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Institute for Biological Psychiatry - a part of Copenhagen University Hospital
  1. 2015
  2. Published

    Correction: Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate

    Andreassen, O. A., Thompson, W. K., Schork, A. J., Ripke, S., Mattingsdal, M., Kelsoe, J. R., Kendler, K. S., O'Donovan, M. C., Rujescu, D., Werge, T., Sklar, P., Roddey, J. C., Chen, C-H., McEvoy, L., Desikan, R. S., Djurovic, S., Dale, A. M. & Psychiatric Genomics Consortium (PGC), Nov 2015, In : P L o S Genetics (Online). 11, 11, p. e1005544

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Partitioning heritability by functional annotation using genome-wide association summary statistics

    Finucane, H. K., Bulik-Sullivan, B., Gusev, A., Trynka, G., Reshef, Y., Loh, P-R., Anttila, V., Xu, H., Zang, C., Farh, K., Ripke, S., Day, F. R., Purcell, S., Stahl, E., Lindstrom, S., Perry, J. R. B., Okada, Y., Raychaudhuri, S., Daly, M. J., Patterson, N., Neale, B. M., Price, A. L. & ReproGen Consortium, Nov 2015, In : Nature Genetics. 47, 11, p. 1228-35 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Population genetic differentiation of height and body mass index across Europe

    Robinson, M. R., Hemani, G., Medina-Gomez, C., Mezzavilla, M., Esko, T., Shakhbazov, K., Powell, J. E., Vinkhuyzen, A., Berndt, S. I., Gustafsson, S., Justice, A. E., Kahali, B., Locke, A. E., Pers, T. H., Vedantam, S., Wood, A. R., van Rheenen, W., Andreassen, O. A., Gasparini, P., Metspalu, A., Berg, L. H. V. D., Veldink, J. H., Rivadeneira, F., Werge, T. M., Abecasis, G. R., Boomsma, D. I., Chasman, D. I., de Geus, E. J. C., Frayling, T. M., Hirschhorn, J. N., Hottenga, J. J., Ingelsson, E., Loos, R. J. F., Magnusson, P. K. E., Martin, N. G., Montgomery, G. W., North, K. E., Pedersen, N. L., Spector, T. D., Speliotes, E. K., Goddard, M. E., Yang, J. & Visscher, P. M., Nov 2015, In : Nature Genetics. 47, 11, p. 1357-62 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Genetic Markers of Human Evolution Are Enriched in Schizophrenia

    Srinivasan, S., Bettella, F., Mattingsdal, M., Wang, Y., Witoelar, A., Schork, A. J., Thompson, W. K., Zuber, V., Winsvold, B. S., Zwart, J-A., Collier, D. A., Desikan, R. S., Melle, I., Werge, T., Dale, A. M., Djurovic, S., Andreassen, O. A. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, The International Headache Genetics Consortium, 21 Oct 2015, In : Biological Psychiatry.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

    Vilhjálmsson, B. J., Yang, J., Finucane, H. K., Gusev, A., Lindström, S., Ripke, S., Genovese, G., Loh, P-R., Bhatia, G., Do, R., Hayeck, T., Won, H-H., Kathiresan, S., Pato, M., Pato, C., Tamimi, R., Stahl, E., Zaitlen, N., Pasaniuc, B., Belbin, G., Kenny, E. E., Schierup, M. H., De Jager, P., Patsopoulos, N. A., McCarroll, S., Daly, M., Purcell, S., Chasman, D., Neale, B., Goddard, M., Visscher, P. M., Kraft, P., Patterson, N., Price, A. L. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 1 Oct 2015, In : American Journal of Human Genetics. 97, 4, p. 576-92 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case–control sample of schizophrenia

    Ingason, A., Giegling, I., Harmann, AM., Genius, J., Konte, B., Fried, M., of the Psychaitric Genomics Consortium, S. W. G., Ripke, S., Sullivan, P. F., St Clair, D., Collier, D., O'Donovan, M. C., Mirnics, K., Rujescu, D., Hansen, T. F., Werge, T. M. & Olsen, L., Oct 2015, In : Translational Psychiatry. 5, 10, p. e656 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

