FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

Ahluwalia, T. S., Eliasen, A. U., Sevelsted, A., Pedersen, C-E. T., Stokholm, J., Chawes, B., Bork-Jensen, J., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Sharma, A., Weiss, S. T., Evans, M. D., Jackson, D. J., Morin, A., Krogfelt, K. A., Schjørring, S., Mortensen, P. B., Hougaard, D. M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Mors, O., Nordentoft, M., Børglum, A. D., Werge, T., Agerbo, E., Gern, J. E., Lemanske, R. F., Ober, C., Pedersen, A. G., Bisgaard, H. & Bønnelykke, K., 16 Dec 2020, In : Nature Communications. 11, 1, p. 6398

Research output: Contribution to journal › Journal article › Research › peer-review

Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial

Hjelmsø, M. H., Shah, S. A., Thorsen, J., Rasmussen, M., Vestergaard, G., Mortensen, M. S., Brejnrod, A., Brix, S., Chawes, B., Bønnelykke, K., Sørensen, S. J., Stokholm, J. & Bisgaard, H., 1 Dec 2020, In : Nature Communications. 11, 1, p. 426 426.

Research output: Contribution to journal › Journal article › Research › peer-review

Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age

Morin, A., McKennan, C. G., Pedersen, C-E. T., Stokholm, J., Chawes, B. L., Malby Schoos, A-M., Naughton, K. A., Thorsen, J., Mortensen, M. S., Vercelli, D., Trivedi, U., Sørensen, S. J., Bisgaard, H., Nicolae, D. L., Bønnelykke, K. & Ober, C., Dec 2020, In : The Journal of allergy and clinical immunology. 146, 6, p. 1358-1366 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

Stokholm, J., Thorsen, J., Blaser, M. J., Rasmussen, M. A., Hjelmsø, M., Shah, S., Christensen, E. D., Chawes, B. L., Bønnelykke, K., Brix, S., Mortensen, M. S., Brejnrod, A., Vestergaard, G., Trivedi, U., Sørensen, S. J. & Bisgaard, H., 11 Nov 2020, In : Science translational medicine. 12, 569, p. aax9929 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Airway immune mediator levels during asthma-like symptoms in young children and their possible role in response to azithromycin

Carlsson, C. J., Rasmussen, M. A., Pedersen, S. B., Wang, N., Stokholm, J., Chawes, B. L., Bønnelykke, K. & Bisgaard, H., 4 Nov 2020, In : Allergy.

Research output: Contribution to journal › Journal article › Research › peer-review

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Vogelezang, S., Bradfield, J. P., Ahluwalia, T. S., Curtin, J. A., Lakka, T. A., Grarup, N., Scholz, M., van der Most, P. J., Monnereau, C., Stergiakouli, E., Heiskala, A., Horikoshi, M., Fedko, I. O., Vilor-Tejedor, N., Cousminer, D. L., Standl, M., Wang, C. A., Viikari, J., Geller, F., Íñiguez, C., Pitkänen, N., Chesi, A., Bacelis, J., Yengo, L., Torrent, M., Ntalla, I., Helgeland, Ø., Selzam, S., Vonk, J. M., Zafarmand, M. H., Heude, B., Farooqi, I. S., Alyass, A., Beaumont, R. N., Have, C. T., Rzehak, P., Bilbao, J. R., Schnurr, T. M., Barroso, I., Bønnelykke, K., Chawes, B., Hansen, T., Michaelsen, K. F., Morgen, C. S., Nielsen, T. R. H., Stokholm, J., Vinding, R. K., Sørensen, T. I. A., Holm, J-C., Bisgaard, H. & Early Growth Genetics Consortium, 12 Oct 2020, In : P L o S Genetics. 16, 10, p. e1008718 e1008718.

