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The Capital Region of Denmark - a part of Copenhagen University Hospital
  1. 2022
  2. Published

    Trial Sequential Analysis in Critical Care Medicine: The Way Forward

    Lew, C. C. H., Lee, Z-Y. & Gluud, C., 1 Dec 2022, In: Critical Care Medicine. 50, 12, p. e809-e810

    Research output: Contribution to journalLetterResearchpeer-review

  3. Published

    Interactions in the 2×2×2 factorial randomised clinical STEPCARE trial and the potential effects on conclusions: a protocol for a simulation study

    Olsen, M. H., Jensen, A. K. G., Dankiewicz, J., Skrifvars, M. B., Reinikainen, M., Tiainen, M., Saxena, M., Aneman, A., Gluud, C., Ullén, S., Nielsen, N. & Jakobsen, J. C., 22 Oct 2022, In: Trials. 23, 1, p. 889 889.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published
  5. Published
  6. Published

    Goal directed fluid removal with furosemide versus placebo in intensive care patients with fluid overload: A trial protocol for a randomised, blinded trial (GODIF trial)

    Wichmann, S., Itenov, T. S., Berthelsen, R. E., Lange, T., Perner, A., Gluud, C., Lawson-Smith, P., Nebrich, L., Wiis, J., Brøchner, A. C., Hildebrandt, T., Behzadi, M. T., Strand, K., Andersen, F. H., Strøm, T., Järvisalo, M., Damgaard, K. A. J., Vang, M. L., Wahlin, R. R., Sigurdsson, M. I. & 4 others, Thormar, K. M., Ostermann, M., Keus, F. & Bestle, M. H., Oct 2022, In: Acta Anaesthesiologica Scandinavica. 66, 9, p. 1138-1145 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published
  8. Published
  9. Published

    Liver support systems for adults with acute liver failure

    Martí-Carvajal, A. J., Gluud, C., Gluud, L. L., Pavlov, C. S., Mauro, E., Monge Martín, D., Liu, J. P., Nicola, S., Comunián-Carrasco, G. & Martí-Amarista, C. E., 28 Jul 2022, In: Cochrane Database of Systematic Reviews. 2022, 7, p. 1-32 32 p., CD015059.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Anticoagulants for thrombosis prophylaxis in acutely ill patients admitted to hospital: systematic review and network meta-analysis

    Eck, R. J., Elling, T., Sutton, A. J., Wetterslev, J., Gluud, C., van der Horst, I. C. C., Gans, R. O. B., Meijer, K. & Keus, F., 4 Jul 2022, In: BMJ. 378, p. e070022 e070022.

    Research output: Contribution to journalReviewResearchpeer-review

  11. Published
  12. Published
  13. Published
  14. Published

    Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia

    Granholm, A., Kjær, M-B. N., Munch, M. W., Myatra, S. N., Vijayaraghavan, B. K. T., Cronhjort, M., Wahlin, R. R., Jakob, S. M., Cioccari, L., Vesterlund, G. K., Meyhoff, T. S., Helleberg, M., Møller, M. H., Benfield, T., Venkatesh, B., Hammond, N. E., Micallef, S., Bassi, A., John, O., Jha, V. & 29 others, Kristiansen, K. T., Ulrik, C. S., Jørgensen, V. L., Smitt, M., Bestle, M. H., Andreasen, A. S., Poulsen, L. M., Rasmussen, B. S., Brøchner, A. C., Strøm, T., Møller, A., Khan, M. S., Padmanaban, A., Divatia, J. V., Saseedharan, S., Borawake, K., Kapadia, F., Dixit, S., Chawla, R., Shukla, U., Amin, P., Chew, M. S., Wamberg, C. A., Bose, N., Shah, M. S., Darfelt, I. S., Gluud, C., Lange, T. & Perner, A., May 2022, In: Intensive Care Medicine. 48, 5, p. 580-589 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Control interventions in randomised trials among people with mental health disorders

    Faltinsen, E., Todorovac, A., Staxen Bruun, L., Hróbjartsson, A., Gluud, C., Kongerslev, M. T., Simonsen, E. & Storebø, O. J., 4 Apr 2022, In: Cochrane Database of Systematic Reviews. 4, 4, 341 p., MR000050.

