Personal profile
Research areas
Type 1 diabetes, beta cells, autoimmunity, stem cells
Main research areas
The focus of my research lies in the loss of beta cell mass with type 1 diabetes, in addition to the dysfunction observed in alpha cells following type 1 diabetes development. With the use of pro-inflammatory in vitro setups we investigate the potential of using induced pluripotent stem cells to model type 1 diabetes. These investigation are with an aim to widen our knowlegde of beta- and alpha-cell pathogenesis to define new terapeutic targets.
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Collaborations and top research areas from the last five years
Research output
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Dysregulated insulin signaling and inflammation contribute to the pathogenesis of Alzheimer's disease: from animal models to human cells
Rytter, M. E., Svane, C. A. B., Størling, J. & Chen, W., 1 Mar 2026, In: Neural Regeneration Research. 21, 3, p. 1126-1127 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Evaluation of the pharmacological cathepsin S inhibitor LY3000328 on autoimmune diabetes in mice
Frørup, C., Svane, C. A. S., Jensen, M. H., Holm, L. J., Pedersen, K., Mønsted, M. Ø., Buschard, K. S., Størling, J., Pociot, F., Haupt-Jorgensen, M. & Fløyel, T., Dec 2025, In: Biomedicine & Pharmacotherapy. 193, 118744.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploring the functional, protective, and transcriptomic effects of GIP on cytokine-exposed human pancreatic islets and EndoC-βH5 cells
Henriksen, K., Jørgensen, A., Kaur, S., Gerwig, R., Brøgger Svane, C. A., Knop, F. K. & Størling, J., 15 May 2025, In: Molecular and Cellular Endocrinology. 602, p. 112522 112522.Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Pro-inflammatory cytokines prime human islets for gasdermin D-mediated pyroptosis
Mitani, F., Henriksen, K., Svane, C. A. S., Jørgensen, A., Kaur, S., Frørup, C. & Størling, J., Jun 2025, p. 73.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Pro-inflammatory cytokine treatment of human islets is permissive for gasdermin D-mediated pyroptosis by toll-like receptor 4 and inflammasome activators
Mitani, F., Henriksen, K., Svane, C. A. S., Jørgensen, A., Kaur, S., Frørup, C. & Størling, J., Oct 2025, In: Diabetologia. 68, Suppl 1, p. S257 495.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Activities
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European Islet Study Group 2024
Svane, C. A. (Participant)
18 Jun 2024 → 20 Jun 2024Activity: Participating in or organising an event › Organisation of and participation in conference
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Islet Study Group
Svane, C. A. S. (Participant)
19 Jun 2023 → 21 Jun 2023Activity: Participating in or organising an event › Organisation of and participation in conference
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Stem Cells (Journal)
Svane, C. A. S. (Reviewer)
Jun 2023 → Oct 2023Activity: Publication peer-review and editorial work › Peer review of manuscripts › Research
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In vitro investigation of Mesenchymal Stem Cell Secretomes molecular mechanisms in β-cell protection
Svane, C. A. S. (Lecturer)
17 Jun 2022Activity: Talk or presentation › Lecture and oral contribution
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Dansk Endokrinologisk Selskab Årsmøde 2022
Svane, C. A. S. (Speaker)
17 Jun 2022 → 18 Jun 2022Activity: Participating in or organising an event › Participation in workshop, seminar, course