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The Capital Region of Denmark - a part of Copenhagen University Hospital
  1. 2019
  2. E-pub ahead of print

    Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome

    McElreavey, K., Jorgensen, A., Eozenou, C., Merel, T., Bignon-Topalovic, J., Tan, D. S., Houzelstein, D., Buonocore, F., Warr, N., Kay, R. G. G., Peycelon, M., Siffroi, J-P., Mazen, I., Achermann, J. C., Shcherbak, Y., Leger, J., Sallai, A., Carel, J-C., Martinerie, L., Le Ru, R., Conway, G. S., Mignot, B., Van Maldergem, L., Bertalan, R., Globa, E., Brauner, R., Jauch, R., Nef, S., Greenfield, A. & Bashamboo, A., 24 Jul 2019, In : Genetics in medicine : official journal of the American College of Medical Genetics.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing

    Gannon, A-L., O'Hara, L., Mason, J. I., Jørgensen, A., Frederiksen, H., Milne, L., Smith, S., Mitchell, R. T. & Smith, L. B., 18 Jul 2019, In : Scientific Reports. 9, 1, p. 10457

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. E-pub ahead of print

    Response to Letter: "Clinical but not histological outcomes in males with 45,X/46,XY mosaicism vary depending on reason for diagnosis"

    Ljubicic, M. L., Jørgensen, A., Ribeiro de Andrade, J. G., Balsamo, A., Bertelloni, S., Cools, M., Cuccaro, R. T., Darendeliler, F., Flück, C. E., Grinspon, R. P., Maciel-Guerra, A., Guran, T., Hannema, S. E., Lucas-Herald, A. K., Hiort, O., Holterhus, P. M., Lichiardopol, C., Looijenga, L. H. J., Ortolano, R., Riedl, S., Ahmed, S. F. & Juul, A., 5 Jul 2019, In : The Journal of clinical endocrinology and metabolism.

    Research output: Contribution to journalComment/debateResearch

  5. E-pub ahead of print

    Tracing the origin of adult intestinal stem cells

    Guiu, J., Hannezo, E., Yui, S., Demharter, S., Ulyanchenko, S., Maimets, M., Jørgensen, A., Perlman, S., Lundvall, L., Mamsen, L. S., Larsen, A., Olesen, R. H., Andersen, C. Y., Thuesen, L. L., Hare, K. J., Pers, T. H., Khodosevich, K., Simons, B. D. & Jensen, K. B., 15 May 2019, In : Nature.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. E-pub ahead of print

    Clinical but not histological outcomes in males with 45,X/46,XY mosaicism vary depending on reason for diagnosis

    Ljubicic, M. L., Jørgensen, A., Acerini, C., Andrade, J., Balsamo, A., Bertelloni, S., Cools, M., Cuccaro, R. T., Darendeliler, F., Flück, C. E., Grinspon, R. P., Maciel-Guerra, A., Guran, T., Hannema, S. E., Lucas-Herald, A. K., Hiort, O., Holterhus, P. M., Lichiardopol, C., Looijenga, L. H. J., Ortolano, R., Riedl, S., Ahmed, S. F. & Juul, A., 25 Apr 2019, In : The Journal of clinical endocrinology and metabolism.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. E-pub ahead of print

    Role of Nodal signalling in testis development and initiation of testicular cancer

    Harpelunde Poulsen, K. & Jorgensen, A., 1 Apr 2019, In : Reproduction (Cambridge, England).

    Research output: Contribution to journalReviewResearchpeer-review

  8. Published

    Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders

    Gannon, A-L., O'Hara, L., Mason, J. I., Rebourcet, D., Smith, S., Traveres, A., Alcaide-Corral, C. J., Frederiksen, H., Jørgensen, A., Milne, L., Mitchell, R. T. & Smith, L. B., 1 Mar 2019, In : Scientific Reports. 9, 1, p. 3250

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    A young testicular microenvironment protects Leydig cells against age-related dysfunction in a mouse model of premature aging

    Curley, M., Milne, L., Smith, S., Jørgensen, A., Frederiksen, H., Hadoke, P., Potter, P. & Smith, L. B., 2019, In : FASEB Journal. 33, 1, p. 978-995

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2018
  11. Published

    Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis

    Jørgensen, A., Macdonald, J., Nielsen, J. E., Kilcoyne, K. R., Perlman, S., Lundvall, L., Langhoff Thuesen, L., Juul Hare, K., Frederiksen, H., Andersson, A-M., Skakkebæk, N. E., Juul, A., Sharpe, R. M., Rajpert-De Meyts, E. & Mitchell, R. T., 13 Nov 2018, In : Cell Reports. 25, 7, p. 1924-1937.e4

