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The Capital Region of Denmark - a part of Copenhagen University Hospital

Christina Vorbeck


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vulvar cancer; survival and pattern of failure after radiotherapy

Main research areas

Vulvar cancer; chemoradiation

Current research

Vulvar cancer is a relatively rare disease, and there is therefore very little knowledge about the pattern of loco-regional failures after radiotherapy. This lack of knowledge represents a missed opportunity as it impedes rational risk/benefit assessments when prescribing the radiation; the optimal radiation dose prescription strategy is disputed and many treatment decisions are guided from clinical trials of cervical cancer in the absence of vulvar cancer research.

In this PhD project, our research group proposes a systematic analysis of loco-regional recurrences observed in vulvar cancer patients treated in MD Anderson, Houston and Rigshospitalet, Copenhagen. We will generate a map of failure probability to suggest a modified, data driven dose prescription strategy targeting more of the radiation dose at regions with high risk of recurrence in patients with poor prognosis with current treatment. The potential to test such a strategy in a prospective trial will be assessed using biostatistical methods.


Potential conflicts of interest

Travel to conferences with Astra Zeneca, MSD and Roche

ID: 46034192