., Ogden, R. T., Svarer, C. & Schain, M., Sep 2023, In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 43, 9, p. 1544-1556 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evaluation of the α-synuclein PET radiotracer (d3)-[11C]MODAG-001 in pigs
Raval, N. R., Madsen, C. A., Shalgunov, V., Nasser, A., Battisti, U. M., Beaman, E. E., Juhl, M., Jørgensen, L. M., Herth, M. M., Hansen, H. D., Plavén-Sigray, P. & Knudsen, G. M., 2022, In: Nuclear Medicine and Biology. 114-115, p. 42-48 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PET-BIDS, an extension to the brain imaging data structure for positron emission tomography
Norgaard, M., Matheson, G. J., Hansen, H. D., Thomas, A., Searle, G., Rizzo, G., Veronese, M., Giacomel, A., Yaqub, M., Tonietto, M., Funck, T., Gillman, A., Boniface, H., Routier, A., Dalenberg, J. R., Betthauser, T., Feingold, F., Markiewicz, C. J., Gorgolewski, K. J., Blair, R. W., & 12 others, 2 Mar 2022, In: Scientific Data. 9, 1, p. 1-7 7 p., 65.Research output: Contribution to journal › Comment/debate › Research › peer-review
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A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain
Raval, N. R., Johansen, A., Donovan, L. L., Ros, N. F., Ozenne, B., Hansen, H. D. & Knudsen, G. M., 15 Jan 2021, In: International Journal of Molecular Sciences. 22, 2, p. 1-14 14 p., 835.Research output: Contribution to journal › Journal article › Research › peer-review
67 Citations (Scopus) -
Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig
Donovan, L. L., Johansen, J. V., Ros, N. F., Jaberi, E., Linnet, K., Johansen, S. S., Ozenne, B., Issazadeh-Navikas, S., Hansen, H. D. & Knudsen, G. M., Jan 2021, In: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 42, p. 1-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
11 Citations (Scopus)