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The Capital Region of Denmark - a part of Copenhagen University Hospital

Bo Torben Porse

Klinikchef

Københavns Biocenter, Ole Maaløes Vej 5

2200 København N

Denmark

  1. 2019
  2. Published

    Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

    Jakobsen, J. S., Laursen, L. G., Schuster, M. B., Pundhir, S., Schoof, E., Ge, Y., d'Altri, T., Vitting-Seerup, K., Rapin, N., Gentil, C., Jendholm, J., Theilgaard-Mönch, K., Reckzeh, K., Bullinger, L., Döhner, K., Hokland, P., Fitzgibbon, J. & Porse, B. T., Jul 2019, In : Scientific American. 5, 7, p. eaaw4304

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Heterozygous loss of Srp72 in mice is not associated with major hematological phenotypes

    D'Altri, T., Schuster, M. B., Wenzel, A. & Porse, B. T., 29 Jun 2019, In : European Journal of Haematology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

    Morgan, M., Kabayama, Y., Much, C., Ivanova, I., Di Giacomo, M., Auchynnikava, T., Monahan, J. M., Vitsios, D. M., Vasiliauskaitė, L., Comazzetto, S., Rappsilber, J., Allshire, R. C., Porse, B. T., Enright, A. J. & O'Carroll, D., 1 Mar 2019, In : Experimental Cell Research. 29, 3, p. 221-232 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The splicing factor RBM25 controls MYC activity in acute myeloid leukemia

    Ge, Y., Schuster, M. B., Pundhir, S., Rapin, N., Bagger, F. O., Sidiropoulos, N., Hashem, N. & Porse, B. T., 11 Jan 2019, In : Nature Communications. 10, 1, p. 172

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2018
  7. Published

    Leukemogenic nucleophosmin mutation disrupts the transcription factor hub regulating granulo-monocytic fates

    Gu, X., Ebrahem, Q., Mahfouz, R. Z., Hasipek, M., Enane, F., Radivoyevitch, T., Rapin, N., Przychodzen, B., Hu, Z., Balusu, R., Cotta, C. V., Wald, D., Argueta, C., Landesman, Y., Martelli, M. P., Falini, B., Carraway, H., Porse, B. T., Maciejewski, J. P., Jha, B. K. & Saunthararajah, Y., 1 Oct 2018, In : The Journal of clinical investigation. 128, 10, p. 4260-4279

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment

    Lauridsen, F. K. B., Jensen, T. L., Rapin, N., Aslan, D., Wilhelmson, A. S., Pundhir, S., Rehn, M., Paul, F., Giladi, A., Hasemann, M. S., Serup, P., Amit, I. & Porse, B. T., 17 Jul 2018, In : Cell Reports. 24, 3, p. 766-780 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    A new genetic tool to improve immune-compromised mouse models: Derivation and CRISPR/Cas9-mediated targeting of NRG embryonic stem cell lines

    Martin Gonzalez, J., Baudet, A., Abelechian, S., Bonderup, K., d'Altri, T., Porse, B., Brakebusch, C., Juliusson, G. & Cammenga, J., 16 Jul 2018, In : Genesis (New York, N.Y. : 2000). 56, 9, p. e23238

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin

    Reckzeh, K., Kizilkaya, H., Helbo, A. S., Alrich, M. E., Deslauriers, A. G., Grover, A., Rapin, N., Asmar, F., Grønbæk, K., Porse, B., Borregaard, N., Vestweber, D., Nerlov, C. & Theilgaard-Mönch, K., 10 Jul 2018, In : Blood advances. 2, 13, p. 1628-1632 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published
  12. Published

    Testosterone is an endogenous regulator of BAFF and splenic B cell number

    Wilhelmson, A. S., Lantero Rodriguez, M., Stubelius, A., Fogelstrand, P., Johansson, I., Buechler, M. B., Lianoglou, S., Kapoor, V. N., Johansson, M. E., Fagman, J. B., Duhlin, A., Tripathi, P., Camponeschi, A., Porse, B. T., Rolink, A. G., Nissbrandt, H., Turley, S. J., Carlsten, H., Mårtensson, I-L., Karlsson, M. C. I. & Tivesten, Å., 25 May 2018, In : Nature Communications. 9, 1, p. 2067

