Weight change later in life and colon and rectal cancer risk in participants in the EPIC-PANACEA study

Charlotte N Steins Bisschop; Carla H van Gils; Marleen J Emaus; H Bas Bueno-de-Mesquita; Evelyn M Monninkhof; Heiner Boeing; Krasmira Aleksandrova; Mazda Jenab; Teresa Norat; Elio Riboli; Marie-Christine Boutron-Rualt; Guy Fagherazzi; Antoine Racine; Domenico Palli; Vittorio Krogh; Rosario Tumino; Alessio Naccarati; Amalia Mattiello; Marcial Vicente Argüelles; Maria José Sanchez; Maria José Tormo; Eva Ardanaz; Miren Dorronsoro; Catalina Bonet; Kay-Tee Khaw; Tim Key; Antonia Trichopoulou; Philippos Orfanos; Androniki Naska; Rudolph R Kaaks; Annekatrin Lukanova; Tobias Pischon; Ingrid Ljuslinder; Karin Jirström; Bodil Ohlsson; Kim Overvad; Tina Landsvig Berentzen; Jytte Halkjaer; Anne Tjonneland; Elisabete Weiderpass; Guri Skeie; Tonje Braaten; Peter D Siersema; Heinz Freisling; Pietro Ferrari; Petra H M Peeters; Anne M May

doi:10.3945/ajcn.113.066530

Weight change later in life and colon and rectal cancer risk in participants in the EPIC-PANACEA study

Charlotte N Steins Bisschop, Carla H van Gils, Marleen J Emaus, H Bas Bueno-de-Mesquita, Evelyn M Monninkhof, Heiner Boeing, Krasmira Aleksandrova, Mazda Jenab, Teresa Norat, Elio Riboli, Marie-Christine Boutron-Rualt, Guy Fagherazzi, Antoine Racine, Domenico Palli, Vittorio Krogh, Rosario Tumino, Alessio Naccarati, Amalia Mattiello, Marcial Vicente Argüelles, Maria José SanchezMaria José Tormo, Eva Ardanaz, Miren Dorronsoro, Catalina Bonet, Kay-Tee Khaw, Tim Key, Antonia Trichopoulou, Philippos Orfanos, Androniki Naska, Rudolph R Kaaks, Annekatrin Lukanova, Tobias Pischon, Ingrid Ljuslinder, Karin Jirström, Bodil Ohlsson, Kim Overvad, Tina Landsvig Berentzen, Jytte Halkjaer, Anne Tjonneland, Elisabete Weiderpass, Guri Skeie, Tonje Braaten, Peter D Siersema, Heinz Freisling, Pietro Ferrari, Petra H M Peeters, Anne M May

37 Citationer (Scopus)

Abstract

BACKGROUND: A moderate association exists between body mass index (BMI) and colorectal cancer. Less is known about the effect of weight change.

OBJECTIVE: We investigated the relation between BMI and weight change and subsequent colon and rectal cancer risk.

DESIGN: This was studied among 328,781 participants in the prospective European Prospective Investigation into Cancer-Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating study (mean age: 50 y). Body weight was assessed at recruitment and on average 5 y later. Self-reported weight change (kg/y) was categorized in sex-specific quintiles, with quintiles 2 and 3 combined as the reference category (men: -0.6 to 0.3 kg/y; women: -0.4 to 0.4 kg/y). In the subsequent years, participants were followed for the occurrence of colon and rectal cancer (median period: 6.8 y). Multivariable Cox proportional hazards regression analyses were used to study the association.

RESULTS: A total of 1261 incident colon cancer and 747 rectal cancer cases were identified. BMI at recruitment was statistically significantly associated with colon cancer risk in men (HR: 1.04; 95% CI: 1.02, 1.07). Moderate weight gain (quintile 4) in men increased risk further (HR: 1.32; 95% CI: 1.04, 1.68), but this relation did not show a clear trend. In women, BMI or weight gain was not related to subsequent risk of colon cancer. No statistically significant associations for weight loss and colon cancer or for BMI and weight changes and rectal cancer were found.

