Research
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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Education and academic degrees

1988    

Cand.Scient (MSci) in biology at University of Copenhagen

1992

Ph.D in Cellular and Molecular biology at the Protein laboratory, University of Copenhagen

 

Positions

1992 - 1995

Post doc at Dept. of Growth and Reproduction, Rigshospitalet

Since 1992

Scientific supervisor of the Hormone Laboratory, Dept. of Growth and Reproduction, Rigshospitalet

1995 - 2000

Senior research fellow, Dept. of Growth and Reproduction, Rigshospitalet

2000 -    

Research director, Dept. of Growth and Reproduction, Rigshospitalet, with the Hormone laboratory, to which an analytical chemistry unit was added in 2004, as my special area of ​​responsibility. 

Since 2006  

Member of the Department’s Management Group

Since 2008

Director of the National Danish Centre on Endocrine Disrupting Chemicals (cend.dk)

Since 2014

Member of the EDMaRC Management Group (edmarc.net);                 

 

Research areas

Since the early 1990s, my main research area has been the endocrinology of sex development and male reproduction.  By immunological methods, I have described the natural history of the reproductive hormone inhibin B during different stages of life and in different cases of impaired reproductive health. Based on my work, serum inhibin B measurement is today a valuable clinical tool in the work-up of andrology patients.

 In my studies of male reproductive hormone levels in large population studies and male patients with impaired testicular function I showed a declining secular trend in male serum testosterone levels in Denmark since the early 1980’ies and that men with impaired spermatogenesis also have lower testosterone production. I have also showed in epidemiological studies that an impaired Leydig cell function (the cells in the testis that produce testosterone) is associated with higher morbidity and mortality.

My interest in the hormone regulation of sex development and male reproduction also led to an interest in the impact of environmental factors - including endocrine disrupting chemicals - on human reproductive health. In 2004, I was involved in establishing an analytical biochemical laboratory for biomonitoring of non-persistent small molecules and metabolites using LC-MS/MS technology, which has provided the first data on exposure of the Danish population to non-persistent chemicals with known or suspected endocrine disrupting abilities based on measurement of urinary levels of these compounds and their metabolites:  e.g. phthalates, bisphenol A, parabens, UV-filters. This exposure data has been used to study associations of exposure to reproductive health outcomes in population studies.

In recent years, I have also turned my interest to the development of analyses for reproductive steroid hormones (testosterone and estradiol and their precursors) and peptide hormones (e.g. Insl3) based on LC-MS/MS technology.

Comments to list of publications

Publications at a glance pr. May 2019

Total number of original papers: +200, Total citations: >10,000, H-index (last updated August 2019): 62 (ISI, web of science), 72 (google scholar)

OrcID: 0000-0002-7300-1659

 

Expertises

As senior researcher and group leader of the Hormone and Endocrine Disrupter Laboratory Group at Dept. of Growth and Repro my main area of ​​responsibility is the development and quality assurance of the Hormone laboratory and the affiliated analytical chemistry unit.

I have more than 25 years of experience in immunoassays for measuring hormones and I have over the years been involved in the implementation a number of hormone analyzes, which are currently used as diagnostic tools in our clinic. In 2014, I was the driving force in the accreditation of our Hormone laboratory according to DS / EN ISO 15189 standard for medical laboratories (DANAK). Our analytical chemistry unit has subsequently also been accredited.

I have a broad knowledge of reproductive endocrinology, especially with focus on male reproduction including physiological and molecular biological processes involved in the endocrine regulation of growth and reproduction.

I have many years of experience working with database, data management and data processing, including statistical analyzes using software as SPSS, Access, Excel etc.

Finally, I am developer and admin on several webpages related to our research projects and research dissemination activities including conferences (e.g. vækstkurver.dk, edmarc.net, cehos.dk) and for this I am an experienced user of software like filezilla, website X5, and paint.net.

Main research areas

Reproductive endocrinology with emphasis on physiology and regulation of male reproductive hormones throughout life.

Hormone levels as clinical markers of health and disease related to growth and reproduction.

The effect of environmental and lifestyle factors on hormone function and regulation.

Human biomonitoring and epidemiological studies on the effects of chemical exposure on human health

Current research

Human exposure to non-persistent endocrine disrupting chemicals and effects on child development and male reproductive function. 

 

ID: 40863