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Copenhagen Trial Unit - a part of Copenhagen University Hospital
  1. 2021
  2. E-pub ahead of print

    Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

    HOT-ICU Investigators, 20 Jan 2021, In : The New England journal of medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published
  4. Published

    Higher vs Lower Oxygenation Strategies in Acutely Ill Adults: A Systematic Review With Meta-Analysis and Trial Sequential Analysis

    Barbateskovic, M., Schjørring, O. L., Krauss, S. R., Meyhoff, C. S., Jakobsen, J. J., Rasmussen, B. S., Perner, A. & Wetterslev, J., Jan 2021, In : Chest. 159, 1, p. 154-173 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Risk factors for long-term cognitive impairment in ICU survivors: A multicenter, prospective cohort study

    Collet, M. O., Egerod, I., Thomsen, T., Wetterslev, J., Lange, T., Ebdrup, B. H. & Perner, A., Jan 2021, In : Acta Anaesthesiologica Scandinavica. 65, 1, p. 92-99 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2020
  7. Published

    Comparison of different mobile health applications for intervention in children and adolescent with overweight: a protocol for systematic review with meta-analysis and trial sequential analysis

    Perego, P., Rashid, R., Gluud, C., Jakobsen, J. C., Andreoni, G. & Lissau, I., 7 Dec 2020, In : BMJ Open. 10, 12, p. e032570

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    COVID-19 clinical trials: Ethical and scientific consequences of the RECOVERY trial results

    Dal-Ré, R., Porcher, R. & Gluud, C., Dec 2020, In : Basic & clinical pharmacology & toxicology. 127, 6, p. 445-447 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  9. Published

    Using Trial Sequential Analysis for estimating the sample sizes of further trials: example using smoking cessation intervention

    Claire, R., Gluud, C., Berlin, I., Coleman, T. & Leonardi-Bee, J., 30 Nov 2020, In : BMC Medical Research Methodology. 20, 1, p. 284

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published
  11. E-pub ahead of print

    Ethical and Scientific Considerations Regarding the Early Approval and Deployment of a COVID-19 Vaccine

    Dal-Ré, R., Caplan, A. L., Gluud, C. & Porcher, R., 20 Nov 2020, In : Annals of Internal Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project)

    Korang, S. K., Juul, S., Nielsen, E. E., Feinberg, J., Siddiqui, F., Ong, G., Klingenberg, S., Veroniki, A. A., Bu, F., Thabane, L., Thomsen, A. R., Jakobsen, J. C. & Gluud, C., 20 Nov 2020, In : Systematic Reviews. 9, 1, p. 262

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published
  14. E-pub ahead of print
  15. E-pub ahead of print
  16. Published
  17. Published

    Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest: a statistical analysis plan

    Jakobsen, J. C., Dankiewicz, J., Lange, T., Cronberg, T., Lilja, G., Levin, H., Bělohlávek, J., Callaway, C., Cariou, A., Erlinge, D., Hovdenes, J., Joannidis, M., Nordberg, P., Oddo, M., Pelosi, P., Kirkegaard, H., Eastwood, G., Rylander, C., Saxena, M., Storm, C., Taccone, F. S., Wise, M. P., Morgan, M. P. G., Young, P., Nichol, A., Friberg, H., Ullén, S. & Nielsen, N., 7 Oct 2020, In : Trials. 21, 1, p. 831 831.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published
  19. Published

    Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis plan

    Petersen, M. W., Meyhoff, T. S., Helleberg, M., Kjær, M-B. N., Granholm, A., Hjortsø, C. J. S., Jensen, T. S., Møller, M. H., Hjortrup, P. B., Wetterslev, M., Vesterlund, G. K., Russell, L., Jørgensen, V. L., Tjelle, K., Benfield, T., Ulrik, C. S., Andreasen, A. S., Mohr, T., Bestle, M. H., Poulsen, L. M., Hitz, M. F., Hildebrandt, T., Knudsen, L. S., Møller, A., Sølling, C. G., Brøchner, A. C., Rasmussen, B. S., Nielsen, H., Christensen, S., Strøm, T., Cronhjort, M., Wahlin, R. R., Jakob, S., Cioccari, L., Venkatesh, B., Hammond, N., Jha, V., Myatra, S. N., Gluud, C., Lange, T. & Perner, A., 1 Oct 2020, In : Acta Anaesthesiologica Scandinavica. 64, 9, p. 1365-1375 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    The Agents Intervening against Delirium in the Intensive Care Unit-Trial (AID-ICU trial):- a detailed statistical analysis plan

