Research output per year
Research output per year
Personal profile
Expertises
Specialist in Respiratory Medicine; Clinical researcher; translational scientist.
Obstructive airways disease; asthma; COPD; inflammation; pathophysiology
Main research areas
My research interests revolve around the diagnosis and phenotyping of asthma, with a focus on airway pathophysiology and inflammation. Hence, my Ph.D. thesis from 2006 described the usefulness of bronchial provocation testing with mannitol for assessing inflammation driven airway hyperresponsiveness. The mannitol test is now widely used as a diagnostic test for asthma in the clinical setting.
During my post doc with Prof Peter Gibsons group and Prof Greg King in Australia in 2010-11, I described the relationships between airway pathophysiology and subtypes of airway inflammation in older adults with asthma. These findings have added to our understanding of older asthma patients; an overlooked and often undertreated group of asthma patients.
Current research
Current research projects include studies on severe asthma: Prevalence, disease mechanisms, phenotypes immunology, novel treatments. Furthermore COPD: Immunological phenotypes and prognosis
A key aim of my research is to address key clinical problems in translational research studies, in order to provide better solutions to the management of the most severely ill patients with obstructive airways disease.
Potential conflicts of interest
Unrestricted research grants, honoraria for scientific presentations, consultancies from pharmaceutical companies:
Novartis
Teva
Nigaard
Takeda
Pharmaxis
Norpharma
Boehringer
Astra Zeneca
Jannsen
GSK
Sandoz
Roche
Icepharma
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Airway hyperresponsiveness reflects corticosteroid-sensitive mast cell involvement across asthma phenotypes
Hvidtfeldt, M., Sverrild, A., Pulga, A., Frøssing, L., Silberbrandt, A., Hostrup, M., Thomassen, M., Sanden, C., Clausson, C. M., Siddhuraj, P., Bornesund, D., Nieto-Fontarigo, J. J., Uller, L., Erjefält, J. & Porsbjerg, C., 10 Mar 2023, In: The Journal of allergy and clinical immunology.Research output: Contribution to journal › Journal article › Research › peer-review
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Allergen Immunotherapy Enhances Airway Epithelial Antiviral Immunity in Patients with Allergic Asthma (VITAL Study): A Double Blind Randomized Controlled Trial
Woehlk, C., Ramu, S., Sverrild, A., Nieto-Fontarigo, J. J., Vázquez-Mera, S., Cerps, S., Pulga, A., Andreasson, L. M., Eriksen, L. L., Dyhre-Petersen, N., Menzel, M., Klein, D. K., Hansen, S., Uller, L. & Porsbjerg, C., 1 May 2023, In: American Journal of Respiratory and Critical Care Medicine. 207, 9, p. 1161-1170 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Asthma
Porsbjerg, C., Melén, E., Lehtimäki, L. & Shaw, D., 11 Mar 2023, In: Lancet. 401, 10379, p. 858-873 16 p.Research output: Contribution to journal › Review › peer-review
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Asthma: Closing in on the Biology of a Complex Life-Course Disease
Bush, A., Holguin, F., Porsbjerg, C. & Saglani, S., 4 Jan 2023, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in patients with severe asthma eligible for both
Pfeffer, P. E., Ali, N., Murray, R., Ulrik, C., Tran, T. N., Maspero, J., Peters, M., Christoff, G. C., Sadatsafavi, M., Torres-Duque, C. A., Altraja, A., Lehtimäki, L., Papadopoulos, N. G., Salvi, S., Costello, R. W., Cushen, B., Heffler, E., Iwanaga, T., Al-Ahmad, M., Larenas-Linnemann, D., & 49 others, 17 Mar 2023, (E-pub ahead of print) In: Allergy.Research output: Contribution to journal › Journal article › Research › peer-review