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads

    Macdonald, J., Kilcoyne, K. R., Sharpe, R. M., Kavanagh, Á., Anderson, R. A., Brown, P., Smith, L. B., Jørgensen, A. & Mitchell, R. T., 1 Nov 2018, In : Human reproduction (Oxford, England). 33, 11, p. 2107-2121 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    At the crossroads of fate - somatic cell lineage specification in the fetal gonad

    Rotgers, E., Jørgensen, A. & Yao, H. H-C., 1 Oct 2018, In : Endocrine Reviews. 39, 5, p. 739–759

    Research output: Contribution to journalReviewResearchpeer-review

  14. Published

    Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems

    Hurtado-Gonzalez, P., Anderson, R. A., Macdonald, J., van den Driesche, S., Kilcoyne, K., Jørgensen, A., McKinnell, C., Macpherson, S., Sharpe, R. M. & Mitchell, R. T., 16 Apr 2018, In : Environmental Health Perspectives. 126, 4, p. 047006

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Experimental models of testicular development and function using human tissue and cells

    Tharmalingam, M. D., Jorgensen, A. & Mitchell, R. T., 2018, In : Molecular and Cellular Endocrinology. 468, p. 95-110

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published

    Loss of Function of the Nuclear Receptor NR2F2, Encoding COUP-TF2, Causes Testis Development and Cardiac Defects in 46,XX Children

    Bashamboo, A., Eozenou, C., Jorgensen, A., Bignon-Topalovic, J., Siffroi, J-P., Hyon, C., Tar, A., Nagy, P., Sólyom, J., Halász, Z., Paye-Jaouen, A., Lambert, S., Rodriguez-Buritica, D., Bertalan, R., Martinerie, L., Rajpert-De Meyts, E., Achermann, J. C. & McElreavey, K., 2018, In : American Journal of Human Genetics. 102, 3, p. 487-93

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published
  18. 2017
  19. Published

    Experimentally induced testicular dysgenesis syndrome originates in the masculinization programming window

    van den Driesche, S., Kilcoyne, K. R., Wagner, I. W., Rebourcet, D., Boyle, A., Mitchell, R., McKinnell, C., Macpherson, S., Donat, R., Shukla, C. J., Jørgensen, A., Rajpert-De Meyts, E., Skakkebæk, N. E. & Sharpe, R., 23 Mar 2017, In : JCI Insight. 2, 6, e91204.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours

    Rudolph, C., Melau, C., Nielsen, J. E., Vile Jensen, K., Liu, D., Pena-Diaz, J., Rajpert-De Meyts, E., Rasmussen, L. J. & Jørgensen, A., 2017, In : Cellular oncology (Dordrecht). 40, 4, p. 341-55

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2015
  22. Published
  23. Published

    Ex vivo culture of human fetal gonads: manipulation of meiosis signalling by retinoic acid treatment disrupts testis development

    Jørgensen, A., Nielsen, J. E., Perlman, S., Lundvall, L., Mitchell, R. T., Juul, A. & Rajpert-De Meyts, E., 6 Aug 2015, In : Human reproduction (Oxford, England). 30, 10, p. 2351-63

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model

    van den Driesche, S., Macdonald, J., Anderson, R. A., Johnston, Z. C., Chetty, T., Smith, L. B., McKinnell, C., Dean, A., Homer, N. Z., Jorgensen, A., Camacho-Moll, M. E., Sharpe, R. M. & Mitchell, R. T., 20 May 2015, In : Science translational medicine. 7, 288, p. 288ra80

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Biglycan is a novel binding partner of fibroblast growth factor receptor 3c (FGFR3c) in the human testis

    Winge, S. B., Nielsen, J., Jørgensen, A., Owczarek, S., Ewen, K. A., Nielsen, J. E., Juul, A., Berezin, V. & Rajpert-De Meyts, E., 5 Jan 2015, In : Molecular and Cellular Endocrinology. 399, p. 235-43 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published
  27. 2014
  28. Published

    Interaction between paraoxonase 1 polymorphism and prenatal pesticide exposure on metabolic markers in children using a multiplex approach

    Jørgensen, A., Nellemann, C., Wohlfahrt-Veje, C., Jensen, T. K., Main, K. M. & Andersen, H. R., 22 Nov 2014, In : Reproductive toxicology (Elmsford, N.Y.). 51C, p. 22-30 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Regulation of meiotic entry and gonadal sex differentiation in the human: normal and disrupted signaling

    Jørgensen, A. & Rajpert-De Meyts, E., Aug 2014, In : Biomolecular Concepts. 5, 4, p. 331-41 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Validation of endogenous normalizing genes for expression analyses in adult human testis and germ cell neoplasms

