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The Capital Region of Denmark - a part of Copenhagen University Hospital
Filip Krag Knop

Filip Krag Knop

Chief Consultant

Niels Steensens Vej 2-4

2820 Gentofte

Denmark

​Gentofte Hospital

Building: Opgang ​7, 3. sal, Kildegårdsvej 28

2900 Hellerup

Denmark

  1. 2011
  2. Published

    Inhibition of glucagon secretion by GLP-1 agonists and DPP4 inhibitors

    Hansen, M., Holst, J. J. & Knop, F. K., Jun 2011, In : Journal of Clinical Metabolism & Diabetes. 2, 1, p. 7-13

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    Gastric emptying of orally administered glucose solutions and incretin hormone responses are unaffected by laparoscopic adjustable gastric banding

    Usinger, L., Hansen, K. B., Kristiansen, V. B., Larsen, S., Holst, J. J. & Knop, F. K., 1 May 2011, In : Obesity Surgery. 21, 5, p. 625-32 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes

    Holst, J. J., Knop, F. K., Vilsbøll, T., Krarup, T. & Madsbad, S., 1 May 2011, In : Diabetes Care. 34 Suppl 2, p. S251-7

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published
  6. Published

    Lixisenatide for type 2 diabetes mellitus

    Christensen, M., Knop, F. K., Vilsbøll, T. & Holst, J. J., 1 Apr 2011, In : Expert Opinion on Investigational Drugs. 20, 4, p. 549-57 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Inhibition de la sécrétion du glucagon par les antagonistes du GLP-1 et les inhibiteurs de la DPP-4

    Hansen, M., Knop, F. K. & Holst, J. J., Apr 2011, In : Medecine des Maladies Metaboliques. 5, 2

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published
  9. Published

    Impaired regulation of the incretin effect in patients with type 2 diabetes

    Bagger, J. I., Knop, F. K., Lund, A., Vestergaard, H., Holst, J. J. & Vilsbøll, T., 1 Mar 2011, In : The Journal of clinical endocrinology and metabolism. 96, 3, p. 737-45 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published
  11. Published

    2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

    Hansen, K. B., Rosenkilde, M. M., Knop, F. K., Wellner, N., Diep, T. A., Rehfeld, J. F., Andersen, U. B., Holst, J. J. & Hansen, E. H., 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 9, p. E1409-17

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Emerging GLP-1 receptor agonists

    Lund, A., Knop, F. K. & Vilsbøll, T., 2011, In : Expert Opinion on Emerging Drugs. 16, 4, p. 607-18 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    First case associating chronic pancreatitis and Ehlers-Danlos syndrome

    Hansen, K. B. & Knop, F. K., 2011, In : Pancreas. 40, 1

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Glucagon antagonism as a potential therapeutic target in type 2 diabetes

    Bagger, J. I., Knop, F. K., Holst, J. J. & Vilsbøll, T., 2011, In : Diabetes, Obesity and Metabolism. 13, 11, p. 965-71 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans

    Christensen, M., Vedtofte, L., Holst, J. J., Vilsbøll, T. & Knop, F. K., 2011, In : Diabetes. 60, 12, p. 3103-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Improvement in psoriasis after treatment with the glucagon-like peptide-1 receptor agonist liraglutide

    Faurschou, A., Knop, F. K., Thyssen, J. P., Zachariae, C., Skov, L. & Vilsbøll, T., 2011, In : Acta Diabetologica.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    The alpha-cell as target for type 2 diabetes therapy

    Christensen, M., Bagger, J. I., Vilsboll, T. & Knop, F. K., 2011, In : Review of Diabetic Studies. 8, 3, p. 369-81 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Therapy for obesity based on gastrointestinal hormones

    Bagger, J. I., Christensen, M., Knop, F. K. & Vilsboll, T., 2011, In : Review of Diabetic Studies. 8, 3, p. 339-47 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2010
  20. Published

