Whole exome sequencing of patients with varicella-zoster virus and herpes simplex virus induced acute retinal necrosis reveals rare disease-associated genetic variants

Keyphrases

• Rare Diseases 100%
• Varicella Zoster Virus 100%
• Whole Exome Sequencing 100%
• Herpes Simplex Virus 100%
• Acute Retinal Necrosis 100%
• Virus-induced 100%
• Disease-associated Genetic Variants 100%
• Virus 40%
• Healthy Controls 20%
• Apoptosis 20%
• Severe Disease 20%
• Latency 20%
• Cause of Disease 20%
• Genetic Variants 20%
• Biological Relevance 20%
• Genetic Defects 20%
• Frameshift 20%
• Eye Diseases 20%
• Innate Immunity 20%
• Missense 20%
• Primary Infection 20%
• Viral Control 20%
• Ocular Diseases 20%
• Adaptive Immunity 20%
• Illumina 20%
• Sight-threatening 20%
• Necrosis 20%
• In-frame Deletion 20%
• Host Factors 20%
• Autophagy 20%
• Herpes Simplex Virus Infection 20%
• Diagnostic Applications 20%
• Knowledge Base 20%
• Read Depth 20%
• Isolated DNA 20%
• Prophylactic Application 20%
• GnomAD 20%
• Human alphaherpesvirus 20%
• Gene Modification 20%
• CADD Score 20%
• Biological Filter 20%
• Therapeutic Applications 20%
• Splice Site Variant 20%
• Disease Presentation 20%
• Neurotropic 20%
• Deleteriousness 20%

Immunology and Microbiology

• Herpes Simplex Virus 100%
• Varicella Zoster Virus 100%
• Whole Exome Sequencing 100%
• Virus 50%
• Adaptive Immune System 25%
• Innate Immune System 25%
• Infectious Disease 25%
• Host Factor 25%
• Autophagy 25%
• Knowledge Base 25%
• Programmed Cell Death 25%
• Infection 25%
• Virus Infection 25%