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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Curriculum

Expertise

With an educational background in molecular tumor biology, a PhD in molecular diagnostics and 3 years of experience in epidemiology, I am able to cover many aspects of hereditary colorectal cancer (HNPCC), which I have been working with for 9 years.

Research areas

Colorectal cancer is the third most common cancer type in the world with more than 1 million new diagnoses each year. Approximately 20% is estimated to be caused by hereditary factors and 5% are caused by known germline mutations. The Danish HNPCC Register holds more than 6000 Danish families with verified or suspected genetic defects, who are at increased risk of developing primarily colorectal cancer, but also cancer in other organs. We wish to identify the genetic causes of colorectal cancer, to investigate the genetic alterations and features that promote tumor development and to estimate phenotype-specific risk for tumor development in different organs.

Current research

The HNPCC Register holds 7 distinct family subtypes. Each of these subtypes has specific issues to be addressed. In the families with yet unidentified genetic defects (FCCTX and Late Onset), we are applying next generation sequencing methods to search for new cancer genes that can explain their increased risk of colorectal cancer. In the families with verified genetic mutations (Lynch syndrome), we are estimating the phenotype-specific risk of extra-colonic cancer and investigating different prognostic and treatment-predictive biomarkers.

Education

2013: PhD, Hvidovre Hospital: Genomic profiling of Lynch syndrome and familial colorectal cancer type X.

2007: Master degree in biochemistry, University of Copenhagen. Master project: HU-induced cell cycle arrest and apoptosis in lymphoblastoid cells, Department of Cell Cycle and Cancer, The Danish Cancer Society.

Expertises

With an educational background in molecular tumor biology, a PhD in molecular diagnostics and 3 years of experience in epidemiology, I am able to cover many aspects of hereditary colorectal cancer (HNPCC), which I have been working with for 9 years.

Main research areas

Colorectal cancer is the third most common cancer type in the world with more than 1 million new diagnoses each year. Approximately 20% is estimated to be caused by hereditary factors and 5% are caused by known germline mutations. The Danish HNPCC Register holds more than 6000 Danish families with verified or suspected genetic defects, who are at increased risk of developing primarily colorectal cancer, but also cancer in other organs. We wish to identify the genetic causes of colorectal cancer, to investigate the genetic alterations and features that promote tumor development and to estimate phenotype-specific risk for tumor development in different organs. 

Current research

The HNPCC Register holds 7 distinct family subtypes. Each of these subtypes has specific issues to be addressed. In the families with yet unidentified genetic defects (FCCTX and Late Onset), we are applying next generation sequencing methods to search for new cancer genes that can explain their increased risk of colorectal cancer. In the families with verified genetic mutations (Lynch syndrome), we are estimating the phenotype-specific risk of extra-colonic cancer and investigating different prognostic and treatment-predictive biomarkers. 

Potential conflicts of interest

None to declare

ID: 173852