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The Capital Region of Denmark - a part of Copenhagen University Hospital
  1. 2021
  2. E-pub ahead of print

    Associations between oxidative stress and perceived stress in patients with bipolar disorder and healthy control individuals

    Knorr, U., Blom, R. A., Simonsen, A. H., Poulsen, H. E., Akhøj, M., Forman, J., Hasselbalch, S. G. & Kessing, L. V., 29 Mar 2021, (E-pub ahead of print) In: Nordic Journal of Psychiatry. p. 1-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus: A Systematic Literature Review

    Lolansen, S. D., Rostgaard, N., Oernbo, E. K., Juhler, M., Simonsen, A. H. & MacAulay, N., 2021, In: Disease Markers. 2021, p. 8834822 8834822.

    Research output: Contribution to journalReviewResearchpeer-review

  4. 2020
  5. Published

    Cerebrospinal Fluid/Plasma Albumin Ratio as a Biomarker for Blood-Brain Barrier Impairment Across Neurodegenerative Dementias

    Musaeus, C. S., Gleerup, H. S., Høgh, P., Waldemar, G., Hasselbalch, S. G. & Simonsen, A. H., May 2020, In: Journal of Alzheimer's Disease. 75, 2, p. 429-436 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Cerebrospinal Fluid Biomarkers to Differentiate Idiopathic Normal Pressure Hydrocephalus from Subcortical Ischemic Vascular Disease

    Manniche, C., Simonsen, A. H., Hasselbalch, S. G., Andreasson, U., Zetterberg, H., Blennow, K., Høgh, P., Juhler, M. & Hejl, A-M., 2020, In: Journal of Alzheimer's Disease. 75, 3, p. 937-947 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Evaluating 2-[F-18]FDG-PET in differential diagnosis of dementia using a data-driven decision model

    Gjerum, L., Frederiksen, K. S., Henriksen, O. M., Law, I., Bruun, M., Simonsen, A. H., Mecocci, P., Baroni, M., Dottorini, M. E., Koikkalainen, J., Lötjönen, J. & Hasselbalch, S. G., 2020, In: NeuroImage. Clinical. 27, p. 102267 102267.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published
  9. 2019
  10. Published
  11. Published

    Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma

    Jensen, C. S., Bahl, J. M., Østergaard, L. B., Høgh, P., Wermuth, L., Heslegrave, A., Zetterberg, H., Heegaard, N. H. H., Hasselbalch, S. G. & Simonsen, A. H., 1 Jul 2019, In: Experimental Gerontology. 121, p. 91-98 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study

    Lleó, A., Alcolea, D., Martínez-Lage, P., Scheltens, P., Parnetti, L., Poirier, J., Simonsen, A. H., Verbeek, M. M., Rosa-Neto, P., Slot, R. E. R., Tainta, M., Izaguirre, A., Reijs, B. L. R., Farotti, L., Tsolaki, M., Vandenbergue, R., Freund-Levi, Y., Verhey, F. R. J., Clarimón, J., Fortea, J., Frolich, L., Santana, I., Molinuevo, J. L., Lehmann, S., Visser, P. J., Teunissen, C. E., Zetterberg, H. & Blennow, K., Jun 2019, In: Alzheimer's & dementia : the journal of the Alzheimer's Association. 15, 6, p. 742-753 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published
  14. Published

    Biomarkers for Alzheimer's Disease in Saliva: A Systematic Review

    Gleerup, H. S., Hasselbalch, S. G. & Simonsen, A. H., 1 Jan 2019, In: Disease Markers. 2019, p. 4761054 4761054.

