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Copenhagen Trial Unit - a part of Copenhagen University Hospital
  1. 2020
  2. Published
  3. Published

    Prognosis and Reclassification by YKL-40 in Stable Coronary Artery Disease

    Schroder, J., Jakobsen, J. C., Winkel, P., Hilden, J., Jensen, G. B., Sajadieh, A., Larsson, A., Ärnlöv, J., Harutyunyan, M., Johansen, J. S., Kjøller, E., Gluud, C. & Kastrup, J., 3 Mar 2020, In : Journal of the American Heart Association. 9, 5, p. e014634

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published
  5. E-pub ahead of print

    The handling oxygenation targets in the intensive care unit (HOT-ICU) trial: Detailed statistical analysis plan

    Schjørring, O. L., Klitgaard, T. L., Perner, A., Wetterslev, J., Lange, T., Keus, F., Laake, J. H., Morgan, M., Bäcklund, M., Siegemund, M., Thormar, K. M. & Rasmussen, B. S., 18 Feb 2020, In : Acta Anaesthesiologica Scandinavica.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. E-pub ahead of print
  7. E-pub ahead of print

    DEX-2-TKA - DEXamethasone twice for pain treatment after Total Knee Arthroplasty. Detailed statistical analysis plan for a randomized, blinded, three-group multicentre clinical trial

    Gasbjerg, K. S., Hägi-Pedersen, D., Lunn, T. H., Overgaard, S., Pedersen, N. A., Bagger, J., Lindholm, P., Brorson, S., Schrøder, H. M., Thybo, K. H., Mathiesen, O. & Jakobsen, J. C., 11 Feb 2020, In : Acta Anaesthesiologica Scandinavica.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Health apps targeting children with overweight-a protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials

    Rashid, R., Perego, P., Condon, L., Jakobsen, J. C., Lindschou, J., Gluud, C., Andreoni, G. & Lissau, I., 11 Feb 2020, In : Systematic Reviews. 9, 1, 28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Haloperidol for the treatment of delirium in critically ill patients: a systematic review with meta-analysis and Trial Sequential Analysis

    Barbateskovic, M., Krauss, S. R., Collet, M. O., Andersen-Ranberg, N. C., Mathiesen, O., Jakobsen, J. C., Perner, A. & Wetterslev, J., Feb 2020, In : Acta Anaesthesiologica Scandinavica. 64, 2, p. 254-266 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  10. E-pub ahead of print

    Assessment of assumptions of statistical analysis methods in randomised clinical trials: the what and how

    Nørskov, A. K., Lange, T., Nielsen, E. E., Gluud, C., Winkel, P., Beyersmann, J., de Uña-Álvarez, J., Torri, V., Billot, L., Putter, H., Wetterslev, J., Thabane, L. & Jakobsen, J. C., 27 Jan 2020, In : BMJ Evidence-Based Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study

    Volf, C., Aggestrup, A. S., Petersen, P. M., Dam-Hansen, C., Knorr, U., Petersen, E. E., Engstrøm, J., Jakobsen, J. C., Hansen, T. S., Madsen, H. Ø., Hageman, I. & Martiny, K., 26 Jan 2020, In : BMJ Open. 10, 1, p. e032233

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Lower versus higher fluid volumes during initial management of sepsis - a systematic review with meta-analysis and trial sequential analysis

    Meyhoff, T. S., Møller, M. H., Hjortrup, P. B., Cronhjort, M., Perner, A. & Wetterslev, J., 23 Jan 2020, In : Chest. 20, p. 30123-9 pii: S0012-3692.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Pregnancy Associated Plasma Protein-A as a Cardiovascular Risk Marker in Patients with Stable Coronary Heart Disease During 10 Years Follow-Up-A CLARICOR Trial Sub-Study

    Nilsson, E., Kastrup, J., Sajadieh, A., Boje Jensen, G., Kjøller, E., Kolmos, H. J., Wuopio, J., Nowak, C., Larsson, A., Jakobsen, J. C., Winkel, P., Gluud, C., Iversen, K. K., Ärnlöv, J. & Carlsson, A. C., 18 Jan 2020, In : Journal of Clinical Medicine. 9, 1

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. E-pub ahead of print

    Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial

    Granholm, A., Marker, S., Krag, M., Zampieri, F. G., Thorsen-Meyer, H-C., Kaas-Hansen, B. S., van der Horst, I. C. C., Lange, T., Wetterslev, J., Perner, A. & Møller, M. H., 14 Jan 2020, In : Intensive Care Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Sertraline in primary care: comments on the PANDA trial