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    SinaPlot: An Enhanced Chart for Simple and Truthful Representation of Single Observations Over Multiple Classes

    Sidiropoulos, N., Sohi, S. H., Pedersen, T. L., Porse, B. T., Winther, O., Rapin, N. & Bagger, F. O., 17 May 2018, In : Journal of Computational and Graphical Statistics. p. 1-4 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2017
  15. Published

    EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

    Mohammad, F., Weissmann, S., Leblanc, B., Pandey, D. P., Højfeldt, J. W., Comet, I., Zheng, C., Johansen, J. V., Rapin, N., Porse, B. T., Tvardovskiy, A., Jensen, O. N., Olaciregui, N. G., Lavarino, C., Suñol, M., de Torres, C., Mora, J., Carcaboso, A. M. & Helin, K., Feb 2017, In : Nature Medicine. 23, 4, p. 483-492 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2016
  17. Published

    The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

    Stunnenberg, H. G., Hirst, M., International Human Epigenome Consortium,( Members:) & Porse, B. T., 17 Nov 2016, In : Cell. 167, 5, p. 1145-1149 5 p.

    Research output: Contribution to journalJournal articleResearch

  18. Published

    UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts

    Bao, J., Vitting-Seerup, K., Waage, J., Tang, C., Ge, Y., Porse, B. T. & Yan, W., May 2016, In : P L o S Genetics. 12, 5, p. e1005863

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Peak-valley-peak pattern of histone modifications delineates active regulatory elements and their directionality

    Pundir, S., Bagger, F. O., Lauridsen, F. K. B., Rapin, N. & Porse, B. T., 19 Apr 2016, In : Nucleic Acids Research. 44, 9, p. 4037-51

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    The presence of C/EBPα and its degradation are both required for TRIB2-mediated leukaemia

    O'Connor, C., Lohan, F., Campos, J., Ohlsson, E., Salomè, M., Forde, C., Artschwager, R., Liskamp, R. M., Cahill, M. R., Kiely, P. A., Porse, B. & Keeshan, K., 21 Mar 2016, In : Oncogene. 35, 40, p. 5272-5281

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4

    Di Stefano, B., Collombet, S., Jakobsen, J. S., Wierer, M., Sardina, J. L., Lackner, A., Stadhouders, R., Segura-Morales, C., Francesconi, M., Limone, F., Mann, M., Porse, B., Thieffry, D. & Graf, T., 14 Mar 2016, In : Nature Cell Biology. 18, 4, p. 371-81

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis

    Bagger, F. O., Sasivarevic, D., Sohi, S. H., Laursen, L., Pundir, S., Sønderby, C. K., Winther, O., Rapin, N. & Porse, B. T., 2016, In : Nucleic Acids Research. 44, D1, p. D917-D924

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The multifaceted functions of C/EBPα in normal and malignant hematopoiesis

    Ohlsson, E., Schuster, M. B., Hasemann, M. & Porse, B. T., 2016, In : Leukemia. 30, p. 767-775

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2015
  25. Published

    Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

    Paul, F., Arkin, Y., Giladi, A., Jaitin, D. A., Kenigsberg, E., Keren-Shaul, H., Winter, D., Lara-Astiaso, D., Gury, M., Weiner, A., David, E., Cohen, N., Lauridsen, F. K. B., Haas, S., Schlitzer, A., Mildner, A., Ginhoux, F., Jung, S., Trumpp, A., Porse, B. T., Tanay, A. & Amit, I., 17 Dec 2015, In : Cell. 163, 7, p. 1663-77

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published
  27. Published

    Disease evolution and outcomes in familial AML with germline CEBPA mutations

    Tawana, K., Wang, J., Renneville, A., Bödör, C., Hills, R., Loveday, C., Savic, A., Van Delft, F. W., Treleaven, J., Georgiades, P., Uglow, E., Asou, N., Uike, N., Debeljak, M., Jazbec, J., Ancliff, P., Gale, R., Thomas, X., Mialou, V., Döhner, K., Bullinger, L., Mueller, B., Pabst, T., Stelljes, M., Schlegelberger, B., Wozniak, E., Iqbal, S., Okosun, J., Araf, S., Frank, A-K., Lauridsen, F. B., Porse, B., Nerlov, C., Owen, C., Dokal, I., Gribben, J., Smith, M., Preudhomme, C., Chelala, C., Cavenagh, J. & Fitzgibbon, J., 3 Sep 2015, In : Blood. 126, 10, p. 1214-1223

