Research output per year
Research output per year
Personal profile
Expertises
FACS analysis of hematopoietic cells in bonemarrow, spleen or blood.
in vitro and in vivo assays used to study selfrenewal and differentiation potential of hematopoietic cells.
Animal models of leukemia.
Main research areas
Our main research interest is the hematopoietic stem cells in both normal and malignant settings and the factors governing the them.
Current research
We are currently trying to indentify novel regulators of normal hematopoietic stem cells and their malignant counterparts in leukemia.
Fingerprint
Dive into the research topics where Anne-Katrine Frank is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Engineering human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia, and solid tumor metastasis
Grigoryan, A., Zacharaki, D., Balhuizen, A., Côme, C. R., Garcia, A. G., Hidalgo Gil, D., Frank, A-K., Aaltonen, K., Mañas, A., Esfandyari, J., Kjellman, P., Englund, E., Rodriguez, C., Sime, W., Massoumi, R., Kalantari, N., Prithiviraj, S., Li, Y., Dupard, S. J., Isaksson, H., & 4 others, 12 Oct 2022, In: Science translational medicine. 14, 666, p. eabm6391 eabm6391.Research output: Contribution to journal › Journal article › Research › peer-review
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PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents
Rehn, M., Wenzel, A., Frank, A-K., Schuster, M. B., Pundhir, S., Jørgensen, N., Vitting-Seerup, K., Ge, Y., Jendholm, J., Michaut, M., Schoof, E. M., Jensen, T. L., Rapin, N., Sapio, R. T., Andersen, K. L., Lund, A. H., Solimena, M., Holzenberger, M., Pestov, D. G. & Porse, B. T., 10 May 2022, In: Cell reports. 39, 6, p. 110793 110793.Research output: Contribution to journal › Journal article › Research › peer-review
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ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation
Knudsen, K. J., Rehn, M. C., Hasemann, M. S., Rapin, N., Bagger, F. O., Ohlsson, E., Willer, A., Frank, A. K., Søndergaard, E., Jendholm, J., Thorén, L., Lee, J., Rak, J., Theilgaard-Mönch, K. & Porse, B. T., 15 Sep 2015, In: Genes & Development. 29, 18, p. 1915-29 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
55 Citations (Scopus) -
The role of JARID2 in normal and malignant hematopoiesis: The PRC2 component JARID2 is dispensable for hematopoietic stem cells but critical for the maintenance of leukemic stem cells
Frank, A. K., 7 Apr 2015, 123 p.Research output: Book/Report › Ph.D. thesis
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Regulation of Trib2 by an E2F1-C/EBPalpha feedback loop in AML cell proliferation
Rishi, L., Hannon, M., Salomè, M., Hasemann, M., Frank, A. K., Campos, J., Timoney, J., O'Connor, C., Cahill, M. R., Porse, B. & Keeshan, K., 10 Feb 2014, In: Blood. 123, 15, p. 2389-400Research output: Contribution to journal › Journal article › Research › peer-review
41 Citations (Scopus)