    Lee, S. H., Byrne, E. M., Hultman, C. M., Kähler, A., Vinkhuyzen, A. A., Ripke, S., Andreassen, O. A., Frisell, T., Gusev, A., Hu, X., Karlsson, R., Mantzioris, V. X., McGrath, J. J., Mehta, D., Stahl, E. A., Zhao, Q., Kendler, K. S., Sullivan, P. F., Price, A. L., O'Donovan, M., Okada, Y., Mowry, B. J., Raychaudhuri, S., Wray, N. R., Byerley, W., Cahn, W., Cantor, R. M., Cichon, S., Cormican, P., Curtis, D., Djurovic, S., Escott-Price, V., Gejman, P. V., Georgieva, L., Giegling, I., Hansen, T. F., Ingason, A., Kim, Y., Konte, B., Lee, P. H., McIntosh, A., McQuillin, A., Morris, D. W., Nöthen, M. M., O'Dushlaine, C., Olincy, A., Olsen, L., Pato, C. N., Rasmussen, H. B., Werge, T. & Schizophrenia Working Group of the Psychiatric Genomics Consortium and Rheumatoid Arthritis Consortium International, Oct 2015, In : International Journal of Epidemiology. 44, 5, p. 1706-1721

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Risk factors and mortality among patients with severe muco-cutaneous drug reactions

    Crüger, A-M. T., Kaur-Knudsen, D., Zachariae, C., Rasmussen, H. B. & Thomsen, S. F., Aug 2015, In : Danish Medical Bulletin (Online). 62, 8, A5122.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Genetic characterization of blood spot-derived DNA from 209 individuals known to carry 22q11Del reveals a new nested deletion

    Sparsø, T. H., Jun 2015, In : European journal of human genetics : EJHG. PS09.003

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  11. Published

    Evaluating historical candidate genes for schizophrenia

    Farrell, M. S., Werge, T., Sklar, P., Owen, M. J., Ophoff, R. A., O'Donovan, M. C., Corvin, A., Cichon, S. & Sullivan, P. F., May 2015, In : Molecular Psychiatry. 20, 5, p. 555-62 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics

    Rasmussen, H. B., Bjerre, D., Linnet, K., Jürgens, G., Dalhoff, K., Stefansson, H., Hankemeier, T., Kaddurah-Daouk, R., Taboureau, O., Brunak, S., Houmann, T., Jeppesen, P., Pagsberg, A. K., Plessen, K., Dyrborg, J., Hansen, P. R., Hansen, P. E., Hughes, T., Werge, T., INDICES Consortium & Kaalund-Brok, K., 21 Apr 2015, In : Pharmacogenomics. 16, 6, p. 649-665 17 p.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Antipsychotic-Like Effect of the Muscarinic Acetylcholine Receptor Agonist BuTAC in Non-Human Primates

    Andersen, M. B., Croy, C. H., Dencker, D., Werge, T., Bymaster, F. P., Felder, C. C. & Fink-Jensen, A., 17 Apr 2015, In : P L o S One. 10, 4, p. e0122722

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published
  15. Published

    Genetics of Complex Traits and Disorders Discovery and impact of rare variants

    Thygesen, J. H., Mar 2015

    Research output: Book/ReportPh.D. thesisResearch

  16. Published

    LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

    Bulik-Sullivan, B. K., Loh, P-R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., Daly, M. J., Price, A. L., Neale, B. M. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, Mar 2015, In : Nature Genetics. 47, 3, p. 291-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published
  18. Published

    Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder

    Maier, R., Moser, G., Chen, G-B., Ripke, S., Coryell, W., Potash, J. B., Scheftner, W. A., Shi, J., Weissman, M. M., Hultman, C. M., Landén, M., Levinson, D. F., Kendler, K. S., Smoller, J. W., Wray, N. R., Lee, S. H. & Cross-Disorder Working Group of the Psychiatric Genomics Consortium, 5 Feb 2015, In : American Journal of Human Genetics. 96, 2, p. 283-94 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published
  20. Published

    Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

    The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium, 19 Jan 2015, In : Nature Neuroscience.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    A nation-wide study of the family aggregation and risk factors in anorexia nervosa over three generations

    Steinhausen, H-C., Jakobsen, H., Helenius, D., Munk-Jørgensen, P. & Strober, M., 2015, In : International Journal of Eating Disorders. 48, 1, p. 1-8

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons

    Mellerup, E., Andreassen, O. A., Bennike, B., Dam, O. H., Djurovic, S., Hansen, T., Jorgensen, M. B., Kessing, L. V., Koefoed, P., Melle, I., Mors, O., Werge, T. & Moeller, G. L., 2015, In : P L o S One. 10, 11, p. e0143432

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published
  24. Published

    Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci

    Andreassen, O. A., Harbo, H. F., Wang, Y., Thompson, W. K., Schork, A. J., Mattingsdal, M., Zuber, V., Bettella, F., Ripke, S., Kelsoe, J. R., Kendler, K. S., O'Donovan, M. C., Sklar, P., McEvoy, L. K., Desikan, R. S., Lie, B. A., Djurovic, S., Dale, A. M. & The Psychiatric Genomics Consortium (PGC) Bipolar Disorder and Schizophrenia Work Groups, 2015, In : Molecular Psychiatry. 20, 2, p. 207-214 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published
  26. Published

    Soluble Urokinase-Type Plasminogen Activator Receptor Levels in Patients With Schizophrenia

    Nielsen, J., Røge, R., Pristed, S. G., Viuff, A. G., Ullum, H., Thørner, L. W., Werge, T. & Vang, T., 2015, In : Schizophrenia Bulletin. 41, 3, p. e764-71

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Synthetic cannabimimetic agents metabolized by carboxylesterases

    Thomsen, R., Nielsen, L. M., Holm, N. B., Rasmussen, H. B., Linnet, K., the INDICES Consortium, Plessen, K. J., Jeppesen, P., Houmann, T., Kaalund-Brok, K. & Pagsberg, A. K., 2015, In : Drug Testing and Analysis. 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    The Danish 22q11 research initiative

    Schmock, H., Vangkilde, A., Larsen, K. M., Fischer, E., Birknow, M. R., Jepsen, J. R. M., Olesen, C., Skovby, F., Plessen, K. J., Mørup, M., Hulme, O., Baaré, W. F. C., Didriksen, M., Siebner, H. R., Werge, T. & Olsen, L., 2015, In : B M C Psychiatry. 15, 1, p. 220

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Usefulness of the SNP microarray technology to identify rare mutations in the case of perinatal death

    Hoeffding, L. K., Kock, K. F., Johnsen, I. G., Hansen, T. & Werge, T., 2015, In : Case Reports in Perinatal Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2014
  31. Published

    Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

    Gusev, A., Lee, S. H., Trynka, G., Finucane, H., Vilhjálmsson, B. J., Xu, H., Zang, C., Ripke, S., Bulik-Sullivan, B., Stahl, E., Kähler, A. K., Hultman, C. M., Purcell, S. M., McCarroll, S. A., Daly, M., Pasaniuc, B., Sullivan, P. F., Neale, B. M., Wray, N. R., Raychaudhuri, S., Price, A. L., Schizophrenia Working Group of the Psychiatric Genomics Consortium & Werge, T. M., 6 Nov 2014, In : American Journal of Human Genetics. 95, 5, p. 535-52 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published
  33. Published

    3D facial landmarks: Inter-operator variability of manual annotation

    Fagertun, J., Harder, S., Rosengren, A., Moeller, C., Werge, T., Paulsen, R. R. & Hansen, T., 11 Oct 2014, In : BMC Medical Imaging. 14, 1, p. 35

