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Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis

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@article{a96c8527b09c4210941dbf90bcd5bc9f,
title = "Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis",
abstract = "In schizophrenia patients, cognitive functions appear linked to widespread alterations in cerebral white matter microstructure. Here we examine patterns of associations between regional white matter and cognitive functions in individuals at ultra-high risk for psychosis. One hundred and sixteen individuals at ultra-high risk for psychosis and 49 matched healthy controls underwent 3 T magnetic resonance diffusion-weighted imaging and cognitive assessments. Group differences on fractional anisotropy were tested using tract-based spatial statistics. Group differences in cognitive functions, voxel-wise as well as regional fractional anisotropy were tested using univariate general linear modeling. Multivariate partial least squares correlation analyses tested for associations between patterns of regional fractional anisotropy and cognitive functions. Univariate analyses revealed significant impairments on cognitive functions and lower fractional anisotropy in superior longitudinal fasciculus and cingulate gyrus in individuals at ultra-high risk for psychosis. Partial least squares correlation analysis revealed different associations between patterns of regional fractional anisotropy and cognitive functions in individuals at ultra-high risk for psychosis compared to healthy controls. Widespread higher fractional anisotropy was associated with better cognitive functioning for individuals at ultra-high risk for psychosis, but not for the healthy controls. Furthermore, patterns of cognitive functions were associated with an interaction-effect on regional fractional anisotropy in fornix, medial lemniscus, uncinate fasciculus, and superior cerebellar peduncle. Aberrant associations between patterns of cognitive functions to white matter may be explained by dysmyelination.",
keywords = "cognition, diffusion tensor imaging, partial least squares correlation analysis, ultra-high risk for psychosis, white matter",
author = "Kristensen, {Tina D} and Mandl, {Ren{\'e} C W} and Raghava, {Jayachandra M} and Kasper Jessen and Jepsen, {Jens Richardt M} and Birgitte Fagerlund and Glenth{\o}j, {Louise B} and Christina Wenneberg and Kristine Krakauer and Christos Pantelis and Merete Nordentoft and Glenth{\o}j, {Birte Y} and Ebdrup, {Bj{\o}rn H}",
note = "{\circledC} 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.",
year = "2019",
month = "12",
day = "15",
doi = "10.1002/hbm.24765",
language = "English",
volume = "40",
pages = "5185--5201",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "18",

}

RIS

TY - JOUR

T1 - Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis

AU - Kristensen, Tina D

AU - Mandl, René C W

AU - Raghava, Jayachandra M

AU - Jessen, Kasper

AU - Jepsen, Jens Richardt M

AU - Fagerlund, Birgitte

AU - Glenthøj, Louise B

AU - Wenneberg, Christina

AU - Krakauer, Kristine

AU - Pantelis, Christos

AU - Nordentoft, Merete

AU - Glenthøj, Birte Y

AU - Ebdrup, Bjørn H

N1 - © 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.

PY - 2019/12/15

Y1 - 2019/12/15

N2 - In schizophrenia patients, cognitive functions appear linked to widespread alterations in cerebral white matter microstructure. Here we examine patterns of associations between regional white matter and cognitive functions in individuals at ultra-high risk for psychosis. One hundred and sixteen individuals at ultra-high risk for psychosis and 49 matched healthy controls underwent 3 T magnetic resonance diffusion-weighted imaging and cognitive assessments. Group differences on fractional anisotropy were tested using tract-based spatial statistics. Group differences in cognitive functions, voxel-wise as well as regional fractional anisotropy were tested using univariate general linear modeling. Multivariate partial least squares correlation analyses tested for associations between patterns of regional fractional anisotropy and cognitive functions. Univariate analyses revealed significant impairments on cognitive functions and lower fractional anisotropy in superior longitudinal fasciculus and cingulate gyrus in individuals at ultra-high risk for psychosis. Partial least squares correlation analysis revealed different associations between patterns of regional fractional anisotropy and cognitive functions in individuals at ultra-high risk for psychosis compared to healthy controls. Widespread higher fractional anisotropy was associated with better cognitive functioning for individuals at ultra-high risk for psychosis, but not for the healthy controls. Furthermore, patterns of cognitive functions were associated with an interaction-effect on regional fractional anisotropy in fornix, medial lemniscus, uncinate fasciculus, and superior cerebellar peduncle. Aberrant associations between patterns of cognitive functions to white matter may be explained by dysmyelination.

AB - In schizophrenia patients, cognitive functions appear linked to widespread alterations in cerebral white matter microstructure. Here we examine patterns of associations between regional white matter and cognitive functions in individuals at ultra-high risk for psychosis. One hundred and sixteen individuals at ultra-high risk for psychosis and 49 matched healthy controls underwent 3 T magnetic resonance diffusion-weighted imaging and cognitive assessments. Group differences on fractional anisotropy were tested using tract-based spatial statistics. Group differences in cognitive functions, voxel-wise as well as regional fractional anisotropy were tested using univariate general linear modeling. Multivariate partial least squares correlation analyses tested for associations between patterns of regional fractional anisotropy and cognitive functions. Univariate analyses revealed significant impairments on cognitive functions and lower fractional anisotropy in superior longitudinal fasciculus and cingulate gyrus in individuals at ultra-high risk for psychosis. Partial least squares correlation analysis revealed different associations between patterns of regional fractional anisotropy and cognitive functions in individuals at ultra-high risk for psychosis compared to healthy controls. Widespread higher fractional anisotropy was associated with better cognitive functioning for individuals at ultra-high risk for psychosis, but not for the healthy controls. Furthermore, patterns of cognitive functions were associated with an interaction-effect on regional fractional anisotropy in fornix, medial lemniscus, uncinate fasciculus, and superior cerebellar peduncle. Aberrant associations between patterns of cognitive functions to white matter may be explained by dysmyelination.

KW - cognition

KW - diffusion tensor imaging

KW - partial least squares correlation analysis

KW - ultra-high risk for psychosis

KW - white matter

UR - http://www.scopus.com/inward/record.url?scp=85070923395&partnerID=8YFLogxK

U2 - 10.1002/hbm.24765

DO - 10.1002/hbm.24765

M3 - Journal article

VL - 40

SP - 5185

EP - 5201

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 18

ER -

ID: 57822177