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise

    Jensen, C. S., Simonsen, A. H., Siersma, V., Beyer, N., Frederiksen, K. S., Gottrup, H., Hoffman, K., Høgh, P., Frikke-Schmidt, R., Sobol, N. A., Waldemar, G., Wermuth, L. & Hasselbalch, S. G., Jan 2019, In: Alzheimer's & dementia (New York, N. Y.). 5, p. 99-106 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Impact of a clinical decision support tool on dementia diagnostics in memory clinics: The PredictND validation study

    Bruun, M., Frederiksen, K. S., Rhodius-Meester, H. F. M., Baroni, M., Gjerum, L., Koikkalainen, J., Urhemaa, T., Tolonen, A., van Gils, M., Tong, T., Guerrero, R., Rueckert, D., Dyremose, N., Andersen, B. B., Simonsen, A. H., Lemstra, A., Hallikainen, M., Kurl, S., Herukka, S-K., Remes, A. M., Waldemar, G., Soininen, H., Mecocci, P., van der Flier, W. M., Lötjönen, J. & Hasselbalch, S. G., 2019, In: Current Alzheimer Research. 16, 2, p. 91-101 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2018
  18. Published

    Inflammatory markers of CHMP2B-mediated frontotemporal dementia

    Roos, P., von Essen, M. R., Nielsen, T. T., Johannsen, P., Stokholm, J., Bie, A. S., Waldemar, G., Simonsen, A. H., Heslegrave, A., Zetterberg, H., Sellebjerg, F., Nielsen, J. E. & FReJA Consortium, 15 Nov 2018, In: Journal of Neuroimmunology. 324, p. 136-142 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment: Results from a Nordic Multicenter Cohort Study

    Schjønning Nielsen, M., Simonsen, A. H., Siersma, V., Engedal, K., Jelic, V., Andersen, B. B., Naik, M., Hasselbalch, S. G. & Høgh, P., Nov 2018, In: Dementia and Geriatric Cognitive Disorders Extra. 8, 3, p. 426-438 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published
  21. Published

    A Parallel Reaction Monitoring Mass Spectrometric Method for Analysis of Potential CSF Biomarkers for Alzheimer's Disease

    Brinkmalm, G., Sjödin, S., Simonsen, A. H., Hasselbalch, S. G., Zetterberg, H., Brinkmalm, A. & Blennow, K., 2018, In: Proteomics - Clinical Applications. 12, 1, p. e

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    CSF neurofilament light concentration is increased in presymptomatic CHMP2B mutation carriers

    Rostgaard, N., Roos, P., Portelius, E., Blennow, K., Zetterberg, H., Simonsen, A. H. & Nielsen, J. E., 2018, In: Neurology. 90, 2, p. e157-e163

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published
  24. Published

    Progressive DNA and RNA damage from oxidation after aneurysmal subarachnoid haemorrhage in humans

    Jorgensen, A., Staalsoe, J. M., Simonsen, A. H., Hasselbalch, S. G., Høgh, P., Weimann, A., Poulsen, H. E. & Olsen, N. V., 2018, In: Free Radical Research. 52, 1, p. 51-56 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers

    Ramos de Matos, M., Ferreira, C., Herukka, S-K., Soininen, H., Janeiro, A., Santana, I., Baldeiras, I., Almeida, M. R., Lleó, A., Dols-Icardo, O., Alcolea, D., Benussi, L., Binetti, G., Paterlini, A., Ghidoni, R., Nacmias, B., Meulenbroek, O., van Waalwijk van Doorn, L. J. C., Kuiperi, H. B. J., Hausner, L., Waldemar, G., Simonsen, A. H., Tsolaki, M., Gkatzima, O., Resende de Oliveira, C., Verbeek, M. M., Clarimon, J., Hiltunen, M., de Mendonça, A. & Martins, M., 2018, In: Journal of Alzheimer's disease : JAD. 66, 2, p. 639-652 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    The Diagnostic and Prognostic Value of a Dual-Tasking Paradigm in a Memory Clinic

    Nielsen, M. S., Simonsen, A. H., Siersma, V., Hasselbalch, S. G. & Hoegh, P., 2018, In: Journal of Alzheimer's disease : JAD. 61, 3, p. 1189-1199 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. 2017
  28. Published