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published
  17. E-pub ahead of print

    Cerebral near-infrared spectroscopy monitoring (NIRS) in children and adults: a systematic review with meta-analysis

    Hansen, M. L., Hyttel-Sørensen, S., Jakobsen, J. C., Gluud, C., Kooi, E. M. W., Mintzer, J., de Boode, W. P., Fumagalli, M., Alarcon, A., Alderliesten, T., Greisen, G. & European Society for Paediatric Research Special Interest Group ‘NearInfraRed Spectroscopy’ (NIRS), 22 Feb 2022, (E-pub ahead of print) In: Pediatric Research.

    Research output: Contribution to journalReviewResearchpeer-review

  18. E-pub ahead of print

    Methylphenidate denied access to the WHO List of Essential Medicines for the second time

    Pereira Ribeiro, J., Lunde, C., Gluud, C., Simonsen, E. & Storebø, O. J., 19 Feb 2022, (E-pub ahead of print) In: BMJ Evidence-Based Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial

    Granholm, A., Munch, M. W., Myatra, S. N., Vijayaraghavan, B. K. T., Cronhjort, M., Wahlin, R. R., Jakob, S. M., Cioccari, L., Kjær, M-B. N., Vesterlund, G. K., Meyhoff, T. S., Helleberg, M., Møller, M. H., Benfield, T., Venkatesh, B., Hammond, N. E., Micallef, S., Bassi, A., John, O., Jha, V. & 26 others, Kristiansen, K. T., Ulrik, C. S., Jørgensen, V. L., Smitt, M., Bestle, M. H., Andreasen, A. S., Poulsen, L. M., Rasmussen, B. S., Brøchner, A. C., Strøm, T., Møller, A., Khan, M. S., Padmanaban, A., Divatia, J. V., Saseedharan, S., Borawake, K., Kapadia, F., Dixit, S., Chawla, R., Shukla, U., Amin, P., Chew, M. S., Wamberg, C. A., Gluud, C., Lange, T. & Perner, A., Jan 2022, In: Intensive Care Medicine. 48, 1, p. 45-55 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published
  21. Published

    Vaccines to prevent COVID-19: A living systematic review with Trial Sequential Analysis and network meta-analysis of randomized clinical trials

    Korang, S. K., von Rohden, E., Veroniki, A. A., Ong, G., Ngalamika, O., Siddiqui, F., Juul, S., Nielsen, E. E., Feinberg, J. B., Petersen, J. J., Legart, C., Kokogho, A., Maagaard, M., Klingenberg, S., Thabane, L., Bardach, A., Ciapponi, A., Thomsen, A. R., Jakobsen, J. C. & Gluud, C., 2022, In: PLoS One. 17, 1, p. e0260733 e0260733.

    Research output: Contribution to journalReviewResearchpeer-review

  22. 2021
  23. Published
  24. Published

    Short-term outcomes of phosphodiesterase type 5 inhibitors for fetal growth restriction: a study protocol for a systematic review with individual participant data meta-analysis, aggregate meta-analysis, and trial sequential analysis

    Liauw, J., Groom, K., Ganzevoort, W., Gluud, C., McKinlay, C. J. D., Sharp, A., Mackay, L., Kariya, C., Lim, K., von Dadelszen, P., Limpens, J., Jakobsen, J. C. & STRIDER Consortium, 3 Dec 2021, In: Systematic Reviews. 10, 1, 11 p., 305.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Early specialised palliative care: interventions, symptoms, problems

    Skjoedt, N., Johnsen, A. T., Sjøgren, P., Neergaard, M. A., Damkier, A., Gluud, C., Lindschou, J., Fayers, P., Higginson, I. J., Strömgren, A. S. & Groenvold, M., Dec 2021, In: BMJ Supportive and Palliative Care. 11, 4, p. 444-453 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published
  27. Published

    Was amorphous aluminium hydroxyphosphate sulfate adequately evaluated before authorisation in Europe?

    Petersen, S. B. & Gluud, C., Dec 2021, In: BMJ Evidence-Based Medicine. 26, 6, p. 285-289 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Interventions for altering blood pressure in people with acute subarachnoid haemorrhage

    Maagaard, M., Karlsson, W. K., Ovesen, C., Gluud, C. & Jakobsen, J. C., 17 Nov 2021, In: Cochrane Database of Systematic Reviews. 2021, 11, p. CD013096 CD013096.

