Center for Cancer Immune Therapy (CCIT)

2014

Harnessing PD-L1-specific cytotoxic T cells for anti-leukemia immunotherapy to defeat mechanisms of immune escape mediated by the PD-1 pathway

Ahmad, S. M., Larsen, S. K., Svane, I. M. & Andersen, M. H., Jan 2014, In: Leukemia. 28, 1, p. 236-8 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

"Immunotherapy of cancer : present status and future promise": Danish Cancer Society Symposium, Copenhagen, Denmark, 23rd-25th September 2013

Donia, M., Skou, R. B. L. & Hadrup, S. R., Sept 2014, In: Cancer immunology, immunotherapy. 63, 9, p. 985-9 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Induction of Bcl-xL-specific cytotoxic T lymphocytes in mice

Larsen, H. L., Andersen, M. H., Wandall, H. H., Madsen, C. B., Christensen, R. E., Petersen, T. R. & Pedersen, A. E., Aug 2014, In: Scandinavian Journal of Immunology. 80, 2, p. 111-20 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Long-lasting Disease Stabilization in the Absence of Toxicity in Metastatic Lung Cancer Patients Vaccinated with an Epitope Derived from Indoleamine 2,3 Dioxygenase

Iversen, T. Z., Engell-Noerregaard, L., Ellebaek, E., Andersen, R., Larsen, S. K., Bjoern, J., Zeyher, C., Gouttefangeas, C., Thomsen, I. B. M., Holm, B., Thor Straten, P., Mellemgaard, A., Andersen, M. H. & Svane, I. M., 1 Jan 2014, In: Clinical Cancer Research. 20, 1, p. 221-32 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

109 Citations (Scopus)

Self-reactive T cells: suppressing the suppressors

Becker, J. C., thor Straten, P. & Andersen, M. H., Apr 2014, In: Cancer immunology, immunotherapy. 63, 4, p. 313-319 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Simplified protocol for clinical-grade tumor-infiltrating lymphocyte manufacturing with use of the Wave bioreactor

Donia, M., Larsen, S. M., Met, O. & Svane, I. M., Aug 2014, In: Cytotherapy. 16, 8, p. 1117-20 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

44 Citations (Scopus)

Spontaneous presence of FOXO3-specific T cells in cancer patients

Larsen, S. K., Ahmad, S. M., Idorn, M., Met, O., thor Straten, P., Svane, I. M., Andersen, M. H. & Martinenaite, E., 14 Nov 2014, In: OncoImmunology. 3, 8, p. e953411

Research output: Contribution to journal › Journal article › Research › peer-review

Successful treatment with Ipilimumab and Interleukin-2 in two patients with metastatic melanoma and systemic autoimmune disease

Pedersen, M., Andersen, R., Nørgaard, P. H., Jacobsen, S., Thielsen, P., thor Straten, P. & Svane, I. M., Dec 2014, In: Cancer immunology, immunotherapy. 63, 12, p. 1341-6 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

52 Citations (Scopus)

T-cell Recognition of Immune Modulatory Molecules in Cancer

Hjortsø, M. D., Jun 2014, Det Sundhedsvidenskabelige Fakultet, KU.

Research output: Book/Report › Ph.D. thesis

T-cell responses to oncogenic merkel cell polyomavirus proteins distinguish patients with merkel cell carcinoma from healthy donors

Skou, R. B. L., Pedersen, N. W., Schrama, D., Thrue, C. A., Ibrani, D., Met, O., thor Straten, P., Nghiem, P., Becker, J. C. & Hadrup, S. R., 1 Apr 2014, In: Clinical Cancer Research. 20, 7, p. 1768-78 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

81 Citations (Scopus)

The expression, function and targeting of haem oxygenase-1 in cancer

Hjortsø, M. D. & Andersen, M. H., May 2014, In: Current Cancer Drug Targets. 14, 4, p. 337-47 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

The stimulation of PD-L1-specific cytotoxic T lymphocytes can both directly and indirectly enhance antileukemic immunity

Ahmad, S. M., Svane, I. M. & Andersen, M. H., 2014, In: Blood Cancer Journal. 4, p. e230 4.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

The targeting of immunosuppressive mechanisms in hematological malignancies

Andersen, M. H., Sept 2014, In: Leukemia. 28, 9, p. 1784-92 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

79 Citations (Scopus)

2013

Biological insights into BRAF(V600) mutations in melanoma patient: Not mere therapeutic targets

Improta, G., Pelosi, G., Tamborini, E., Donia, M., Santinami, M., de Braud, F. & Fraggetta, F., 1 Aug 2013, In: OncoImmunology. 2, 8, p. e25594

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Clonal expansion of renal cell carcinoma-infiltrating T lymphocytes

Sittig, S., Køllgaard, T., Grønbæk, K., Idorn, M., Hennenlotter, J., Stenzl, A., Gouttefangeas, C. & thor Straten, P., 1 Sept 2013, In: OncoImmunology. 2, 9, p. e26014

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

Comment on "Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer"

Andersen, M. H., 1 Jun 2013, In: Journal of Immunology. 190, 11, p. 5341-5342 2 p.