Research output: Contribution to journal › Journal article › Research › peer-review

Allergen Specificity in Specific IgE Cutoff

Schoos, A-M. M., Hansen, S. M., Skov, F. R., Stokholm, J., Bønnelykke, K., Bisgaard, H. & Chawes, B. L., 1 Oct 2020, In : JAMA Pediatrics. 174, 10, p. 993-995 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Association between childhood asthma and attention deficit hyperactivity or autism spectrum disorders: A systematic review with meta-analysis

Kaas, T. H., Vinding, R. K., Stokholm, J., Bønnelykke, K., Bisgaard, H. & Chawes, B. L., 30 Sep 2020, In : Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Research output: Contribution to journal › Journal article › Research › peer-review

Symptom burden of atopic dermatitis in early childhood assessed from daily monitoring of symptoms and topical steroid usage

Ruge, I. F., Thorsteinsdóttir, S., Nørgaard, S., Chawes, B. L., Bønnelykke, K., Stokholm, J. & Bisgaard, H., 17 Sep 2020, In : Journal of the American Academy of Dermatology.

Research output: Contribution to journal › Journal article › Research › peer-review

Delayed Motor Milestones Achievement in Infancy Associates with Perturbations of Amino Acids and Lipid Metabolic Pathways

Vinding, R. K., Rago, D., Kelly, R. S., Gürdeniz, G., Rasmussen, M. A., Stokholm, J., Bønnelykke, K., Litonjua, A. A., Weiss, S. T., Lasky-Su, J., Bisgaard, H. & Chawes, B. L., 19 Aug 2020, In : Metabolites. 10, 9, 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Maternal High-Dose Vitamin D Supplementation and Offspring Bone Mineralization Until Age 6 Years-Reply

Brustad, N., Bisgaard, H. & Chawes, B. L., 10 Aug 2020, In : JAMA Pediatrics.

Research output: Contribution to journal › Journal article › Research › peer-review

Early life bacterial airway colonization, local immune mediator response and risk of otitis media

Christensen, E. D., Thorsen, J., Stokholm, J., Pedersen, T. M., Brix, S., Krogfelt, K. A., Schjørring, S., Chawes, B., Bønnelykke, K., Bisgaard, H. & Rasmussen, M. A., Aug 2020, In : Journal of Medical Microbiology. 69, 8, p. 1124-1131 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Parent-specific effects on risk of developing allergic sensitization and asthma in childhood

Schoos, A-M. M., Hansen, B. R., Stokholm, J., Chawes, B. L., Bønnelykke, K. & Bisgaard, H., Aug 2020, In : Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 50, 8, p. 915-921 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Asthma-like Symptoms in Young Children Increase the Risk of COPD

Bisgaard, H., Nørgaard, S., Sevelsted, A., Chawes, B., Stokholm, J., Mortensen, E. L., Ulrik, C. S. & Bønnelykke, K., 11 Jun 2020, In : The Journal of allergy and clinical immunology.

Research output: Contribution to journal › Journal article › Research › peer-review

Season of Birth Impacts the Neonatal Nasopharyngeal Microbiota

Schoos, A-M. M., Kragh, M., Ahrens, P., Kuhn, K. G., Rasmussen, M. A., Chawes, B. L., Jensen, J. S., Brix, S., Bisgaard, H. & Stokholm, J., 11 May 2020, In : Children (Basel, Switzerland). 7, 5, 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial

Brustad, N., Garland, J., Thorsen, J., Sevelsted, A., Krakauer, M., Vinding, R. K., Stokholm, J., Bønnelykke, K., Bisgaard, H. & Chawes, B. L., 1 May 2020, In : JAMA Pediatrics. 174, 5, p. 419-427 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Plasma 25-Hydroxyvitamin D Concentrations are Associated with Polyunsaturated Fatty Acid Metabolites in Young Children: Results from the Vitamin D Antenatal Asthma Reduction Trial

Huang, M., Kelly, R. S., Kachroo, P., Chu, S. H., Lee-Sarwar, K., Chawes, B. L., Bisgaard, H., Litonjua, A. A., Weiss, S. T. & Lasky-Su, J., 14 Apr 2020, In : Metabolites. 10, 4, p. E151 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Distinct immune phenotypes in infants developing asthma during childhood

Thysen, A. H., Waage, J., Larsen, J. M., Rasmussen, M. A., Stokholm, J., Chawes, B., Fink, N. R., Pedersen, T. M., Wolsk, H., Thorsteinsdottir, S., Litman, T., Renz, H., Bønnelykke, K., Bisgaard, H. & Brix, S., 5 Feb 2020, In : Science translational medicine. 12, 529

Research output: Contribution to journal › Journal article › Research › peer-review

Fish oil supplementation during pregnancy is protective against asthma/wheeze in offspring