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial

    Munch, M. W., Myatra, S. N., Vijayaraghavan, B. K. T., Saseedharan, S., Benfield, T., Wahlin, R. R., Rasmussen, B. S., Andreasen, A. S., Poulsen, L. M., Cioccari, L., Khan, M. S., Kapadia, F., Divatia, J. V., Brøchner, A. C., Bestle, M. H., Helleberg, M., Michelsen, J., Padmanaban, A., Bose, N., Møller, A. & 31 others, Borawake, K., Kristiansen, K. T., Shukla, U., Chew, M. S., Dixit, S., Ulrik, C. S., Amin, P. R., Chawla, R., Wamberg, C. A., Shah, M. S., Darfelt, I. S., Jørgensen, V. L., Smitt, M., Granholm, A., Kjær, M-B. N., Møller, M. H., Meyhoff, T. S., Vesterlund, G. K., Hammond, N. E., Micallef, S., Bassi, A., Gluud, C., Marcussen, K. V., Nielsen, H., Schjørring, O. L., Kristensen, C. M., Hjortsø, C. J. S., Metcalf-Clausen, M., Engstrøm, J., Perner, A. & COVID STEROID 2 Trial Group, 9 Nov 2021, In: JAMA - Journal of the American Medical Association. 326, 18, p. 1807-1817 11 p., 18295.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Beta-blockers in patients without heart failure after myocardial infarction

    Safi, S., Sethi, N. J., Korang, S. K., Nielsen, E. E., Feinberg, J., Gluud, C. & Jakobsen, J. C., 5 Nov 2021, In: Cochrane Database of Systematic Reviews. 11, 11, p. CD012565 CD012565.

    Research output: Contribution to journalReviewResearchpeer-review

  31. Published

    Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia: the COVID STEROID randomised, placebo-controlled trial

    Munch, M. W., Meyhoff, T. S., Helleberg, M., Kjaer, M-B. N., Granholm, A., Hjortsø, C. J. S., Jensen, T. S., Møller, M. H., Hjortrup, P. B., Wetterslev, M., Vesterlund, G. K., Russell, L., Jørgensen, V. L., Tjelle Kristiansen, K., Benfield, T., Ulrik, C. S., Andreasen, A. S., Bestle, M. H., Poulsen, L. M., Hildebrandt, T. & 52 others, Knudsen, L. S., Møller, A., Sølling, C. G., Brøchner, A. C., Rasmussen, B. S., Nielsen, H., Christensen, S., Strøm, T., Cronhjort, M., Wahlin, R. R., Jakob, S. M., Cioccari, L., Venkatesh, B., Hammond, N., Jha, V., Myatra, S. N., Jensen, M. Q., Leistner, J. W., Mikkelsen, V. S., Svenningsen, J. S., Laursen, S. B., Hatley, E. V., Kristensen, C. M., Al-Alak, A., Clapp, E., Jonassen, T. B., Bjerregaard, C. L., Østerby, N. C. H., Jespersen, M. M., Abou-Kassem, D., Lassen, M. L., Zaabalawi, R., Daoud, M. M., Abdi, S., Meier, N., la Cour, K., Derby, C. B., Damlund, B. R., Laigaard, J., Andersen, L. L., Mikkelsen, J., Jensen, J. L. S., Rasmussen, A. H., Arnerlöv, E., Lykke, M., Holst-Hansen, M. Z. B., Tøstesen, B. W., Schwab, J., Madsen, E. K., Gluud, C., Lange, T. & Perner, A., Nov 2021, In: Acta Anaesthesiologica Scandinavica. 65, 10, p. 1421-1430 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Ongoing and future COVID-19 vaccine clinical trials: challenges and opportunities

    Dal-Ré, R., Bekker, L-G., Gluud, C., Holm, S., Jha, V., Poland, G. A., Rosendaal, F. R., Schwarzer-Daum, B., Sevene, E., Tinto, H., Voo, T. C. & Sreeharan, N., Nov 2021, In: The Lancet Infectious Diseases. 21, 11, p. e342-e347

    Research output: Contribution to journalReviewResearchpeer-review

  33. Published

    A screening method to spot biomarkers that may warn of serious events in a chronic disease - illustrated by cardiological CLARICOR trial data