Research output: Contribution to journal › Comment/debate › Research › peer-review

Comparison of clinical grade type 1 polarized and standard matured dendritic cells for cancer immunotherapy

Hansen, M., Hjortø, G. M., Donia, M., Met, O., Larsen, N. B., Andersen, M. H., thor Straten, P. & Svane, I. M., 2013, In: Vaccine. 31, 4, p. 639-46 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Cutaneous T cell lymphoma cells are targets for immune checkpoint ligand PD-L1-specific, cytotoxic T cells

Munir, S., Andersen, G. H., Woetmann, A., Ødum, N., Becker, J. & Andersen, M. H., Nov 2013, In: Leukemia. 27, 11, p. 2251-3 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

43 Citations (Scopus)

Depletion of T lymphocytes is correlated with response to temozolomide in melanoma patients

Iversen, T. Z., Brimnes, M. K., Nikolajsen, K., Andersen, R. S., Hadrup, S. R., Andersen, M. H., Bastholt, L. & Svane, I. M., 1 Feb 2013, In: OncoImmunology. 2, 2, p. e23288

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Functional characterization of Foxp3-specific spontaneous immune responses

Larsen, S. K., Munir, S., Woetmann, A., Mørch Frøsig, T., Ødum, N., Svane, I. M., Becker, J. C. & Andersen, M. H., Dec 2013, In: Leukemia. 27, 12, p. 2332-40 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Hierarchical Bayesian mixture modelling for antigen-specific T-cell subtyping in combinatorially encoded flow cytometry studies

Lin, L., Chan, C., Hadrup, S. R., Mørch Frøsig, T., Wang, Q. & West, M., Jun 2013, In: Statistical Applications in Genetics and Molecular Biology. 12, 3, p. 309-31 23 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

High frequency of T cells specific for cryptic epitopes in melanoma patients

Andersen, R. S., Andersen, S. R., Hjortsø, M. D., Skou, R. B. L., Idorn, M., Køllgård, T. M., Met, O., thor Straten, P. & Hadrup, S. R., 1 Jul 2013, In: OncoImmunology. 2, 7, p. e25374

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

High-throughput identification of antigen-specific TCRs by TCR gene capture

Linnemann, C., Heemskerk, B., Kvistborg, P., Kluin, R. J. C., Bolotin, D. A., Chen, X., Bresser, K., Nieuwland, M., Schotte, R., Michels, S., Gomez-Eerland, R., Jahn, L., Hombrink, P., Legrand, N., Shu, C. J., Mamedov, I. Z., Velds, A., Blank, C. U., Haanen, J. B. A. G. & Turchaninova, M. A. & 8 others, Kerkhoven, R. M., Spits, H., Hadrup, S. R., Heemskerk, M. H. M., Blankenstein, T., Chudakov, D. M., Bendle, G. M. & Schumacher, T. N. M., Nov 2013, In: Nature Medicine. 19, 11, p. 1534-41 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

144 Citations (Scopus)

HLA-restricted CTL that are specific for the immune checkpoint ligand PD-L1 occur with high frequency in cancer patients

Munir, S., Andersen, G. H., Met, Ö., Donia, M., Frøsig, T. M., Larsen, S. K., Klausen, T. W., Svane, I. M. & Andersen, M. H., 15 Mar 2013, In: Cancer Research. 73, 6, p. 1764-76 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

74 Citations (Scopus)

Immune Modulations during Chemo-Immunotherapy & Novel Vaccine Strategies - In Metastatic Melanoma and Non Small-Cell Lung Cancer

Iversen, T. Z., 10 Oct 2013, University of Copenhagen.

Research output: Book/Report › Ph.D. thesis

Immune-suppressive properties of the tumor microenvironment

Becker, J. C., Andersen, M. H., Schrama, D. & thor Straten, P., Jul 2013, In: Cancer immunology, immunotherapy. 62, 7, p. 1137-48 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

170 Citations (Scopus)

In-chip fabrication of free-form 3D constructs for directed cell migration analysis

Olsen, M. H., Hjortø, G. M., Hansen, M., Met, Ö., Svane, I. M. & Larsen, N., 21 Dec 2013, In: Lab on a Chip. 13, 24, p. 4800-9 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

55 Citations (Scopus)

Keeping each other in check: a reciprocal relationship between cytokines and miRNA

Andersen, M. H., 15 Jul 2013, In: Cell cycle (Georgetown, Tex.). 12, 14, p. 2171

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Methods to Improve Adoptive T-Cell Therapy for Melanoma: IFN-γ Enhances Anticancer Responses of Cell Products for Infusion

Donia, M., Hansen, M., Sendrup, S. L., Iversen, T. Z., Ellebæk, E., Andersen, M. H., thor Straten, P. & Svane, I. M., 2013, In: Journal of Investigative Dermatology. 133, 2, p. 545-52 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

Methods to improve Adoptive T cell therapy with tumor infiltrating lymphocytes

Donia, M., 2013, University of Copenhagen.

