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The Capital Region of Denmark - a part of Copenhagen University Hospital
Filip Krag Knop

Filip Krag Knop

Chief Consultant

Niels Steensens Vej 2-4

2820 Gentofte

Denmark

​Gentofte Hospital

Building: Opgang ​7, 3. sal, Kildegårdsvej 28

2900 Hellerup

Denmark

  1. 2018
  2. Published

    Individual and combined glucose-lowering effects of glucagon receptor antagonism and dipeptidyl peptidase-4 inhibition

    Maagensen, H., Hædersdal, S., Lund, A., Nielsen-Hannerup, E., Holst, J. J., Knop, F. K. & Vilsbøll, T., 1 Oct 2018, In : Diabetologia. 61, suppl 1, p. S246-S247 1 p., 504.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  3. Published

    Individual and combined glucose-lowering effects of glucagon receptor antagonism and sodium-glucose cotransporter 2 inhibition

    Hædersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Holst, J. J., Knop, F. K. & Vilsbøll, T., 1 Oct 2018, In : Diabetologia. 61, Suppl 1, p. S312-S312 1 p., 642.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  4. Published

    Metabolomics reveal changes in plasma concentrations of 3-hydroxybutyric acid, citric acid, oleic acid and proline in gestational diabetes

    Johansen, N. J., Demant, M. G., Suvitaival, T., Trošt, K., Ahonen, L. L., Bonde, L., Svare, J., Quigley, C., Vilsbøll, T. & Knop, F. K., 1 Oct 2018, In : Diabetologia. 61, Suppl 1, p. S252-S252 1 p., 514.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  5. Published

    Mono- and co-activation of the GIP and GLP-1 receptors inhibits bone resorption

    Bergmann, N., Lund, A., Heimbürger, S. M., Gasbjerg, L. S., Jørgensen, N. R., Jessen, L., Hartmann, B., Holst, J. J., Christensen, M., Vilsbøll, T. & Knop, F. K., 1 Oct 2018, In : Diabetologia. 61, suppl 1, p. S348-S348 1 p., 717.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  6. Published

    More subjects achieved composite reductions of ≥1% HbA1c, ≥5% body weight and ≥5 mmHg SBP with semaglutide vs comparators across the SUSTAIN 1-5 and 7 trials

    Dungan, K., Aroda, V. R., Knop, F. K., Leiter, L. A., Lausvig, N., Lindberg, S., Ferløv Schwensen, J. & Meier, J., 1 Oct 2018, In : Diabetologia. 61, suppl1, p. S359-S360 1 p., 738.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  7. Published

    Novel Biomarker Discovery in Non-Alcoholic Steatohepatitis (NASH): Translation of Complex Data into Clear Results

    Veidal, S., Rigbolt, K., Petersen, P. S., Suppli, M., Bagger, J. I., Lund, A., Heeboll, S., Gronbaek, H., Vilsboll, T., Knop, F. K., Vrang, N. & Jelsing, J., 1 Oct 2018, In : Hepatology. 68, 1, p. 1013A

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  8. Published

    Postprandial effects of individual and combined GIP and GLP-1 receptor antagonism in healthy subjects

    Gasbjerg, L. S., Helsted, M. M., Sparre-Ulrich, A. H., Lanng, A. R., Stensen, S., Jakobsen, M. H., Hartmann, B., Christensen, M., Holst, J. J., Vilsbøll, T., Rosenkilde, M. M. & Knop, F. K., 1 Oct 2018, In : Diabetologia. 61, suppl 1, p. S246-S246 1 p., 503.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  9. Published

    The effect of Roux-en-Y gastric bypass surgery on the gut mucosal gene expression profile and circulating gut hormones

    Christensen, M. M., Jorsal, T., Mortensen, B., Wandall, E. P., Langholz, E., Friis, S. U., Worm, D., Støving, R. K., Aldries, A., Juhl, C. B., Rehfeld, J. F., Vrang, N., Jelsing, J., Vilsbøll, T. & Knop, F. K., 1 Oct 2018, In : Diabetologia. 61, Suppl 1, p. S248-S249 1 p., 508.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  10. Published