    Winkel, P., Hilden, J., Jakobsen, J. C., Lindschou, J., Jensen, G. B., Kjøller, E., Sajadieh, A., Kastrup, J., Kolmos, H. J., Larsson, A., Ärnlöv, J., Bjerre, M. & Gluud, C., 26 Oct 2021, In: Clinical Chemistry and Laboratory Medicine. 59, 11, p. 1852-1860 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published
  35. Published

    The effects of adding quinolones to beta-lactam antibiotics for sepsis

    Korang, S. K., Maagaard, M., Feinberg, J. B., Perner, A., Gluud, C. & Jakobsen, J. C., Sep 2021, In: Acta Anaesthesiologica Scandinavica. 65, 8, p. 1023-1032 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  36. Published

    Vitamin D supplementation for chronic liver diseases in adults

    Bjelakovic, M., Nikolova, D., Bjelakovic, G. & Gluud, C., 25 Aug 2021, In: Cochrane Database of Systematic Reviews. 8, p. CD011564 CD011564.

    Research output: Contribution to journalReviewResearchpeer-review

  37. Published
  38. Published

    Does Methylphenidate Work in Children and Adolescents with Attention Deficit Hyperactivity Disorder?

    Pereira Ribeiro, J., Arthur, E. J., Gluud, C., Simonsen, E. & Storebø, O. J., 1 Aug 2021, In: Pediatric Reports. 13, 3, p. 434-443 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Methylphenidate for ADHD rejected from the WHO Essential Medicines List due to uncertainties in benefit-harm profile

    Storebø, O. J. & Gluud, C., 1 Aug 2021, In: BMJ Evidence-Based Medicine. 26, 4, p. 172-175 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Tranexamic Acid for Prevention of Hematoma Expansion in Intracerebral Hemorrhage Patients With or Without Spot Sign

    Ovesen, C., Jakobsen, J. C., Gluud, C., Steiner, T., Law, Z., Flaherty, K., Dineen, R. A., Christensen, L. M., Overgaard, K., Rasmussen, R. S., Bath, P. M., Sprigg, N., Christensen, H. & TICH-2 Investigators, Aug 2021, In: Stroke. 52, 8, p. 2629-2636 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Central data monitoring in the multicentre randomised SafeBoosC-III trial - a pragmatic approach

    Olsen, M. H., Hansen, M. L., Safi, S., Jakobsen, J. C., Greisen, G., Gluud, C. & SafeBoosC-III Trial Group, 31 Jul 2021, In: BMC Medical Research Methodology. 21, 1, p. 160 160.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published
  43. Published

    A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions

    Barbateskovic, M., Koster, T. M., Eck, R. J., Maagaard, M., Afshari, A., Blokzijl, F., Cronhjort, M., Dieperink, W., Fabritius, M. L., Feinberg, J., French, C., Gareb, B., Geisler, A., Granholm, A., Hiemstra, B., Hu, R., Imberger, G., Jensen, B. T., Jonsson, A. B., Karam, O. & 25 others, Kong, D. Z., Korang, S. K., Koster, G., Lai, B., Liang, N., Lundstrøm, L. H., Marker, S., Meyhoff, T., Nielsen, E. E., Nørskov, A. K., Munch, M. W., Risom, E. C., Rygård, S. L., Safi, S., Sethi, N., Sjövall, F., Lauridsen, S. V., van Bakelen, N., Volbeda, M., van der Horst, I., Gluud, C., Perner, A., Møller, M. H., Keus, F. & Wetterslev, J., Jul 2021, In: Journal of Clinical Epidemiology. 135, p. 29-41 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Higher vs. Lower Doses of Dexamethasone in Patients with COVID-19 and Severe Hypoxia (COVID STEROID 2) trial: protocol and statistical analysis plan

