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Copenhagen Trial Unit - a part of Copenhagen University Hospital
  1. 2020
  2. Published

    Prognostic value of 12 novel cardiological biomarkers in stable coronary artery disease. A 10-year follow-up of the placebo group of the Copenhagen CLARICOR trial

    Winkel, P., Jakobsen, J. C., Hilden, J., Jensen, G. B., Kjøller, E., Sajadieh, A., Kastrup, J., Kolmos, H. J., Iversen, K. K., Bjerre, M., Larsson, A., Ärnlöv, J. & Gluud, C., 20 Aug 2020, In : BMJ Open. 10, 8, e033720.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published
  4. E-pub ahead of print

    Was amorphous aluminium hydroxyphosphate sulfate adequately evaluated before authorisation in Europe?

    Petersen, S. B. & Gluud, C., 6 Aug 2020, In : BMJ Evidence-Based Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published
  6. Published

    The PANSAID Randomized Clinical Trial: A pre-planned 1-year follow-up regarding harm

    Thybo, K. H., Hägi-Pedersen, D., Wetterslev, J., Overgaard, S. & Mathiesen, O., Aug 2020, In : Acta Anaesthesiologica Scandinavica. 64, 7, p. 910-912 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. E-pub ahead of print

    Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis plan

    Petersen, M. W., Meyhoff, T. S., Helleberg, M., Kjær, M-B. N., Granholm, A., Hjortsø, C. J. S., Jensen, T. S., Møller, M. H., Hjortrup, P. B., Wetterslev, M., Vesterlund, G. K., Russell, L., Jørgensen, V. L., Tjelle, K., Benfield, T., Ulrik, C. S., Andreasen, A. S., Mohr, T., Bestle, M. H., Poulsen, L. M., Hitz, M. F., Hildebrandt, T., Knudsen, L. S., Møller, A., Sølling, C. G., Brøchner, A. C., Rasmussen, B. S., Nielsen, H., Christensen, S., Strøm, T., Cronhjort, M., Wahlin, R. R., Jakob, S., Cioccari, L., Venkatesh, B., Hammond, N., Jha, V., Myatra, S. N., Gluud, C., Lange, T. & Perner, A., 21 Jul 2020, In : Acta Anaesthesiologica Scandinavica.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. E-pub ahead of print

    Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes

    CIMT Trial group, 18 Jul 2020, In : Journal of Diabetes and its Complications. p. 107681

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. E-pub ahead of print

    Higher versus lower oxygenation strategies in acutely ill adults. A systematic review with meta-analysis and Trial Sequential Analysis

    Barbateskovic, M., Schjørring, O. L., Krauss, S. R., Meyhoff, C. S., Jakobsen, J. J., Rasmussen, B. S., Perner, A. & Wetterslev, J., 17 Jul 2020, In : Chest.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    DEX-2-TKA - DEXamethasone twice for pain treatment after Total Knee Arthroplasty. Detailed statistical analysis plan for a randomized, blinded, three-group multicentre clinical trial

    Gasbjerg, K. S., Hägi-Pedersen, D., Lunn, T. H., Overgaard, S., Pedersen, N. A., Bagger, J., Lindholm, P., Brorson, S., Schrøder, H. M., Thybo, K. H., Mathiesen, O. & Jakobsen, J. C., Jul 2020, In : Acta Anaesthesiologica Scandinavica. 64, 6, p. 839-846 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Dr. Uhre et al. Reply

    Uhre, V. F., Uhre, C. F., Lønfeldt, N. N., Pretzmann, L., Vangkilde, S., Plessen, K. J., Gluud, C., Jakobsen, J. C. & Pagsberg, A. K., Jul 2020, In : Journal of the American Academy of Child and Adolescent Psychiatry. 59, 7, p. 787-791 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published
  13. Published

    Response

    Meyhoff, T. S., Møller, M. H., Hjortrup, P. B., Cronhjort, M., Perner, A. & Wetterslev, J., Jul 2020, In : Chest. 158, 1, p. 428

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The handling oxygenation targets in the intensive care unit (HOT-ICU) trial: Detailed statistical analysis plan

