Research output per year
Research output per year
Personal profile
Expertises
skeletal muscle; hypertrophy; atrophy; myogenesis; satellite cells; sarcopenia; muscle regeneration
Main research areas
The overall aim is to gain insight into mechanisms of skeletal muscle adaptation in elderly individuals. Models of injury and overload are employed to study the activity of muscle stem cells (satellite cells) and muscle extracellular matrix.
Current research
Investigations into potent influencing factors, such as changed levels of inflammation and loading, are designed with the goal of deepening our understanding of the ageing muscle. In addition to this, we are currently studying cross-talk between the muscle and its extracellular matrix, throughout the muscle as well as specifically at the myotendinous junction, in human models of regeneration and overload. This is being done in human studies in vivo and in vitro.
Potential conflicts of interest
None.
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Distinct myofibre domains of the human myotendinous junction revealed by single-nucleus RNA sequencing
Karlsen, A., Yeung, C-Y. C., Schjerling, P., Denz, L., Hoegsbjerg, C., Jakobsen, J. R., Krogsgaard, M. R., Koch, M., Schiaffino, S., Kjaer, M. & Mackey, A. L., 15 Apr 2023, In: Journal of Cell Science. 136, 8, jcs260913.Research output: Contribution to journal › Journal article › Research › peer-review
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Larger interface area at the human myotendinous junction in type 1 compared with type 2 muscle fibers
Jakobsen, J. R., Mackey, A. L., Koch, M., Imhof, T., Hannibal, J., Kjaer, M. & Krogsgaard, M. R., 6 Feb 2023, In: Scandinavian journal of medicine & science in sports. 33, 2, p. 136-145 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
2 Citations (Scopus) -
Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
Roberts, M. D., McCarthy, J. J., Hornberger, T. A., Phillips, S. M., Mackey, A. L., Nader, G. A., Boppart, M. D., Kavazis, A. N., Reidy, P. T., Ogasawara, R., Libardi, C. A., Ugrinowitsch, C., Booth, F. W. & Esser, K. A., 29 Jun 2023, (E-pub ahead of print) In: Physiological Reviews.Research output: Contribution to journal › Review › peer-review
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PCM1 labeling reveals myonuclear and nuclear dynamics in skeletal muscle across species
Viggars, M. R., Owens, D. J., Stewart, C., Coirault, C., Mackey, A. L. & Jarvis, J. C., 1 Jan 2023, In: American Journal of Physiology: Cell Physiology. 324, 1, p. C85-C97Research output: Contribution to journal › Journal article › Research › peer-review
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Aging is associated with an altered macrophage response during human skeletal muscle regeneration
Ahmadi, M., Karlsen, A., Mehling, J., Soendenbroe, C., Mackey, A. L. & Hyldahl, R. D., Nov 2022, In: Experimental Gerontology. 169, p. 111974 111974.Research output: Contribution to journal › Journal article › Research › peer-review
Activities
- 3 Other
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Ph.d.-vejleder for Casper Søndenbroe
Abigail Louise Mackey (Participant) & Jesper Løvind Andersen (Participant)
2022Activity: Other
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Ph.d.-vejleder for Jens Rithamer Jakobsen
Michael Rindom Krogsgaard (Participant) & Abigail Louise Mackey (Participant)
2022Activity: Other