YKL-40, a biomarker of inflammation, is elevated in patients with type 2 diabetes and is related to insulin resistance

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    Abstract

    OBJECTIVE AND DESIGN: YKL-40 participates in inflammatory states and vascular processes, which implies that comparison can be made with other inflammatory markers associated with insulin resistance and type 2 diabetes (T2D). In the present study levels of plasma YKL-40 and serum hsCRP were evaluated in patients with T2D.

    MATERIALS AND METHODS: Patients with T2D and age-matched healthy controls participated in the study. Insulin resistance was estimated using HOMA-IR model. Biochemical parameters were measured in venous blood after a 10 h fast.

    RESULTS: Patients with T2D were insulin resistant (p<0.001) and had raised levels of plasma YKL-40 (p<0.001) and serum hsCRP (p<0.001). YKL-40 was correlated with HOMA-IR (r=0.23, p<0.01), NEFA (r=0.32, p<0.001) and triglycerides (r=0.24, p<0.05). YKL-40 and hsCRP were not correlated (r=0.17, p=NS). All participants with hsCRP<1 mg/l had higher insulin sensitivity (p<0.05 and p<0.01, respectively). HsCRP were predicted by HOMA-IR and BMI (r2=0.48, p<0.01). Plasma YKL-40 was predicted by HOMA-IR and triglycerides (r2=0.27, p<0.01).

    CONCLUSIONS: YKL-40 and hsCRP are elevated in patients with T2D and are related to insulin resistance. No correlation was found between YKL-40 and hsCRP indicating that increased levels of YKL-40 occur independently from elevated plasma hsCRP.

    OriginalsprogEngelsk
    TidsskriftInflammation research : official journal of the European Histamine Research Society ... [et al.]
    Vol/bind55
    Udgave nummer2
    Sider (fra-til)53-9
    Antal sider7
    ISSN1023-3830
    DOI
    StatusUdgivet - feb. 2006

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