Research output per year
Research output per year
Personal profile
Expertises
Childhood acute lymphoblastic leukemia; Treatment related toxicities: Bioinformatics; Asparaginase-associated pancreatitis.
Main research areas
Childhood acute lymphoblastic leukemia; Treatment related toxicities: Bioinformatics; Asparaginase-associated pancreatitis.
Current research
Currently I am working on an international study on asparaginase-associated pancreatitis (AAP). We have collected data on the largest number of patients ever, and will document new data on AAP at diagnosis, risk of complications and risk of re-exposing AAP patients to asparaginase.
Furthermore, we will explore host genome variants associated to developing AAP during ALL therapy. This will be done in collaboration with Chirag Patel's group at Harvard, Department of Bioinformatics.
Potential conflicts of interest
None
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia: phenotypes, risk factors and genotypes
Anastasopoulou, S., Nielsen, R. L., Als-Nielsen, B., Banerjee, J., Eriksson, M. A., Helenius, M., Heyman, M. M., Johannsdottir, I. M., Jonsson, O. G., MacGregor, S., Mateos, M. K., Mayoh, C., Mikkel, S., Myrberg, I. H., Niinimäki, R., Schmiegelow, K., Taskinen, M., Vaitkeviciene, G., Warnqvist, A., Wolthers, B., & 2 others, 1 Oct 2022, In: Haematologica. 107, 10, p. 2318-2328 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Asparaginase Enzyme Activity Levels and Toxicity in Childhood Acute Lymphoblastic Leukemia: a NOPHO ALL2008 study
Lynggaard, L. S., Rank, C. U., Hansen, S. N., Gottschalk Højfeldt, S., Henriksen, L. T., Jarvis, K. B., Ranta, S., Niinimäki, R., Harila-Saari, A., Wolthers, B. O., Frandsen, T. L., Heyman, M., Schmiegelow, K. & Albertsen, B. K., 11 Jan 2022, In: Blood advances. 6, 1, p. 138-147 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Can Machine Learning Models Predict Asparaginase-associated Pancreatitis in Childhood Acute Lymphoblastic Leukemia
Nielsen, R. L., Wolthers, B. O., Helenius, M., Albertsen, B. K., Clemmensen, L., Nielsen, K., Kanerva, J., Niinimäki, R., Frandsen, T. L., Attarbaschi, A., Barzilai, S., Colombini, A., Escherich, G., Aytan-Aktug, D., Liu, H-C., Möricke, A., Samarasinghe, S., van der Sluis, I. M., Stanulla, M., Tulstrup, M., & 4 others, 1 Apr 2022, In: Journal of Pediatric Hematology/Oncology. 44, 3, p. e628-e636 9 p., 0000000000002292.Research output: Contribution to journal › Journal article › Research › peer-review
2 Citations (Scopus) -
Acute liver failure in a four-year old girl during maintenance therapy of acute lymphoblastic leukemia
Raja, R. A., Wolthers, B. O., Frandsen, T. L., Albertsen, B. K., Nielsen, A. S., Damholt, M. B., Schmiegelow, K. & Jørgensen, M. H., Oct 2021, In: Pediatric Hematology and Oncology. 38, 7, p. 669-675 7 p.Research output: Contribution to journal › Letter › peer-review
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Impact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository
Saito, T., Wei, Y., Wen, L., Srinivasan, C., Wolthers, B. O., Tsai, C-Y., Harris, M. H., Stevenson, K., Byersdorfer, C., Oparaji, J-A., Fernandez, C., Mukherjee, A., Abu-El-Haija, M., Agnihotri, S., Schmiegelow, K., Showalter, M. R., Fogle, P. W., McCulloch, S., Contrepois, K., Silverman, L. B., & 2 others, 27 Jun 2021, In: Metabolomics : Official journal of the Metabolomic Society. 17, 7, p. 64 64.Research output: Contribution to journal › Journal article › Research › peer-review