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Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis

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  2. Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study

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Most Staphylococcus aureus isolates can cause invasive disease given the right circumstances, but it is unknown if some isolates are more likely to cause severe infections than others. S. aureus bloodstream isolates from 120 patients with definite infective endocarditis and 121 with S. aureus bacteraemia without infective endocarditis underwent whole-genome sequencing. Genome-wide association analysis was performed using a variety of bioinformatics approaches including SNP analysis, accessory genome analysis and k-mer based analysis. Core and accessory genome analyses found no association with either of the two clinical groups. In this study, the genome sequences of S. aureus bloodstream isolates did not discriminate between bacteraemia and infective endocarditis. Based on our study and the current literature, it is not convincing that a specific S. aureus genotype is clearly associated to infective endocarditis in patients with S. aureus bacteraemia.

OriginalsprogEngelsk
TidsskriftOMICS A Journal of Integrative Biology
Vol/bind3
Udgave nummer11
Sider (fra-til)e- doi: 10.1099/mgen.0.000138
ISSN1557-8100
DOI
StatusUdgivet - nov. 2017

ID: 52564673