    Schjørring, O. L., Klitgaard, T. L., Perner, A., Wetterslev, J., Lange, T., Keus, F., Laake, J. H., Morgan, M., Bäcklund, M., Siegemund, M., Thormar, K. M. & Rasmussen, B. S., Jul 2020, In : Acta Anaesthesiologica Scandinavica. 64, 6, p. 847-856 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published
  16. E-pub ahead of print

    The Agents Intervening against Delirium in the Intensive Care Unit-Trial (AID-ICU trial):- a detailed statistical analysis plan

    Andersen-Ranberg, N., Poulsen, L. M., Perner, A., Wetterslev, J., Mathiesen, O., Mortensen, C. B., Estrup, S., Ebdrup, B. H., Hästbacka, J., Citerio, G., Caballero, J., Morgan, M. P. G., Oxenbøll-Collet, M., Weber, S-O., Andreasen, A. S., Bestle, M. H., Pedersen, H. B. S., Nielsen, L. G., Uslu, B., Jensen, T. B., Thee, C., Dey, N. & Lange, T., 27 Jun 2020, In : Acta Anaesthesiologica Scandinavica.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. E-pub ahead of print
  18. Published

    Maternal Sildenafil vs Placebo in Pregnant Women With Severe Early-Onset Fetal Growth Restriction: A Randomized Clinical Trial

    Dutch STRIDER Trial Group, 1 Jun 2020, In : JAMA network open. 3, 6, p. e205323

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. E-pub ahead of print

    Internet-based therapy with FearFighter for anxiety disorders: a randomised clinical trial

    Fenger, M., Lindschou, J., Gluud, C., Winkel, P., Jørgensen, L., Dybkjaer, J. H. & Lau, M., 13 May 2020, In : Nordic Journal of Psychiatry. p. 1-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project)

    Juul, S., Nielsen, N., Bentzer, P., Veroniki, A. A., Thabane, L., Linder, A., Klingenberg, S., Gluud, C. & Jakobsen, J. C., 9 May 2020, In : Systematic Reviews. 9, 1, p. 108

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. E-pub ahead of print
  22. Published
  23. Published

    Protocol for outcome reporting and follow-up in the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest trial (TTM2)

    Lilja, G., Nielsen, N., Ullén, S., Nordstrom, E. B., Dankiewicz, J., Friberg, H., Heimburg, K., Jakobsen, J. C., Levin, H., Callaway, C., Cariou, A., Eastwood, G. M., Helbok, R., Hovdenes, J., Kirkegaard, H., Leithner, C., Morgan, M. P. G., Nordberg, P., Oddo, M., Pelosi, P., Rylander, C., Saxena, M., Taccone, F. S., Siranec, M., Wise, M. P., Young, P. J. & Cronberg, T., May 2020, In : Resuscitation. 150, p. 104-112 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published
  25. Published

    Serum osteoprotegerin as a long-term predictor for patients with stable coronary artery disease and its association with diabetes and statin treatment: A CLARICOR trial 10-year follow-up substudy

    Bjerre, M., Hilden, J., Winkel, P., Jensen, G. B., Kjøller, E., Sajadieh, A., Kastrup, J., Kolmos, H. J., Larsson, A., Ärnlöv, J., Jakobsen, J. C. & Gluud, C., May 2020, In : Atherosclerosis. 301, p. 8-14 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. E-pub ahead of print

    Methylphenidate for ADHD rejected from the WHO Essential Medicines List due to uncertainties in benefit-harm profile

    Storebø, O. J. & Gluud, C., 24 Apr 2020, In : BMJ Evidence-Based Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Eversion technique versus conventional endarterectomy with patch angioplasty in carotid surgery: protocol for a systematic review with meta-analyses and trial sequential analysis of randomised clinical trials

    Marsman, M. S., Wetterslev, J., Vriens, P. W. H. E., Bleys, R. L. A. W., Jahrome, A. K., Moll, F. L., Keus, F. & Koning, G. G., 19 Apr 2020, In : BMJ Open. 10, 4, p. e030503

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Arterial oxygen tensions in mechanically ventilated ICU patients and mortality: a retrospective, multicentre, observational cohort study

    Schjørring, O. L., Jensen, A. K. G., Nielsen, C. G., Ciubotariu, A., Perner, A., Wetterslev, J., Lange, T. & Rasmussen, B. S., Apr 2020, In : British Journal of Anaesthesia. 124, 4, p. 420-429 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial

