Research output per year
Research output per year
Personal profile
Expertises
I am appointed as professor i Gastroenterology and Hepatology with special focus on liver failure. The focus is primarily on patients with acute liver failure and patients with cirrhosis that suddenly decompensate ("acute-on-chronic-liver failure").
Besides these two main areas of focus we also do RCT in patients with autoimmune liver disease, in patients with alcoholic hepatitis, as well as in chronic viral hepatitis.
Main research areas
Focus is mainly two folded: We study the pathophysiology and try to improvemanagement of the many extrahepatic complications that often develop, such as hepatic encephalopathy, brain edema and cardiovascular dysfunction. The second main focus area is concerned with liver assist devices (high-volume plasmapheresis (HVP), MARS, TetraMARS ect).
The clinic also focuses on alcohol-related liver disease. This applies to both alcoholic hepatitis and alcoholic cirrhosis and is based both on epidemiological and genetic studies.
Articles are published in national and international journals.
Current research
HVP improve the survival in patients with acute liver failure. We are now about to launch as similar study in patients with acute-on-chronic-liver failure in cooperation with 6 ICU centers in the US and 16 centers here in Europe. The primary end point will be survival in a RCT design
Potential conflicts of interest
None
External positions
University of Copenhagen
2005 → …
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Collaborations and top research areas from the last five years
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Etiology and Outcome of Adult and Pediatric Acute Liver Failure in Europe
Lenz, D., Jørgensen, M. H., Kelly, D., Cardinale, V., Geerts, A., Gonçalves Costa, I., Fichtner, A., Garbade, S. F., Hegen, B., Hilberath, J., de Kleine, R., Kupčinskas, L., McLin, V., Niesert, M., Prado Gonzalez, V., Sturm, E., Staufner, C., Tjwa, E., Willemse, J. & Zecher, B. F. & 3 others, , 1 Jul 2023, In: Journal of Pediatric Gastroenterology and Nutrition. 77, 1, p. 115-120 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain
Shahbazi, A., Sepehrinezhad, A., Vahdani, E., Jamali, R., Ghasempour, M., Massoudian, S., Sahab Negah, S. & Larsen, F. S., 25 Apr 2023, In: Biomedicines. 11, 5, 1272.Research output: Contribution to journal › Review › peer-review
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High yield on aetiology using a systematic diagnostic approach to paediatric acute liver failure, analysis of a nationwide cohort
Nordmann Winther, T., Nielsen, A. Y., Lund, A., Larsen, F. S. & Jørgensen, M. H., May 2023, In: Acta paediatrica. 112, 5, p. 1082-1090 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Inhibition of autotaxin alleviates pathological features of hepatic encephalopathy at the level of gut-liver-brain axis: an experimental and bioinformatic study
Sepehrinezhad, A., Shahbazi, A., Joghataei, M. T., Larsen, F. S. & Sahab Negah, S., 1 Aug 2023, In: Cell death & disease. 14, 8, 490.Research output: Contribution to journal › Journal article › Research › peer-review
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Liver support systems and liver transplantation in acute liver failure
Larsen, F. S. & Saliba, F., 8 Jun 2023, (E-pub ahead of print) In: Liver international : official journal of the International Association for the Study of the Liver.Research output: Contribution to journal › Review › peer-review