    Munch, M. W., Granholm, A., Myatra, S. N., Vijayaraghavan, B. K. T., Cronhjort, M., Wahlin, R. R., Jakob, S. M., Cioccari, L., Kjaer, M-B. N., Vesterlund, G. K., Meyhoff, T. S., Helleberg, M., Møller, M. H., Benfield, T., Venkatesh, B., Hammond, N., Micallef, S., Bassi, A., John, O., Jha, V. & 25 others, Tjelle Kristiansen, K., Ulrik, C. S., Jørgensen, V. L., Smitt, M., Bestle, M. H., Andreasen, A. S., Poulsen, L. M., Rasmussen, B. S., Brøchner, A. C., Strøm, T., Møller, A., Khan, M. S., Padmanaban, A., Divatia, J. V., Saseedharan, S., Borawake, K., Kapadia, F., Dixit, S., Chawla, R., Shukla, U., Amin, P., Chew, M. S., Gluud, C., Lange, T. & Perner, A., Jul 2021, In: Acta Anaesthesiologica Scandinavica. 65, 6, p. 834-845 12 p., 13795.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published
  46. Published

    Assessment of assumptions of statistical analysis methods in randomised clinical trials: the what and how

    Nørskov, A. K., Lange, T., Nielsen, E. E., Gluud, C., Winkel, P., Beyersmann, J., de Uña-Álvarez, J., Torri, V., Billot, L., Putter, H., Wetterslev, J., Thabane, L. & Jakobsen, J. C., Jun 2021, In: BMJ Evidence-Based Medicine. 26, 3, p. 121-126 6 p., 111268.

    Research output: Contribution to journalReviewResearchpeer-review

  47. Published

    Blinding in randomised clinical trials of psychological interventions: a retrospective study of published trial reports

    Juul, S., Gluud, C., Simonsen, S., Frandsen, F. W., Kirsch, I. & Jakobsen, J. C., Jun 2021, In: BMJ Evidence-Based Medicine. 26, 3, p. 109 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Considerations on the strengths and limitations of using disease-related mortality as an outcome in clinical research

    Jakobsen, J. C., Wetterslev, J. & Gluud, C., Jun 2021, In: BMJ Evidence-Based Medicine. 26, 3, p. 127-130 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published
  50. Published

    Carotid endarterectomy with patch angioplasty versus primary closure in patients with symptomatic and significant stenosis: a systematic review with meta-analyses and trial sequential analysis of randomized clinical trials

    Marsman, M. S., Wetterslev, J., Jahrome, A. K., Gluud, C., Moll, F. L., Keus, F. & Koning, G. G., 6 May 2021, In: Systematic Reviews. 10, 1, p. 139 139.

    Research output: Contribution to journalReviewResearchpeer-review

  51. Published

    Higher vs. Lower Doses of Dexamethasone in Patients with COVID-19 and Severe Hypoxia (COVID STEROID 2) trial: protocol for a secondary Bayesian analysis

    Granholm, A., Munch, M. W., Myatra, S. N., Vijayaraghavan, B. K. T., Cronhjort, M., Wahlin, R. R., Jakob, S. M., Cioccari, L., Kjaer, M-B. N., Vesterlund, G. K., Meyhoff, T. S., Helleberg, M., Møller, M. H., Benfield, T., Venkatesh, B., Hammond, N., Micallef, S., Bassi, A., John, O., Jha, V. & 25 others, Tjelle Kristiansen, K., Ulrik, C. S., Jørgensen, V. L., Smitt, M., Bestle, M. H., Andreasen, A. S., Poulsen, L. M., Rasmussen, B. S., Brøchner, A. C., Strøm, T., Møller, A., Khan, M. S., Padmanaban, A., Vasishtha Divatia, J., Saseedharan, S., Borawake, K., Kapadia, F., Dixit, S., Chawla, R., Shukla, U., Amin, P., Chew, M. S., Gluud, C., Lange, T. & Perner, A., May 2021, In: Acta Anaesthesiologica Scandinavica. 65, 5, p. 702-710 9 p., 13793.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    The clinical effects of cerebral near-infrared spectroscopy monitoring (NIRS) versus no monitoring: a protocol for a systematic review with meta-analysis and trial sequential analysis

    Hansen, M. L., Hyttel-Sørensen, S., Jakobsen, J. C., Gluud, C., Kooi, E. M. W., Mintzer, J., de Boode, W. P., Fumagalli, M., Alarcon, A., Alderliesten, T. & Greisen, G., 16 Apr 2021, In: Systematic Reviews. 10, 1, p. 111 111.

    Research output: Contribution to journalJournal articleResearchpeer-review

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