    Dulaglutide, a long-acting GLP-1 analog fused with an Fc antibody fragment for the potential treatment of type 2 diabetes

    Jimenez-Solem, E., Rasmussen, M. H., Christensen, M. & Knop, F. K., 1 Dec 2010, In : Current Opinion in Molecular Therapeutics. 12, 6, p. 790-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Glucagon suppression during OGTT worsens while suppression during IVGTT sustains alongside development of glucose intolerance in patients with chronic pancreatitis

    Knop, F. K., Vilsbøll, T., Larsen, S., Madsbad, S., Holst, J. M. & Krarup, T., 24 Sep 2010, In : Regulatory Peptides. 164, 2-3, p. 144-50 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes

    Christensen, M., Knop, F. K., Vilsbøll, T., Aaboe, K., Holst, J. J., Madsbad, S. & Krarup, T., 9 Aug 2010, In : Regulatory Peptides. 163, 1-3, p. 96-101 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Bile-induced secretion of glucagon-like peptide-1: pathophysiological implications in type 2 diabetes?

    Knop, F. K., 1 Jul 2010, In : American Journal of Physiology: Endocrinology and Metabolism. 299, 1, p. E10-3

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Incretin hormones and beta cell function in chronic pancreatitis

    Knop, F. K., 1 Jul 2010, In : Danish Medical Bulletin (Online). 57, 7, p. B4163

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published
  26. Published

    The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action

    Hare, K. J., Vilsbøll, T., Asmar, M., Deacon, C. F., Knop, F. K. & Holst, J. J., 1 Jul 2010, In : Diabetes. 59, 7, p. 1765-70 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Comment on: Villareal et al. (2009) TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes;59:479-485

    Knop, F. K., 1 Jun 2010, In : Diabetes. 59, 6, p. e4; author reply e5-6

    Research output: Contribution to journalLetterResearchpeer-review

  28. Published

    Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans?

    Asmar, M., Bache, M., Knop, F. K., Madsbad, S. & Holst, J. J., 1 May 2010, In : The Journal of clinical endocrinology and metabolism. 95, 5, p. 2367-75 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Inappropriate glucagon response after oral compared with isoglycemic intravenous glucose administration in patients with type 1 diabetes

    Hare, K. J., Vilsbøll, T., Holst, J. J. & Knop, F. K., 1 Apr 2010, In : American Journal of Physiology: Endocrinology and Metabolism. 298, 4, p. E832-7

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Once-weekly GLP-1 agonists: How do they differ from exenatide and liraglutide?

    Christensen, M. & Knop, F. K., 1 Apr 2010, In : Current Diabetes Reports. 10, 2, p. 124-32 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published
  32. Published

    Increased postprandial response of glucagon-like peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency

    Hornum, M., Pedersen, J., Larsen, S., Olsen, O., Holst, J. J. & Knop, F. K., 1 Jan 2010, In : Pancreatology. 10, 2-3, p. 201-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Incretin mimetics: a novel therapeutic option for patients with type 2 diabetes - a review

    Hansen, K. B., Vilsbøll, T. & Knop, F. K., 1 Jan 2010, In : Diabetes, Metabolic Syndrome and Obesity. 3, p. 155-63 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  34. Published

    Incretin-based therapy and type 2 diabetes

    Hare, K. J. & Knop, F. K., 1 Jan 2010, In : Vitamins and Hormones. 84, p. 389-413 25 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published
  36. 2009
  37. Published

    Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus

    Hare, K. J., Knop, F. K., Asmar, M., Madsbad, S., Deacon, C. F., Holst, J. J. & Vilsbøll, T., 1 Dec 2009, In : The Journal of clinical endocrinology and metabolism. 94, 12, p. 4679-87 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Resolution of type 2 diabetes following gastric bypass surgery: involvement of gut-derived glucagon and glucagonotropic signalling?