    Effect of physical exercise on markers of neuronal dysfunction in cerebrospinal fluid in patients with Alzheimer's disease

    Jensen, C. S., Portelius, E., Høgh, P., Wermuth, L., Blennow, K., Zetterberg, H., Hasselbalch, S. G. & Simonsen, A. H., Jun 2017, In: Alzheimer's & dementia (New York, N. Y.). 3, 2, p. 284-290 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Recommendations for cerebrospinal fluid Alzheimer's disease biomarkers in the diagnostic evaluation of mild cognitive impairment

    Herukka, S-K., Simonsen, A. H., Andreasen, N., Baldeiras, I., Bjerke, M., Blennow, K., Engelborghs, S., Frisoni, G. B., Gabryelewicz, T., Galluzzi, S., Handels, R., Kramberger, M. G., Kulczyńska, A., Molinuevo, J. L., Mroczko, B., Nordberg, A., de Oliveira, C. R., Otto, M., Rinne, J. O., Rot, U., Saka, E., Soininen, H., Struyfs, H., Suardi, S., Visser, P. J., Winblad, B., Zetterberg, H. & Waldemar, G., Mar 2017, In: Alzheimer's & dementia : the journal of the Alzheimer's Association. 13, 3, p. 285-295 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia

    Simonsen, A. H., Herukka, S-K., Andreasen, N., Baldeiras, I., Bjerke, M., Blennow, K., Engelborghs, S., Frisoni, G. B., Gabryelewicz, T., Galluzzi, S., Handels, R., Kramberger, M. G., Kulczyńska, A., Molinuevo, J. L., Mroczko, B., Nordberg, A., de Oliveira, C. R., Otto, M., Rinne, J. O., Rot, U., Saka, E., Soininen, H., Struyfs, H., Suardi, S., Visser, P. J., Winblad, B., Zetterberg, H. & Waldemar, G., Mar 2017, In: Alzheimer's & dementia : the journal of the Alzheimer's Association. 13, 3, p. 274-284 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. 2016
  32. Published

    Are CSF Biomarkers Useful as Prognostic Indicators in Diagnostically Unresolved Cognitively Impaired Patients in a Normal Clinical Setting

    Schjønning Nielsen, M., Simonsen, A. H., Siersma, V., Hasselbalch, S. G. & Høgh, P., 16 Nov 2016, In: Dementia and Geriatric Cognitive Disorders Extra. 6, 3, p. 465-476 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease

    Steen Jensen, C., Portelius, E., Siersma, V., Høgh, P., Wermuth, L., Blennow, K., Zetterberg, H., Waldemar, G., Hasselbalch, S. & Hviid Simonsen, A., 2016, In: Dementia and Geriatric Cognitive Disorders. 42, 3-4, p. 146-158 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    The utility of α-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature

    Simonsen, A. H., Kuiperij, B., El-Agnaf, O. M. A., Engelborghs, S., Herukka, S-K., Parnetti, L., Rektorova, I., Vanmechelen, E., Kapaki, E., Verbeek, M. & Mollenhauer, B., 2016, In: Biomarkers in Medicine. 10, 1, p. 19-34 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2015
  36. Published

    Ubiquitin: a potential cerebrospinal fluid progression marker in Huntington's disease

    Vinther-Jensen, T., Simonsen, A. H., Budtz-Jørgensen, E., Hjermind, L. E. & Nielsen, J. E., Oct 2015, In: European Journal of Neurology. 22, 10, p. 1378-84 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published
  38. Published

    Cerebrospinal Fluid Biomarkers in Familial Forms of Alzheimer's Disease and Frontotemporal Dementia

    Rostgaard, N., Waldemar, G., Nielsen, J. E. & Simonsen, A. H., 2015, In: Dementia and Geriatric Cognitive Disorders. 40, 1-2, p. 54-62 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Chasing the Effects of Pre-Analytical Confounders - A Multicenter Study on CSF-AD Biomarkers

    Leitão, M. J., Baldeiras, I., Herukka, S-K., Pikkarainen, M., Leinonen, V., Simonsen, A. H., Perret-Liaudet, A., Fourier, A., Quadrio, I., Veiga, P. M. & de Oliveira, C. R., 2015, In: Frontiers in Neurology. 6, p. 153

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-β Levels in Patients with Alzheimer's Disease?