    Andersen-Ranberg, N., Poulsen, L. M., Perner, A., Wetterslev, J., Mathiesen, O., Mortensen, C. B., Estrup, S., Ebdrup, B. H., Hästbacka, J., Citerio, G., Caballero, J., Morgan, M. P. G., Oxenbøll-Collet, M., Weber, S-O., Andreasen, A. S., Bestle, M. H., Pedersen, H. B. S., Nielsen, L. G., Uslu, B., Jensen, T. B., Thee, C., Dey, N. & Lange, T., 1 Oct 2020, In : Acta Anaesthesiologica Scandinavica. 64, 9, p. 1357-1364 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Effects of adding ivabradine to usual care in patients with angina pectoris: a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis

    Maagaard, M., Nielsen, E. E., Sethi, N. J., Ning, L., Yang, S-H., Gluud, C. & Jakobsen, J. C., Oct 2020, In : Open Heart. 7, 2, 001288.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Internet-based therapy with FearFighter for anxiety disorders: a randomised clinical trial

    Fenger, M., Lindschou, J., Gluud, C., Winkel, P., Jørgensen, L., Dybkjaer, J. H. & Lau, M., Oct 2020, In : Nordic Journal of Psychiatry. 74, 7, p. 518-524 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes

    CIMT Trial group, Oct 2020, In : Journal of Diabetes and its Complications. 34, 10, p. 107681 107681.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. E-pub ahead of print

    Blinding in randomised clinical trials of psychological interventions: a retrospective study of published trial reports

    Juul, S., Gluud, C., Simonsen, S., Frandsen, F. W., Kirsch, I. & Jakobsen, J. C., 30 Sep 2020, In : BMJ Evidence-Based Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published
  26. Published

    Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)

    Juul, S., Nielsen, E. E., Feinberg, J., Siddiqui, F., Jørgensen, C. K., Barot, E., Nielsen, N., Bentzer, P., Veroniki, A. A., Thabane, L., Bu, F., Klingenberg, S., Gluud, C. & Jakobsen, J. C., Sep 2020, In : PLOS Medicine. 17, 9, p. e1003293 1003293.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published
  28. Published

    Prognostic value of 12 novel cardiological biomarkers in stable coronary artery disease. A 10-year follow-up of the placebo group of the Copenhagen CLARICOR trial

    Winkel, P., Jakobsen, J. C., Hilden, J., Jensen, G. B., Kjøller, E., Sajadieh, A., Kastrup, J., Kolmos, H. J., Iversen, K. K., Bjerre, M., Larsson, A., Ärnlöv, J. & Gluud, C., 20 Aug 2020, In : BMJ Open. 10, 8, e033720.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published
  30. E-pub ahead of print

    Was amorphous aluminium hydroxyphosphate sulfate adequately evaluated before authorisation in Europe?

    Petersen, S. B. & Gluud, C., 6 Aug 2020, In : BMJ Evidence-Based Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published
  32. Published

    Should antidepressants be used for major depressive disorder?

    Jakobsen, J. C., Gluud, C. & Kirsch, I., Aug 2020, In : BMJ Evidence-Based Medicine. 25, 4, p. 130-136 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  33. Published

    The PANSAID Randomized Clinical Trial: A pre-planned 1-year follow-up regarding harm

    Thybo, K. H., Hägi-Pedersen, D., Wetterslev, J., Overgaard, S. & Mathiesen, O., Aug 2020, In : Acta Anaesthesiologica Scandinavica. 64, 7, p. 910-912 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published
  35. Published

    Dr. Uhre et al. Reply

    Uhre, V. F., Uhre, C. F., Lønfeldt, N. N., Pretzmann, L., Vangkilde, S., Plessen, K. J., Gluud, C., Jakobsen, J. C. & Pagsberg, A. K., 1 Jul 2020, In : Journal of the American Academy of Child and Adolescent Psychiatry. 59, 7, p. 787-791 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  36. Published

    DEX-2-TKA - DEXamethasone twice for pain treatment after Total Knee Arthroplasty. Detailed statistical analysis plan for a randomized, blinded, three-group multicentre clinical trial

    Gasbjerg, K. S., Hägi-Pedersen, D., Lunn, T. H., Overgaard, S., Pedersen, N. A., Bagger, J., Lindholm, P., Brorson, S., Schrøder, H. M., Thybo, K. H., Mathiesen, O. & Jakobsen, J. C., Jul 2020, In : Acta Anaesthesiologica Scandinavica. 64, 6, p. 839-846 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published
  38. Published

    Response

    Meyhoff, T. S., Møller, M. H., Hjortrup, P. B., Cronhjort, M., Perner, A. & Wetterslev, J., Jul 2020, In : Chest. 158, 1, p. 428

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The handling oxygenation targets in the intensive care unit (HOT-ICU) trial: Detailed statistical analysis plan

