20022024

Research activity per year

Personal profile

Expertises

Specialist in Respiratory Medicine; Clinical researcher; translational scientist.

Obstructive airways disease; asthma; COPD; inflammation; pathophysiology

Main research areas

My research interests revolve around the diagnosis and phenotyping of asthma, with a focus on airway pathophysiology and inflammation. Hence, my Ph.D. thesis from 2006 described the usefulness of bronchial provocation testing with mannitol for assessing inflammation driven airway hyperresponsiveness. The mannitol test is now widely used as a diagnostic test for asthma in the clinical setting.

During my post doc with Prof Peter Gibsons group and Prof Greg King in Australia in 2010-11, I described the relationships between airway pathophysiology and subtypes of airway inflammation in older adults with asthma. These findings have added to our understanding of older asthma patients; an overlooked and often undertreated group of asthma patients.

Current research

Current research projects include studies on severe asthma: Prevalence, disease mechanisms, phenotypes immunology, novel treatments. Furthermore COPD: Immunological phenotypes and prognosis

A key aim of my research is to address key clinical problems in translational research studies, in order to provide better solutions to the management of the most severely ill patients with obstructive airways disease.

Potential conflicts of interest

Unrestricted research grants, honoraria for scientific presentations, consultancies from pharmaceutical companies:

Novartis
Teva
Nigaard
Takeda
Pharmaxis
Norpharma
Boehringer
Astra Zeneca
Jannsen
GSK
Sandoz
Roche
Icepharma

External positions

University of Copenhagen

2005 → …

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Collaborations and top research areas from the last five years

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  • Airway hyperresponsiveness correlates with airway TSLP in asthma independent of eosinophilic inflammation

    Andreasson, L. M., Dyhre-Petersen, N., Hvidtfeldt, M., Jørgensen, G. Ø., Von Bülow, A., Klein, D. K., Uller, L., Erjefält, J., Porsbjerg, C. & Sverrild, A., Apr 2024, In: The Journal of allergy and clinical immunology. 153, 4, p. 988-997.e11

    Research output: Contribution to journalJournal articleResearchpeer-review

    2 Citations (Scopus)
  • Airway hyperresponsiveness in asthma: the role of the epithelium

    Bradding, P., Porsbjerg, C., Côté, A., Dahlén, S-E., Hallstrand, T. S. & Brightling, C. E., 21 Feb 2024, (E-pub ahead of print) In: The Journal of allergy and clinical immunology.

    Research output: Contribution to journalReviewpeer-review

  • Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry

    Scelo, G., Torres-Duque, C. A., Maspero, J., Tran, T. N., Murray, R., Martin, N., Menzies-Gow, A. N., Hew, M., Peters, M. J., Gibson, P. G., Christoff, G. C., Popov, T. A., Côté, A., Bergeron, C., Dorscheid, D., FitzGerald, J. M., Chapman, K. R., Boulet, L. P., Bhutani, M., Sadatsafavi, M., & 66 othersJiménez-Maldonado, L., Duran-Silva, M., Rodriguez, B., Celis-Preciado, C. A., Cano-Rosales, D. J., Solarte, I., Fernandez-Sanchez, M. J., Parada-Tovar, P., Bülow, A. V., Bjerrum, A. S., Ulrik, C. S., Assing, K. D., Rasmussen, L. M., Hansen, S., Altraja, A., Bourdin, A., Taille, C., Charriot, J., Roche, N., Papaioannou, A. I., Kostikas, K., Papadopoulos, N. G., Salvi, S., Long, D., Mitchell, P. D., Costello, R., Sirena, C., Cardini, C., Heffler, E., Puggioni, F., Canonica, G. W., Guida, G., Iwanaga, T., Al-Ahmad, M., Linnemann, D. L., García, U., Kuna, P., Fonseca, J. A., Al-Lehebi, R., Koh Siyue, M., Rhee, C. K., Cosio, B. G., de Llano, L. P., Perng Steve, D-W., Huang, E. W-C., Wang, H-C., Tsai, M-J., Mahboub, B., Jaber Salameh, L. I., Jackson, D., Busby, J., Heaney, L. G., Pfeffer, P., Goddard, A. G., Wang, E., Hoyte, F., Wechsler, M. E., Chapman, N., Katial, R., Carter, V., Bulathsinhala, L., Eleangovan, N., Ariti, C., Lyu, J., Price, D. & Porsbjerg, C., Jan 2024, In: Annals of Allergy, Asthma, & Immunology. 132, 1, p. 42-53 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    2 Citations (Scopus)
  • Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma

    Porsbjerg, C. M., Townend, J., Bergeron, C., Christoff, G. C., Katsoulotos, G. P., Larenas-Linnemann, D., Tran, T. N., Al-Lehebi, R., Bosnic-Anticevich, S. Z., Busby, J., Hew, M., Kostikas, K., Papadopoulos, N. G., Pfeffer, P. E., Popov, T. A., Rhee, C. K., Sadatsafavi, M., Tsai, M-J., Ulrik, C. S., Al-Ahmad, M., & 67 othersAltraja, A., Beastall, A., Bulathsinhala, L., Carter, V., Cosio, B. G., Fletton, K., Hansen, S., Heaney, L. G., Hubbard, R. B., Kuna, P., Murray, R. B., Nagano, T., Pini, L., Cano Rosales, D. J., Schleich, F., Wechsler, M. E., Amaral, R., Bourdin, A., Brusselle, G. G., Chen, W., Chung, L. P., Denton, E., Fonseca, J. A., Hoyte, F., Jackson, D. J., Katial, R., Kirenga, B. J., Koh, M. S., Ławkiedraj, A., Lehtimäki, L., Liew, M. F., Mahboub, B., Martin, N., Menzies-Gow, A. N., Pang, P. H., Papaioannou, A. I., Patel, P. H., Perez-De-Llano, L., Peters, M. J., Ricciardi, L., Rodríguez-Cáceres, B., Solarte, I., Tay, T. R., Torres-Duque, C. A., Wang, E., Zappa, M., Abisheganaden, J., Assing, K. D., Costello, R. W., Gibson, P. G., Heffler, E., Máspero, J., Nicola, S., Perng Steve, D-W., Puggioni, F., Salvi, S., Sheu, C-C., Sirena, C., Taillé, C., Tan, T. L., Bjermer, L., Canonica, G. W., Iwanaga, T., Jiménez-Maldonado, L., Taube, C., Brussino, L. & Price, D. B., 2024, In: Frontiers in Immunology. 15, p. 1361891 1361891.

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma

    Wechsler, M. E., Scelo, G., Larenas-Linnemann, D. E. S., Torres-Duque, C. A., Maspero, J., Tran, T. N., Murray, R. B., Martin, N., Menzies-Gow, A. N., Hew, M., Peters, M. J., Gibson, P. G., Christoff, G. C., Popov, T. A., Côté, A., Bergeron, C., Dorscheid, D., FitzGerald, J. M., Chapman, K. R., Boulet, L. P., & 66 othersBhutani, M., Sadatsafavi, M., Jiménez-Maldonado, L., Duran-Silva, M., Rodriguez, B., Celis-Preciado, C. A., Cano-Rosales, D. J., Solarte, I., Fernandez-Sanchez, M. J., Parada-Tovar, P., von Bülow, A., Bjerrum, A. S., Ulrik, C. S., Assing, K. D., Rasmussen, L. M., Hansen, S., Altraja, A., Bourdin, A., Taille, C., Charriot, J., Roche, N., Papaioannou, A. I., Kostikas, K., Papadopoulos, N. G., Salvi, S., Long, D., Mitchell, P. D., Costello, R., Sirena, C., Cardini, C., Heffler, E., Puggioni, F., Canonica, G. W., Guida, G., Iwanaga, T., Al-Ahmad, M., García, U., Kuna, P., Fonseca, J. A., Al-Lehebi, R., Koh, M. S., Rhee, C. K., Cosio, B. G., Perez de Llano, L., Perng, D-W., Huang, E. W-C., Wang, H-C., Tsai, M-J., Mahboub, B., Salameh, L. I. J., Jackson, D. J., Busby, J., Heaney, L. G., Pfeffer, P. E., Goddard, A. G., Wang, E., Hoyte, F. C. L., Chapman, N. M., Katial, R., Carter, V., Bulathsinhala, L., Eleangovan, N., Ariti, C., Lyu, J., Porsbjerg, C. & Price, D. B., 1 Feb 2024, In: American Journal of Respiratory and Critical Care Medicine. 209, 3, p. 262-272 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review