    Travassos, M., Santana, I., Baldeiras, I., Tsolaki, M., Gkatzima, O., Sermin, G., Yener, G. G., Simonsen, A., Hasselbalch, S. G., Kapaki, E., Mara, B., Cunha, R. A., Agostinho, P., Blennow, K., Zetterberg, H., Mendes, V. M., Manadas, B. & de Mendon, A., 2015, In: Journal of Alzheimer's disease : JAD. 47, 4, p. 1069-78 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies on Neurodegenerative Diseases

    Reijs, B. L. R., Teunissen, C. E., Goncharenko, N., Betsou, F., Blennow, K., Baldeiras, I., Brosseron, F., Cavedo, E., Fladby, T., Froelich, L., Gabryelewicz, T., Gurvit, H., Kapaki, E., Koson, P., Kulic, L., Lehmann, S., Lewczuk, P., Lleó, A., Maetzler, W., de Mendonça, A., Miller, A-M., Molinuevo, J. L., Mollenhauer, B., Parnetti, L., Rot, U., Schneider, A., Simonsen, A. H., Tagliavini, F., Tsolaki, M., Verbeek, M. M., Verhey, F. R. J., Zboch, M., Winblad, B., Scheltens, P., Zetterberg, H. & Visser, P. J., 2015, In: Frontiers in Neurology. 6, p. 216

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. 2014
  43. Published

    YKL-40 in cerebrospinal fluid in Huntington's disease - A role in pathology or a nonspecific response to inflammation?

    Vinther-Jensen, T., Budtz-Jørgensen, E., Simonsen, A. H., Nielsen, J. E. & Hjermind, L. E., Nov 2014, In: Parkinsonism & related disorders. 20, 11, p. 1301-3 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    The potential of microRNAs as biofluid markers of neurodegenerative diseases - a systematic review

    Danborg, P. B., Simonsen, A. H., Waldemar, G. & Heegaard, N. H. H., 19 Jun 2014, In: Biomarkers. 19, 4, p. 259-68

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Distinct transthyretin oxidation isoform profile in spinal fluid from patients with Alzheimer's disease and mild cognitive impairment

    Poulsen, K., Bahl, J. M., Simonsen, A. H., Hasselbalch, S. G. & Heegaard, N. H., 29 Mar 2014, In: Clinical Proteomics. 11, 1, p. 12 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Application of the PredictAD Decision Support Tool to a Danish Cohort of Patients with Alzheimer's Disease and Other Dementias

    Simonsen, A. H., Mattila, J., Hejl, A. M., Garde, E., van Gils, M., Thomsen, C., Lötjönen, J., Soininen, H. & Waldemar, G., 2014, In: Dementia and Geriatric Cognitive Disorders. 37, 3-4, p. 207-213 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2013
  48. Published

    Pre-analytical factors influencing the stability of cerebrospinal fluid proteins

    Simonsen, A. H., Bahl, J. M. C., Danborg, P. B., Lindstrom, V., Larsen, S. O., Grubb, A., Heegaard, N. H. H. & Waldemar, G., 15 May 2013, In: Journal of Neuroscience Methods. 215, 2, p. 234-40 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    The PredictAD project: development of novel biomarkers and analysis software for early diagnosis of the Alzheimer's disease

    Antila, K., Lötjönen, J., Thurfjell, L., Laine, J., Massimini, M., Rueckert, D., Zubarev, R., Orešič, M., van Gils, M., Mattila, J., Hviid Simonsen, A., Waldemar, G. & Soininen, H., 6 Apr 2013, In: Interface Focus. 3, 2, p. 20120072

