Personal profile
Expertises
ELISA; Immunoblotting; rheumatoid arthritis; autoantibodies; monoclonal antibodies; arthritis mice models; peptidylarginine deiminase; citrullination
Main research areas
Studies on peptidylarginine deiminases (PADs) that catalyzes posttranslational conversion of protein arginine residues into citrulline and the impact on human disease, e.g. rheumatoid arthritis. I focus on how PADs are activated in vivo and the individual role of each isoenzyme.
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Collaborations and top research areas from the last five years
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A quantitative and site-specific atlas of the citrullinome reveals widespread existence of citrullination and insights into PADI4 substrates
Rebak, A. S., Hendriks, I. A., Elsborg, J. D., Buch-Larsen, S. C., Nielsen, C. H., Terslev, L., Kirsch, R., Damgaard, D., Doncheva, N. T., Lennartsson, C., Rykær, M., Jensen, L. J., Christophorou, M. A. & Nielsen, M. L., Jun 2024, In: Nature Structural and Molecular Biology. 31, 6, p. 977-995 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
23 Citations (Scopus) -
Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis
Massarenti, L., Enevold, C., Damgaard, D., Hansen, P. R., Frisch, M., Ødum, N., Jacobsen, S. & Nielsen, C. H., 23 Aug 2022, In: International Journal of Molecular Sciences. 23, 17, 9536.Research output: Contribution to journal › Journal article › Research › peer-review
6 Citations (Scopus) -
Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4
Martín Monreal, M. T., Rebak, A. S., Massarenti, L., Mondal, S., Šenolt, L., Ødum, N., Nielsen, M. L., Thompson, P. R., Nielsen, C. H. & Damgaard, D., 19 Oct 2021, In: Frontiers in Immunology. 12, p. 716250 716250.Research output: Contribution to journal › Journal article › Research › peer-review
41 Citations (Scopus) -
Identification of potential autoantigens in anti-CCP-positive and anti-CCP-negative rheumatoid arthritis using citrulline-specific protein arrays
Poulsen, T. B. G., Damgaard, D., Jørgensen, M. M., Senolt, L., Blackburn, J. M., Nielsen, C. H. & Stensballe, A., 27 Aug 2021, In: Scientific Reports. 11, 1, p. 17300 17300.Research output: Contribution to journal › Journal article › Research › peer-review
12 Citations (Scopus) -
Objective and noninvasive biochemical markers in rheumatoid arthritis: where are we and where are we going?
Bay-Jensen, A. C., Siebuhr, A. S., Damgaard, D., Drobinski, P., Thudium, C., Mortensen, J. & Nielsen, C. H., Mar 2021, In: Expert review of proteomics. 18, 3, p. 159-175 17 p.Research output: Contribution to journal › Review › peer-review
7 Citations (Scopus)