Kachroo, P., Kelly, R. S., Mirzakhani, H., Lee-Sarwar, K., Chawes, B. L., Blighe, K., Davaasambuu, G., Bisgaard, H., Litonjua, A. A., Weiss, S. T. & Lasky-Su, J., 1 Jan 2020, In : The journal of allergy and clinical immunology. In practice. 8, 1, p. 388-391.e2

Research output: Contribution to journal › Journal article › Research › peer-review

Children with Asthma have Fixed Airway Obstruction through Childhood Unaffected by Exacerbations

Hallas, H. W., Chawes, B. L. K., Arianto, L., Rasmussen, M. A., Kunøe, A., Stokholm, J., Bønnelykke, K. & Bisgaard, H., 2020, In : The journal of allergy and clinical immunology. In practice. 8, 4, p. 1263-1271.e3

Research output: Contribution to journal › Journal article › Research › peer-review

Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

Thyssen, J. P., Ahluwalia, T. S., Paternoster, L., Ballardini, N., Bergström, A., Melén, E., Chawes, B., Stokholm, J., Hourihane, J. OB., O'Sullivan, D. M., Bager, P., Maelbye, M., Bustamante, M., Torrent, M., Esplugues, A., Duijts, L., Hu, C., Elbert, N. J., Pasmans, S. G. M. A., Nijsten, T. E. C., von Berg, A., Standl, M., Schikowski, T., Herberth, G., Heinrich, J., Lee, Y-A., Marenholz, I., Lau, S., Curtin, J. A., Simpson, A., Custovic, A., Pennell, C. E., Wang, C. A., Holt, P. G., Bisgaard, H. & Bønnelykke, K., 26 Dec 2019, In : Allergy.

Research output: Contribution to journal › Journal article › Research › peer-review

Children Monosensitized to Can f 5 Show Different Reactions to Male and Female Dog Allergen Extract Provocation: A Randomized Controlled Trial

Schoos, A-M. M., Chawes, B. L., Bloch, J., Hansen, B., Stokholm, J., Bønnelykke, K., Kristensen, B. & Bisgaard, H., 19 Dec 2019, In : The journal of allergy and clinical immunology. In practice.

Research output: Contribution to journal › Journal article › Research › peer-review

Antibiotic exposure in infancy and development of BMI and body composition in childhood

Sejersen, T. S., Vinding, R. K., Stokholm, J., Chawes, B., Bønnelykke, K., Krakauer, M. & Bisgaard, H., 1 Dec 2019, In : EClinicalMedicine. 17, 100209.

Research output: Contribution to journal › Journal article › Research › peer-review

Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children with asthma

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 2019, In : Chest. 156, 6, p. 1068-1079 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Infant airway microbiota and topical immune perturbations in the origins of childhood asthma

Thorsen, J., Rasmussen, M. A., Waage, J., Mortensen, M., Brejnrod, A., Bønnelykke, K., Chawes, B. L., Brix, S., Sørensen, S. J., Stokholm, J. & Bisgaard, H., 1 Nov 2019, In : Nature Communications. 10, 1, p. 5001 8 p., 5001.

Research output: Contribution to journal › Journal article › Research › peer-review

Single and multiple time-point allergic sensitization during childhood and risk of asthma by age 13

Schoos, A-M. M., Jelding-Dannemand, E., Stokholm, J., Bønnelykke, K., Bisgaard, H. & Chawes, B. L., Nov 2019, In : Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 30, 7, p. 716-723 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Environmental and Genetic Determinants of Serum 25(OH)-Vitamin D Levels during Pregnancy and Early Childhood

Schoos, A-M. M., Vinther, C., Nørgaard, S., Brustad, N., Stokholm, J., Bønnelykke, K., Bisgaard, H. & Chawes, B. L., 21 Oct 2019, In : Children (Basel, Switzerland). 6, 10, 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring: A 6-Year Follow-up of a Randomized Clinical Trial

Nørrisgaard, P. E., Haubek, D., Kühnisch, J., Chawes, B. L., Stokholm, J., Bønnelykke, K. & Bisgaard, H., 1 Oct 2019, In : JAMA Pediatrics. 173, 10, p. 924-930 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The Role of the 17q21 Genotype in the Prevention of Early Childhood Asthma and Recurrent Wheeze by Vitamin D