    Knop, F. K., 1 Nov 2009, In : Diabetologia. 52, 11, p. 2270-6 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Lixisenatide, a novel GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus

    Christensen, M., Knop, F. K., Holst, J. J. & Vilsbøll, T., 1 Aug 2009, In : IDrugs : the investigational drugs journal. 12, 8, p. 503-13 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    The spectrum of antidiabetic actions of GLP-1 in patients with diabetes

    Vilsbøll, T., Holst, J. J. & Knop, F. K., 1 Aug 2009, In : Best Practice & Research: Clinical Endocrinology & Metabolism. 23, 4, p. 453-62 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

    Højberg, P. V., Vilsbøll, T., Rabøl, R., Knop, F. K., Bache, M., Krarup, T., Holst, J. M. & Madsbad, S., 1 Feb 2009, In : Diabetologia. 52, 2, p. 199-207 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Incretin-based therapy of type 2 diabetes mellitus

    Knop, F. K., Vilsbøll, T. & Holst, J. J., 1 Feb 2009, In : Current Protein and Peptide Science. 10, 1, p. 46-55 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

    Aaboe, K., Knop, F. K., Vilsbøll, T., Vølund, A., Simonsen, U., Deacon, C. F., Madsbad, S., Holst, J. J. & Krarup, T., 1 Feb 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 2, p. 603-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists

    Hansen, K. B., Knop, F. K., Holst, J. J., Vilsbøll, T. & Holst, J. J., 2009, In : International Journal of Clinical Practice. 63, 8, p. 1154-60 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2008
  46. Published

    Four weeks of near-normalization of blood glucose has no effect on postprandial GLP-1 and GIP secretion, but augments pancreatic B-cell responsiveness to a meal in patients with Type 2 diabetes

    Højberg, P. V., Vilsbøll, T., Zander, P-O. M., Knop, F. K., Krarup, T., Vølund, A., Holst, J. M. & Madsbad, S., 1 Nov 2008, In : Diabetic Medicine. 25, 11, p. 1268-75 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Replacing SUs with incretin-based therapies for type 2 diabetes mellitus: challenges and feasibility

    Knop, F. K., Holst, J. J. & Vilsbøll, T., 1 Jul 2008, In : I Drugs: the Investigational Drugs Journal. 11, 7, p. 497-501 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes

    Højberg, P. V., Zander, P-O. M., Vilsbøll, T., Knop, F. K., Krarup, T., Vølund, A., Holst, J. M. & Madsbad, S., 1 Apr 2008, In : Diabetologia. 51, 4, p. 632-40 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Long-acting GLP-1 analogs for the treatment of type 2 diabetes mellitus

    Vilsbøll, T. & Knop, F. K., 1 Jan 2008, In : BioDrugs. 22, 4, p. 251-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. 2007
  51. Published
  52. Published

    Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?

    Knop, F. K., Vilsbøll, T., Højberg, P. V., Larsen, S., Madsbad, S., Vølund, A., Holst, J. J. & Krarup, T., 1 Aug 2007, In : Diabetes. 56, 8, p. 1951-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Betydningen af inkretinhormonerne glucose-dependent insulinotropic peptide og glucagon-like peptide-1 for patogenesen ved type 2-diabetes mellitus

    Vilsbøll, T. & Knop, F. K., 28 May 2007, In : Ugeskrift for Laeger. 169, 22, p. 2101-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Glucagon-like peptide 1-baseret behandling af type 2-diabetes mellitus

    Knop, F. K. & Vilsbøll, T., 28 May 2007, In : Ugeskrift for Laeger. 169, 22, p. 2095-9 5 p.

    Research output: Contribution to journalReviewResearchpeer-review

  55. Published

    Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus

    Knop, F. K., Vilsbøll, T., Madsbad, S., Holst, J. M. & Krarup, T., 1 Apr 2007, In : Diabetologia. 50, 4, p. 797-805 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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