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia

    Ruderfer, D. M., Fanous, A. H., Ripke, S., McQuillin, A., Amdur, R. L., Gejman, P. V., O'Donovan, M. C., Andreassen, O. A., Djurovic, S., Hultman, C. M., Kelsoe, J. R., Jamain, S., Landén, M., Leboyer, M., Nimgaonkar, V., Nurnberger, J., Smoller, J. W., Craddock, N., Corvin, A., Sullivan, P. F., Holmans, P., Sklar, P., Kendler, K. S. & Schizophrenia Working Group of Psychiatric Genomics Consortium, Sep 2014, In : Molecular Psychiatry. 19, 9, p. 1017-24 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Biological insights from 108 schizophrenia-associated genetic loci

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 24 Jul 2014, In : Nature. 511, 7510, p. 421-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway

    Schizophrenia Psychiatric Genome-wide Association Study (GWAS) Consortium & PGC schizophrenia working group (Thomas M Werge, Thomas Folkmann Hansen, members) , 1 Jul 2014, In : JAMA Psychiatry. 71, 7, p. 778-85 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis

    Hargreaves, A., Anney, R., O'Dushlaine, C., Nicodemus, K. K., Gill, M., Corvin, A., Morris, D., Donohoe, G. & Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ), Jul 2014, In : Psychological Medicine. 44, 10, p. 2177-87 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Erratum to: Dose-Specific Adverse Drug Reaction Identification in Electronic Patient Records: Temporal Data Mining in an Inpatient Psychiatric Population

    Eriksson, R., Werge, T., Jensen, L. J. & Brunak, S., 9 Apr 2014, 11 p.

    Research output: Other contributionResearch

  39. Published

    Concordance Rates and Heritability in Schizophrenia, Data from a Danish Twin Cohort

    Hilker, R., Helenius, D., Fagerlund, B., Skytte, A., Nordentoft, M. & Glenthøj, B. Y., Apr 2014, In : Schizophrenia Research. 153, Suppl. 1, p. 322 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  40. Published

    Metabolomics has the potential to improve drug therapy

    Stage, C., Jürgens, G., Dalhoff, K. P. & Rasmussen, H. B., 17 Mar 2014, In : Ugeskrift for læger [online]. 176, 6

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Dose-Specific Adverse Drug Reaction Identification in Electronic Patient Records: Temporal Data Mining in an Inpatient Psychiatric Population

    Eriksson, R., Werge, T., Jensen, L. J. & Brunak, S., 15 Mar 2014, In : Drug Safety. 37, 4, p. 237-247

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    CNVs conferring risk of autism or schizophrenia affect cognition in controls

    Stefansson, H., Meyer-Lindenberg, A., Steinberg, S., Magnusdottir, B., Morgen, K., Arnarsdottir, S., Bjornsdottir, G., Walters, G. B., Jonsdottir, G. A., Doyle, O. M., Tost, H., Grimm, O., Kristjansdottir, S., Snorrason, H., Davidsdottir, S. R., Gudmundsson, L. J., Jonsson, G. F., Stefansdottir, B., Helgadottir, I., Haraldsson, M., Jonsdottir, B., Thygesen, J. H., Schwarz, A. J., Didriksen, M., Stensbøl, T. B., Brammer, M., Kapur, S., Halldorsson, J. G., Hreidarsson, S., Saemundsen, E., Sigurdsson, E. & Stefansson, K., 16 Jan 2014, In : Nature. 505, 7483, p. 361-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Introducing the hypothome: a way to integrate predicted proteins in interactomes

    Desler, C., Zambach, S., Suravajhala, P. & Rasmussen, L. J., 1 Jan 2014, In : International Journal of Bioinformatics Research and Applications. 10, 6, p. 647-52 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors

    Thomsen, R., Rasmussen, H. B., Linnet, K. & INDICES Consortium, Jan 2014, In : Drug Metabolism and Disposition. 42, 1, p. 126-33 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Sequence analysis of 17 NRXN1 deletions

    Hoeffding, L. K. E., Hansen, T., Ingason, A., Doung, L., Thygesen, J. H., Møller, R. S., Tommerup, N., Kirov, G., Rujescu, D., Larsen, L. & Werge, T., Jan 2014, In : American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 165, 1, p. 52-61 10 p.