    Schjørring, O. L., Klitgaard, T. L., Perner, A., Wetterslev, J., Lange, T., Keus, F., Laake, J. H., Morgan, M., Bäcklund, M., Siegemund, M., Thormar, K. M. & Rasmussen, B. S., Jul 2020, In : Acta Anaesthesiologica Scandinavica. 64, 6, p. 847-856 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published
  41. Published

    Maternal Sildenafil vs Placebo in Pregnant Women With Severe Early-Onset Fetal Growth Restriction: A Randomized Clinical Trial

    Dutch STRIDER Trial Group, 1 Jun 2020, In : JAMA network open. 3, 6, p. e205323

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project)

    Juul, S., Nielsen, N., Bentzer, P., Veroniki, A. A., Thabane, L., Linder, A., Klingenberg, S., Gluud, C. & Jakobsen, J. C., 9 May 2020, In : Systematic Reviews. 9, 1, p. 108

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published
  44. Published

    Protocol for outcome reporting and follow-up in the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest trial (TTM2)

    Lilja, G., Nielsen, N., Ullén, S., Nordstrom, E. B., Dankiewicz, J., Friberg, H., Heimburg, K., Jakobsen, J. C., Levin, H., Callaway, C., Cariou, A., Eastwood, G. M., Helbok, R., Hovdenes, J., Kirkegaard, H., Leithner, C., Morgan, M. P. G., Nordberg, P., Oddo, M., Pelosi, P., Rylander, C., Saxena, M., Taccone, F. S., Siranec, M., Wise, M. P., Young, P. J. & Cronberg, T., May 2020, In : Resuscitation. 150, p. 104-112 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Serum osteoprotegerin as a long-term predictor for patients with stable coronary artery disease and its association with diabetes and statin treatment: A CLARICOR trial 10-year follow-up substudy

    Bjerre, M., Hilden, J., Winkel, P., Jensen, G. B., Kjøller, E., Sajadieh, A., Kastrup, J., Kolmos, H. J., Larsson, A., Ärnlöv, J., Jakobsen, J. C. & Gluud, C., May 2020, In : Atherosclerosis. 301, p. 8-14 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. E-pub ahead of print

    Methylphenidate for ADHD rejected from the WHO Essential Medicines List due to uncertainties in benefit-harm profile

    Storebø, O. J. & Gluud, C., 24 Apr 2020, In : BMJ Evidence-Based Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Eversion technique versus conventional endarterectomy with patch angioplasty in carotid surgery: protocol for a systematic review with meta-analyses and trial sequential analysis of randomised clinical trials

    Marsman, M. S., Wetterslev, J., Vriens, P. W. H. E., Bleys, R. L. A. W., Jahrome, A. K., Moll, F. L., Keus, F. & Koning, G. G., 19 Apr 2020, In : BMJ Open. 10, 4, p. e030503

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Arterial oxygen tensions in mechanically ventilated ICU patients and mortality: a retrospective, multicentre, observational cohort study

    Schjørring, O. L., Jensen, A. K. G., Nielsen, C. G., Ciubotariu, A., Perner, A., Wetterslev, J., Lange, T. & Rasmussen, B. S., Apr 2020, In : British Journal of Anaesthesia. 124, 4, p. 420-429 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial

    Granholm, A., Marker, S., Krag, M., Zampieri, F. G., Thorsen-Meyer, H-C., Kaas-Hansen, B. S., van der Horst, I. C. C., Lange, T., Wetterslev, J., Perner, A. & Møller, M. H., Apr 2020, In : Intensive Care Medicine. 46, 4, p. 717-726 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Letter to the Editor: Glucocorticosteroids for Alcohol-Associated Hepatitis

    Varganova, D. L., Pavlov, C. S., Casazza, G., Nikolova, D. & Gluud, C., Apr 2020, In : Hepatology (Baltimore, Md.). 71, 4, p. 1524

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. E-pub ahead of print

    Early specialised palliative care: interventions, symptoms, problems

    Skjoedt, N., Johnsen, A. T., Sjøgren, P., Neergaard, M. A., Damkier, A., Gluud, C., Lindschou, J., Fayers, P., Higginson, I. J., Strömgren, A. S. & Groenvold, M., 27 Mar 2020, In : BMJ Supportive and Palliative Care.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Prognosis and Reclassification by YKL-40 in Stable Coronary Artery Disease

    Schroder, J., Jakobsen, J. C., Winkel, P., Hilden, J., Jensen, G. B., Sajadieh, A., Larsson, A., Ärnlöv, J., Harutyunyan, M., Johansen, J. S., Kjøller, E., Gluud, C. & Kastrup, J., 3 Mar 2020, In : Journal of the American Heart Association. 9, 5, p. e014634

    Research output: Contribution to journalJournal articleResearchpeer-review

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