Kelly, R. S., Chawes, B. L., Guo, F., Zhang, L., Blighe, K., Litonjua, A. A., Raby, B. A., Levy, B. D., Rago, D., Stokholm, J., Bønnelykke, K., Bisgaard, H., Zhou, X., Lasky-Su, J. A. & Weiss, S. T., 1 Oct 2019, In : The European Respiratory Journal. 54, 4

Research output: Contribution to journal › Journal article › Research › peer-review

Neonatal Urine Metabolic Profiling and Development of Childhood Asthma

Chawes, B. L., Giordano, G., Pirillo, P., Rago, D., Rasmussen, M. A., Stokholm, J., Bønnelykke, K., Bisgaard, H. & Baraldi, E., 16 Sep 2019, In : Metabolites. 9, 9, p. 1-16 16 p., 185.

Research output: Contribution to journal › Journal article › Research › peer-review

Determinants of Neurodevelopment in Early Childhood - Results from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010 ) Mother-Child Cohort

Bjarnadóttir, E., Stokholm, J., Chawes, B., Thorsen, J., Moïra, D., Deleuran, M., Bønnelykke, K., Lauritzen, L. & Bisgaard, H., Sep 2019, In : Acta paediatrica. 108, 9, p. 1632-1641 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Fish-oil supplementation in pregnancy, child metabolomics and asthma risk

Rago, D., Rasmussen, M. A., Lee-Sarwar, K. A., Weiss, S. T., Lasky-Su, J., Stokholm, J., Bønnelykke, K., Chawes, B. L. & Bisgaard, H., Aug 2019, In : EBioMedicine. 46, p. 399-410 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Sensitivity of Multiple Breath Washout to Detect Mild to Moderate Asthma in Adolescence

Arianto, L., Hallas, H. W., Stokholm, J., Bønnelykke, K., Bisgaard, H. & Chawes, B. L., Jul 2019, In : The journal of allergy and clinical immunology. In practice. 7, 6, p. 2052-2054 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Reduced IL-2 response from peripheral blood mononuclear cells exposed to bacteria at 6 months of age is associated with elevated total-IgE and allergic rhinitis during the first 7 years of life

Wang, N., Schoos, A-M. M., Larsen, J. M., Brix, S., Thysen, A. H., Rasmussen, M. A., Stokholm, J., Bønnelykke, K., Bisgaard, H. & Chawes, B. L., 1 May 2019, In : EBioMedicine. 43, p. 587-593 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

EGG Consortium, May 2019, In : Nature Genetics. 51, 5, p. 804-814 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Multiple Breath Washout for Diagnosing Asthma and Persistent Wheeze in Young Children

Arianto, L., Hallas, H., Stokholm, J., Bønnelykke, K., Bisgaard, H. & Chawes, B. L., May 2019, In : Annals of the American Thoracic Society. 16, 5, p. 599-605 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Fish Oil Supplementation in Pregnancy Increases Gestational Age, Size for Gestational Age, and Birth Weight in Infants: A Randomized Controlled Trial

Vinding, R. K., Stokholm, J., Sevelsted, A., Chawes, B. L., Bønnelykke, K., Barman, M., Jacobsson, B. & Bisgaard, H., Apr 2019, In : The Journal of Nutrition. 149, 4, p. 628-634 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years

Brustad, N., Eliasen, A. U., Stokholm, J., Bønnelykke, K., Bisgaard, H. & Chawes, B. L., 12 Mar 2019, In : JAMA - Journal of the American Medical Association. 321, 10, p. 1003-1005 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Levels of Systemic Low-grade Inflammation in Pregnant Mothers and Their Offspring are Correlated

Fink, N. R., Chawes, B., Bønnelykke, K., Thorsen, J., Stokholm, J., Rasmussen, M. A., Brix, S. & Bisgaard, H., 28 Feb 2019, In : Scientific Reports. 9, 1, p. 3043 3043.

