@article{a4edbb00779511df9abd000ea68e967b,
title = "What can be learned from the history of recurrence in migraine? A comment",
abstract = "Recurrence was first recognised as a clinical problem in 1989 with the advent of sumatriptan. The history of recurrence in early sumatriptan randomised clinical trials is described. Recurrence has been ascribed to patient-dependent factors but experience with ergot alkaloids suggested that recurrence can also be treatment-dependent. Possible mechanisms for recurrence are discussed.",
author = "Peer Tfelt-Hansen",
note = "Keywords: Clinical Trials as Topic; Humans; Migraine Disorders; Recurrence; Sumatriptan; Vasoconstrictor Agents",
year = "2009",
doi = "10.1007/s10194-009-0144-0",
language = "English",
volume = "10",
pages = "311--5",
journal = "Journal of Headache and Pain",
issn = "1129-2369",
publisher = "BioMed Central",
number = "5",
}