What you always needed to know about electroporation based DNA vaccines

Anita Gothelf, Julie Gehl

63 Citationer (Scopus)

Abstract

Vaccinations are increasingly used to fight infectious disease, and DNA vaccines offer considerable advantages, including broader possibilities for vaccination and lack of need for cold storage. It has been amply demonstrated, that electroporation augments uptake of DNA in both skin and muscle, and it is foreseen that future DNA vaccination may to a large extent be coupled with and dependent upon electroporation based delivery. Understanding the basic science of electroporation and exploiting knowledge obtained on optimization of DNA electrotransfer to muscle and skin, may greatly augment efforts on vaccine development. The purpose of this review is to give a succinct but comprehensive overview of electroporation as a delivery modality including electrotransfer to skin and muscle. As well, this review will speculate and discuss future uses for this powerful electrotransfer technology.
OriginalsprogEngelsk
TidsskriftHuman vaccines & immunotherapeutics
Vol/bind8
Udgave nummer11
StatusUdgivet - 2012

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