    The role of the incretins in the postprandial bone remodelling

    Helsted, M. M., Gasbjerg, L. S., Lanng, A. R., Stensen, S., Hartmann, B., Christensen, M., Holst, J. J., Vilsbøll, T., Rosenkilde, M. & Knop, F. K., 1 Oct 2018, In : Diabetologia. 61, Suppl 1, p. S221-S221 1 p., 449.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  11. Published

    Preclinical discovery and development of colesevelam for the treatment of type 2 diabetes

    Nerild, H. H., Christensen, M. B., Knop, F. K. & Brønden, A., Oct 2018, In : Expert Opinion on Drug Discovery. 13, 12, p. 1161-1167 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course

    Mikkelsen, K. H., Vilsbøll, T., Holst, J. J., Hartmann, B., Knop, F. K. & Frost, M., 4 Sep 2018, In : BMC Endocrine Disorders. 18, 1, p. 60

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Differences Between Randomized Clinical Trial Patients and Real-World Initiators of the Glucagon-Like Peptide 1 Receptor Agonist Liraglutide

    Knudsen, J. S., Thomsen, R. W., Pottegård, A., Knop, F. K. & Sørensen, H. T., Sep 2018, In : Diabetes Care. 41, 9, p. e133-e135 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

  14. Published

    Model-Based Prediction of Plasma Concentration and Enterohepatic Circulation of Total Bile Acids in Humans

    Guiastrennec, B., Sonne, D. P., Bergstrand, M., Vilsbøll, T., Knop, F. K. & Karlsson, M. O., Sep 2018, In : CPT: pharmacometrics & systems pharmacology. 7, 9, p. 603-612 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Is glucagon-like peptide-1 fully protected by dipeptidyl peptidase 4 inhibitor administration in patients with type 2 diabetes?

    Andersen, E. S., Lund, A., Bagger, J. I., Andreasen, C., Grøndahl, M. F., Deacon, C. F., Hartmann, B., Holst, J. J., Knop, F. K. & Vilsbøll, T., Aug 2018, In : Diabetes, Obesity and Metabolism. 20, 8, p. 1937-1943 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The Effect of Ethanol on Inflammation Markers and FGF-21 in Healthy Individuals

    Lanng, A. R., Gasbjerg, L. S., Bergmann, N., Møller, H. J., Gillum, M. P., Grønbæk, H., Vilsbøll, T. & Knop, F. K., 1 Jul 2018, In : Diabetes. 67, Suppl 1

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  17. Published

    Glucose-lowering effects and mechanisms of the bile acid-sequestering resin sevelamer

    Brønden, A., Mikkelsen, K., Sonne, D. P., Hansen, M., Våben, C., Gabe, M. N., Rosenkilde, M., Tremaroli, V., Wu, H., Bäckhed, F., Rehfeld, J. F., Holst, J. J., Vilsbøll, T. & Knop, F. K., Jul 2018, In : Diabetes, Obesity and Metabolism. 20, 7, p. 1623-1631 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published
  19. Published

    Cardiovascular biomarkers in clinical studies of type 2 diabetes

    Baldassarre, M. P. A., Andersen, A., Consoli, A., Knop, F. K. & Vilsbøll, T., Jun 2018, In : Diabetes, Obesity and Metabolism. 20, 6, p. 1350–1360 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    Effects of Smoking Versus Nonsmoking on Postprandial Glucose Metabolism in Heavy Smokers Compared With Nonsmokers

    Grøndahl, M. F., Bagger, J. I., Lund, A., Faurschou, A., Rehfeld, J. F., Holst, J. J., Vilsbøll, T. & Knop, F. K., Jun 2018, In : Diabetes Care. 41, 6, p. 1260-1267 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    EJE PRIZE 2018: A gut feeling about glucagon

    Knop, F. K., Jun 2018, In : European Journal of Endocrinology. 178, 6, p. R267-R280

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Ghrelin secretion in humans - a role for the vagus nerve?