CONCLUSIONS: BMI attained at adulthood was associated with colon cancer risk. Subsequent weight gain or loss was not related to colon or rectal cancer risk in men or women.

Originalsprog	Engelsk
Tidsskrift	The American journal of clinical nutrition
Vol/bind	99
Udgave nummer	1
Sider (fra-til)	139-47
Antal sider	9
ISSN	0002-9165
DOI	https://doi.org/10.3945/ajcn.113.066530
Status	Udgivet - jan. 2014

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10.3945/ajcn.113.066530

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Steins Bisschop, C. N., van Gils, C. H., Emaus, M. J., Bueno-de-Mesquita, H. B., Monninkhof, E. M., Boeing, H., Aleksandrova, K., Jenab, M., Norat, T., Riboli, E., Boutron-Rualt, M.-C., Fagherazzi, G., Racine, A., Palli, D., Krogh, V., Tumino, R., Naccarati, A., Mattiello, A., Argüelles, M. V., ... May, A. M. (2014). Weight change later in life and colon and rectal cancer risk in participants in the EPIC-PANACEA study. The American journal of clinical nutrition, 99(1), 139-47. https://doi.org/10.3945/ajcn.113.066530

Steins Bisschop, CN, van Gils, CH, Emaus, MJ, Bueno-de-Mesquita, HB, Monninkhof, EM, Boeing, H, Aleksandrova, K, Jenab, M, Norat, T, Riboli, E, Boutron-Rualt, M-C, Fagherazzi, G, Racine, A, Palli, D, Krogh, V, Tumino, R, Naccarati, A, Mattiello, A, Argüelles, MV, Sanchez, MJ, Tormo, MJ, Ardanaz, E, Dorronsoro, M, Bonet, C, Khaw, K-T, Key, T, Trichopoulou, A, Orfanos, P, Naska, A, Kaaks, RR, Lukanova, A, Pischon, T, Ljuslinder, I, Jirström, K, Ohlsson, B, Overvad, K, Berentzen, TL, Halkjaer, J, Tjonneland, A, Weiderpass, E, Skeie, G, Braaten, T, Siersema, PD, Freisling, H, Ferrari, P, Peeters, PHM & May, AM 2014, 'Weight change later in life and colon and rectal cancer risk in participants in the EPIC-PANACEA study', The American journal of clinical nutrition, bind 99, nr. 1, s. 139-47. https://doi.org/10.3945/ajcn.113.066530

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title = "Weight change later in life and colon and rectal cancer risk in participants in the EPIC-PANACEA study",

abstract = "BACKGROUND: A moderate association exists between body mass index (BMI) and colorectal cancer. Less is known about the effect of weight change.OBJECTIVE: We investigated the relation between BMI and weight change and subsequent colon and rectal cancer risk.DESIGN: This was studied among 328,781 participants in the prospective European Prospective Investigation into Cancer-Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating study (mean age: 50 y). Body weight was assessed at recruitment and on average 5 y later. Self-reported weight change (kg/y) was categorized in sex-specific quintiles, with quintiles 2 and 3 combined as the reference category (men: -0.6 to 0.3 kg/y; women: -0.4 to 0.4 kg/y). In the subsequent years, participants were followed for the occurrence of colon and rectal cancer (median period: 6.8 y). Multivariable Cox proportional hazards regression analyses were used to study the association.RESULTS: A total of 1261 incident colon cancer and 747 rectal cancer cases were identified. BMI at recruitment was statistically significantly associated with colon cancer risk in men (HR: 1.04; 95% CI: 1.02, 1.07). Moderate weight gain (quintile 4) in men increased risk further (HR: 1.32; 95% CI: 1.04, 1.68), but this relation did not show a clear trend. In women, BMI or weight gain was not related to subsequent risk of colon cancer. No statistically significant associations for weight loss and colon cancer or for BMI and weight changes and rectal cancer were found.CONCLUSIONS: BMI attained at adulthood was associated with colon cancer risk. Subsequent weight gain or loss was not related to colon or rectal cancer risk in men or women.",