    Hengartner, M. P., Plöderl, M., Braillon, A., Jakobsen, J. C. & Gluud, C., Jan 2020, In : The Lancet. Psychiatry. 7, 1, p. 17

    Research output: Contribution to journalComment/debateResearchpeer-review

  16. Published
  17. Published

    Benefits and harm of paracetamol and ibuprofen in combination for postoperative pain: preplanned subgroup analyses of the multicenter randomized PANSAID trial

    Thybo, K. H., Hägi-Pedersen, D., Wetterslev, J., Dahl, J. B., Jakobsen, J. C., Pedersen, N. A., Jakobsen, K., Bülow, H. H., Ibsen, L., Overgaard, S. & Mathiesen, O., 2020, In : Acta Anaesthesiologica Scandinavica. 64, 2, p. 245-253

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. E-pub ahead of print
  19. Published

    Dynamic LED light versus static LED light for depressed inpatients: results from a randomized feasibility trial

    Volf, C., Aggestrup, A. S., Svendsen, S. D., Hansen, T. S., Petersen, P. M., Dam-Hansen, C., Knorr, U., Petersen, E. E., Engstrøm, J., Hageman, I., Jakobsen, J. C. & Martiny, K., 2020, In : Pilot and Feasibility Studies. 6, p. 5

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. E-pub ahead of print

    Letter to the Editor: Glucocorticosteroids for alcoholic hepatitis

    Varganova, D., Pavlov, C. S., Nikolova, D., Gluud, C. & Casazza, G., 2020, In : Hepatology (Baltimore, Md.).

    Research output: Contribution to journalLetterResearchpeer-review

  21. Published

    Long-term patient-important outcomes after septic shock: a protocol for 1-year follow-up of the CLASSIC-trial

    Kjaer, M-B. N., Meyhoff, T. S., Madsen, M. B., Hjortrup, P. B., Møller, M. H., Egerod, I., Wetterslev, J., Lange, T., Cronhjort, M., Laake, J. H., Jakob, S. M., Nalos, M., Pettilä, V., van der Horst, I. C. C., Ostermann, M., Mouncey, P., Cecconi, M., Ferrer, R., L N G Malbrain, M., Ahlstedt, C., Hoffmann, S., Bestle, M. H., Gyldensted, L., Nebrich, L., Russell, L., Vang, M., Sølling, C., Brøchner, A. C., Rasmussen, B. S. & Perner, A., 2020, In : Acta Anaesthesiologica Scandinavica. 64, p. 410–416

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Plexus anesthesia versus general anesthesia in patients for carotid endarterectomy with patch angioplasty: Protocol for a systematic review with meta-analyses and Trial Sequential Analysis of randomized clinical trials

    Marsman, M. S., Wetterslev, J., Keus, F., van Aalst, D., van Rooij, F. G., Heyligers, J. M. M., Moll, F. L., Jahrome, A. K., Vriens, P. W. H. E. & Koning, G. G., 2020, In : International journal of surgery protocols. 19, p. 1-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. E-pub ahead of print

    Should antidepressants be used for major depressive disorder?

    Jakobsen, J. C., Gluud, C. & Kirsch, I., 2020, In : BMJ Evidence-Based Medicine.

    Research output: Contribution to journalReviewResearchpeer-review

  24. 2019
  25. Published

    Cerebral near-infrared spectroscopy monitoring versus treatment as usual for extremely preterm infants: a protocol for the SafeBoosC randomised clinical phase III trial

    Hansen, M. L., Pellicer, A., Gluud, C., Dempsey, E., Mintzer, J., Hyttel-Sørensen, S., Heuchan, A. M., Hagmann, C., Ergenekon, E., Dimitriou, G., Pichler, G., Naulaers, G., Cheng, G., Guimarães, H., Tkaczyk, J., Kreutzer, K. B., Fumagalli, M., Claris, O., Lemmers, P., Fredly, S., Szczapa, T., Austin, T., Jakobsen, J. C. & Greisen, G., 30 Dec 2019, In : Trials. 20, 1, p. 811

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Detailed statistical analysis plan for the SafeBoosC III trial: a multinational randomised clinical trial assessing treatment guided by cerebral oxygenation monitoring versus treatment as usual in extremely preterm infants

    Hansen, M. L., Pellicer, A., Gluud, C., Dempsey, E., Mintzer, J., Hyttel-Sorensen, S., Heuchan, A. M., Hagmann, C., Dimitriou, G., Pichler, G., Naulaers, G., Cheng, G., Vilan, A., Tkaczyk, J., Kreutzer, K. B., Fumagalli, M., Claris, O., Fredly, S., Szczapa, T., Lange, T., Jakobsen, J. C. & Greisen, G., 19 Dec 2019, In : Trials. 20, 1, p. 746