Research output: Book/Report › Ph.D. thesis

PD-L1 expression in B-cell lymphomas and virus-associated malignancies--letter

Andersen, M. H., 15 Jul 2013, In: Clinical Cancer Research. 19, 14, p. 4017

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Silencing of the glucocorticoid-induced leucine zipper improves the immunogenicity of clinical-grade dendritic cells

Cathelin, D., Met, Ö. & Svane, I. M., Jun 2013, In: Cytotherapy. 15, 6, p. 740-9 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

The immune checkpoint regulator PD-L1 is a specific target for naturally occurring CD4(+) T cells

Munir, S., Andersen, G. H., Svane, I. M. & Andersen, M. H., 1 Apr 2013, In: OncoImmunology. 2, 4, p. e23991 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

55 Citations (Scopus)

2012

Adoptive cell therapy with autologous tumor infiltrating lymphocytes and low-dose Interleukin-2 in metastatic melanoma patients

Ellebaek, E., Iversen, T. Z., Junker, N., Donia, M., Engell-Noerregaard, L., Met, Ö., Hölmich, L. R., Andersen, R. S., Hadrup, S. R., Andersen, M. H., thor Straten, P. & Svane, I. M., 2012, In: Journal of Translational Medicine. 10, p. 169

Research output: Contribution to journal › Journal article › Research › peer-review

135 Citations (Scopus)

Analysis of Vδ1 T cells in clinical grade melanoma-infiltrating lymphocytes

Donia, M., Ellebaek, E., Andersen, M. H., thor Straten, P. & Svane, I. M., 2012, In: OncoImmunology. 1, 8, p. 1297-1304 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

A promiscuous survivin-derived T-cell epitope restricted to the HLA-A3 super-type alleles

Junker, N., Munir, S., Kvistborg, P., thor Straten, P., Svane, I. M. & Andersen, M. H., 2012, In: Journal of Investigative Dermatology. 132, 8, p. 2115-2118 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Association of a functional Indoleamine 2,3-dioxygenase 2 genotype with specific immune responses

Køllgaard, T., Klausen, T. W., Idorn, M., Holmgaard, R. B., thor Straten, P. & Andersen, M. H., 2012, In: OncoImmunology. 1, 4, p. 441-447 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

BRAF inhibition improves tumor recognition by the immune system: Potential implications for combinatorial therapies against melanoma involving adoptive T-cell transfer

Donia, M., Fagone, P., Nicoletti, F., Andersen, R. S., Høgdall, E., thor Straten, P., Andersen, M. H. & Svane, I. M., 2012, In: OncoImmunology. 1, 9, p. 1476-1483 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

71 Citations (Scopus)

CD4 responses against IDO

Andersen, M. H., 2012, In: OncoImmunology. 1, 7, p. 1211-1212 2 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Cellular based cancer vaccines: type 1 polarization of dendritic cells

Hansen, M., Met, O., Svane, I. M. & Andersen, M. H., 2012, In: Current Medicinal Chemistry. 19, 25, p. 4239-46 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Characterization and comparison of "Standard" and "Young" tumor infiltrating lymphocytes for adoptive cell therapy at a Danish Translational Research Institution

Donia, M., Junker, N., Ellebaek, E., Andersen, M. H., thor Straten, P. & Svane, I. M., 2012, In: Scandinavian Journal of Immunology. 75, 2, p. 157-167 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

80 Citations (Scopus)

Characterization of Spontaneous Immune Responses against Long Peptides Derived from Bcl-X(L) in Cancer Patients Using Elispot

Larsen, S. K., Hansen, M., Svane, I. M., thor Straten, P. & Andersen, M. H., 2012, In: Cells. 1, 2, p. 51-60 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Characterization of T-cell responses against IκBα in cancer patients

Munir, S., Frøsig, T. M., Hansen, M., Svane, I. M. & Andersen, M. H., 2012, In: OncoImmunology. 1, 8, p. 1290-1296 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Comment on "Adoptive T-cell therapy for malignant melanoma patients with TILs obtained by ultrasound-guided needle biopsy" by Gustav J. Ullenhag et al

Svane, I. M., 2012, In: Cancer immunology, immunotherapy. 61, 5, p. 747; author reply 749

Research output: Contribution to journal › Journal article › Research › peer-review

129 Citations (Scopus)

Effector and regulatory T cells in patients with acute optic neuritis

Tsakiri, A., Kjærsgaard, E., Grigoriadis, N., Svane, I. M. & Frederiksen, J. L., 2012, In: NeuroImmunoModulation. 19, 2, p. 111-20 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Eleventh international conference on progress in vaccination against cancer (PIVAC-11), 10-13 October 2011, Copenhagen, Denmark

Køllgaard, T., van den Berg, J. H., Donia, M. & thor Straten, P., 2012, In: Cancer immunology, immunotherapy. 61, 8, p. 1349-53 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

FDG PET scans as evaluation of clinical response to dendritic cell vaccination in patients with malignant melanoma

Engell-Noerregaard, L., Hendel, H. W., Johannesen, H. H., Alslev, L. & Svane, I. M., 22 Jun 2012, In: Cancer immunology, immunotherapy. 62, 1, p. 17-25 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Center for Cancer Immune Therapy (CCIT)

Research output

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