Organisation profile

Aims and objectives

Our aim is to improve the health in the general population.
We produce new knowledge on biological pathways relevant for the health. Thereby, we contribute to the knowledge necessary for providing better risk prediction/screening, more precise diagnoses, better prediction of therapeutic effects, and more detailed monitoring of treatment effects.

Focus areas

Our focus areas:
Cardiovascular diseases: dyslipoproteinaemia, hypercholesterolemia, atrial fibrillation, stroke, hypertension.
Neoplastic diseases: breast, prostate, haematological, lung cancer, and melanoma.
Lung diseases: asthma and chronic obstructive pulmonary diseases.
Other diseases: haemachromatosis, inflammatory bowel disease, psychiatric diseases, etc. 


Disciplines, methods and tools

We use classical clinical biochemistry, genetic epidemiology, and evaluate new biomarkers.

The main material are very large samples from the general population, ie. the

Copenhagen City Heart Study (n=20,000), initiated 1976 and the Copenhagen Gene

ral Population Study. This a single-center study with >100,000 participants who have answered questions of lifestyle and health, have been examined physically, have had measured > 70 parameters from the blood, and from whom DNA has been isolated.

We also use patient cohorts with ischaemic heart disease (n>10,000), breast (n>9,000), prostate (n>3,000), lung (n>1000) cancer, melanoma (n>3,000), and others.

In Denmark, national registers record hospital diagnoses, cancer diagnoses, causes and date of death, use of prescription medicine and more demographic information like family information, income, education, etc. this information is 100% accurate for practical purposes.
We receive this yearly on all participants.

This material constitutes the basis for our studies of many aspects of human health and disease.


Useful links

Original publications
Other publications


Dive into the research topics where Clinical Biochemistry is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
  • A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

    Middha, P., Wang, X., Behrens, S., Bolla, M. K., Wang, Q., Dennis, J., Michailidou, K., Ahearn, T. U., Andrulis, I. L., Anton-Culver, H., Arndt, V., Aronson, K. J., Auer, P. L., Augustinsson, A., Baert, T., Freeman, L. E. B., Becher, H., Beckmann, M. W., Benitez, J., Bojesen, S. E., & 31 othersBrauch, H., Brenner, H., Brooks-Wilson, A., Campa, D., Canzian, F., Carracedo, A., Castelao, J. E., Chanock, S. J., Chenevix-Trench, G., Cordina-Duverger, E., Couch, F. J., Cox, A., Cross, S. S., Czene, K., Dossus, L., Dugué, P-A., Eliassen, A. H., Eriksson, M., Evans, D. G., Fasching, P. A., Figueroa, J. D., Fletcher, O., Flyger, H., Gabrielson, M., Gago-Dominguez, M., Giles, G. G., González-Neira, A., Grassmann, F., Nielsen, S. F., Nordestgaard, B. G. & CTS Consortium, 9 Aug 2023, In: Breast Cancer Research. 25, 1, p. 93 93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry

    Mueller, S. H., Lai, A. G., Valkovskaya, M., Michailidou, K., Bolla, M. K., Wang, Q., Dennis, J., Lush, M., Abu-Ful, Z., Ahearn, T. U., Andrulis, I. L., Anton-Culver, H., Antonenkova, N. N., Arndt, V., Aronson, K. J., Augustinsson, A., Baert, T., Freeman, L. E. B., Beckmann, M. W., Behrens, S., & 31 othersBenitez, J., Bermisheva, M., Blomqvist, C., Bogdanova, N. V., Bojesen, S. E., Bonanni, B., Brenner, H., Brucker, S. Y., Buys, S. S., Castelao, J. E., Chan, T. L., Chang-Claude, J., Chanock, S. J., Choi, J-Y., Chung, W. K., Colonna, S. V., Cornelissen, S., Couch, F. J., Czene, K., Daly, M. B., Devilee, P., Dörk, T., Dossus, L., Dwek, M., Eccles, D. M., Ekici, A. B., Eliassen, A. H., Engel, C., Evans, D. G., Flyger, H. & NBCS Collaborators, 26 Jan 2023, In: Genome Medicine. 15, 1, p. 7 7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  • APOE and vascular disease: Sequencing and genotyping in general population cohorts

    Rasmussen, K. L., Luo, J., Nordestgaard, B. G., Tybjærg-Hansen, A. & Frikke-Schmidt, R., 9 Aug 2023, (E-pub ahead of print) In: Atherosclerosis. p. 117218 117218.

    Research output: Contribution to journalJournal articleResearchpeer-review