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Adding exercise to usual care in patients with hypertension, type 2 diabetes mellitus and/or cardiovascular disease: a protocol for a systematic review with meta-analysis and trial sequential analysis

    Rijal, A., Nielsen, E. E., Hemmingsen, B., Neupane, D., Gæde, P. H., Olsen, M. H. & Jakobsen, J. C., 17 Dec 2019, In : Systematic Reviews. 8, 1, p. 330

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Beta-blockers for suspected or diagnosed acute myocardial infarction

    Safi, S., Sethi, N. J., Nielsen, E. E., Feinberg, J., Jakobsen, J. C. & Gluud, C., 17 Dec 2019, In : Cochrane Database of Systematic Reviews. 12, p. CD012484

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    DEBATE-statistical analysis plans for observational studies

    Hiemstra, B., Keus, F., Wetterslev, J., Gluud, C. & van der Horst, I. C. C., 9 Dec 2019, In : BMC Medical Research Methodology. 19, 1, p. 233

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis

    Korang, S. K., Safi, S., Gluud, C., Lausten-Thomsen, U. & Jakobsen, J. C., 5 Dec 2019, In : Systematic Reviews. 8, 1, p. 306

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published
  32. Published

    Low Dose Low-Molecular-Weight Heparin for Thrombosis Prophylaxis: Systematic Review with Meta-Analysis and Trial Sequential Analysis

    Eck, R. J., Bult, W., Wetterslev, J., Gans, R. O. B., Meijer, K., van der Horst, I. C. C. & Keus, F., 21 Nov 2019, In : Journal of Clinical Medicine. 8, 12, p. pii:E2039

    Research output: Contribution to journalReviewResearchpeer-review

  33. Published

    Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B

    Kong, D. Z., Liang, N., Yang, G. L., Zhang, Z., Liu, Y., Li, J., Liu, X., Liang, S., Nikolova, D., Jakobsen, J. C., Gluud, C. & Liu, J., 7 Nov 2019, In : Cochrane Database of Systematic Reviews. 2019, 11

    Research output: Contribution to journalReviewResearchpeer-review

  34. Published

    Fever control interventions versus placebo, sham or no intervention in adults: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis

    Sethi, N., Naqash, A. I., Nielsen, N. & Jakobsen, J. C., 3 Nov 2019, In : BMJ Open. 9, 11, p. e032389

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published
  36. Published

    Agents Intervening against Delirium in the Intensive Care Unit (AID-ICU) - Protocol for a randomised placebo-controlled trial of haloperidol in patients with delirium in the ICU

    Andersen-Ranberg, N., Poulsen, L. M., Perner, A., Wetterslev, J., Estrup, S., Lange, T., Ebdrup, B., Hästbacka, J., Morgan, M. P. G., Citerio, G., Zafrani, L., Caballero, J., Collet, M. O., Weber, S., Andreasen, A. S., Bestle, M., Pedersen, H. B. S., Hildebrandt, T., Thee, C., Jensen, T. B., Dey, N., Nielsen, L. G. & Mathiesen, O., Nov 2019, In : Acta Anaesthesiologica Scandinavica. 63, 10, p. 1426-1433 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Storage time of red blood cells among ICU patients with septic shock

    Rygård, S. L., Grønlykke, L., Perner, A., Winkel, P., Lange, T., Holst, L. B., Johansson, P. I., Aneman, A., Brodersen, T., Laurén, E., Ullum, H. & Wetterslev, J., Nov 2019, In : Acta Anaesthesiologica Scandinavica. 63, 10, p. 1366-1377 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Cannabinoids versus placebo or no intervention for pain: protocol for a systematic review with meta-analysis and trial sequential analysis

    Barakji, J. A., Korang, S. K., Feinberg, J., Maagard, M., Gluud, C., Mathiesen, O. & Jakobsen, J. C., 31 Oct 2019, In : BMJ Open. 9, 10, p. e031574

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The effects of adding angiotensin receptor neprilysin inhibitors to usual care in patients with heart failure: a protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

    Nielsen, E. E., Feinberg, J., Raymond, I., Olsen, M. H., Steensgaard-Hansen, F. V. & Jakobsen, J. C., 31 Oct 2019, In : Systematic Reviews. 8, 1, p. 251

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published
  41. Published

    Outcomes of Prophylactic Pantoprazole in Adult Intensive Care Unit Patients Receiving Dialysis: Results of a Randomized Trial

    Schefold, J. C., Krag, M., Marker, S., Perner, A., Wetterslev, J., Wise, M. P., Borthwick, M., Bendel, S., Keus, F., Guttormsen, A. B., Lange, T., the SUP-ICU investigators & Møller, M. H., 1 Oct 2019, In : American Journal of Nephrology. 50, 4, p. 312-319 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published
  43. Published

    A difficulty with the DIFFMASK score is the difficult statistics - a reply

    Lundstrøm, L. H., Rosenstock, C. V., Wetterslev, J. & Nørskov, A. K., Oct 2019, In : Anaesthesia. 74, 10, p. 1338 1 p.

