Research output per year
Research output per year
Personal profile
Expertises
cancer biology; tumor microenvironment; tumor stroma; mouse models; transgenic mice; extracellular matrix; tumor immunology; collagen; cancer immunotherapy; tumor-associated macrophages; cancer-associated fibroblasts
Main research areas
The impact of the tumor microenvironment on cancer immunotherapy
Current research
Transgenic mice, 3D cell culture assays, and clinical samples are used to investigate how specific components of the tumor microenvironment affect the efficiency of cancer immunotherapy. These components include the extracellular matrix, tumor-associated macrophages and stromal fibroblasts.
Potential conflicts of interest
None
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ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion
Gnosa, S. P., Puig Blasco, L., Piotrowski, K. B., Freiberg, M. L., Savickas, S., Madsen, D. H., Auf dem Keller, U., Kronqvist, P. & Kveiborg, M., 22 Sep 2022, In: JCI Insight. 7, 18, e155296.Research output: Contribution to journal › Journal article › Research › peer-review
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Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells
Weis-Banke, S. E., Lisle, T. L., Perez-Penco, M., Schina, A., Hübbe, M. L., Siersbæk, M., Holmström, M. O., Jørgensen, M. A., Marie Svane, I., Met, Ö., Ødum, N., Madsen, D. H., Donia, M., Grøntved, L. & Andersen, M. H., 1 Oct 2022, In: Journal for ImmunoTherapy of Cancer. 10, 10, e005326.Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment
Fjæstad, K. Y., Rømer, A. M. A., Goitea, V., Johansen, A. Z., Thorseth, M-L., Carretta, M., Engelholm, L. H., Grøntved, L., Junker, N. & Madsen, D. H., Feb 2022, In: Oncogene. 41, 9, p. 1364-1375 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chitooligosaccharides Improve the Efficacy of Checkpoint Inhibitors in a Mouse Model of Lung Cancer
Johansen, A. Z., Carretta, M., Thorseth, M-L., Khan, S., Fjæstad, K. Y., Brøchner, C. B., Linder, H., Ankjærgaard, C., Donia, M., Chen, I., Nielsen, D. L., Behrens, C. P. & Madsen, D. H., 12 May 2022, In: Pharmaceutics. 14, 5, 1046.Research output: Contribution to journal › Journal article › Research › peer-review
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Fibrotic activity quantified in serum by measurements of type III collagen pro-peptides can be used for prognosis across different solid tumor types
Willumsen, N., Jensen, C., Green, G., Nissen, N. I., Neely, J., Nelson, D. M., Pedersen, R. S., Frederiksen, P., Chen, I. M., Boisen, M. K., Johansen, A. Z., Madsen, D. H., Svane, I. M., Lipton, A., Leitzel, K., Ali, S. M., Erler, J. T., Hurkmans, D. P., Mathijssen, R. H. J., Aerts, J., & 5 others, 25 Mar 2022, In: Cellular and Molecular Life Sciences. 79, 4, p. 204 204.Research output: Contribution to journal › Review › peer-review