    Svingen, T., Jørgensen, A. & Rajpert-De Meyts, E., Aug 2014, In : Molecular Human Reproduction. 20, 8, p. 709-18 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Hanging drop cultures of human testis and testis cancer samples: a model used to investigate activin treatment effects in a preserved niche

    Jørgensen, A., Young, J., Nielsen, J. E., Joensen, U. N., Toft, B. G., Rajpert-De Meyts, E. & Loveland, K. L., 13 May 2014, In : B J C. 110, 10, p. 2604-14 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published
  33. 2013
  34. Published

    Characterization of the testicular, epididymal and endocrine phenotypes in the Leuven Vdr-deficient mouse model: targeting estrogen signalling

    Blomberg Jensen, M., Lieben, L., Nielsen, J. E., Willems, A., Jørgensen, A., Juul, A., Toppari, J., Carmeliet, G. & Rajpert-De Meyts, E., 5 Sep 2013, In : Molecular and Cellular Endocrinology. 377, 1-2, p. 93-102 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published
  36. Published

    Dysregulation of the mitosis-meiosis switch in testicular carcinoma in situ

    Jørgensen, A., Nielsen, J. E., Almstrup, K., Toft, B. G., Petersen, B. L. & Rajpert-De Meyts, E., Mar 2013, In : Journal of Pathology. 229, 4, p. 588-98 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published
  38. Published
  39. 2012
  40. Published
  41. Published
  42. Published
  43. Published

    Vitamin D metabolism and effects on pluripotency genes and cell differentiation in testicular germ cell tumors in vitro and in vivo

    Blomberg Jensen, M., Jørgensen, A., Nielsen, J. E., Steinmeyer, A., Leffers, H., Juul, A. & Rajpert-De Meyts, E., 2012, In : Neoplasia. 14, 10, p. 952-63 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. 2011
  45. Published

    Microdissection of gonadal tissues for gene expression analyses

    Jørgensen, A., Dalgaard, M. D. & Sonne, S. B., 1 Jan 2011, In : Methods in Molecular Biology. 755, p. 307-13 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. 2010
  47. Published
  48. Published

    Expression of prostaglandin synthases (pgds and pges) during zebrafish gonadal differentiation

    Jørgensen, A., Nielsen, J. E., Nielsen, B. F., Morthorst, J. E., Bjerregaard, P. & Leffers, H., 1 Sep 2010, In : Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology. 157, 1, p. 102-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published
  50. Published
  51. 2009
  52. Published

    TBT pollution and effects in molluscs at US Virgin Islands, Caribbean Sea

    Strand, J., Jørgensen, A. & Tairova, Z., May 2009, In : Environment International. 35, 4, p. 707-11 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Laser capture microdissection of gonads from juvenile zebrafish

    Jørgensen, A., Nielsen, J. E., Morthorst, J. E., Bjerregaard, P. & Leffers, H., 2009, In : Reproductive Biology and Endocrinology. 7, p. 97

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. 2008
  55. Published

    Biotransformation of polycyclic aromatic hydrocarbons in marine polychaetes

    Jørgensen, A., Giessing, A. M. B., Rasmussen, L. J. & Andersen, O., Mar 2008, In : Marine Environmental Research. 65, 2, p. 171-86 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Expression profiles for six zebrafish genes during gonadal sex differentiation

    Jørgensen, A., Morthorst, J. E., Andersen, O., Rasmussen, L. J. & Bjerregaard, P., 2008, In : Reproductive Biology and Endocrinology. 6, p. 25

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. 2007
  58. Published

    Identification and characterisation of an androgen receptor from zebrafish Danio rerio

    Jørgensen, A., Andersen, O., Bjerregaard, P. & Rasmussen, L. J., Nov 2007, In : Comparative Biochemistry and Physiology. Part C: Toxicology & Pharmacology. 146, 4, p. 561-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. 2005
  60. Published

    Biotransformation of the polycyclic aromatic hydrocarbon pyrene in the marine polychaete Nereis virens

    Jørgensen, A., Glessing, A. M. B., Rasmussen, L. J. & Andersen, O., Nov 2005, In : Environmental toxicology and chemistry / SETAC. 24, 11, p. 2796-805 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Characterisation of two novel CYP4 genes from the marine polychaete Nereis virens and their involvement in pyrene hydroxylase activity

    Jørgensen, A., Rasmussen, L. J. & Andersen, O., 28 Oct 2005, In : Biochemical and Biophysical Research Communications. 336, 3, p. 890-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. 2004
  63. Published

    Identification of two Nereis virens (Annelida: Polychaeta) cytochromes P450 and induction by xenobiotics

    Rewitz, K. F., Kjellerup, C., Jørgensen, A., Petersen, C. & Andersen, O., May 2004, In : Comparative Biochemistry and Physiology. Part C: Toxicology & Pharmacology. 138, 1, p. 89-96 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 30784239