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The Capital Region of Denmark - a part of Copenhagen University Hospital

Journal of Biological Chemistry, 0021-9258

Journal

  1. 2020
  2. Published
  3. Published

    Thrombin-derived C-terminal fragments aggregate and scavenge bacteria and their proinflammatory products

    Petrlova, J., Petruk, G., Huber, R. G., McBurnie, E. W., van der Plas, M. J. A., Bond, P. J., Puthia, M. & Schmidtchen, A., 13 Mar 2020, In: Journal of Biological Chemistry. 295, 11, p. 3417-3430 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2019
  5. Published

    Did evolution create a flexible ligand-binding cavity in the urokinase receptor through deletion of a plesiotypic disulfide bond?

    Leth, J. M., Mertens, H. D. T., Leth-Espensen, K. Z., Jørgensen, T. J. D. & Ploug, M., 1 Jan 2019, In: Journal of Biological Chemistry. 294, 18, p. 7403-7418 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor

    Hansen, L. H., Madsen, T. D., Goth, C. K., Clausen, H., Chen, Y., Dzhoyashvili, N., Iyer, S. R., Sangaralingham, S. J., Burnett, J. C., Rehfeld, J. F., Vakhrushev, S. Y., Schjoldager, K. T. & Goetze, J. P., 1 Jan 2019, In: Journal of Biological Chemistry. 294, 34, p. 12567-12578 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Erratum: Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions (Journal of Biological Chemistry (2018) 293 (7408-7422) DOI: 10.1074/jbc.M117.817981)

    Wang, S., Mao, Y., Narimatsu, Y., Ye, Z., Tian, W., Goth, C. K., Lira-Navarrete, E., Pedersen, N. B., Benito-Vicente, A., Martin, C., Uribe, K. B., Hurtado-Guerrero, R., Christoffersen, C., Seidah, N. G., Nielsen, R., Christensen, E. I., Hansen, L., Bennett, E. P., Vakhrushev, S. Y., Schjoldager, K. T. & Clausen, H., 1 Jan 2019, In: Journal of Biological Chemistry. 294, 21, p. 8349 1 p.

    Research output: Contribution to journalComment/debateResearch

  8. 2018
  9. Published

    Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions

    Wang, S., Mao, Y., Narimatsu, Y., Ye, Z., Tian, W., Goth, C. K., Lira-Navarrete, E., Pedersen, N. B., Benito-Vicente, A., Martin, C., Uribe, K. B., Hurtado-Guerrero, R., Christoffersen, C., Seidah, N. G., Nielsen, R., Christensen, E. I., Hansen, L., Bennett, E. P., Vakhrushev, S. Y., Schjoldager, K. T. & Clausen, H., 11 May 2018, In: Journal of Biological Chemistry. 293, 19, p. 7408-7422 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2017
  11. Published

    Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β1-Adrenergic Receptor N-terminal Cleavage

    Goth, C. K., Tuhkanen, H. E., Khan, H., Lackman, J. J., Wang, S., Narimatsu, Y., Hansen, L. H., Overall, C. M., Clausen, H., Schjoldager, K. T. & Petäjä-Repo, U. E., 17 Mar 2017, In: Journal of Biological Chemistry. 292, 11, p. 4714-4726 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function

    Jørgensen, S., Have, C. T., Underwood, C. R., Johansen, L. D., Wellendorph, P., Gjesing, A. P., Jørgensen, C. V., Quan, S., Rui, G., Inoue, A., Linneberg, A., Grarup, N., Jun, W., Pedersen, O., Hansen, T. & Bräuner-Osborne, H., 27 Jan 2017, In: Journal of Biological Chemistry. 292, 4, p. 1524-1534 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2016
  14. Published

    Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding

    Barington, L., Rummel, P. C., Lückmann, M., Pihl, H., Larsen, O., Daugvilaite, V., Johnsen, A. H., Frimurer, T. M., Karlshøj, S. & Rosenkilde, M. M., 29 Jul 2016, In: Journal of Biological Chemistry. 291, 31, p. 16208-20 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice

    Fan, M-H., Zhu, Q., Li, H-H., Ra, H-J., Majumdar, S., Gulick, D. L., Jerome, J. A., Madsen, D. H., Christofidou-Solomidou, M., Speicher, D. W., Bachovchin, W. W., Feghali-Bostwick, C. & Puré, E., 8 Apr 2016, In: Journal of Biological Chemistry. 291, 15, p. 8070-89 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2015
  17. Published

    Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon Cells

    Herchenhan, A., Uhlenbrock, F. K., Eliasson, P., Weis, M., Eyre, D., Kadler, K. E., Magnusson, S. P. & Kjaer, M., 26 Jun 2015, In: Journal of Biological Chemistry. 290, 26, p. 16440-50 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Cardiomyocyte expression and cell-specific processing of procholecystokinin

    Goetze, J. P., Johnsen, A. H., Kistorp, C., Gustafsson, F., Johnbeck, C. B. & Rehfeld, J. F., 13 Mar 2015, In: Journal of Biological Chemistry. 290, 11, p. 6837-43 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin

    Friis, S., Madsen, D. H. & Bugge, T. H., Feb 2015, In: Journal of Biological Chemistry. 291, 6, p. :2577-8

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Functional consequences of glucagon-like peptide-1 receptor cross-talk and trafficking

    Roed, S. N., Nøhr, A. C., Wismann, P., Iversen, H., Bräuner-Osborne, H., Knudsen, S. M. & Waldhoer, M., 9 Jan 2015, In: Journal of Biological Chemistry. 290, 2, p. 1233-43 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    T cell epitope mapping of the autoimmune response against human Oligodendrocyte Specific Protein in HLA DR2 Tg mice

    Kaushasnky, N., Hansen, B. E., Nielsen, C. H., Lassmann, H. & Ben-Nun, A., 2015, In: Journal of Biological Chemistry. p. 15260-78

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2014
  23. Published

    Phosphorylation of rat melanopsin at Ser-381 and Ser-398 by light/dark and its importance for intrinsically photosensitive ganglion cells (ipRGCs) cellular Ca2+ signaling

    Fahrenkrug, J., Falktoft, B., Georg, B., Hannibal, J., Kristiansen, S. B. & Klausen, T. K., 19 Dec 2014, In: Journal of Biological Chemistry. 289, 51, p. 35482-93 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Multimerization of GPIHBP1 and Familial Chylomicronemia from a Serine-to-Cysteine Substitution in GPIHBP1's Ly6 Domain

    Plengpanich, W., Young, S. G., Khovidhunkit, W., Bensadoun, A., Karnman, H., Ploug, M., Gårdsvoll, H., Leung, C. S., Adeyo, O., Larsson, M., Muanpetch, S., Charoen, S., Fong, L. G., Niramitmahapanya, S. & Beigneux, A. P., 20 May 2014, In: Journal of Biological Chemistry. 289, 28, p. 19491-9

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Complex Determinants in Specific Members of the Mannose Receptor Family Govern Collagen Endocytosis

    Jürgensen, H. J., Johansson, K. B. C., Madsen, D. H., Porse, A., Carlsen Melander, E. M., Nielsen, C., Sørensen, K. R., Bugge, T. H., Behrendt, N. & Engelholm, L. H., 14 Mar 2014, In: Journal of Biological Chemistry. p. 7935-7947

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Localization and functionality of the inflammasome in neutrophils

    Bakele, M., Joos, M., Burdi, S., Allgaier, N., Pöschel, S., Fehrenbacher, B., Schaller, M., Marcos, V., Kümmerle-Deschner, J., Rieber, N., Borregaard, N., Yazdi, A., Hector, A. & Hartl, D., 21 Feb 2014, In: Journal of Biological Chemistry. 289, 8, p. 5320-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice

    Fjære, E., Aune, U. L., Røen, K., Keenan, A. H., Ma, T., Borkowski, K., Kristensen, D. M., Novotny, G. W., Mandrup-Poulsen, T., Hudson, B. D., Milligan, G., Xi, Y., Newman, J. W., Haj, F. G., Liaset, B., Kristiansen, K. & Madsen, L., 2014, In: Journal of Biological Chemistry. 289, 23, p. 16032-45 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2013
  29. Published