    Veedfald, S., Plamboeck, A., Hartmann, B., Vilsbøll, T., Knop, F. K., Deacon, C. F., Svendsen, L. B. & Holst, J. J., Jun 2018, In : Neurogastroenterology and Motility. 30, 6, p. e13295

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published
  24. Published

    FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest

    Søberg, S., Andersen, E. S., Dalgaard, N. B., Jarlhelt, I., Hansen, N. L., Hoffmann, N., Vilsbøll, T., Chenchar, A., Jensen, M., Grevengoed, T. J., Trammell, S. A. J., Knop, F. K. & Gillum, M. P., 1 May 2018, In : Molecular Metabolism. 11, p. 96-103 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Hemodynamic Effects of Glucagon - A Literature Review

    Meidahl Petersen, K., Bøgevig, S., Holst, J. J., Knop, F. K. & Christensen, M. B., 1 May 2018, In : The Journal of clinical endocrinology and metabolism. 103, 5, p. 1804-1812 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published
  27. Published
  28. Published

    Glucagon-like peptide 1 in health and disease

    Andersen, A., Lund, A., Knop, F. K. & Vilsbøll, T., May 2018, In : Nature reviews. Endocrinology. 14, p. 390-403 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    Restoration of enteroendocrine and pancreatic function after internal hernia and short bowel syndrome in a young woman with gastric bypass - a 2-year follow-up

    Borghede, M., Vinter-Jensen, L., Rasmussen, H. H., Veedfald, S., Rehfeld, J. F., Hartmann, B., Holst, J. J., Knop, F. K. & Sonne, D. P., May 2018, In : Physiological Reports. 6, 9, p. e13686

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Metformin er en mulig glukagonlignende peptid-1-stimulator

    Bahne, E., Brønden, A., Vilsbøll, T. & Knop, F. K., 19 Mar 2018, In : Ugeskrift for Laeger. 180, 12, p. 2-5 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Effects of glucagon-like peptide-1 (GLP-1) receptor agonists on cardiovascular risk factors: a narrative review of head-to-head comparisons

    Dalsgaard, N. B., Vilsbøll, T. & Knop, F. K., Mar 2018, In : Diabetes, Obesity and Metabolism. 20, 3, p. 205-2019 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Evidence of a liver-alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino acids

    Wewer Albrechtsen, N. J., Færch, K., Jensen, T. M., Witte, D. R., Pedersen, J., Mahendran, Y., Jonsson, A. E., Galsgaard, K. D., Winther-Sørensen, M., Torekov, S. S., Lauritzen, T., Pedersen, O., Knop, F. K., Hansen, T., Jørgensen, M. E., Vistisen, D. & Holst, J. J., Mar 2018, In : Diabetologia. 61, 3, p. 671-680 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

    Fernandez-Cachon, M. L., Pedersen, S. L., Rigbolt, K. T., Zhang, C., Fabricius, K., Hansen, H. H., Elster, L., Fink, L. N., Schäfer, M., Rhee, N. A., Langholz, E., Wandall, E., Friis, S. U., Vilmann, P., Kristiansen, V. B., Schmidt, C., Schreiter, K., Breitschopf, K., Hübschle, T., Jorsal, T., Vilsbøll, T., Schmidt, T., Theis, S., Knop, F. K., Larsen, P. J. & Jelsing, J., Mar 2018, In : Peptides. 101, p. 32-43

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Diagnostik og behandling af maturity onset diabetes of the young type 3

    Rose, K., Christensen, A. S., Storgaard, H., Hædersdal, S., Hansen, T., Knop, F. K. & Vilsbøll, T., 5 Feb 2018, In : Ugeskrift for Laeger. 180, 6, p. 2-6 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes

    Hædersdal, S., Lund, A., Knop, F. K. & Vilsbøll, T., 1 Feb 2018, In : Mayo Clinic Proceedings. 93, 2, p. 217-239 22 p.