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

    Rasmussen, K. D., Jia, G., Johansen, J. V., Pedersen, M. T., Rapin, N., Bagger, F. O., Porse, B. T., Bernard, O. A., Christensen, J. & Helin, K., 1 May 2015, In : Genes & Development. 29, 9, p. 910-22 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq

    Jakobsen, J. S., Bagger, F. O., Hasemann, M. S., Schuster, M. B., Frank, A-K., Waage, J., Vitting-Seerup, K. & Porse, B. T., 5 Feb 2015, In : B M C Genomics. 16, 1, p. 46

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    The liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: A critical role for IL-6/STAT3

    Xu, M-J., Feng, D., Wu, H., Wang, H., Chan, Y., Kolls, J., Borregaard, N., Porse, B., Berger, T., Mak, T. W., Cowland, J. B., Kong, X. & Gao, B., Feb 2015, In : Hepatology (Baltimore, Md.). 62, 2, p. 692-702

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome

    Bao, J., Tang, C., Yuan, S., Porse, B. T. & Yan, W., 15 Jan 2015, In : Development. 142, 2, p. 352-62 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Cellular origin of prognostic chromosomal aberrations in AML patients

    Mora-Jensen, H., Jendholm, J., Rapin, N., Andersen, M. K., Roug, A. S., Bagger, F. O., Bullinger, L., Winther, O., Borregaard, N., Porse, B. T. & Theilgaard-Mönch, K., 2015, In : Leukemia. 29, 8, p. 1785-1789

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia

    Willer, A., Jakobsen, J. S., Ohlsson, E., Rapin, N., Waage, J., Billing, M., Bullinger, L., Karlsson, S. & Porse, B. T., 2015, In : Leukemia. 29, p. 1018-1031

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2014
  35. Published

    Oncogenic fusion proteins expressed in immature hematopoietic cells fail to recapitulate the transcriptional changes observed in human AML

    Rapin, N. & Porse, B. T., 16 Jun 2014, In : Oncogenesis. 3, p. e106

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    spliceR: an R package for classification of alternative splicing and prediction of coding potential from RNA-seq data

    Vitting-Seerup, K., Porse, B. T., Sandelin, A. G. & Waage, J., 23 Mar 2014, In : B M C Bioinformatics. 15, 1, p. 81

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Regulation of Trib2 by an E2F1-C/EBPalpha feedback loop in AML cell proliferation

    Rishi, L., Hannon, M., Salomè, M., Hasemann, M., Frank, A. K., Campos, J., Timoney, J., O'Connor, C., Cahill, M. R., Porse, B. & Keeshan, K., 10 Feb 2014, In : Blood. 123, 15, p. 2389-400

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    shRNA screening identifies JMJD1C as being required for leukemia maintenance

    Sroczynska, P. A., Cruickshank, V. A. L., Bukowski, J-P., Miyagi, S., Bagger, F. O., Walfridsson, J., Schuster, M. B., Porse, B. & Helin, K., 5 Feb 2014, In : Blood. 123, 12, p. 1870-82

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Integrative analysis of histone ChIP-seq and transcription data using Bayesian mixture models

    Klein, H-U., Schäfer, M., Porse, B. T., Hasemann, M. S., Ickstadt, K. & Dugas, M., 22 Jan 2014, In : Bioinformatics. 30, 8, p. 1154-62

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Initiation of MLL-rearranged AML is dependent on C/EBPα

    Ohlsson, E., Hasemann, M. S., Willer, A., Lauridsen, F. K. B., Rapin, N., Jendholm, J. & Porse, B. T., 13 Jan 2014, In : Journal of Experimental Medicine. 211, 1, p. 5-13

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published
  42. Published
  43. Published

    Comparing cancer vs. normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients

    Rapin, N., Bagger, F. O., Jendholm, J., Mora-Jensen, H., Krogh, A., Kohlmann, A., Thiede, C., Borregaard, N., Bullinger, L., Winther, O., Theilgaard-Mönch, K. & Porse, B. T., 2014, In : Blood. 123, 6, p. 894-904

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    The functional consequences of intron retention: Alternative splicing coupled to NMD as a regulator of gene expression

    Ge, Y. & Porse, B. T., 2014, In : BioEssays. 36, 3, p. 236-43

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2013
  46. Published

    microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

    Leucci, E., Patella, F., Waage, J., Holmstrøm, K., Lindow, M., Porse, B., Kauppinen, M. S. & Lund, A. H., 29 Aug 2013, In : Scientific Reports. 3, p. 2535

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells

    Thoren, L. A., Fog, C. K., Jensen, K. T., Buza-Vidas, N., Côme, C. R. M., Lund, A. H. & Porse, B. T., 9 Aug 2013, In : Stem Cell Research. 11, 3, p. 1129-1136 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published
  49. Published

    Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay

    Colak, D., Ji, S-J., Porse, B. T. & Jaffrey, S. R., 6 Jun 2013, In : Cell. 153, 6, p. 1252-65 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published
  51. Published

    HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

    Bagger, F. O., Rapin, N., Theilgaard-Mönch, K., Kaczkowski, B., Thoren, L. A., Jendholm, J., Winther, O. & Porse, B. T., 2013, In : Nucleic Acids Research. 41, Database issue, p. D1034-9

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. 2012
  53. Published

    Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML

    Treppendahl, M. B., Qiu, X., Søgaard, A., Yang, X., Nandrup-Bus, C., Hother, C., Andersen, M. K., Kjeldsen, L., Möllgaard, L., Hellström-Lindberg, E., Jendholm, J., Porse, B. T., Jones, P. A., Liang, G. & Grønbæk, K., 2012, In : Blood. 119, 1, p. 206-16 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    BLUEPRINT to decode the epigenetic signature written in blood

    Adams, D., Altucci, L., Antonarakis, S. E., Ballesteros, J., Beck, S., Bird, A., Bock, C., Boehm, B., Campo, E., Caricasole, A., Dahl, F., Dermitzakis, E. T., Enver, T., Esteller, M., Estivill, X., Ferguson-Smith, A., Fitzgibbon, J., Flicek, P., Giehl, C., Graf, T., Grosveld, F., Guigo, R., Gut, I., Helin, K., Jarvius, J., Küppers, R., Lehrach, H., Lengauer, T., Lernmark, Å., Leslie, D., Loeffler, M., Macintyre, E., Mai, A., Martens, J. H. A., Minucci, S., Ouwehand, W. H., Pelicci, P. G., Pendeville, H., Porse, B., Rakyan, V., Reik, W., Schrappe, M., Schübeler, D., Seifert, M., Siebert, R., Simmons, D., Soranzo, N., Spicuglia, S., Stratton, M., Stunnenberg, H. G., Tanay, A., Torrents, D., Valencia, A., Vellenga, E., Vingron, M., Walter, J. & Willcocks, S., 2012, In : Nature Biotechnology. 30, 3, p. 224-6 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    HemaExplorer: a Web server for easy and fast visualization of gene expression in normal and malignant hematopoiesis

    Bagger, F. O., Rapin, N., Theilgaard-Mönch, K., Kaczkowski, B., Jendholm, J., Winther, O. & Porse, B., 2012, In : Blood. 119, 26, p. 6394-5 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

    Weischenfeldt, J., Waage, J., Tian, G., Zhao, J., Damgaard, I., Jakobsen, J. S., Kristiansen, K., Krogh, A. S., Wang, J. & Porse, B. T., 2012, In : Genome Biology (Online Edition). 13, 5, p. R35

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency

    Hasemann, M. S., Schuster, M. B., Frank, A-K., Theilgaard-Mönch, K., Pedersen, T., Nerlov, C. & Porse, B. T., 2012, In : P L o S One. 7, 6, p. e38841

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2

    Zheng, S., Gray, E. E., Chawla, G., Porse, B. T., O'Dell, T. J. & Black, D. L., 2012, In : Nature Neuroscience. 15, 3, p. 381-8, S1

    Research output: Contribution to journalJournal articleResearchpeer-review

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