    New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms

    Bode, A., Wood, S-E., Mullins, J. G. L., Keramidas, A., Cushion, T. D., Thomas, R. H., Pickrell, W. O., Drew, C. J. G., Masri, A., Jones, E. A., Vassallo, G., Born, A. P., Alehan, F., Aharoni, S., Bannasch, G., Bartsch, M., Kara, B., Krause, A., Karam, E. G., Matta, S., Jain, V., Mandel, H., Freilinger, M., Graham, G. E., Hobson, E., Chatfield, S., Vincent-Delorme, C., Rahme, J. E., Afawi, Z., Berkovic, S. F., Howell, O. W., Vanbellinghen, J-F., Rees, M. I., Chung, S-K. & Lynch, J. W., 22 Nov 2013, In: Journal of Biological Chemistry. 288, 47, p. 33745-59 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release

    Rickhag, K. M., Owens, W. A., Winkler, M-T., Strandfelt, K. N., Rathje, M., Sørensen, G., Andresen, B., Madsen, K., Jørgensen, T. N., Wörtwein, G., Woldbye, D. P. D., Sitte, H., Daws, L. C. & Gether, U., 20 Sep 2013, In: Journal of Biological Chemistry. 288, 38, p. 27534-44 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Investigations on collectin liver 1

    Axelgaard, E., Jensen, L., Dyrlund, T. F., Nielsen, H. J., Enghild, J. J., Thiel, S. & Jensenius, J. C., 9 Aug 2013, In: Journal of Biological Chemistry. 288, 32, p. 23407-20 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion

    Ejlerskov, P., Rasmussen, I. Z., Nielsen, T. T., Bergström, A-L., Tohyama, Y., Jensen, P. H. & Vilhardt, F., 14 Jun 2013, In: Journal of Biological Chemistry. 288, 24, p. 17313-35 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP. Impact on lymphangiogenesis

    Ingvarsen, S., Porse, A., Erpicum, C., Maertens, L., Jürgensen, H. J., Madsen, D. H., Carlsen Melander, E. M., Gårdsvoll, H., Høyer-Hansen, G., Noel, A., Holmbeck, K., Engelholm, L. H. & Behrendt, N., 12 Apr 2013, In: Journal of Biological Chemistry. 288, 15, p. 10195-204

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2012
  35. Published

    Identification and characterization of a chitin-binding protein purified from coelomic fluid of the lugworm Arenicola marina defining a novel protein sequence family

    Vitashenkova, N., Moeller, J. B., Leth-Larsen, R., Schlosser, A., Lund, K. P., Tornøe, I., Vitved, L., Hansen, S., Willis, A., Kharazova, A. D., Skjødt, K., Sorensen, G. L. & Holmskov, U. L., 14 Dec 2012, In: Journal of Biological Chemistry. 287, 51, p. 42846-55 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)

    Mertens, H. D. T., Kjaergaard, M., Mysling, S., Gårdsvoll, H., Jørgensen, T., Svergun, D. I. & Ploug, M., 2012, In: Journal of Biological Chemistry. 287, 41, p. 34304-15 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Crystal structure and functional characterization of the complement regulator MBL/ficolin-associated protein-1 (MAP-1)

    Skjoedt, M-O., Roversi, P., Hummelshøj, T., Palarasah, Y., Rosbjerg, A., Johnson, S., Lea, S. M. & Garred, P., 2012, In: Journal of Biological Chemistry. 287, p. 32913-32921 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published
  39. Published

    Urokinase-type plasminogen activator-like proteases in teleosts lack genuine receptor-binding epidermal growth factor-like domains

    Bager, R., Kristensen, T. K., Jensen, J., Szczur, A., Christensen, A., Andersen, L., Johansen, J. S., Larsen, N. N., Baatrup, E., Huang, M., Ploug, M. & Andreasen, K. P., 2012, In: Journal of Biological Chemistry. 287, 33, p. 27526-36 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. 2011
  41. Published

    The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains

    Dahlbäck, M., Jørgensen, L. M., Nielsen, M. A., Clausen, T., Ditlev, S. B., Resende, M., Valadão Vaz dos Santos Pinto, V. M., Arnot, D. E., Theander, T. G. & Salanti, A., 6 May 2011, In: Journal of Biological Chemistry. 286, 18, p. 15908-17 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system

    Ma, Y. J., Doni, A., Skjødt, M-O., Honoré, C. L. F., Arendrup, M., Mantovani, A. & Garred, P., 4 Feb 2011, In: Journal of Biological Chemistry. 286, 5, p. 3405-17 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published
  44. Published
  45. Published

    Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor

    Gårdsvoll, H., Kjaergaard, M., Jacobsen, B., Kriegbaum, M. C., Huang, M. & Ploug, M., 2011, In: Journal of Biological Chemistry. 286, 50, p. 43515-26 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    The non-phagocytic route of collagen uptake: a distinct degradation pathway

    Madsen, D. H., Ingvarsen, S., Jürgensen, H. J., Melander, M. C., Kjøller, L., Moyer, A., Honoré, C., Madsen, M. C., Garred, P., Burgdorf, S., Bugge, T. H., Behrendt, N. & Engelholm, L. H., 2011, In: Journal of Biological Chemistry. 286, 30, p. 26996-7010 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2010
  48. Published
  49. Published

    Expression of apolipoprotein B in the kidney attenuates renal lipid accumulation

    Krzystanek, M., Pedersen, T. X., Bartels, E. D., Kjæhr, J., Straarup, E. M. & Nielsen, L. B., 2 Apr 2010, In: Journal of Biological Chemistry. 285, 14, p. 10583-90 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy

    Lin, L., Gårdsvoll, H., Huai, Q., Huang, M. & Ploug, M., 2 Apr 2010, In: Journal of Biological Chemistry. 285, 14, p. 10982-92 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation

    Skjoedt, M-O., Hummelshoj, T., Palarasah, Y., Honoré, C., Koch, C., Skjodt, K. & Garred, P., 12 Mar 2010, In: Journal of Biological Chemistry. 285, 11, p. 8234-43 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    The Cytomegalovirus UL146 Gene Product vCXCL1 Targets Both CXCR1 and CXCR2 as an Agonist

    Luttichau, H. R., 2010, In: Journal of Biological Chemistry. 285, 12, p. 9137-9146 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. 2009
  54. Published

    Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition

    Ma, Y. J., Doni, A., Hummelshøj, T., Honoré, C., Bastone, A., Mantovani, A., Thielens, N. M. & Garred, P., 9 Oct 2009, In: Journal of Biological Chemistry. 284, 41, p. 28263-75 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. 2008
  56. Published
  57. Published
  58. 2007
  59. Published

    Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation

    Madsen, D. H., Engelholm, L. H., Ingvarsen, S., Hillig, T., Wagenaar-Miller, R. A., Kjøller, L., Gårdsvoll, H., Høyer-Hansen, G., Holmbeck, K., Bugge, T. H. & Behrendt, N., 14 Sep 2007, In: Journal of Biological Chemistry. 282, 37, p. 27037-45 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. 2006
  61. Published

    Molecular pharmacological phenotyping of EBI2 - an orphan 7TM receptor with constitutive activity

    Rosenkilde, M. M., Benned-Jensen, T., Andersen, H., Holst, P. J., Kledal, T. N., Lüttichau, HR., Larsen, J. K., Geisler, C., Christensen, JP. & Schwartz, TW., 2006, In: J Biol Chem. 281, 19, p. 13199-208

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. 2005
  63. Published

    Stability of the topoisomerase II closed clamp conformation may influence DNA-stimulated ATP hydrolysis

    Vaughn, J., Huang, S., Wessel, I., Sorensen, T. K., Hsieh, T., Jensen, L. H., Jensen, P. B., Sehested, M. & Nitiss, J. L., 25 Mar 2005, In: Journal of Biological Chemistry. 280, 12, p. 11920-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor.

    Casarosa, P., Waldhoers, M., LiWang, P. J., Vischer, H. F., Kledal, T. N., Timmerman, H., Schwartz, T. W., Smit, M. J. & Leurs, R., 2005, In: J Biol Chem. 280, 5, p. 3275-85

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types

    Dümmler, B. A., Hauge, C., Silber, J., Yntema, H. G., Kruse, L. S., Kofoed, B., Hemmings, B. A., Alessi, D. R. & Frödin, M., 2005, In: Journal of Biological Chemistry. 280, 14, p. 13304-14 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Mutation in apolipoprotein B associated with hypobetalipoproteinemia despite decreased binding to the low density lipoprotein receptor

    Benn, M., Nordestgaard, B. G., Jensen, J. S., Nilausen, K. S., Meinertz, H. & Tybjaerg-Hansen, A., 2005, In: Journal of Biological Chemistry. 280, 22, p. 21052-60 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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