    Granholm, A., Marker, S., Krag, M., Zampieri, F. G., Thorsen-Meyer, H-C., Kaas-Hansen, B. S., van der Horst, I. C. C., Lange, T., Wetterslev, J., Perner, A. & Møller, M. H., Apr 2020, In : Intensive Care Medicine. 46, 4, p. 717-726 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Letter to the Editor: Glucocorticosteroids for Alcohol-Associated Hepatitis

    Varganova, D. L., Pavlov, C. S., Casazza, G., Nikolova, D. & Gluud, C., Apr 2020, In : Hepatology (Baltimore, Md.). 71, 4, p. 1524

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. E-pub ahead of print

    Early specialised palliative care: interventions, symptoms, problems

    Skjoedt, N., Johnsen, A. T., Sjøgren, P., Neergaard, M. A., Damkier, A., Gluud, C., Lindschou, J., Fayers, P., Higginson, I. J., Strömgren, A. S. & Groenvold, M., 27 Mar 2020, In : BMJ Supportive and Palliative Care.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Prognosis and Reclassification by YKL-40 in Stable Coronary Artery Disease

    Schroder, J., Jakobsen, J. C., Winkel, P., Hilden, J., Jensen, G. B., Sajadieh, A., Larsson, A., Ärnlöv, J., Harutyunyan, M., Johansen, J. S., Kjøller, E., Gluud, C. & Kastrup, J., 3 Mar 2020, In : Journal of the American Heart Association. 9, 5, p. e014634

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published
  34. Published

    Health apps targeting children with overweight-a protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials

    Rashid, R., Perego, P., Condon, L., Jakobsen, J. C., Lindschou, J., Gluud, C., Andreoni, G. & Lissau, I., 11 Feb 2020, In : Systematic Reviews. 9, 1, 28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Haloperidol for the treatment of delirium in critically ill patients: a systematic review with meta-analysis and Trial Sequential Analysis

    Barbateskovic, M., Krauss, S. R., Collet, M. O., Andersen-Ranberg, N. C., Mathiesen, O., Jakobsen, J. C., Perner, A. & Wetterslev, J., Feb 2020, In : Acta Anaesthesiologica Scandinavica. 64, 2, p. 254-266 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  36. E-pub ahead of print

    Assessment of assumptions of statistical analysis methods in randomised clinical trials: the what and how

    Nørskov, A. K., Lange, T., Nielsen, E. E., Gluud, C., Winkel, P., Beyersmann, J., de Uña-Álvarez, J., Torri, V., Billot, L., Putter, H., Wetterslev, J., Thabane, L. & Jakobsen, J. C., 27 Jan 2020, In : BMJ Evidence-Based Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study

    Volf, C., Aggestrup, A. S., Petersen, P. M., Dam-Hansen, C., Knorr, U., Petersen, E. E., Engstrøm, J., Jakobsen, J. C., Hansen, T. S., Madsen, H. Ø., Hageman, I. & Martiny, K., 26 Jan 2020, In : BMJ Open. 10, 1, p. e032233

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Lower versus higher fluid volumes during initial management of sepsis - a systematic review with meta-analysis and trial sequential analysis

    Meyhoff, T. S., Møller, M. H., Hjortrup, P. B., Cronhjort, M., Perner, A. & Wetterslev, J., 23 Jan 2020, In : Chest. 20, p. 30123-9 pii: S0012-3692.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Pregnancy Associated Plasma Protein-A as a Cardiovascular Risk Marker in Patients with Stable Coronary Heart Disease During 10 Years Follow-Up-A CLARICOR Trial Sub-Study

    Nilsson, E., Kastrup, J., Sajadieh, A., Boje Jensen, G., Kjøller, E., Kolmos, H. J., Wuopio, J., Nowak, C., Larsson, A., Jakobsen, J. C., Winkel, P., Gluud, C., Iversen, K. K., Ärnlöv, J. & Carlsson, A. C., 18 Jan 2020, In : Journal of Clinical Medicine. 9, 1

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Sertraline in primary care: comments on the PANDA trial

    Hengartner, M. P., Plöderl, M., Braillon, A., Jakobsen, J. C. & Gluud, C., Jan 2020, In : The Lancet. Psychiatry. 7, 1, p. 17