keywords = "Adult, Body Mass Index, Colorectal Neoplasms, Endpoint Determination, Female, Follow-Up Studies, Humans, Incidence, Life Style, Male, Middle Aged, Motor Activity, Nutritional Status, Proportional Hazards Models, Prospective Studies, Questionnaires, Risk Assessment, Risk Factors, Self Report, Weight Gain, Weight Loss",

author = "{Steins Bisschop}, {Charlotte N} and {van Gils}, {Carla H} and Emaus, {Marleen J} and Bueno-de-Mesquita, {H Bas} and Monninkhof, {Evelyn M} and Heiner Boeing and Krasmira Aleksandrova and Mazda Jenab and Teresa Norat and Elio Riboli and Marie-Christine Boutron-Rualt and Guy Fagherazzi and Antoine Racine and Domenico Palli and Vittorio Krogh and Rosario Tumino and Alessio Naccarati and Amalia Mattiello and Arg{\"u}elles, {Marcial Vicente} and Sanchez, {Maria Jos{\'e}} and Tormo, {Maria Jos{\'e}} and Eva Ardanaz and Miren Dorronsoro and Catalina Bonet and Kay-Tee Khaw and Tim Key and Antonia Trichopoulou and Philippos Orfanos and Androniki Naska and Kaaks, {Rudolph R} and Annekatrin Lukanova and Tobias Pischon and Ingrid Ljuslinder and Karin Jirstr{\"o}m and Bodil Ohlsson and Kim Overvad and Berentzen, {Tina Landsvig} and Jytte Halkjaer and Anne Tjonneland and Elisabete Weiderpass and Guri Skeie and Tonje Braaten and Siersema, {Peter D} and Heinz Freisling and Pietro Ferrari and Peeters, {Petra H M} and May, {Anne M}",

year = "2014",

month = jan,

doi = "10.3945/ajcn.113.066530",

language = "English",

volume = "99",

pages = "139--47",

journal = "The American journal of clinical nutrition",

issn = "0002-9165",

publisher = "Elsevier BV",

number = "1",

}

TY - JOUR

T1 - Weight change later in life and colon and rectal cancer risk in participants in the EPIC-PANACEA study