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Neprilysin-like activity correlates with CSF-Tau and phospho-tau in patients with Alzheimer's disease

    Sorensen, K. C. N., Simonsen, A. H., Holmetoft, U. B., Hasselbalch, S. G. & Heegaard, N. H. H., 2013, In: Journal of Alzheimer's disease : JAD. 37, 2, p. 379-87 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX Trial): Rationale and Design

    Hoffmann, K., Frederiksen, K. S., Sobol, N. A., Beyer, N., Vogel, A., Simonsen, A. H., Johannsen, P., Lolk, A., Terkelsen, O., Cotman, C. W., Hasselbalch, S. G. & Waldemar, G., 2013, In: Neuroepidemiology. 41, 3-4, p. 198-207 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. 2012
  53. Published

    Application of the PredictAD Software Tool to Predict Progression in Patients with Mild Cognitive Impairment

    Simonsen, A. H., Mattila, J., Hejl, A-M., Frederiksen, K. S., Herukka, S-K., Hallikainen, M., van Gils, M., Lötjönen, J., Soininen, H. & Waldemar, G., 2012, In: Dementia and Geriatric Cognitive Disorders. 34, 5-6, p. 344-350 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Characterization and stability of transthyretin isoforms in cerebrospinal fluid examined by immunoprecipitation and high-resolution mass spectrometry of intact protein

    Poulsen, K., Bahl, J. M. C., Tanassi, J. T., Simonsen, A. H. & Heegaard, N., 2012, In: Methods (San Diego, Calif.). 56, 2, p. 284-92 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Effect of ageing on the passive and active tension and pharmacodynamic characteristics of rat coronary arteries: age-dependent increase in sensitivity to 5-HT and K+

    Sheykhzade, M., Simonsen, A. H., Boonen, H. C. M., Outzen, E. M. & Nyborg, N. C. B., 2012, In: Pharmacology Fast. 90, 3-4, p. 160-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Protein profiling of cerebrospinal fluid

    Simonsen, A. H., 2012, In: Methods in Molecular Biology. 818, p. 109-17 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Recommendations to standardize preanalytical confounding factors in Alzheimer's and Parkinson's disease cerebrospinal fluid biomarkers: an update

    del Campo, M., Mollenhauer, B., Bertolotto, A., Engelborghs, S., Hampel, H., Simonsen, A. H., Kapaki, E., Kruse, N., Le Bastard, N., Lehmann, S., Molinuevo, J. L., Parnetti, L., Perret-Liaudet, A., Sáez-Valero, J., Saka, E., Urbani, A., Vanmechelen, E., Verbeek, M., Visser, P. J. & Teunissen, C., 2012, In: Biomarkers in Medicine. 6, 4, p. 419-30 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Software tool for improved prediction of Alzheimer's disease

    Soininen, H., Mattila, J., Koikkalainen, J., van Gils, M., Simonsen, A. H., Waldemar, G., Rueckert, D., Thurfjell, L., Lötjönen, J. & Alzheimer’s Disease Neuroimaging Initiative, 2012, In: Neuro-degenerative diseases. 10, 1-4, p. 149-52 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. 2011
  60. Published

    A disease state fingerprint for evaluation of Alzheimer's disease

    Mattila, J., Koikkalainen, J., Virkki, A., Simonsen, A., van Gils, M., Waldemar, G., Soininen, H. & Lötjönen, J., 1 Jan 2011, In: Journal of Alzheimer's Disease. 27, 1, p. 163-76 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Biofluid Protein Markers for the Diagnosis of Vascular Dementia

    Simonsen, A. H. & Waldemar, G., 2011, Vascular Dementia: Risk factors, Diagnosis and Treatment: Neuroscience Research Progress. Jacobsen, S. R. (ed.). Nova Science Publishers, Incorporated, p. 189-202 14 p. (Neuroscience Research Progress).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

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