cancer biology; tumor microenvironment; tumor stroma; mouse models; transgenic mice; extracellular matrix; tumor immunology; collagen; cancer immunotherapy; tumor-associated macrophages; cancer-associated fibroblasts

The impact of the tumor microenvironment on cancer immunotherapy

Transgenic mice, 3D cell culture assays, and clinical samples are used to investigate how specific components of the tumor microenvironment affect the efficiency of cancer immunotherapy. These components include the extracellular matrix, tumor-associated macrophages and stromal fibroblasts.

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