    Research output: Contribution to journalComment/debateResearchpeer-review

  41. Published
  42. Published

    Benefits and harm of paracetamol and ibuprofen in combination for postoperative pain: preplanned subgroup analyses of the multicenter randomized PANSAID trial

    Thybo, K. H., Hägi-Pedersen, D., Wetterslev, J., Dahl, J. B., Jakobsen, J. C., Pedersen, N. A., Jakobsen, K., Bülow, H. H., Ibsen, L., Overgaard, S. & Mathiesen, O., 2020, In : Acta Anaesthesiologica Scandinavica. 64, 2, p. 245-253

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. E-pub ahead of print
  44. Published

    Dynamic LED light versus static LED light for depressed inpatients: results from a randomized feasibility trial

    Volf, C., Aggestrup, A. S., Svendsen, S. D., Hansen, T. S., Petersen, P. M., Dam-Hansen, C., Knorr, U., Petersen, E. E., Engstrøm, J., Hageman, I., Jakobsen, J. C. & Martiny, K., 2020, In : Pilot and Feasibility Studies. 6, p. 5

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published
  46. Published

    Long-term patient-important outcomes after septic shock: a protocol for 1-year follow-up of the CLASSIC-trial

    Kjaer, M-B. N., Meyhoff, T. S., Madsen, M. B., Hjortrup, P. B., Møller, M. H., Egerod, I., Wetterslev, J., Lange, T., Cronhjort, M., Laake, J. H., Jakob, S. M., Nalos, M., Pettilä, V., van der Horst, I. C. C., Ostermann, M., Mouncey, P., Cecconi, M., Ferrer, R., L N G Malbrain, M., Ahlstedt, C., Hoffmann, S., Bestle, M. H., Gyldensted, L., Nebrich, L., Russell, L., Vang, M., Sølling, C., Brøchner, A. C., Rasmussen, B. S. & Perner, A., 2020, In : Acta Anaesthesiologica Scandinavica. 64, p. 410–416

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Plexus anesthesia versus general anesthesia in patients for carotid endarterectomy with patch angioplasty: Protocol for a systematic review with meta-analyses and Trial Sequential Analysis of randomized clinical trials

    Marsman, M. S., Wetterslev, J., Keus, F., van Aalst, D., van Rooij, F. G., Heyligers, J. M. M., Moll, F. L., Jahrome, A. K., Vriens, P. W. H. E. & Koning, G. G., 2020, In : International Journal of Surgery Protocols. 19, p. 1-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. E-pub ahead of print

    Should antidepressants be used for major depressive disorder?

    Jakobsen, J. C., Gluud, C. & Kirsch, I., 2020, In : BMJ Evidence-Based Medicine.

    Research output: Contribution to journalReviewResearchpeer-review

  49. Published
  50. 2019
  51. Published

    Cerebral near-infrared spectroscopy monitoring versus treatment as usual for extremely preterm infants: a protocol for the SafeBoosC randomised clinical phase III trial

    Hansen, M. L., Pellicer, A., Gluud, C., Dempsey, E., Mintzer, J., Hyttel-Sørensen, S., Heuchan, A. M., Hagmann, C., Ergenekon, E., Dimitriou, G., Pichler, G., Naulaers, G., Cheng, G., Guimarães, H., Tkaczyk, J., Kreutzer, K. B., Fumagalli, M., Claris, O., Lemmers, P., Fredly, S., Szczapa, T., Austin, T., Jakobsen, J. C. & Greisen, G., 30 Dec 2019, In : Trials. 20, 1, p. 811

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Detailed statistical analysis plan for the SafeBoosC III trial: a multinational randomised clinical trial assessing treatment guided by cerebral oxygenation monitoring versus treatment as usual in extremely preterm infants

    Hansen, M. L., Pellicer, A., Gluud, C., Dempsey, E., Mintzer, J., Hyttel-Sorensen, S., Heuchan, A. M., Hagmann, C., Dimitriou, G., Pichler, G., Naulaers, G., Cheng, G., Vilan, A., Tkaczyk, J., Kreutzer, K. B., Fumagalli, M., Claris, O., Fredly, S., Szczapa, T., Lange, T., Jakobsen, J. C. & Greisen, G., 19 Dec 2019, In : Trials. 20, 1, p. 746

    Research output: Contribution to journalJournal articleResearchpeer-review

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