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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Zinc, copper, and selenium tissue levels and their relation to subcutaneous abscess, minor surgery, and wound healing in humans

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DOI

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  3. Anastomotic Leakage After Stoma Reversal Combined with Incisional Hernia Repair

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Trace element involvement in wounds left to heal by secondary intention needs clarification. We have previously reported faster healing of wounds following acute surgery compared with elective excision of pilonidal sinus disease. The effect of topical zinc on the closure of the excisional wounds was mediocre compared with placebo. In contrast, parenteral zinc, copper, and selenium combined appear effective for wound healing in humans. We have investigated zinc, copper, and selenium with respect to (a) impact of acute versus chronic pilonidal sinus and (b) regional concentrations within granulating wounds treated topically with placebo or zinc in 42 (33 males) pilonidal disease patients. Baseline serum and skin concentrations of copper correlated (r S = 0.351, p = 0.033, n = 37), but not of zinc or selenium. Patients with abscesses had elevated serum C-reactive protein (CRP) and copper levels (+29 %; p 
OriginalsprogEngelsk
TidsskriftBiological Trace Element Research
Vol/bind153
Udgave nummer1-3
Sider (fra-til)76-83
Antal sider8
ISSN0163-4984
DOI
StatusUdgivet - jun. 2013

ID: 38708647