    Research output: Contribution to journalJournal articleResearch

  46. Published

    A Mouse Model that Recapitulates Cardinal Features of the 15q13.3 Microdeletion Syndrome Including Schizophrenia- and Epilepsy-Related Alterations

    Fejgin, K., Nielsen, J., Birknow, M. R., Bastlund, J. F., Nielsen, V., Lauridsen, J. B., Stefansson, H., Steinberg, S., Sorensen, H. B. D., Mortensen, T. E., Larsen, P. H., Klewe, I. V., Rasmussen, S. V., Stefansson, K., Werge, T. M., Kallunki, P., Christensen, K. V. & Didriksen, M., 2014, In : Biological Psychiatry. 76, 2, p. 128-137

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles

    Goldstein, J. I., Fredrik Jarskog, L., Hilliard, C., Alfirevic, A., Duncan, L., Fourches, D., Huang, H., Lek, M., Neale, B. M., Ripke, S., Shianna, K., Szatkiewicz, J. P., Tropsha, A., van den Oord, E. J., Cascorbi, I., Dettling, M., Gazit, E., Goff, D. C., Holden, A. L., Kelly, D. L., Malhotra, A. K., Nielsen, J., Pirmohamed, M., Rujescu, D., Werge, T., Levy, D. L., Josiassen, R. C., Kennedy, J. L., Lieberman, J. A., Daly, M. J. & Sullivan, P. F., 2014, In : Nature Communications. 5, p. 4757

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Common variant at 16p11.2 conferring risk of psychosis

    Steinberg, S., de Jong, S., Mattheisen, M., Costas, J., Demontis, D., Jamain, S., Pietiläinen, O. P. H., Lin, K., Papiol, S., Huttenlocher, J., Sigurdsson, E., Vassos, E., Giegling, I., Breuer, R., Fraser, G., Walker, N., Melle, I., Djurovic, S., Agartz, I., Tuulio-Henriksson, A., Suvisaari, J., Lönnqvist, J., Paunio, T., Olsen, L., Hansen, T. F., Ingason, A., Pirinen, M., Strengman, E., Hougaard, D. M., Orntoft, T., Didriksen, M., Hollegaard, M. V., Nordentoft, M., Abramova, L., Kaleda, V., Arrojo, M., Sanjuán, J., Arango, C., Etain, B., Bellivier, F., Méary, A., Schürhoff, F., Szoke, A., Ribolsi, M., Magni, V., Siracusano, A., Sperling, S., Rossner, M., Christiansen, C., Werge, T. & GROUP, 2014, In : Molecular Psychiatry. 19, p. 108–114

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    EHMTI-0377. The influence of genetic constitution on migraine drug responses

    Christensen, A. F., Esserlind, AL., Werge, T., Stefansson, H. & Olesen, J., 2014, In : Journal of Headache and Pain. 15, 1, p. 1-1 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  50. Published

    EHMTI-0380. The association of migraine susceptibility loci with severe migraine characteristics in a clinic-based migraine sample

    Esserlind, A., Christensen, AF., Steinberg, S., Grarup, N., Pedersen, O., Hansen, T., Werge, T., Folkmann-Hansen, T., Husemoen, LL., Linneberg, A., Budtz-Jørgensen, E., Westergaard, M. L., Stefansson, H. & Olesen, J., 2014, In : Journal of Headache and Pain. 15, 1, p. 1-1 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  51. Published

    Erratum: Sequence analysis of 17 NRXN1 deletions

    Hoeffding, L. K., Hansen, T., Ingason, A., Duong, L., Thygesen, J. H., Møller, R. S., Tommerup, N., Kirov, G., Rujescu, D. & Larsen, L. A., 2014, 1 p.

    Research output: Other contributionResearch

  52. Published

    Family load estimates and risk factors of anxiety disorders in a nationwide three generation study

    Helenius, D., Munk-Jørgensen, P. & Steinhausen, H-C., 2014, In : Psychiatry Research. 216, 3, p. 351-356

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 49228305