Research output: Contribution to journal › Journal article › Research › peer-review

Optimal timing of influenza vaccine during pregnancy: A systematic review and meta-analysis

Cuningham, W., Geard, N., Fielding, J. E., Braat, S., Madhi, S. A., Nunes, M. C., Christian, L. M., Lin, S-Y., Lee, C-N., Yamaguchi, K., Bisgaard, H., Chawes, B., Chao, A-S., Blanchard-Rohner, G., Schlaudecker, E. P., Fisher, B. M., McVernon, J. & Moss, R., 1 Jan 2019, In : Influenza and other Respiratory Viruses. 13, 5, p. 438-452 15 p.

Research output: Contribution to journal › Review › Research › peer-review

Airway obstruction and bronchial reactivity from age 1 month until 13 years in children with asthma: A prospective birth cohort study

Hallas, H. W., Chawes, B. L., Rasmussen, M. A., Arianto, L., Stokholm, J., Bønnelykke, K. & Bisgaard, H., Jan 2019, In : PLOS Medicine. 16, 1, p. e1002722

Research output: Contribution to journal › Journal article › Research › peer-review

Genetic, Clinical, and Environmental Factors Associated With Persistent Atopic Dermatitis in Childhood

Thorsteinsdottir, S., Stokholm, J., Thyssen, J. P., Nørgaard, S., Thorsen, J., Chawes, B. L., Bønnelykke, K., Waage, J. & Bisgaard, H., Jan 2019, In : JAMA Dermatology. 155, 1, p. 50-57 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Limited clinical value of exhaled volatile organic compound measurements in childhood asthma

Fuglsbjerg, M. G., Rasmussen, M. A., Hansen, K. S., Smolinska, A., Dallinga, J. W., van Schooten, F-J., Stokholm, J., Bønnelykke, K., Bisgaard, H. & Chawes, B. L., Oct 2018, In : ERJ Open Research. 4, 4

Research output: Contribution to journal › Journal article › Research › peer-review

Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years: randomised clinical trial

Vinding, R. K., Stokholm, J., Sevelsted, A., Sejersen, T., Chawes, B. L., Bønnelykke, K., Thorsen, J., Howe, L. D., Krakauer, M. & Bisgaard, H., 4 Sep 2018, In : BMJ. 362, p. k3312

Research output: Contribution to journal › Journal article › Research › peer-review

Gene editing in the context of an increasingly complex genome

Blighe, K., DeDionisio, L., Christie, K. A., Chawes, B., Shareef, S., Kakouli-Duarte, T., Chao-Shern, C., Harding, V., Kelly, R. S., Castellano, L., Stebbing, J., Lasky-Su, J. A., Nesbit, M. A. & Moore, C. B. T., 8 Aug 2018, In : BMC Genomics. 19, 1, p. 595

Research output: Contribution to journal › Review › Research › peer-review

An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma

Kelly, R. S., Chawes, B. L., Blighe, K., Virkud, Y. V., Croteau-Chonka, D. C., McGeachie, M. J., Clish, C. B., Bullock, K., Celedón, J. C., Weiss, S. T. & Lasky-Su, J. A., Aug 2018, In : Chest. 154, 2, p. 335-348 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Prenatal Vitamin D Supplementation to Improve Health in Offspring

Chawes, B., Bønnelykke, K. & Bisgaard, H., 1 Jul 2018, In : JAMA Pediatrics. 172, 7, p. 617-618 2 p.

Research output: Contribution to journal › Journal article › Research › peer-review

NKG2D gene variation and susceptibility to viral bronchiolitis in childhood

Pasanen, A., Karjalainen, M. K., Kummola, L., Waage, J., Bønnelykke, K., Ruotsalainen, M., Piippo-Savolainen, E., Goksör, E., Nuolivirta, K., Chawes, B., Vissing, N., Bisgaard, H., Jartti, T., Wennergren, G., Junttila, I., Hallman, M., Korppi, M. & Rämet, M., 9 Jun 2018, In : Pediatric Research. 84, p. 451-457 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Epidemiology and Risk Factors of Infection in Early Childhood

Vissing, N. H., Chawes, B. L., Rasmussen, M. A. & Bisgaard, H., Jun 2018, In : Pediatrics. 141, 6, p. e:20170933 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Cat exposure in early life decreases asthma risk from the 17q21 high-risk variant

Stokholm, J., Chawes, B. L., Vissing, N., Bønnelykke, K. & Bisgaard, H., May 2018, In : The Journal of allergy and clinical immunology. 141, 5, p. 1598-1606 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review