    Research output: Contribution to journalReviewResearchpeer-review

  36. Published

    Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

    Jorsal, T., Rhee, N. A., Pedersen, J., Wahlgren, C. D., Mortensen, B., Jepsen, S. L., Jelsing, J., Dalbøge, L. S., Vilmann, P., Hassan, H., Hendel, J. W., Poulsen, S. S., Holst, J. J., Vilsbøll, T. & Knop, F. K., Feb 2018, In : Diabetologia. 61, 2, p. 284-294 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study

    Gasbjerg, L. S., Christensen, M. B., Hartmann, B., Lanng, A. R., Sparre-Ulrich, A. H., Gabe, M. B. N., Dela, F., Vilsbøll, T., Holst, J. J., Rosenkilde, M. M. & Knop, F. K., Feb 2018, In : Diabetologia. 61, 2, p. 413-423 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents

    Gasbjerg, L. S., Gabe, M. B. N., Hartmann, B., Christensen, M. B., Knop, F. K., Holst, J. J. & Rosenkilde, M. M., Feb 2018, In : Peptides. 100, p. 173-181 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published
  40. Published
  41. Published
  42. Published
  43. Published

    Glucose-Dependent Insulinotropic Polypeptide (GIP) Inhibits Bone Resorption independently of Insulin and Glycemia

    Christensen, M. B., Lund, A., Calanna, S., Jørgensen, N. R., Holst, J. J., Vilsbøll, T. & Knop, F. K., 2018, In : The Journal of clinical endocrinology and metabolism. 103, 1, p. 288-294 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Submitted

    Kender vi til DPP-4 hæmmernes egentlig virkningsmekanisme?

    Andersen, E. S., Knop, F. K. & Vilsbøll, T., 2018, (Submitted) Best Practice

    Research output: Other contributionResearch

  45. 2017
  46. Published

    Dilemma med danske julefrokoster

    Lanng, A. R., Gasbjerg, L. S. & Knop, F. K., 11 Dec 2017, In : Ugeskrift for Laeger. 179, 50

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Impaired beta cell sensitivity to incretins in type 2 diabetes is insufficiently compensated by higher incretin response

    Tura, A., Bagger, J. I., Ferrannini, E., Holst, J. J., Knop, F. K., Vilsbøll, T. & Mari, A., Dec 2017, In : Nutrition, metabolism, and cardiovascular diseases : NMCD. 27, 12, p. 1123-1129 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

    Wewer Albrechtsen, N. J., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jørgensen, N. B., Gabe, M. N., Balk-Møller, E., Albrechtsen, R., Winther-Sørensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsbøll, T., Eliasen, R., Bojsen-Møller, K. N., Idorn, T., Deacon, C. F., Knop, F. K., Rosenkilde, M. M., Hartmann, B., Feldt-Rasmussen, B., Mann, M., Madsbad, S. & Holst, J. J., 1 Nov 2017, In : Cell Reports. 21, 6, p. 1452-1460

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Single-dose Metformin Enhances Bile Acid-Induced GLP-1 Secretion in Patients with Type 2 Diabetes

    Brønden, A., Albér, A., Rohde, U., Rehfeld, J. F., Holst, J. J., Vilsbøll, T. & Knop, F. K., 1 Nov 2017, In : The Journal of clinical endocrinology and metabolism. 102, 11, p. 4153-4162 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published
  51. Published

    Current Therapies That Modify Glucagon Secretion: What Is the Therapeutic Effect of Such Modifications?

    Grøndahl, M. F., Keating, D. J., Vilsbøll, T. & Knop, F. K., 28 Oct 2017, In : Current Diabetes Reports. 17, 12, p. 128

    Research output: Contribution to journalReviewResearchpeer-review

  52. Published

    Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

    Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., Knop, F. K., Blaak, E. E., Zhao, J., Smidt, H., Harms, A. C., Hankemeijer, T., Bergman, J. J. G. H. M., Romijn, H. A., Schaap, F. G., Olde Damink, S. W. M., Ackermans, M. T., Dallinga-Thie, G. M., Zoetendal, E., de Vos, W. M., Serlie, M. J., Stroes, E. S. G., Groen, A. K. & Nieuwdorp, M., 3 Oct 2017, In : Cell Metabolism. 26, 4, p. 611-619.e6

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 31007257