    Research output: Contribution to journalLetterResearchpeer-review

  44. Published

    Conservative vs liberal fluid therapy in septic shock (CLASSIC) trial—Protocol and statistical analysis plan

    Meyhoff, T. S., Hjortrup, P. B., Møller, M. H., Wetterslev, J., Lange, T., Kjaer, M-B. N., Jonsson, A. B., Hjortsø, C. J. S., Cronhjort, M., Laake, J. H., Jakob, S. M., Nalos, M., Pettilä, V., van der Horst, I., Ostermann, M., Mouncey, P., Rowan, K., Cecconi, M., Ferrer, R., Malbrain, M. L. N. G., Ahlstedt, C., Hoffmann, S., Bestle, M. H., Nebrich, L., Russell, L., Vang, M., Rasmussen, M. L., Sølling, C., Rasmussen, B. S., Brøchner, A. C. & Perner, A., Oct 2019, In : Acta Anaesthesiologica Scandinavica. 63, 9, p. 1262-1271 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Pantoprazole in ICU patients at risk for gastrointestinal bleeding-1-year mortality in the SUP-ICU trial

    Marker, S., Krag, M., Perner, A., Wetterslev, J., Lange, T., Wise, M. P., Borthwick, M., Bendel, S., Keus, F., Guttormsen, A. B., Schefold, J. C., Rasmussen, B. S., Elkmann, T., Bestle, M., Arenkiel, B., Laake, J. H., Kamper, M. K., Lång, M., Pawlowicz-Dworzanska, M. B., Karlsson, S., Liisanantti, J., Dey, N., Knudsen, H., Granholm, A., SUP-ICU trial investigators & Møller, M. H., Oct 2019, In : Acta Anaesthesiologica Scandinavica. 63, 9, p. 1184-1190 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published
  47. Published

    Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial

    EuroHYP-1 investigators, Sep 2019, In : European Stroke Journal. 4, 3, p. 254-262 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Time to onset of gastrointestinal bleeding in the SUP-ICU trial: a preplanned substudy

    Granholm, A., Lange, T., Anthon, C. T., Marker, S., Krag, M., Meyhoff, T. S., Wise, M. P., Borthwick, M., Bendel, S., Keus, F., Guttormsen, A. B., Schefold, J. C., Wetterslev, J., Perner, A. & Møller, M. H., 23 Aug 2019, In : Acta Anaesthesiologica Scandinavica. 63, 10, p. 1346-1356

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Acupuncture for chronic hepatitis B

    Kong, D. Z., Liang, N., Yang, G. L., Zhang, Z., Liu, Y., Yang, Y., Liu, Y. X., Wang, Q. G., Zhang, F., Zhang, H. Y., Nikolova, D., Jakobsen, J. C., Gluud, C. & Liu, J., 22 Aug 2019, In : Cochrane Database of Systematic Reviews. 8, p. CD013107

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Exercise-Based Rehabilitation for Heart Failure: Cochrane Systematic Review, Meta-Analysis, and Trial Sequential Analysis

    Taylor, R. S., Long, L., Mordi, I. R., Madsen, M. T., Davies, E. J., Dalal, H., Rees, K., Singh, S. J., Gluud, C. & Zwisler, A-D., 1 Aug 2019, In : JACC. Heart failure. 7, 8, p. 691-705 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure

    Schjørring, O. L., Perner, A., Wetterslev, J., Lange, T., Keus, F., Laake, J. H., Okkonen, M., Siegemund, M., Morgan, M., Thormar, K. M., and the HOT-ICU Investigators & Rasmussen, B. S., Aug 2019, In : Acta Anaesthesiologica Scandinavica. 63, 7, p. 956-965 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  52. Published

    Clinical Examination for the Prediction of Mortality in the Critically Ill: The Simple Intensive Care Studies-I

    Hiemstra, B., Eck, R. J., Wiersema, R., Kaufmann, T., Koster, G., Scheeren, T. W. L., Snieder, H., Perner, A., Pettilä, V., Wetterslev, J., Keus, F. & van der Horst, I. C. C., 25 Jul 2019, In : Critical Care Medicine. 47, 10, p. 1301-1309

    Research output: Contribution to journalJournal articleResearchpeer-review

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