Abstrakt
BACKGROUND: Cochrane Reviews are methodologically of high quality but the clinical relevance of analysed efficacy measures (EMs) should also be assessed.
METHODS: The clinical relevance of EMs used in one systematic Cochrane review of oral zolmitriptan for migraine headache was evaluated.
RESULTS: The following EMs were used: pain free at two hours (30%), headache relief at two hours (60%), sustained pain free for 24 hours (19%) and sustained headache relief for 24 hours (39%). These EMs were also used in four other Cochrane reviews of acute migraine treatment. Of these EMs sustained headache relief for 24 h is not judged clinically relevant.
CONCLUSION: Pain free and sustained pain free are clinically relevant, but the responses are rather low, demonstrating that there is a need for improvement of acute drug treatment in migraine.
Originalsprog | Engelsk |
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Tidsskrift | Cephalalgia : an international journal of headache |
Vol/bind | 35 |
Udgave nummer | 5 |
Sider (fra-til) | 457-459 |
ISSN | 0333-1024 |
DOI | |
Status | Udgivet - 2015 |