AU - Steins Bisschop, Charlotte N

AU - van Gils, Carla H

AU - Emaus, Marleen J

AU - Bueno-de-Mesquita, H Bas

AU - Monninkhof, Evelyn M

AU - Boeing, Heiner

AU - Aleksandrova, Krasmira

AU - Jenab, Mazda

AU - Norat, Teresa

AU - Riboli, Elio

AU - Boutron-Rualt, Marie-Christine

AU - Fagherazzi, Guy

AU - Racine, Antoine

AU - Palli, Domenico

AU - Krogh, Vittorio

AU - Tumino, Rosario

AU - Naccarati, Alessio

AU - Mattiello, Amalia

AU - Argüelles, Marcial Vicente

AU - Sanchez, Maria José

AU - Tormo, Maria José

AU - Ardanaz, Eva

AU - Dorronsoro, Miren

AU - Bonet, Catalina

AU - Khaw, Kay-Tee

AU - Key, Tim

AU - Trichopoulou, Antonia

AU - Orfanos, Philippos

AU - Naska, Androniki

AU - Kaaks, Rudolph R

AU - Lukanova, Annekatrin

AU - Pischon, Tobias

AU - Ljuslinder, Ingrid

AU - Jirström, Karin

AU - Ohlsson, Bodil

AU - Overvad, Kim

AU - Berentzen, Tina Landsvig

AU - Halkjaer, Jytte

AU - Tjonneland, Anne

AU - Weiderpass, Elisabete

AU - Skeie, Guri

AU - Braaten, Tonje

AU - Siersema, Peter D

AU - Freisling, Heinz

AU - Ferrari, Pietro

AU - Peeters, Petra H M

AU - May, Anne M

PY - 2014/1

Y1 - 2014/1

N2 - BACKGROUND: A moderate association exists between body mass index (BMI) and colorectal cancer. Less is known about the effect of weight change.OBJECTIVE: We investigated the relation between BMI and weight change and subsequent colon and rectal cancer risk.DESIGN: This was studied among 328,781 participants in the prospective European Prospective Investigation into Cancer-Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating study (mean age: 50 y). Body weight was assessed at recruitment and on average 5 y later. Self-reported weight change (kg/y) was categorized in sex-specific quintiles, with quintiles 2 and 3 combined as the reference category (men: -0.6 to 0.3 kg/y; women: -0.4 to 0.4 kg/y). In the subsequent years, participants were followed for the occurrence of colon and rectal cancer (median period: 6.8 y). Multivariable Cox proportional hazards regression analyses were used to study the association.RESULTS: A total of 1261 incident colon cancer and 747 rectal cancer cases were identified. BMI at recruitment was statistically significantly associated with colon cancer risk in men (HR: 1.04; 95% CI: 1.02, 1.07). Moderate weight gain (quintile 4) in men increased risk further (HR: 1.32; 95% CI: 1.04, 1.68), but this relation did not show a clear trend. In women, BMI or weight gain was not related to subsequent risk of colon cancer. No statistically significant associations for weight loss and colon cancer or for BMI and weight changes and rectal cancer were found.CONCLUSIONS: BMI attained at adulthood was associated with colon cancer risk. Subsequent weight gain or loss was not related to colon or rectal cancer risk in men or women.

AB - BACKGROUND: A moderate association exists between body mass index (BMI) and colorectal cancer. Less is known about the effect of weight change.OBJECTIVE: We investigated the relation between BMI and weight change and subsequent colon and rectal cancer risk.DESIGN: This was studied among 328,781 participants in the prospective European Prospective Investigation into Cancer-Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating study (mean age: 50 y). Body weight was assessed at recruitment and on average 5 y later. Self-reported weight change (kg/y) was categorized in sex-specific quintiles, with quintiles 2 and 3 combined as the reference category (men: -0.6 to 0.3 kg/y; women: -0.4 to 0.4 kg/y). In the subsequent years, participants were followed for the occurrence of colon and rectal cancer (median period: 6.8 y). Multivariable Cox proportional hazards regression analyses were used to study the association.RESULTS: A total of 1261 incident colon cancer and 747 rectal cancer cases were identified. BMI at recruitment was statistically significantly associated with colon cancer risk in men (HR: 1.04; 95% CI: 1.02, 1.07). Moderate weight gain (quintile 4) in men increased risk further (HR: 1.32; 95% CI: 1.04, 1.68), but this relation did not show a clear trend. In women, BMI or weight gain was not related to subsequent risk of colon cancer. No statistically significant associations for weight loss and colon cancer or for BMI and weight changes and rectal cancer were found.CONCLUSIONS: BMI attained at adulthood was associated with colon cancer risk. Subsequent weight gain or loss was not related to colon or rectal cancer risk in men or women.

KW - Adult

KW - Body Mass Index

KW - Colorectal Neoplasms

KW - Endpoint Determination

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Life Style

KW - Male

KW - Middle Aged

KW - Motor Activity

KW - Nutritional Status

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Questionnaires

KW - Risk Assessment

KW - Risk Factors

KW - Self Report

KW - Weight Gain

KW - Weight Loss

U2 - 10.3945/ajcn.113.066530

DO - 10.3945/ajcn.113.066530

M3 - Journal article

C2 - 24225355

SN - 0002-9165

VL - 99

SP - 139

EP - 147

JO - The American journal of clinical nutrition

JF - The American journal of clinical nutrition

IS - 1

ER -

Weight change later in life and colon and rectal cancer risk in participants in the EPIC-PANACEA study

Abstract

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