Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Weekday variation in triglyceride concentrations in 1.8 million blood samples

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Lipoprotein(a): the common, likely causal, yet elusive risk factor for cardiovascular disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Mobility of HSPG-bound LPL explains how LPL is able to reach GPIHBP1 on capillaries

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Monoclonal Antibodies That Bind to the Ly6 Domain of GPIHBP1 Abolish the Binding of LPL

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Polygenic predisposition to breast cancer and the risk of coronary artery disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Loss-of-function mutations in filaggrin gene and malignant melanoma: a case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Triglyceride (TG) concentration is used as a marker of cardiometabolic risk. However, diurnal and possibly weekday variation exists in TG concentrations. The objective of this work was to investigate weekday variation in TG concentrations among 1.8 million blood samples drawn between 2008 and 2015 from patients in the Capital region of Denmark. Plasma TG was extracted from a central clinical laboratory information system. Weekday variation was investigated by means of linear mixed models. In addition to the profound diurnal variation, the TG concentration was 4.5% lower on Fridays compared with Mondays (P < 0.0001). The variation persisted after multiple adjustments for confounders and was consistent across all sensitivity analyses. Out-patients and in-patients, respectively, had 5.0% and 1.9% lower TG concentrations on Fridays compared with Mondays (both P < 0.0001). The highest weekday variations in TG concentrations were recorded for out-patients between the ages of 9 and 26 years, with up to 20% higher values on Mondays compared with Fridays (all P < 0.05). In conclusion, TG concentrations were highest after the weekend and gradually declined during the week. We suggest that unhealthy food intake and reduced physical activity during the weekend increase TG concentrations which track into the week. This weekday variation may carry implications for public health and future research practice.

OriginalsprogEngelsk
TidsskriftJournal of Lipid Research
Vol/bind58
Udgave nummer6
Sider (fra-til)1204-1213
Antal sider10
ISSN0022-2275
DOI
StatusUdgivet - jun. 2017

ID: 52424248